ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID12_LEIDO

TriTrypDb:

LdBPK_280820.1 , LdCL_280012800 , LDHU3_28.0990

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	380	386	PF00089	0.642
CLV_NRD_NRD_1	165	167	PF00675	0.613
CLV_NRD_NRD_1	227	229	PF00675	0.566
CLV_NRD_NRD_1	367	369	PF00675	0.766
CLV_NRD_NRD_1	89	91	PF00675	0.526
CLV_PCSK_KEX2_1	167	169	PF00082	0.626
CLV_PCSK_KEX2_1	179	181	PF00082	0.596
CLV_PCSK_KEX2_1	367	369	PF00082	0.766
CLV_PCSK_KEX2_1	463	465	PF00082	0.702
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.626
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.596
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.702
CLV_PCSK_SKI1_1	112	116	PF00082	0.411
CLV_PCSK_SKI1_1	162	166	PF00082	0.680
CLV_PCSK_SKI1_1	185	189	PF00082	0.668
CLV_PCSK_SKI1_1	329	333	PF00082	0.786
CLV_PCSK_SKI1_1	98	102	PF00082	0.346
DOC_CYCLIN_RxL_1	109	116	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.546
DOC_PP1_RVXF_1	110	116	PF00149	0.512
DOC_PP1_RVXF_1	221	228	PF00149	0.471
DOC_PP2B_LxvP_1	100	103	PF13499	0.411
DOC_PP4_FxxP_1	35	38	PF00568	0.658
DOC_USP7_MATH_1	138	142	PF00917	0.476
DOC_USP7_MATH_1	277	281	PF00917	0.479
DOC_USP7_MATH_1	55	59	PF00917	0.718
DOC_USP7_UBL2_3	474	478	PF12436	0.502
DOC_WW_Pin1_4	1	6	PF00397	0.776
DOC_WW_Pin1_4	202	207	PF00397	0.436
LIG_14-3-3_CanoR_1	166	175	PF00244	0.445
LIG_14-3-3_CanoR_1	223	228	PF00244	0.430
LIG_14-3-3_CanoR_1	306	314	PF00244	0.308
LIG_14-3-3_CanoR_1	351	355	PF00244	0.496
LIG_14-3-3_CanoR_1	383	389	PF00244	0.484
LIG_14-3-3_CanoR_1	393	400	PF00244	0.393
LIG_14-3-3_CanoR_1	449	455	PF00244	0.504
LIG_APCC_ABBA_1	422	427	PF00400	0.631
LIG_BIR_II_1	1	5	PF00653	0.776
LIG_BRCT_BRCA1_1	123	127	PF00533	0.403
LIG_BRCT_BRCA1_1	223	227	PF00533	0.476
LIG_BRCT_BRCA1_2	223	229	PF00533	0.434
LIG_Clathr_ClatBox_1	207	211	PF01394	0.414
LIG_Clathr_ClatBox_1	56	60	PF01394	0.707
LIG_deltaCOP1_diTrp_1	128	137	PF00928	0.396
LIG_FHA_1	124	130	PF00498	0.476
LIG_FHA_1	202	208	PF00498	0.362
LIG_FHA_1	216	222	PF00498	0.337
LIG_FHA_1	233	239	PF00498	0.403
LIG_FHA_1	437	443	PF00498	0.514
LIG_FHA_1	449	455	PF00498	0.484
LIG_FHA_1	48	54	PF00498	0.772
LIG_FHA_1	77	83	PF00498	0.684
LIG_FHA_2	123	129	PF00498	0.393
LIG_FHA_2	210	216	PF00498	0.405
LIG_GBD_Chelix_1	106	114	PF00786	0.512
LIG_HP1_1	55	59	PF01393	0.674
LIG_LIR_Apic_2	33	38	PF02991	0.654
LIG_LIR_Gen_1	25	34	PF02991	0.576
LIG_LIR_Gen_1	291	299	PF02991	0.422
LIG_LIR_Gen_1	386	397	PF02991	0.510
LIG_LIR_Gen_1	431	442	PF02991	0.523
LIG_LIR_Nem_3	25	29	PF02991	0.578
LIG_LIR_Nem_3	265	270	PF02991	0.456
LIG_LIR_Nem_3	291	295	PF02991	0.438
LIG_LIR_Nem_3	303	307	PF02991	0.367
LIG_LIR_Nem_3	358	364	PF02991	0.526
LIG_LIR_Nem_3	386	392	PF02991	0.546
LIG_MYND_1	99	103	PF01753	0.411
LIG_NRBOX	105	111	PF00104	0.512
LIG_Pex14_2	263	267	PF04695	0.401
LIG_PTB_Apo_2	29	36	PF02174	0.572
LIG_REV1ctd_RIR_1	264	272	PF16727	0.462
LIG_SH2_CRK	389	393	PF00017	0.563
LIG_SH2_STAT3	20	23	PF00017	0.704
LIG_SH2_STAT5	34	37	PF00017	0.584
LIG_SH2_STAT5	348	351	PF00017	0.428
LIG_SH2_STAT5	441	444	PF00017	0.539
LIG_SH2_STAT5	453	456	PF00017	0.444
LIG_SH3_3	2	8	PF00018	0.689
LIG_SH3_4	37	44	PF00018	0.704
LIG_SUMO_SIM_par_1	55	60	PF11976	0.672
