Ubiquitin-conjugating enzyme, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID23_LEIDO

TriTrypDb:

LdBPK_242230.1 , LdCL_240027900 , LDHU3_24.2720

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ID23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID23

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.507
CLV_C14_Caspase3-7	86	90	PF00656	0.615
CLV_NRD_NRD_1	258	260	PF00675	0.483
CLV_NRD_NRD_1	26	28	PF00675	0.433
CLV_NRD_NRD_1	263	265	PF00675	0.445
CLV_PCSK_KEX2_1	197	199	PF00082	0.579
CLV_PCSK_KEX2_1	258	260	PF00082	0.483
CLV_PCSK_KEX2_1	26	28	PF00082	0.433
CLV_PCSK_KEX2_1	263	265	PF00082	0.445
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.564
CLV_PCSK_PC7_1	254	260	PF00082	0.596
CLV_PCSK_SKI1_1	197	201	PF00082	0.554
CLV_PCSK_SKI1_1	226	230	PF00082	0.382
CLV_PCSK_SKI1_1	264	268	PF00082	0.501
CLV_PCSK_SKI1_1	27	31	PF00082	0.498
CLV_PCSK_SKI1_1	317	321	PF00082	0.644
CLV_PCSK_SKI1_1	67	71	PF00082	0.522
DEG_APCC_DBOX_1	316	324	PF00400	0.578
DEG_ODPH_VHL_1	99	111	PF01847	0.272
DEG_SCF_FBW7_2	41	46	PF00400	0.602
DEG_SPOP_SBC_1	59	63	PF00917	0.597
DOC_CYCLIN_RxL_1	16	28	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	71	74	PF00134	0.433
DOC_MAPK_DCC_7	132	142	PF00069	0.444
DOC_MAPK_gen_1	197	203	PF00069	0.492
DOC_MAPK_gen_1	26	32	PF00069	0.495
DOC_MAPK_MEF2A_6	214	222	PF00069	0.504
DOC_PP1_RVXF_1	224	230	PF00149	0.439
DOC_PP2B_LxvP_1	70	73	PF13499	0.445
DOC_PP4_FxxP_1	135	138	PF00568	0.344
DOC_USP7_MATH_1	145	149	PF00917	0.369
DOC_USP7_MATH_1	190	194	PF00917	0.737
DOC_USP7_MATH_1	2	6	PF00917	0.646
DOC_USP7_MATH_2	231	237	PF00917	0.517
DOC_WW_Pin1_4	110	115	PF00397	0.324
DOC_WW_Pin1_4	179	184	PF00397	0.734
DOC_WW_Pin1_4	188	193	PF00397	0.735
DOC_WW_Pin1_4	237	242	PF00397	0.488
DOC_WW_Pin1_4	39	44	PF00397	0.678
DOC_WW_Pin1_4	4	9	PF00397	0.707
DOC_WW_Pin1_4	61	66	PF00397	0.566
DOC_WW_Pin1_4	81	86	PF00397	0.717
LIG_14-3-3_CanoR_1	214	218	PF00244	0.419
LIG_14-3-3_CanoR_1	263	273	PF00244	0.529
LIG_Actin_WH2_2	52	69	PF00022	0.640
LIG_APCC_ABBA_1	200	205	PF00400	0.419
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_deltaCOP1_diTrp_1	233	238	PF00928	0.601
LIG_FHA_1	141	147	PF00498	0.489
LIG_FHA_1	265	271	PF00498	0.530
LIG_FHA_1	302	308	PF00498	0.743
LIG_FHA_1	314	320	PF00498	0.496
LIG_FHA_1	32	38	PF00498	0.534
LIG_FHA_1	61	67	PF00498	0.552
LIG_FHA_2	189	195	PF00498	0.662
LIG_FHA_2	243	249	PF00498	0.567
LIG_FHA_2	297	303	PF00498	0.603
LIG_FHA_2	40	46	PF00498	0.729
LIG_LIR_Apic_2	236	241	PF02991	0.474
LIG_LIR_Gen_1	204	215	PF02991	0.496
LIG_LIR_Nem_3	102	108	PF02991	0.362
LIG_LIR_Nem_3	17	23	PF02991	0.502
LIG_LIR_Nem_3	204	210	PF02991	0.433
LIG_MYND_1	97	101	PF01753	0.529
LIG_Pex14_2	125	129	PF04695	0.423
LIG_Pex14_2	288	292	PF04695	0.637
LIG_SH2_NCK_1	207	211	PF00017	0.531
LIG_SH2_STAP1	315	319	PF00017	0.650
