Long-chain-fatty-acid-CoA ligase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

long-chain-fatty-acid-coA ligase protein,putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID29_LEIDO

TriTrypDb:

LdBPK_281250.1 , LdCL_280017100 , LDHU3_28.1570

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ID29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID29

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004467	long-chain fatty acid-CoA ligase activity	3	5
GO:0015645	fatty acid ligase activity	2	5
GO:0016405	CoA-ligase activity	4	9
GO:0016874	ligase activity	2	16
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	9
GO:0016878	acid-thiol ligase activity	4	9
GO:0140657	ATP-dependent activity	1	5
GO:0031957	very long-chain fatty acid-CoA ligase activity	3	1
GO:0016207	4-coumarate-CoA ligase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.447
CLV_NRD_NRD_1	293	295	PF00675	0.547
CLV_NRD_NRD_1	454	456	PF00675	0.386
CLV_NRD_NRD_1	465	467	PF00675	0.393
CLV_NRD_NRD_1	68	70	PF00675	0.364
CLV_PCSK_KEX2_1	197	199	PF00082	0.499
CLV_PCSK_KEX2_1	234	236	PF00082	0.424
CLV_PCSK_KEX2_1	266	268	PF00082	0.600
CLV_PCSK_KEX2_1	293	295	PF00082	0.672
CLV_PCSK_KEX2_1	68	70	PF00082	0.350
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.458
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.579
CLV_PCSK_SKI1_1	171	175	PF00082	0.460
CLV_PCSK_SKI1_1	229	233	PF00082	0.504
CLV_PCSK_SKI1_1	235	239	PF00082	0.556
CLV_PCSK_SKI1_1	26	30	PF00082	0.451
CLV_PCSK_SKI1_1	3	7	PF00082	0.417
CLV_PCSK_SKI1_1	35	39	PF00082	0.415
CLV_PCSK_SKI1_1	678	682	PF00082	0.300
CLV_PCSK_SKI1_1	700	704	PF00082	0.340
CLV_PCSK_SKI1_1	723	727	PF00082	0.267
CLV_PCSK_SKI1_1	732	736	PF00082	0.359
CLV_PCSK_SKI1_1	94	98	PF00082	0.425
CLV_Separin_Metazoa	720	724	PF03568	0.329
DEG_APCC_DBOX_1	38	46	PF00400	0.310
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DEG_ODPH_VHL_1	706	718	PF01847	0.275
DOC_CKS1_1	140	145	PF01111	0.324
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	512	518	PF00134	0.267
DOC_MAPK_gen_1	149	157	PF00069	0.380
DOC_MAPK_gen_1	342	352	PF00069	0.267
DOC_MAPK_gen_1	627	636	PF00069	0.358
DOC_MAPK_gen_1	699	705	PF00069	0.447
DOC_MAPK_gen_1	731	740	PF00069	0.462
DOC_PP1_RVXF_1	676	683	PF00149	0.275
DOC_PP2B_LxvP_1	483	486	PF13499	0.285
DOC_PP2B_LxvP_1	705	708	PF13499	0.275
DOC_PP4_FxxP_1	5	8	PF00568	0.483
DOC_USP7_MATH_1	250	254	PF00917	0.711
DOC_USP7_MATH_1	31	35	PF00917	0.331
DOC_USP7_MATH_1	337	341	PF00917	0.297
DOC_USP7_MATH_1	409	413	PF00917	0.392