LIG_TRAF2_1	155	158	PF00917	0.347
LIG_TRAF2_1	212	215	PF00917	0.474
LIG_TRAF2_1	456	459	PF00917	0.551
LIG_UBA3_1	109	117	PF00899	0.450
LIG_WRC_WIRS_1	263	268	PF05994	0.453
MOD_CK1_1	123	129	PF00069	0.363
MOD_CK1_1	194	200	PF00069	0.405
MOD_CK1_1	202	208	PF00069	0.386
MOD_CK1_1	209	215	PF00069	0.374
MOD_CK1_1	233	239	PF00069	0.490
MOD_CK1_1	353	359	PF00069	0.456
MOD_CK1_1	362	368	PF00069	0.434
MOD_CK1_1	373	379	PF00069	0.401
MOD_CK1_1	4	10	PF00069	0.809
MOD_CK2_1	209	215	PF00069	0.409
MOD_CK2_1	353	359	PF00069	0.426
MOD_CK2_1	442	448	PF00069	0.532
MOD_CK2_1	453	459	PF00069	0.442
MOD_GlcNHglycan	168	171	PF01048	0.624
MOD_GlcNHglycan	193	196	PF01048	0.576
MOD_GlcNHglycan	286	289	PF01048	0.625
MOD_GlcNHglycan	307	310	PF01048	0.723
MOD_GlcNHglycan	361	364	PF01048	0.655
MOD_GlcNHglycan	376	379	PF01048	0.607
MOD_GlcNHglycan	418	421	PF01048	0.623
MOD_GlcNHglycan	443	447	PF01048	0.743
MOD_GlcNHglycan	455	458	PF01048	0.630
MOD_GlcNHglycan	64	67	PF01048	0.501
MOD_GSK3_1	166	173	PF00069	0.435
MOD_GSK3_1	187	194	PF00069	0.399
MOD_GSK3_1	202	209	PF00069	0.318
MOD_GSK3_1	230	237	PF00069	0.464
MOD_GSK3_1	284	291	PF00069	0.494
MOD_GSK3_1	350	357	PF00069	0.495
MOD_GSK3_1	370	377	PF00069	0.350
MOD_GSK3_1	388	395	PF00069	0.519
MOD_N-GLC_1	284	289	PF02516	0.703
MOD_N-GLC_1	387	392	PF02516	0.721
MOD_NEK2_1	121	126	PF00069	0.461
MOD_NEK2_1	129	134	PF00069	0.400
MOD_NEK2_1	156	161	PF00069	0.423
MOD_NEK2_1	191	196	PF00069	0.390
MOD_NEK2_1	199	204	PF00069	0.376
MOD_NEK2_1	284	289	PF00069	0.503
MOD_NEK2_1	318	323	PF00069	0.492
MOD_NEK2_1	387	392	PF00069	0.533
MOD_PIKK_1	215	221	PF00454	0.461
MOD_PIKK_1	448	454	PF00454	0.515
MOD_PK_1	234	240	PF00069	0.410
MOD_PKA_1	166	172	PF00069	0.365
MOD_PKA_1	370	376	PF00069	0.582
MOD_PKA_2	139	145	PF00069	0.413
MOD_PKA_2	305	311	PF00069	0.520
MOD_PKA_2	350	356	PF00069	0.495
MOD_PKA_2	382	388	PF00069	0.478
MOD_PKA_2	392	398	PF00069	0.385
MOD_PKA_2	448	454	PF00069	0.515
MOD_PKB_1	166	174	PF00069	0.356
MOD_PKB_1	368	376	PF00069	0.579
MOD_Plk_1	156	162	PF00069	0.505
MOD_Plk_1	387	393	PF00069	0.485
MOD_Plk_1	435	441	PF00069	0.593
MOD_Plk_1	76	82	PF00069	0.666
MOD_Plk_2-3	336	342	PF00069	0.528
MOD_Plk_4	194	200	PF00069	0.418
MOD_Plk_4	234	240	PF00069	0.487
MOD_Plk_4	262	268	PF00069	0.405
MOD_Plk_4	269	275	PF00069	0.371
MOD_Plk_4	350	356	PF00069	0.441
MOD_Plk_4	376	382	PF00069	0.507
MOD_Plk_4	436	442	PF00069	0.579
MOD_ProDKin_1	1	7	PF00069	0.774
MOD_ProDKin_1	202	208	PF00069	0.434
MOD_SUMO_for_1	150	153	PF00179	0.436
MOD_SUMO_rev_2	226	236	PF00179	0.442
MOD_SUMO_rev_2	330	340	PF00179	0.556
TRG_DiLeu_BaEn_1	77	82	PF01217	0.608
TRG_DiLeu_BaEn_1	97	102	PF01217	0.383
TRG_DiLeu_BaEn_4	13	19	PF01217	0.670
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.426
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.494
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.600
TRG_ENDOCYTIC_2	389	392	PF00928	0.561
TRG_ER_diArg_1	165	168	PF00400	0.408
TRG_ER_diArg_1	367	370	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PES7	Leptomonas seymouri	37%	100%
A4HGB8	Leishmania braziliensis	74%	100%
A4I3F2	Leishmania infantum	98%	100%
E9AZN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8J2	Leishmania major	90%	100%