Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID30_LEIDO

TriTrypDb:

LdBPK_180950.1 , LdCL_180014700 , LDHU3_18.1200

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ID30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.724
CLV_NRD_NRD_1	142	144	PF00675	0.708
CLV_NRD_NRD_1	174	176	PF00675	0.654
CLV_NRD_NRD_1	37	39	PF00675	0.372
CLV_NRD_NRD_1	425	427	PF00675	0.626
CLV_PCSK_FUR_1	140	144	PF00082	0.700
CLV_PCSK_FUR_1	172	176	PF00082	0.591
CLV_PCSK_FUR_1	423	427	PF00082	0.683
CLV_PCSK_KEX2_1	142	144	PF00082	0.708
CLV_PCSK_KEX2_1	174	176	PF00082	0.686
CLV_PCSK_KEX2_1	179	181	PF00082	0.680
CLV_PCSK_KEX2_1	23	25	PF00082	0.379
CLV_PCSK_KEX2_1	36	38	PF00082	0.370
CLV_PCSK_KEX2_1	416	418	PF00082	0.644
CLV_PCSK_KEX2_1	423	425	PF00082	0.593
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.778
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.379
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.644
CLV_PCSK_PC7_1	175	181	PF00082	0.783
CLV_PCSK_PC7_1	419	425	PF00082	0.698
CLV_PCSK_SKI1_1	175	179	PF00082	0.707
CLV_PCSK_SKI1_1	275	279	PF00082	0.472
DEG_Nend_UBRbox_4	1	3	PF02207	0.512
DEG_SPOP_SBC_1	364	368	PF00917	0.516
DEG_SPOP_SBC_1	84	88	PF00917	0.488
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.643
DOC_MAPK_MEF2A_6	26	34	PF00069	0.376
DOC_PP2B_LxvP_1	218	221	PF13499	0.643
DOC_USP7_MATH_1	204	208	PF00917	0.747
DOC_USP7_MATH_1	261	265	PF00917	0.694
DOC_USP7_MATH_1	339	343	PF00917	0.604
DOC_USP7_MATH_1	74	78	PF00917	0.498
DOC_USP7_MATH_1	84	88	PF00917	0.519
DOC_WW_Pin1_4	127	132	PF00397	0.685
DOC_WW_Pin1_4	257	262	PF00397	0.749
DOC_WW_Pin1_4	308	313	PF00397	0.602
DOC_WW_Pin1_4	365	370	PF00397	0.480
DOC_WW_Pin1_4	437	442	PF00397	0.517
DOC_WW_Pin1_4	55	60	PF00397	0.564
DOC_WW_Pin1_4	86	91	PF00397	0.540
LIG_14-3-3_CanoR_1	180	184	PF00244	0.678
LIG_14-3-3_CanoR_1	341	345	PF00244	0.520
LIG_14-3-3_CanoR_1	384	389	PF00244	0.444
LIG_14-3-3_CanoR_1	417	422	PF00244	0.717
LIG_14-3-3_CanoR_1	452	458	PF00244	0.451
LIG_14-3-3_CanoR_1	67	72	PF00244	0.520
LIG_14-3-3_CanoR_1	73	83	PF00244	0.481
LIG_14-3-3_CanoR_1	92	101	PF00244	0.466
LIG_BRCT_BRCA1_1	228	232	PF00533	0.775
LIG_FHA_1	195	201	PF00498	0.772
LIG_FHA_1	318	324	PF00498	0.582
LIG_FHA_1	366	372	PF00498	0.573
LIG_FHA_2	311	317	PF00498	0.663
LIG_LIR_Gen_1	229	238	PF02991	0.639
LIG_LIR_Nem_3	130	135	PF02991	0.648
LIG_LIR_Nem_3	229	235	PF02991	0.678
LIG_PDZ_Class_3	453	458	PF00595	0.661
LIG_Pex14_1	445	449	PF04695	0.495
LIG_SH2_CRK	284	288	PF00017	0.578
LIG_SH2_GRB2like	284	287	PF00017	0.572
LIG_SH2_NCK_1	400	404	PF00017	0.684
LIG_SH2_STAT5	226	229	PF00017	0.674
LIG_SH2_STAT5	449	452	PF00017	0.515
LIG_SH2_STAT5	8	11	PF00017	0.437
LIG_SH3_3	219	225	PF00018	0.727
LIG_SH3_3	230	236	PF00018	0.555
LIG_SH3_3	318	324	PF00018	0.578
LIG_SH3_3	56	62	PF00018	0.555
LIG_Sin3_3	12	19	PF02671	0.335
LIG_SUMO_SIM_par_1	194	201	PF11976	0.614
LIG_TRAF2_1	313	316	PF00917	0.582
LIG_TRAF2_1	427	430	PF00917	0.556
LIG_UBA3_1	14	23	PF00899	0.353
MOD_CDC14_SPxK_1	89	92	PF00782	0.484