DOC_USP7_MATH_1	566	570	PF00917	0.257
DOC_USP7_UBL2_3	234	238	PF12436	0.603
DOC_USP7_UBL2_3	272	276	PF12436	0.459
DOC_USP7_UBL2_3	728	732	PF12436	0.404
DOC_WW_Pin1_4	100	105	PF00397	0.599
DOC_WW_Pin1_4	139	144	PF00397	0.315
DOC_WW_Pin1_4	253	258	PF00397	0.453
DOC_WW_Pin1_4	4	9	PF00397	0.450
DOC_WW_Pin1_4	455	460	PF00397	0.267
DOC_WW_Pin1_4	526	531	PF00397	0.374
LIG_14-3-3_CanoR_1	3	8	PF00244	0.574
LIG_14-3-3_CanoR_1	502	512	PF00244	0.255
LIG_14-3-3_CanoR_1	618	622	PF00244	0.384
LIG_14-3-3_CanoR_1	678	683	PF00244	0.376
LIG_APCC_ABBAyCdc20_2	643	649	PF00400	0.291
LIG_BRCT_BRCA1_1	212	216	PF00533	0.505
LIG_Clathr_ClatBox_1	317	321	PF01394	0.275
LIG_deltaCOP1_diTrp_1	380	384	PF00928	0.356
LIG_EH1_1	396	404	PF00400	0.267
LIG_eIF4E_1	222	228	PF01652	0.428
LIG_FHA_1	114	120	PF00498	0.361
LIG_FHA_1	124	130	PF00498	0.297
LIG_FHA_1	168	174	PF00498	0.574
LIG_FHA_1	213	219	PF00498	0.448
LIG_FHA_1	238	244	PF00498	0.457
LIG_FHA_1	297	303	PF00498	0.525
LIG_FHA_1	370	376	PF00498	0.195
LIG_FHA_1	385	391	PF00498	0.351
LIG_FHA_1	4	10	PF00498	0.405
LIG_FHA_1	442	448	PF00498	0.300
LIG_FHA_1	598	604	PF00498	0.320
LIG_FHA_1	689	695	PF00498	0.342
LIG_FHA_1	724	730	PF00498	0.267
LIG_FHA_2	15	21	PF00498	0.433
LIG_FHA_2	218	224	PF00498	0.350
LIG_FHA_2	342	348	PF00498	0.433
LIG_FHA_2	417	423	PF00498	0.267
LIG_FHA_2	496	502	PF00498	0.267
LIG_FHA_2	579	585	PF00498	0.267
LIG_FHA_2	679	685	PF00498	0.381
LIG_GBD_Chelix_1	402	410	PF00786	0.187
LIG_LIR_Apic_2	246	250	PF02991	0.501
LIG_LIR_Apic_2	81	87	PF02991	0.475
LIG_LIR_Gen_1	180	188	PF02991	0.507
LIG_LIR_Gen_1	20	29	PF02991	0.339
LIG_LIR_Gen_1	437	447	PF02991	0.273
LIG_LIR_Gen_1	554	565	PF02991	0.273
LIG_LIR_Gen_1	713	722	PF02991	0.291
LIG_LIR_Nem_3	180	184	PF02991	0.486
LIG_LIR_Nem_3	20	24	PF02991	0.340
LIG_LIR_Nem_3	437	442	PF02991	0.280
LIG_LIR_Nem_3	444	449	PF02991	0.239
LIG_LIR_Nem_3	51	55	PF02991	0.299
LIG_LIR_Nem_3	554	560	PF02991	0.267
LIG_LIR_Nem_3	568	574	PF02991	0.232
LIG_LIR_Nem_3	713	718	PF02991	0.313
LIG_PCNA_yPIPBox_3	22	35	PF02747	0.316
LIG_Pex14_2	571	575	PF04695	0.249
LIG_SH2_CRK	125	129	PF00017	0.265
LIG_SH2_CRK	15	19	PF00017	0.314
LIG_SH2_CRK	336	340	PF00017	0.370
LIG_SH2_CRK	52	56	PF00017	0.332
LIG_SH2_CRK	613	617	PF00017	0.383
LIG_SH2_CRK	709	713	PF00017	0.272
LIG_SH2_GRB2like	574	577	PF00017	0.383
LIG_SH2_NCK_1	336	340	PF00017	0.226
LIG_SH2_NCK_1	557	561	PF00017	0.246
LIG_SH2_PTP2	446	449	PF00017	0.226
LIG_SH2_PTP2	715	718	PF00017	0.327
LIG_SH2_SRC	557	560	PF00017	0.268
LIG_SH2_STAP1	115	119	PF00017	0.340
