DUF2431 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF2431), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID26_LEIDO

TriTrypDb:

LdBPK_250030.1 , LdCL_250005200 , LDHU3_25.0040

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ID26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID26

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	6
GO:0001510	RNA methylation	4	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009451	RNA modification	5	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	6
GO:0031167	rRNA methylation	5	6
GO:0032259	methylation	2	6
GO:0034470	ncRNA processing	7	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0043414	macromolecule methylation	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0070475	rRNA base methylation	6	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008168	methyltransferase activity	4	6
GO:0008170	N-methyltransferase activity	5	6
GO:0008173	RNA methyltransferase activity	4	6
GO:0008649	rRNA methyltransferase activity	5	6
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0016436	rRNA (uridine) methyltransferase activity	6	6
GO:0016740	transferase activity	2	6
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0070042	rRNA (uridine-N3-)-methyltransferase activity	6	6
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140102	catalytic activity, acting on a rRNA	4	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.381
CLV_NRD_NRD_1	10	12	PF00675	0.584
CLV_NRD_NRD_1	100	102	PF00675	0.229
CLV_NRD_NRD_1	214	216	PF00675	0.518
CLV_NRD_NRD_1	432	434	PF00675	0.599
CLV_NRD_NRD_1	491	493	PF00675	0.577
CLV_NRD_NRD_1	51	53	PF00675	0.399
CLV_NRD_NRD_1	556	558	PF00675	0.555
CLV_NRD_NRD_1	83	85	PF00675	0.281
CLV_PCSK_KEX2_1	214	216	PF00082	0.518
CLV_PCSK_KEX2_1	42	44	PF00082	0.399
CLV_PCSK_KEX2_1	432	434	PF00082	0.599
CLV_PCSK_KEX2_1	491	493	PF00082	0.577
CLV_PCSK_KEX2_1	51	53	PF00082	0.229
CLV_PCSK_KEX2_1	556	558	PF00082	0.555
CLV_PCSK_KEX2_1	99	101	PF00082	0.337
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.399
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.337
CLV_PCSK_SKI1_1	276	280	PF00082	0.473
CLV_PCSK_SKI1_1	404	408	PF00082	0.538
CLV_PCSK_SKI1_1	51	55	PF00082	0.399
CLV_PCSK_SKI1_1	551	555	PF00082	0.532
CLV_PCSK_SKI1_1	556	560	PF00082	0.495
DOC_CKS1_1	388	393	PF01111	0.495
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.402
DOC_MAPK_gen_1	63	71	PF00069	0.399
DOC_MAPK_gen_1	84	92	PF00069	0.362
DOC_MAPK_MEF2A_6	123	131	PF00069	0.274
DOC_MAPK_MEF2A_6	63	71	PF00069	0.362
DOC_PP2B_LxvP_1	385	388	PF13499	0.550
DOC_PP4_FxxP_1	132	135	PF00568	0.399
DOC_PP4_FxxP_1	232	235	PF00568	0.421
DOC_USP7_MATH_1	190	194	PF00917	0.379
DOC_USP7_MATH_1	2	6	PF00917	0.645
DOC_USP7_MATH_1	202	206	PF00917	0.259
DOC_USP7_MATH_1	343	347	PF00917	0.618