MOD_CDK_SPK_2	437	442	PF00069	0.517
MOD_CDK_SPxK_1	86	92	PF00069	0.488
MOD_CDK_SPxxK_3	60	67	PF00069	0.498
MOD_CK1_1	152	158	PF00069	0.760
MOD_CK1_1	246	252	PF00069	0.643
MOD_CK1_1	259	265	PF00069	0.552
MOD_CK1_1	60	66	PF00069	0.494
MOD_CK1_1	86	92	PF00069	0.558
MOD_CK2_1	106	112	PF00069	0.509
MOD_CK2_1	179	185	PF00069	0.764
MOD_CK2_1	225	231	PF00069	0.678
MOD_CK2_1	310	316	PF00069	0.571
MOD_CK2_1	393	399	PF00069	0.676
MOD_Cter_Amidation	414	417	PF01082	0.746
MOD_Cter_Amidation	421	424	PF01082	0.585
MOD_GlcNHglycan	108	111	PF01048	0.693
MOD_GlcNHglycan	194	197	PF01048	0.823
MOD_GlcNHglycan	206	209	PF01048	0.594
MOD_GlcNHglycan	211	214	PF01048	0.459
MOD_GlcNHglycan	250	253	PF01048	0.600
MOD_GlcNHglycan	263	266	PF01048	0.579
MOD_GlcNHglycan	394	398	PF01048	0.641
MOD_GlcNHglycan	5	8	PF01048	0.428
MOD_GlcNHglycan	78	81	PF01048	0.522
MOD_GlcNHglycan	96	99	PF01048	0.531
MOD_GSK3_1	106	113	PF00069	0.617
MOD_GSK3_1	152	159	PF00069	0.738
MOD_GSK3_1	194	201	PF00069	0.830
MOD_GSK3_1	227	234	PF00069	0.734
MOD_GSK3_1	242	249	PF00069	0.714
MOD_GSK3_1	257	264	PF00069	0.642
MOD_GSK3_1	3	10	PF00069	0.443
MOD_GSK3_1	330	337	PF00069	0.510
MOD_GSK3_1	63	70	PF00069	0.508
MOD_GSK3_1	74	81	PF00069	0.487
MOD_GSK3_1	92	99	PF00069	0.529
MOD_NEK2_1	106	111	PF00069	0.708
MOD_NEK2_1	125	130	PF00069	0.622
MOD_NEK2_1	133	138	PF00069	0.654
MOD_NEK2_1	154	159	PF00069	0.748
MOD_NEK2_1	209	214	PF00069	0.647
MOD_NEK2_1	363	368	PF00069	0.547
MOD_NEK2_1	85	90	PF00069	0.543
MOD_PIKK_1	135	141	PF00454	0.627
MOD_PIKK_1	167	173	PF00454	0.811
MOD_PIKK_1	310	316	PF00454	0.674
MOD_PIKK_1	96	102	PF00454	0.453
MOD_PK_1	417	423	PF00069	0.707
MOD_PKA_1	179	185	PF00069	0.764
MOD_PKA_2	110	116	PF00069	0.712
MOD_PKA_2	149	155	PF00069	0.782
MOD_PKA_2	179	185	PF00069	0.685
MOD_PKA_2	287	293	PF00069	0.409
MOD_PKA_2	340	346	PF00069	0.530
MOD_PKA_2	451	457	PF00069	0.430
MOD_PKA_2	91	97	PF00069	0.469
MOD_PKB_1	308	316	PF00069	0.612
MOD_Plk_2-3	194	200	PF00069	0.678
MOD_Plk_4	110	116	PF00069	0.653
MOD_Plk_4	149	155	PF00069	0.818
MOD_Plk_4	179	185	PF00069	0.705
MOD_Plk_4	30	36	PF00069	0.363
MOD_ProDKin_1	127	133	PF00069	0.688
MOD_ProDKin_1	257	263	PF00069	0.743
MOD_ProDKin_1	308	314	PF00069	0.606
MOD_ProDKin_1	365	371	PF00069	0.481
MOD_ProDKin_1	437	443	PF00069	0.509
MOD_ProDKin_1	55	61	PF00069	0.563
MOD_ProDKin_1	86	92	PF00069	0.541
MOD_SUMO_for_1	359	362	PF00179	0.613
MOD_SUMO_for_1	45	48	PF00179	0.425
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.430
TRG_ENDOCYTIC_2	284	287	PF00928	0.572
TRG_ER_diArg_1	140	143	PF00400	0.721
TRG_ER_diArg_1	172	175	PF00400	0.703
TRG_ER_diArg_1	24	27	PF00400	0.383
TRG_ER_diArg_1	35	38	PF00400	0.356
TRG_ER_diArg_1	423	426	PF00400	0.632
TRG_NLS_MonoExtN_4	20	27	PF00514	0.364
TRG_NLS_MonoExtN_4	414	420	PF00514	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9K5	Leishmania braziliensis	75%	100%
A4HXW8	Leishmania infantum	99%	100%
E9ARN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4QDU7	Leishmania major	89%	100%
V5BRT0	Trypanosoma cruzi	36%	100%