LIG_SH2_STAP1	125	129	PF00017	0.227
LIG_SH2_STAP1	15	19	PF00017	0.311
LIG_SH2_STAP1	181	185	PF00017	0.446
LIG_SH2_STAP1	222	226	PF00017	0.346
LIG_SH2_STAP1	346	350	PF00017	0.275
LIG_SH2_STAP1	648	652	PF00017	0.393
LIG_SH2_STAT3	537	540	PF00017	0.275
LIG_SH2_STAT5	108	111	PF00017	0.558
LIG_SH2_STAT5	115	118	PF00017	0.410
LIG_SH2_STAT5	125	128	PF00017	0.283
LIG_SH2_STAT5	156	159	PF00017	0.379
LIG_SH2_STAT5	185	188	PF00017	0.572
LIG_SH2_STAT5	353	356	PF00017	0.266
LIG_SH2_STAT5	446	449	PF00017	0.245
LIG_SH2_STAT5	537	540	PF00017	0.383
LIG_SH2_STAT5	613	616	PF00017	0.383
LIG_SH2_STAT5	715	718	PF00017	0.328
LIG_SH3_1	197	203	PF00018	0.456
LIG_SH3_3	197	203	PF00018	0.470
LIG_SH3_3	40	46	PF00018	0.375
LIG_SH3_3	512	518	PF00018	0.258
LIG_SH3_3	524	530	PF00018	0.231
LIG_SH3_3	535	541	PF00018	0.279
LIG_SH3_3	600	606	PF00018	0.269
LIG_SH3_3	716	722	PF00018	0.249
LIG_SH3_3	84	90	PF00018	0.423
LIG_SH3_5	104	108	PF00018	0.368
LIG_SUMO_SIM_anti_2	619	626	PF11976	0.386
LIG_SUMO_SIM_anti_2	662	669	PF11976	0.346
LIG_TRAF2_1	287	290	PF00917	0.481
LIG_TYR_ITIM	13	18	PF00017	0.325
LIG_WRC_WIRS_1	418	423	PF05994	0.407
MOD_CDK_SPxxK_3	455	462	PF00069	0.327
MOD_CK1_1	209	215	PF00069	0.535
MOD_CK1_1	253	259	PF00069	0.631
MOD_CK1_1	355	361	PF00069	0.306
MOD_CK1_1	495	501	PF00069	0.266
MOD_CK2_1	14	20	PF00069	0.412
MOD_CK2_1	455	461	PF00069	0.267
MOD_CK2_1	495	501	PF00069	0.268
MOD_CK2_1	548	554	PF00069	0.423
MOD_CK2_1	578	584	PF00069	0.267
MOD_CK2_1	629	635	PF00069	0.336
MOD_CK2_1	678	684	PF00069	0.381
MOD_GlcNHglycan	159	163	PF01048	0.445
MOD_GlcNHglycan	252	255	PF01048	0.674
MOD_GlcNHglycan	259	262	PF01048	0.607
MOD_GlcNHglycan	321	324	PF01048	0.418
MOD_GlcNHglycan	339	342	PF01048	0.397
MOD_GlcNHglycan	354	357	PF01048	0.309
MOD_GlcNHglycan	479	482	PF01048	0.310
MOD_GlcNHglycan	493	497	PF01048	0.330
MOD_GlcNHglycan	550	553	PF01048	0.482
MOD_GlcNHglycan	631	634	PF01048	0.342
MOD_GSK3_1	109	116	PF00069	0.487
MOD_GSK3_1	123	130	PF00069	0.276
MOD_GSK3_1	158	165	PF00069	0.482
MOD_GSK3_1	206	213	PF00069	0.616
MOD_GSK3_1	253	260	PF00069	0.450
MOD_GSK3_1	337	344	PF00069	0.292
MOD_GSK3_1	351	358	PF00069	0.297
MOD_GSK3_1	526	533	PF00069	0.326
MOD_GSK3_1	688	695	PF00069	0.380
MOD_N-GLC_1	206	211	PF02516	0.532
MOD_N-GLC_1	576	581	PF02516	0.425
MOD_N-GLC_1	723	728	PF02516	0.311
MOD_NEK2_1	131	136	PF00069	0.377
MOD_NEK2_1	144	149	PF00069	0.449
MOD_NEK2_1	158	163	PF00069	0.319
MOD_NEK2_1	217	222	PF00069	0.466
MOD_NEK2_1	351	356	PF00069	0.310
MOD_NEK2_1	48	53	PF00069	0.302
MOD_NEK2_1	510	515	PF00069	0.265
