Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID39_LEIDO

TriTrypDb:

LdBPK_281400.1 , LdCL_280018600 , LDHU3_28.1760

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.540
CLV_C14_Caspase3-7	286	290	PF00656	0.672
CLV_C14_Caspase3-7	86	90	PF00656	0.596
CLV_NRD_NRD_1	18	20	PF00675	0.534
CLV_NRD_NRD_1	404	406	PF00675	0.532
CLV_NRD_NRD_1	423	425	PF00675	0.471
CLV_NRD_NRD_1	8	10	PF00675	0.597
CLV_NRD_NRD_1	83	85	PF00675	0.451
CLV_PCSK_KEX2_1	114	116	PF00082	0.534
CLV_PCSK_KEX2_1	306	308	PF00082	0.686
CLV_PCSK_KEX2_1	423	425	PF00082	0.563
CLV_PCSK_KEX2_1	8	10	PF00082	0.613
CLV_PCSK_KEX2_1	83	85	PF00082	0.451
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.583
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.685
CLV_PCSK_PC7_1	4	10	PF00082	0.720
CLV_PCSK_SKI1_1	114	118	PF00082	0.543
CLV_PCSK_SKI1_1	147	151	PF00082	0.507
DEG_APCC_KENBOX_2	214	218	PF00400	0.594
DEG_SPOP_SBC_1	190	194	PF00917	0.486
DOC_MAPK_gen_1	114	124	PF00069	0.494
DOC_MAPK_MEF2A_6	118	126	PF00069	0.507
DOC_USP7_MATH_1	103	107	PF00917	0.383
DOC_USP7_MATH_1	185	189	PF00917	0.557
DOC_USP7_MATH_1	190	194	PF00917	0.630
DOC_USP7_MATH_1	273	277	PF00917	0.718
DOC_USP7_MATH_1	31	35	PF00917	0.551
DOC_USP7_MATH_1	361	365	PF00917	0.733
DOC_USP7_UBL2_3	114	118	PF12436	0.570
DOC_WW_Pin1_4	231	236	PF00397	0.443
DOC_WW_Pin1_4	348	353	PF00397	0.590
DOC_WW_Pin1_4	430	435	PF00397	0.588
LIG_14-3-3_CanoR_1	147	153	PF00244	0.440
LIG_14-3-3_CanoR_1	19	23	PF00244	0.564
LIG_CSL_BTD_1	431	434	PF09270	0.602
LIG_FHA_1	251	257	PF00498	0.388
LIG_FHA_1	41	47	PF00498	0.538
LIG_FHA_1	5	11	PF00498	0.617
LIG_FHA_2	153	159	PF00498	0.505
LIG_FHA_2	174	180	PF00498	0.527
LIG_FHA_2	345	351	PF00498	0.586
LIG_Integrin_RGD_1	295	297	PF01839	0.586
LIG_Integrin_RGD_1	328	330	PF01839	0.524
LIG_LIR_Gen_1	156	167	PF02991	0.381
LIG_LIR_Gen_1	67	77	PF02991	0.386
LIG_LIR_Gen_1	89	99	PF02991	0.447
LIG_LIR_Nem_3	108	113	PF02991	0.466
LIG_LIR_Nem_3	156	162	PF02991	0.361
LIG_LIR_Nem_3	216	222	PF02991	0.562
LIG_LIR_Nem_3	330	336	PF02991	0.512
LIG_LIR_Nem_3	67	72	PF02991	0.351
LIG_LIR_Nem_3	89	94	PF02991	0.475
LIG_LYPXL_S_1	109	113	PF13949	0.487
LIG_LYPXL_yS_3	110	113	PF13949	0.495
LIG_PCNA_yPIPBox_3	93	107	PF02747	0.516
LIG_PDZ_Class_3	434	439	PF00595	0.617
LIG_Pex14_2	333	337	PF04695	0.474
LIG_SH2_CRK	159	163	PF00017	0.388
LIG_SH2_CRK	75	79	PF00017	0.401
LIG_SH2_CRK	91	95	PF00017	0.395
LIG_SH2_GRB2like	91	94	PF00017	0.504
LIG_SH2_STAP1	148	152	PF00017	0.553
LIG_SH2_STAP1	159	163	PF00017	0.204
LIG_SH3_1	269	275	PF00018	0.491
LIG_SH3_1	75	81	PF00018	0.402
LIG_SH3_2	78	83	PF14604	0.412
LIG_SH3_3	113	119	PF00018	0.543
LIG_SH3_3	269	275	PF00018	0.491
LIG_SH3_3	71	77	PF00018	0.385
LIG_Sin3_3	203	210	PF02671	0.550
LIG_SUMO_SIM_par_1	135	141	PF11976	0.361
LIG_TRAF2_1	396	399	PF00917	0.433
LIG_TRAF2_1	61	64	PF00917	0.532
