Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID14_LEIDO

TriTrypDb:

LdBPK_140160.1 , LdCL_140006500 , LDHU3_14.0200

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ID14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.471
CLV_NRD_NRD_1	165	167	PF00675	0.687
CLV_NRD_NRD_1	168	170	PF00675	0.683
CLV_NRD_NRD_1	93	95	PF00675	0.725
CLV_PCSK_FUR_1	166	170	PF00082	0.629
CLV_PCSK_FUR_1	93	97	PF00082	0.599
CLV_PCSK_KEX2_1	12	14	PF00082	0.471
CLV_PCSK_KEX2_1	168	170	PF00082	0.578
CLV_PCSK_KEX2_1	190	192	PF00082	0.691
CLV_PCSK_KEX2_1	38	40	PF00082	0.529
CLV_PCSK_KEX2_1	74	76	PF00082	0.605
CLV_PCSK_KEX2_1	78	80	PF00082	0.616
CLV_PCSK_KEX2_1	93	95	PF00082	0.657
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.615
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.552
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.505
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.601
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.615
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.549
CLV_PCSK_SKI1_1	170	174	PF00082	0.626
CLV_PCSK_SKI1_1	208	212	PF00082	0.563
CLV_PCSK_SKI1_1	341	345	PF00082	0.513
CLV_PCSK_SKI1_1	75	79	PF00082	0.736
DEG_SCF_FBW7_2	318	324	PF00400	0.564
DOC_CDC14_PxL_1	180	188	PF14671	0.627
DOC_CDC14_PxL_1	243	251	PF14671	0.497
DOC_CKS1_1	318	323	PF01111	0.563
DOC_MAPK_MEF2A_6	227	234	PF00069	0.436
DOC_MAPK_MEF2A_6	331	339	PF00069	0.417
DOC_MAPK_MEF2A_6	341	349	PF00069	0.341
DOC_MAPK_NFAT4_5	227	235	PF00069	0.435
DOC_PP1_RVXF_1	339	345	PF00149	0.528
DOC_PP2B_LxvP_1	119	122	PF13499	0.718
DOC_PP4_FxxP_1	257	260	PF00568	0.642
DOC_USP7_MATH_1	172	176	PF00917	0.675
DOC_USP7_MATH_1	85	89	PF00917	0.636
DOC_USP7_UBL2_3	74	78	PF12436	0.553
DOC_WW_Pin1_4	208	213	PF00397	0.503
DOC_WW_Pin1_4	280	285	PF00397	0.576
DOC_WW_Pin1_4	308	313	PF00397	0.627
DOC_WW_Pin1_4	317	322	PF00397	0.608
DOC_WW_Pin1_4	80	85	PF00397	0.539
DOC_WW_Pin1_4	98	103	PF00397	0.801
LIG_14-3-3_CanoR_1	169	175	PF00244	0.582
LIG_14-3-3_CanoR_1	236	243	PF00244	0.546
LIG_14-3-3_CanoR_1	276	280	PF00244	0.553
LIG_14-3-3_CanoR_1	331	336	PF00244	0.442
LIG_14-3-3_CanoR_1	96	101	PF00244	0.764
LIG_APCC_ABBA_1	294	299	PF00400	0.552
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_BIR_III_4	130	134	PF00653	0.544
LIG_BRCT_BRCA1_1	282	286	PF00533	0.563
LIG_deltaCOP1_diTrp_1	66	73	PF00928	0.580
LIG_FHA_1	169	175	PF00498	0.684
LIG_FHA_1	320	326	PF00498	0.664
LIG_FHA_1	352	358	PF00498	0.428
LIG_FHA_2	3	9	PF00498	0.502
LIG_FHA_2	59	65	PF00498	0.559
LIG_FHA_2	87	93	PF00498	0.797
LIG_Integrin_RGD_1	123	125	PF01839	0.485
LIG_LIR_Nem_3	338	343	PF02991	0.450
LIG_NRBOX	113	119	PF00104	0.606
LIG_Pex14_2	213	217	PF04695	0.574
LIG_Pex14_2	340	344	PF04695	0.522
LIG_SH2_PTP2	305	308	PF00017	0.451
LIG_SH2_SRC	305	308	PF00017	0.427