DOC_USP7_MATH_1	405	409	PF00917	0.448
DOC_USP7_MATH_1	80	84	PF00917	0.362
DOC_USP7_UBL2_3	409	413	PF12436	0.500
DOC_WW_Pin1_4	387	392	PF00397	0.541
DOC_WW_Pin1_4	469	474	PF00397	0.568
DOC_WW_Pin1_4	529	534	PF00397	0.517
LIG_14-3-3_CanoR_1	11	15	PF00244	0.569
LIG_14-3-3_CanoR_1	315	325	PF00244	0.419
LIG_14-3-3_CanoR_1	378	384	PF00244	0.553
LIG_14-3-3_CanoR_1	51	59	PF00244	0.394
LIG_14-3-3_CanoR_1	517	524	PF00244	0.378
LIG_APCC_ABBA_1	393	398	PF00400	0.559
LIG_BRCT_BRCA1_1	149	153	PF00533	0.399
LIG_BRCT_BRCA1_1	204	208	PF00533	0.399
LIG_eIF4E_1	143	149	PF01652	0.399
LIG_FHA_1	14	20	PF00498	0.535
LIG_FHA_1	159	165	PF00498	0.297
LIG_FHA_1	290	296	PF00498	0.647
LIG_FHA_1	35	41	PF00498	0.324
LIG_FHA_1	388	394	PF00498	0.571
LIG_FHA_2	173	179	PF00498	0.337
LIG_FHA_2	268	274	PF00498	0.365
LIG_FHA_2	405	411	PF00498	0.539
LIG_FHA_2	52	58	PF00498	0.399
LIG_FHA_2	72	78	PF00498	0.386
LIG_LIR_Gen_1	193	203	PF02991	0.375
LIG_LIR_Gen_1	22	29	PF02991	0.423
LIG_LIR_Gen_1	268	277	PF02991	0.439
LIG_LIR_Gen_1	35	44	PF02991	0.294
LIG_LIR_Gen_1	362	371	PF02991	0.452
LIG_LIR_Gen_1	477	486	PF02991	0.581
LIG_LIR_Nem_3	140	146	PF02991	0.424
LIG_LIR_Nem_3	193	198	PF02991	0.379
LIG_LIR_Nem_3	205	211	PF02991	0.328
LIG_LIR_Nem_3	22	28	PF02991	0.427
LIG_LIR_Nem_3	268	272	PF02991	0.439
LIG_LIR_Nem_3	273	277	PF02991	0.409
LIG_LIR_Nem_3	35	41	PF02991	0.294
LIG_LIR_Nem_3	353	359	PF02991	0.458
LIG_LIR_Nem_3	362	368	PF02991	0.352
LIG_LIR_Nem_3	477	482	PF02991	0.587
LIG_MLH1_MIPbox_1	149	153	PF16413	0.399
LIG_MYND_1	325	329	PF01753	0.451
LIG_MYND_1	391	395	PF01753	0.575
LIG_PCNA_PIPBox_1	145	154	PF02747	0.375
LIG_PCNA_yPIPBox_3	236	244	PF02747	0.437
LIG_Pex14_1	365	369	PF04695	0.442
LIG_Pex14_2	92	96	PF04695	0.362
LIG_REV1ctd_RIR_1	150	158	PF16727	0.399
LIG_SH2_CRK	143	147	PF00017	0.337
LIG_SH2_CRK	38	42	PF00017	0.399
LIG_SH2_CRK	479	483	PF00017	0.578
LIG_SH2_GRB2like	211	214	PF00017	0.399
LIG_SH2_NCK_1	269	273	PF00017	0.452
LIG_SH2_PTP2	195	198	PF00017	0.362
LIG_SH2_SRC	359	362	PF00017	0.406
LIG_SH2_SRC	524	527	PF00017	0.490
LIG_SH2_STAP1	284	288	PF00017	0.597
LIG_SH2_STAP1	524	528	PF00017	0.495
LIG_SH2_STAT3	284	287	PF00017	0.617
LIG_SH2_STAT3	369	372	PF00017	0.451
LIG_SH2_STAT5	195	198	PF00017	0.399
LIG_SH2_STAT5	211	214	PF00017	0.407
LIG_SH2_STAT5	231	234	PF00017	0.254
LIG_SH2_STAT5	269	272	PF00017	0.459
LIG_SH2_STAT5	359	362	PF00017	0.444
LIG_SH2_STAT5	417	420	PF00017	0.559
LIG_SH2_STAT5	530	533	PF00017	0.420
LIG_SH2_STAT5	95	98	PF00017	0.475
LIG_SH3_1	389	395	PF00018	0.537
LIG_SH3_3	355	361	PF00018	0.456
LIG_SH3_3	385	391	PF00018	0.606
LIG_SH3_3	470	476	PF00018	0.564
LIG_SH3_3	543	549	PF00018	0.486
LIG_SUMO_SIM_par_1	171	179	PF11976	0.337
LIG_SUMO_SIM_par_1	25	31	PF11976	0.399
LIG_TRAF2_1	523	526	PF00917	0.485
LIG_TYR_ITIM	228	233	PF00017	0.413