LIG_WRC_WIRS_1	130	135	PF05994	0.491
LIG_WRC_WIRS_1	96	101	PF05994	0.401
MOD_CK1_1	132	138	PF00069	0.515
MOD_CK1_1	151	157	PF00069	0.319
MOD_CK1_1	18	24	PF00069	0.551
MOD_CK1_1	234	240	PF00069	0.520
MOD_CK1_1	277	283	PF00069	0.753
MOD_CK1_1	287	293	PF00069	0.742
MOD_CK1_1	348	354	PF00069	0.628
MOD_CK1_1	378	384	PF00069	0.763
MOD_CK1_1	419	425	PF00069	0.692
MOD_CK1_1	95	101	PF00069	0.385
MOD_CK2_1	152	158	PF00069	0.542
MOD_CK2_1	280	286	PF00069	0.761
MOD_CK2_1	344	350	PF00069	0.570
MOD_CK2_1	351	357	PF00069	0.710
MOD_CK2_1	58	64	PF00069	0.568
MOD_CK2_1	95	101	PF00069	0.428
MOD_GlcNHglycan	101	104	PF01048	0.519
MOD_GlcNHglycan	134	137	PF01048	0.350
MOD_GlcNHglycan	193	196	PF01048	0.689
MOD_GlcNHglycan	203	206	PF01048	0.612
MOD_GlcNHglycan	279	282	PF01048	0.807
MOD_GlcNHglycan	289	292	PF01048	0.791
MOD_GlcNHglycan	302	305	PF01048	0.689
MOD_GlcNHglycan	346	350	PF01048	0.531
MOD_GlcNHglycan	380	383	PF01048	0.756
MOD_GSK3_1	147	154	PF00069	0.467
MOD_GSK3_1	169	176	PF00069	0.536
MOD_GSK3_1	185	192	PF00069	0.449
MOD_GSK3_1	231	238	PF00069	0.445
MOD_GSK3_1	273	280	PF00069	0.686
MOD_GSK3_1	281	288	PF00069	0.695
MOD_GSK3_1	344	351	PF00069	0.545
MOD_GSK3_1	378	385	PF00069	0.791
MOD_GSK3_1	95	102	PF00069	0.512
MOD_N-GLC_1	173	178	PF02516	0.564
MOD_N-GLC_1	416	421	PF02516	0.654
MOD_N-GLC_1	92	97	PF02516	0.481
MOD_NEK2_1	152	157	PF00069	0.448
MOD_NEK2_1	191	196	PF00069	0.622
MOD_NEK2_1	375	380	PF00069	0.743
MOD_NEK2_1	416	421	PF00069	0.687
MOD_NEK2_1	428	433	PF00069	0.531
MOD_NEK2_1	99	104	PF00069	0.484
MOD_NEK2_2	218	223	PF00069	0.495
MOD_PIKK_1	235	241	PF00454	0.559
MOD_PIKK_1	394	400	PF00454	0.619
MOD_PKA_2	18	24	PF00069	0.608
MOD_PKA_2	277	283	PF00069	0.729
MOD_Plk_1	173	179	PF00069	0.531
MOD_Plk_1	416	422	PF00069	0.650
MOD_Plk_1	92	98	PF00069	0.479
MOD_Plk_4	173	179	PF00069	0.597
MOD_Plk_4	223	229	PF00069	0.395
MOD_Plk_4	363	369	PF00069	0.725
MOD_Plk_4	95	101	PF00069	0.398
MOD_ProDKin_1	231	237	PF00069	0.446
MOD_ProDKin_1	348	354	PF00069	0.603
MOD_ProDKin_1	430	436	PF00069	0.590
TRG_DiLeu_BaEn_1	158	163	PF01217	0.508
TRG_ENDOCYTIC_2	110	113	PF00928	0.495
TRG_ENDOCYTIC_2	159	162	PF00928	0.371
TRG_ENDOCYTIC_2	219	222	PF00928	0.463
TRG_ENDOCYTIC_2	91	94	PF00928	0.470
TRG_ER_diArg_1	122	125	PF00400	0.563
TRG_ER_diArg_1	423	425	PF00400	0.582
TRG_ER_diArg_1	8	10	PF00400	0.612
TRG_ER_diArg_1	82	84	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFK1	Leptomonas seymouri	63%	100%
A0A0S4JAC2	Bodo saltans	28%	100%
A0A1X0P2Q2	Trypanosomatidae	41%	100%
A0A422NY97	Trypanosoma rangeli	40%	100%
A4HGH6	Leishmania braziliensis	82%	97%
A4I3K8	Leishmania infantum	100%	100%
C9ZPW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AZU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8D7	Leishmania major	95%	100%
V5BAD6	Trypanosoma cruzi	42%	100%