LIG_SH2_STAT5	126	129	PF00017	0.405
LIG_SH2_STAT5	18	21	PF00017	0.475
LIG_SH2_STAT5	24	27	PF00017	0.411
LIG_SH2_STAT5	279	282	PF00017	0.542
LIG_SH2_STAT5	315	318	PF00017	0.653
LIG_SH2_STAT5	76	79	PF00017	0.610
LIG_SH3_3	108	114	PF00018	0.400
LIG_SH3_3	124	130	PF00018	0.296
LIG_SH3_3	131	137	PF00018	0.369
LIG_SH3_3	196	202	PF00018	0.590
LIG_SH3_4	274	281	PF00018	0.681
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.703
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.435
LIG_SUMO_SIM_par_1	138	143	PF11976	0.380
LIG_SUMO_SIM_par_1	28	34	PF11976	0.503
LIG_TRAF2_1	202	205	PF00917	0.521
LIG_TRAF2_1	43	46	PF00917	0.706
LIG_WW_1	73	76	PF00397	0.568
MOD_CDC14_SPxK_1	182	185	PF00782	0.714
MOD_CDC14_SPxK_1	64	67	PF00782	0.414
MOD_CDK_SPxK_1	179	185	PF00069	0.714
MOD_CDK_SPxK_1	61	67	PF00069	0.455
MOD_CDK_SPxxK_3	113	120	PF00069	0.369
MOD_CK1_1	113	119	PF00069	0.485
MOD_CK1_1	12	18	PF00069	0.560
MOD_CK1_1	171	177	PF00069	0.758
MOD_CK1_1	188	194	PF00069	0.677
MOD_CK1_1	237	243	PF00069	0.621
MOD_CK1_1	39	45	PF00069	0.761
MOD_CK1_1	4	10	PF00069	0.741
MOD_CK1_1	58	64	PF00069	0.473
MOD_CK2_1	188	194	PF00069	0.671
MOD_CK2_1	39	45	PF00069	0.730
MOD_GlcNHglycan	163	166	PF01048	0.689
MOD_GlcNHglycan	248	251	PF01048	0.677
MOD_GlcNHglycan	38	41	PF01048	0.665
MOD_GlcNHglycan	85	88	PF01048	0.649
MOD_GSK3_1	168	175	PF00069	0.728
MOD_GSK3_1	184	191	PF00069	0.740
MOD_GSK3_1	233	240	PF00069	0.533
MOD_GSK3_1	242	249	PF00069	0.668
MOD_GSK3_1	292	299	PF00069	0.602
MOD_GSK3_1	301	308	PF00069	0.747
MOD_GSK3_1	51	58	PF00069	0.781
MOD_GSK3_1	79	86	PF00069	0.676
MOD_NEK2_1	1	6	PF00069	0.665
MOD_NEK2_1	19	24	PF00069	0.452
MOD_NEK2_1	213	218	PF00069	0.427
MOD_NEK2_1	30	35	PF00069	0.445
MOD_NEK2_1	303	308	PF00069	0.585
MOD_NEK2_2	192	197	PF00069	0.621
MOD_PIKK_1	264	270	PF00454	0.513
MOD_PK_1	51	57	PF00069	0.725
MOD_PKA_2	213	219	PF00069	0.426
MOD_PKA_2	246	252	PF00069	0.569
MOD_PKA_2	262	268	PF00069	0.498
MOD_Plk_4	213	219	PF00069	0.426
MOD_ProDKin_1	110	116	PF00069	0.324
MOD_ProDKin_1	179	185	PF00069	0.735
MOD_ProDKin_1	188	194	PF00069	0.731
MOD_ProDKin_1	237	243	PF00069	0.487
MOD_ProDKin_1	39	45	PF00069	0.684
MOD_ProDKin_1	4	10	PF00069	0.706
MOD_ProDKin_1	61	67	PF00069	0.561
MOD_ProDKin_1	81	87	PF00069	0.721
TRG_AP2beta_CARGO_1	17	27	PF09066	0.591
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.490
TRG_ENDOCYTIC_2	126	129	PF00928	0.370
TRG_ENDOCYTIC_2	207	210	PF00928	0.430
TRG_ER_diArg_1	25	27	PF00400	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S2	Leptomonas seymouri	51%	100%
A0A1X0NWL0	Trypanosomatidae	34%	100%
A0A3S5IS47	Trypanosoma rangeli	34%	100%
A4HDS5	Leishmania braziliensis	72%	98%
A4I123	Leishmania infantum	99%	100%
E9AX60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAB6	Leishmania major	91%	100%
V5BEA3	Trypanosoma cruzi	34%	100%