LIG_SH2_STAP1	23	27	PF00017	0.396
LIG_SH2_STAT5	305	308	PF00017	0.393
LIG_SH2_STAT5	351	354	PF00017	0.502
LIG_SH2_STAT5	4	7	PF00017	0.576
LIG_SH3_3	209	215	PF00018	0.573
LIG_SH3_3	312	318	PF00018	0.620
LIG_SH3_3	339	345	PF00018	0.468
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.642
LIG_SUMO_SIM_par_1	142	148	PF11976	0.541
LIG_TRAF2_1	137	140	PF00917	0.709
LIG_TRAF2_1	289	292	PF00917	0.551
LIG_TRAF2_1	5	8	PF00917	0.423
LIG_TRAF2_1	61	64	PF00917	0.584
LIG_WW_3	120	124	PF00397	0.550
MOD_CK1_1	88	94	PF00069	0.721
MOD_CK2_1	2	8	PF00069	0.588
MOD_CK2_1	58	64	PF00069	0.599
MOD_CK2_1	86	92	PF00069	0.696
MOD_DYRK1A_RPxSP_1	208	212	PF00069	0.455
MOD_DYRK1A_RPxSP_1	98	102	PF00069	0.736
MOD_GlcNHglycan	153	158	PF01048	0.562
MOD_GlcNHglycan	252	255	PF01048	0.509
MOD_GlcNHglycan	287	290	PF01048	0.640
MOD_GSK3_1	168	175	PF00069	0.697
MOD_GSK3_1	196	203	PF00069	0.481
MOD_GSK3_1	331	338	PF00069	0.440
MOD_GSK3_1	94	101	PF00069	0.750
MOD_LATS_1	239	245	PF00433	0.463
MOD_LATS_1	329	335	PF00433	0.477
MOD_N-GLC_1	159	164	PF02516	0.596
MOD_NEK2_1	159	164	PF00069	0.681
MOD_NEK2_1	250	255	PF00069	0.517
MOD_NEK2_1	275	280	PF00069	0.587
MOD_NEK2_1	285	290	PF00069	0.506
MOD_NEK2_1	353	358	PF00069	0.481
MOD_NEK2_1	86	91	PF00069	0.707
MOD_PK_1	241	247	PF00069	0.473
MOD_PK_1	96	102	PF00069	0.666
MOD_PKA_1	168	174	PF00069	0.567
MOD_PKA_1	94	100	PF00069	0.710
MOD_PKA_2	168	174	PF00069	0.669
MOD_PKA_2	235	241	PF00069	0.530
MOD_PKA_2	275	281	PF00069	0.568
MOD_PKB_1	94	102	PF00069	0.735
MOD_Plk_1	153	159	PF00069	0.558
MOD_Plk_1	32	38	PF00069	0.484
MOD_Plk_4	139	145	PF00069	0.527
MOD_Plk_4	196	202	PF00069	0.523
MOD_Plk_4	335	341	PF00069	0.403
MOD_Plk_4	353	359	PF00069	0.556
MOD_ProDKin_1	208	214	PF00069	0.503
MOD_ProDKin_1	280	286	PF00069	0.579
MOD_ProDKin_1	308	314	PF00069	0.636
MOD_ProDKin_1	317	323	PF00069	0.608
MOD_ProDKin_1	80	86	PF00069	0.544
MOD_ProDKin_1	98	104	PF00069	0.797
MOD_SUMO_for_1	25	28	PF00179	0.401
TRG_DiLeu_BaEn_1	140	145	PF01217	0.555
TRG_DiLeu_BaEn_3	138	144	PF01217	0.585
TRG_DiLeu_BaEn_3	153	159	PF01217	0.410
TRG_ER_diArg_1	12	14	PF00400	0.453
TRG_ER_diArg_1	93	96	PF00400	0.718
TRG_NLS_Bipartite_1	78	99	PF00514	0.662
TRG_NLS_MonoCore_2	165	170	PF00514	0.555
TRG_NLS_MonoExtC_3	165	170	PF00514	0.691
TRG_NLS_MonoExtC_3	93	98	PF00514	0.649
TRG_NLS_MonoExtN_4	166	172	PF00514	0.593
TRG_NLS_MonoExtN_4	93	99	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I624	Leptomonas seymouri	54%	92%
A0A1X0NPE6	Trypanosomatidae	29%	100%
A0A422NX90	Trypanosoma rangeli	31%	100%
A4H7H7	Leishmania braziliensis	82%	100%
A4HVV8	Leishmania infantum	99%	100%
C9ZT68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9APL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFW9	Leishmania major	91%	98%
V5BM97	Trypanosoma cruzi	29%	100%