LIG_TYR_ITSM	475	482	PF00017	0.595
LIG_WW_2	391	394	PF00397	0.580
MOD_CK1_1	114	120	PF00069	0.399
MOD_CK1_1	298	304	PF00069	0.595
MOD_CK1_1	316	322	PF00069	0.394
MOD_CK1_1	346	352	PF00069	0.568
MOD_CK2_1	152	158	PF00069	0.362
MOD_CK2_1	2	8	PF00069	0.644
MOD_CK2_1	267	273	PF00069	0.352
MOD_CK2_1	404	410	PF00069	0.539
MOD_CK2_1	565	571	PF00069	0.544
MOD_CK2_1	75	81	PF00069	0.379
MOD_GlcNHglycan	116	119	PF01048	0.514
MOD_GlcNHglycan	154	157	PF01048	0.399
MOD_GlcNHglycan	192	195	PF01048	0.379
MOD_GlcNHglycan	204	207	PF01048	0.291
MOD_GlcNHglycan	297	300	PF01048	0.583
MOD_GlcNHglycan	306	309	PF01048	0.569
MOD_GlcNHglycan	315	318	PF01048	0.471
MOD_GlcNHglycan	345	348	PF01048	0.523
MOD_GlcNHglycan	418	421	PF01048	0.476
MOD_GlcNHglycan	46	49	PF01048	0.422
MOD_GlcNHglycan	567	570	PF01048	0.541
MOD_GSK3_1	10	17	PF00069	0.571
MOD_GSK3_1	110	117	PF00069	0.493
MOD_GSK3_1	158	165	PF00069	0.337
MOD_GSK3_1	309	316	PF00069	0.579
MOD_GSK3_1	342	349	PF00069	0.646
MOD_GSK3_1	405	412	PF00069	0.512
MOD_GSK3_1	71	78	PF00069	0.399
MOD_N-GLC_1	110	115	PF02516	0.399
MOD_N-GLC_1	313	318	PF02516	0.570
MOD_N-GLC_1	32	37	PF02516	0.399
MOD_N-GLC_2	545	547	PF02516	0.359
MOD_NEK2_1	152	157	PF00069	0.499
MOD_NEK2_1	282	287	PF00069	0.519
MOD_NEK2_1	34	39	PF00069	0.450
MOD_NEK2_1	397	402	PF00069	0.530
MOD_NEK2_1	44	49	PF00069	0.351
MOD_PIKK_1	162	168	PF00454	0.274
MOD_PIKK_1	283	289	PF00454	0.549
MOD_PIKK_1	51	57	PF00454	0.362
MOD_PKA_1	42	48	PF00069	0.399
MOD_PKA_1	51	57	PF00069	0.229
MOD_PKA_2	10	16	PF00069	0.563
MOD_PKA_2	377	383	PF00069	0.512
MOD_PKA_2	42	48	PF00069	0.424
MOD_PKA_2	51	57	PF00069	0.348
MOD_PKA_2	562	568	PF00069	0.531
MOD_Plk_1	110	116	PF00069	0.399
MOD_Plk_1	309	315	PF00069	0.527
MOD_Plk_1	32	38	PF00069	0.399
MOD_Plk_1	397	403	PF00069	0.507
MOD_Plk_2-3	249	255	PF00069	0.359
MOD_Plk_4	301	307	PF00069	0.546
MOD_Plk_4	327	333	PF00069	0.498
MOD_Plk_4	361	367	PF00069	0.479
MOD_Plk_4	397	403	PF00069	0.556
MOD_Plk_4	474	480	PF00069	0.604
MOD_ProDKin_1	387	393	PF00069	0.531
MOD_ProDKin_1	469	475	PF00069	0.569
MOD_ProDKin_1	529	535	PF00069	0.523
TRG_DiLeu_BaEn_2	87	93	PF01217	0.362
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.454
TRG_ENDOCYTIC_2	143	146	PF00928	0.362
TRG_ENDOCYTIC_2	195	198	PF00928	0.399
TRG_ENDOCYTIC_2	230	233	PF00928	0.499
TRG_ENDOCYTIC_2	269	272	PF00928	0.447
TRG_ENDOCYTIC_2	38	41	PF00928	0.399
TRG_ENDOCYTIC_2	479	482	PF00928	0.579
TRG_ER_diArg_1	100	103	PF00400	0.396
TRG_ER_diArg_1	491	493	PF00400	0.577
TRG_ER_diArg_1	50	52	PF00400	0.399
TRG_NLS_Bipartite_1	84	103	PF00514	0.337
TRG_NLS_MonoExtC_3	98	103	PF00514	0.337
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HDV0	Leishmania braziliensis	68%	100%
A4I145	Leishmania infantum	100%	100%
E9AXY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QA93	Leishmania major	88%	100%