MOD_NEK2_1	616	621	PF00069	0.266
MOD_NEK2_2	14	19	PF00069	0.309
MOD_NEK2_2	434	439	PF00069	0.383
MOD_NEK2_2	469	474	PF00069	0.275
MOD_NEK2_2	566	571	PF00069	0.303
MOD_PIKK_1	144	150	PF00454	0.431
MOD_PIKK_1	510	516	PF00454	0.324
MOD_PKA_2	341	347	PF00069	0.290
MOD_PKA_2	384	390	PF00069	0.331
MOD_PKA_2	617	623	PF00069	0.359
MOD_PKB_1	294	302	PF00069	0.495
MOD_PKB_1	676	684	PF00069	0.218
MOD_Plk_1	434	440	PF00069	0.271
MOD_Plk_1	636	642	PF00069	0.243
MOD_Plk_1	78	84	PF00069	0.359
MOD_Plk_4	115	121	PF00069	0.368
MOD_Plk_4	123	129	PF00069	0.273
MOD_Plk_4	14	20	PF00069	0.307
MOD_Plk_4	212	218	PF00069	0.552
MOD_Plk_4	313	319	PF00069	0.357
MOD_Plk_4	386	392	PF00069	0.300
MOD_Plk_4	441	447	PF00069	0.260
MOD_Plk_4	495	501	PF00069	0.268
MOD_Plk_4	533	539	PF00069	0.338
MOD_Plk_4	566	572	PF00069	0.262
MOD_Plk_4	611	617	PF00069	0.398
MOD_Plk_4	636	642	PF00069	0.417
MOD_Plk_4	660	666	PF00069	0.333
MOD_ProDKin_1	100	106	PF00069	0.589
MOD_ProDKin_1	139	145	PF00069	0.321
MOD_ProDKin_1	253	259	PF00069	0.454
MOD_ProDKin_1	4	10	PF00069	0.446
MOD_ProDKin_1	455	461	PF00069	0.267
MOD_ProDKin_1	526	532	PF00069	0.374
MOD_SUMO_rev_2	163	173	PF00179	0.454
MOD_SUMO_rev_2	230	240	PF00179	0.585
MOD_SUMO_rev_2	269	274	PF00179	0.517
MOD_SUMO_rev_2	696	701	PF00179	0.301
TRG_DiLeu_BaEn_1	471	476	PF01217	0.243
TRG_ENDOCYTIC_2	125	128	PF00928	0.235
TRG_ENDOCYTIC_2	15	18	PF00928	0.319
TRG_ENDOCYTIC_2	181	184	PF00928	0.423
TRG_ENDOCYTIC_2	21	24	PF00928	0.247
TRG_ENDOCYTIC_2	446	449	PF00928	0.249
TRG_ENDOCYTIC_2	52	55	PF00928	0.310
TRG_ENDOCYTIC_2	557	560	PF00928	0.246
TRG_ENDOCYTIC_2	613	616	PF00928	0.396
TRG_ENDOCYTIC_2	715	718	PF00928	0.310
TRG_ER_diArg_1	196	198	PF00400	0.438
TRG_ER_diArg_1	292	294	PF00400	0.611
TRG_ER_diArg_1	67	69	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IL67	Bodo saltans	42%	96%
A0A0S4J3H6	Bodo saltans	24%	100%
A0A1X0NYK4	Trypanosomatidae	51%	100%
A0A3R7KRF3	Trypanosoma rangeli	51%	100%
A0A3S7WVH9	Leishmania donovani	21%	100%
A0A3S7WVL1	Leishmania donovani	24%	100%
A4HA52	Leishmania braziliensis	20%	100%
A4HGG0	Leishmania braziliensis	82%	100%
A4HYA8	Leishmania infantum	24%	100%
A4HYB7	Leishmania infantum	21%	100%
A4I3J3	Leishmania infantum	99%	100%
D0A7V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AGS6	Leishmania infantum	24%	100%
E9AZT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P14912	Petroselinum crispum	23%	100%
Q4Q8F1	Leishmania major	92%	100%
Q4QDB5	Leishmania major	21%	100%
Q4QDB6	Leishmania major	24%	100%
V5AUI9	Trypanosoma cruzi	52%	100%