Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID18_LEIDO

TriTrypDb:

LdBPK_242310.1 , LdCL_240028700 , LDHU3_24.2860

Length:

397

Annotations

LeishMANIAdb annotations

Probably a secreted protein, similarly to its distant eukaryotic torsin homologs, involved in secretory processes. Also similar to bacterial ClpB ATPases, with chaperoning function.. Might be associated to known or unknown protein secretion pathways.. Localization: Endosomal (by homology)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 8
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID18

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016462	pyrophosphatase activity	5	16
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	16
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	16
GO:0016887	ATP hydrolysis activity	7	16
GO:0017076	purine nucleotide binding	4	16
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	369	371	PF00675	0.281
CLV_NRD_NRD_1	47	49	PF00675	0.636
CLV_PCSK_FUR_1	80	84	PF00082	0.535
CLV_PCSK_KEX2_1	369	371	PF00082	0.281
CLV_PCSK_KEX2_1	82	84	PF00082	0.522
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.560
CLV_PCSK_SKI1_1	242	246	PF00082	0.434
CLV_PCSK_SKI1_1	316	320	PF00082	0.370
CLV_PCSK_SKI1_1	51	55	PF00082	0.512
DEG_APCC_DBOX_1	102	110	PF00400	0.273
DOC_CYCLIN_RxL_1	238	246	PF00134	0.537
DOC_CYCLIN_RxL_1	313	322	PF00134	0.494
DOC_MAPK_DCC_7	168	176	PF00069	0.274
DOC_MAPK_gen_1	125	134	PF00069	0.361
DOC_MAPK_gen_1	369	375	PF00069	0.472
DOC_MAPK_MEF2A_6	127	136	PF00069	0.353
DOC_MAPK_MEF2A_6	168	176	PF00069	0.382
DOC_MAPK_MEF2A_6	268	277	PF00069	0.521
DOC_MAPK_MEF2A_6	6	14	PF00069	0.451
DOC_PP1_RVXF_1	323	330	PF00149	0.572
DOC_PP2B_LxvP_1	18	21	PF13499	0.440
DOC_PP4_FxxP_1	23	26	PF00568	0.350
DOC_USP7_MATH_1	143	147	PF00917	0.397
DOC_USP7_MATH_1	218	222	PF00917	0.392
DOC_WW_Pin1_4	202	207	PF00397	0.366
DOC_WW_Pin1_4	67	72	PF00397	0.296
LIG_14-3-3_CanoR_1	210	215	PF00244	0.344
LIG_14-3-3_CanoR_1	240	245	PF00244	0.587
LIG_14-3-3_CanoR_1	248	258	PF00244	0.544
LIG_14-3-3_CanoR_1	369	374	PF00244	0.488
LIG_14-3-3_CanoR_1	90	95	PF00244	0.379
LIG_Actin_WH2_2	54	69	PF00022	0.305
LIG_APCC_ABBA_1	187	192	PF00400	0.367
LIG_APCC_ABBAyCdc20_2	370	376	PF00400	0.462
LIG_CtBP_PxDLS_1	274	278	PF00389	0.491
LIG_FHA_1	142	148	PF00498	0.383
LIG_FHA_1	149	155	PF00498	0.341
LIG_FHA_1	3	9	PF00498	0.347
LIG_FHA_1	313	319	PF00498	0.599
LIG_FHA_1	353	359	PF00498	0.713
LIG_FHA_1	370	376	PF00498	0.583
LIG_FHA_2	155	161	PF00498	0.337
LIG_FHA_2	192	198	PF00498	0.402
LIG_FHA_2	277	283	PF00498	0.497
LIG_Integrin_isoDGR_2	323	325	PF01839	0.292
LIG_IRF3_LxIS_1	270	276	PF10401	0.575
LIG_IRF3_LxIS_1	298	304	PF10401	0.459
LIG_KLC1_Yacidic_2	356	361	PF13176	0.534
LIG_LIR_Apic_2	25	31	PF02991	0.469
LIG_LIR_Gen_1	252	263	PF02991	0.558
LIG_LIR_Gen_1	356	367	PF02991	0.658
LIG_LIR_Nem_3	252	258	PF02991	0.506
LIG_LIR_Nem_3	269	275	PF02991	0.454
LIG_LIR_Nem_3	356	362	PF02991	0.692
LIG_LIR_Nem_3	70	76	PF02991	0.378
LIG_NRBOX	14	20	PF00104	0.347
LIG_NRBOX	334	340	PF00104	0.510
LIG_SH2_PTP2	28	31	PF00017	0.356
LIG_SH2_SRC	28	31	PF00017	0.342
LIG_SH2_SRC	359	362	PF00017	0.694
LIG_SH2_SRC	84	87	PF00017	0.265
LIG_SH2_STAP1	259	263	PF00017	0.609
LIG_SH2_STAT5	28	31	PF00017	0.356
LIG_SH2_STAT5	359	362	PF00017	0.642
LIG_SH2_STAT5	76	79	PF00017	0.321
LIG_SH2_STAT5	84	87	PF00017	0.317
LIG_SH3_1	268	274	PF00018	0.541
LIG_SH3_1	62	68	PF00018	0.291
LIG_SH3_3	200	206	PF00018	0.309
LIG_SH3_3	212	218	PF00018	0.380
LIG_SH3_3	268	274	PF00018	0.516
LIG_SH3_3	62	68	PF00018	0.414
LIG_SUMO_SIM_par_1	149	155	PF11976	0.299
LIG_SUMO_SIM_par_1	224	232	PF11976	0.240
LIG_SUMO_SIM_par_1	273	279	PF11976	0.586
LIG_UBA3_1	131	139	PF00899	0.253
MOD_CDK_SPxxK_3	67	74	PF00069	0.286
MOD_CK1_1	155	161	PF00069	0.313
MOD_CK1_1	276	282	PF00069	0.499
MOD_CK2_1	160	166	PF00069	0.333
MOD_CK2_1	191	197	PF00069	0.386
MOD_CK2_1	210	216	PF00069	0.343
MOD_CK2_1	240	246	PF00069	0.571
MOD_CK2_1	94	100	PF00069	0.286
MOD_DYRK1A_RPxSP_1	202	206	PF00069	0.282
MOD_GlcNHglycan	154	157	PF01048	0.474
MOD_GlcNHglycan	293	296	PF01048	0.356
MOD_GlcNHglycan	305	308	PF01048	0.272
MOD_GlcNHglycan	349	352	PF01048	0.394
MOD_GlcNHglycan	62	65	PF01048	0.658
MOD_GSK3_1	143	150	PF00069	0.310
MOD_GSK3_1	192	199	PF00069	0.364
MOD_GSK3_1	236	243	PF00069	0.563
MOD_GSK3_1	262	269	PF00069	0.509
MOD_GSK3_1	377	384	PF00069	0.584
MOD_GSK3_1	385	392	PF00069	0.663
MOD_GSK3_1	90	97	PF00069	0.415
MOD_N-GLC_1	344	349	PF02516	0.361
MOD_NEK2_1	152	157	PF00069	0.274
MOD_NEK2_1	381	386	PF00069	0.609
MOD_NEK2_1	57	62	PF00069	0.351
MOD_OFUCOSY	140	145	PF10250	0.600
MOD_PK_1	90	96	PF00069	0.417
MOD_PKA_1	369	375	PF00069	0.472
MOD_PKA_2	209	215	PF00069	0.346
MOD_PKA_2	369	375	PF00069	0.498
MOD_PKB_1	238	246	PF00069	0.563
MOD_Plk_1	148	154	PF00069	0.310
MOD_Plk_1	191	197	PF00069	0.341
MOD_Plk_1	49	55	PF00069	0.413
MOD_Plk_2-3	160	166	PF00069	0.353
MOD_Plk_2-3	192	198	PF00069	0.390
MOD_Plk_4	148	154	PF00069	0.300
MOD_Plk_4	240	246	PF00069	0.597
MOD_Plk_4	369	375	PF00069	0.584
MOD_Plk_4	94	100	PF00069	0.384
MOD_ProDKin_1	202	208	PF00069	0.365
MOD_ProDKin_1	67	73	PF00069	0.282
TRG_DiLeu_BaEn_2	245	251	PF01217	0.605
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.290
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.269
TRG_ENDOCYTIC_2	159	162	PF00928	0.363
TRG_ENDOCYTIC_2	359	362	PF00928	0.620
TRG_ER_diArg_1	101	104	PF00400	0.379
TRG_ER_diArg_1	368	370	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R1	Leptomonas seymouri	59%	100%
A0A0N1PFB4	Leptomonas seymouri	36%	80%
A0A0S4KNW8	Bodo saltans	39%	100%
A0A1X0NMJ2	Trypanosomatidae	34%	90%
A0A1X0NW12	Trypanosomatidae	43%	100%
A0A3R7RCD3	Trypanosoma rangeli	34%	89%
A0A422N6P1	Trypanosoma rangeli	46%	100%
A4H5R3	Leishmania braziliensis	30%	71%
A4I131	Leishmania infantum	100%	100%
C9ZW77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A9G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	92%
E9AX68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QAA8	Leishmania major	94%	100%
V5B864	Trypanosoma cruzi	34%	89%