40S_ribosomal_protein_S27-1_putative/GeneDB:LmjF. 36.3750

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S27-1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID11_LEIDO

TriTrypDb:

LdBPK_363940.1 , LdCL_180011100 , LdCL_360046400 , LDHU3_18.0800 , LDHU3_36.5280

Length:

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S27-1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 32

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0015935	small ribosomal subunit	4	1
GO:0022627	cytosolic small ribosomal subunit	5	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:1990904	ribonucleoprotein complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8ID11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID11

PDB structure(s): 6az1_c

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	8
GO:0006518	peptide metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009059	macromolecule biosynthetic process	4	8
GO:0009987	cellular process	1	8
GO:0019538	protein metabolic process	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	8
GO:0043043	peptide biosynthetic process	5	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043603	amide metabolic process	3	8
GO:0043604	amide biosynthetic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8
GO:0000028	ribosomal small subunit assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	8
GO:0005198	structural molecule activity	1	8
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.483
CLV_NRD_NRD_1	81	83	PF00675	0.328
CLV_PCSK_KEX2_1	21	23	PF00082	0.503
CLV_PCSK_KEX2_1	81	83	PF00082	0.437
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.503
CLV_PCSK_PC7_1	17	23	PF00082	0.498
CLV_PCSK_SKI1_1	42	46	PF00082	0.391
CLV_PCSK_SKI1_1	71	75	PF00082	0.344
DOC_USP7_MATH_1	51	55	PF00917	0.386
DOC_USP7_UBL2_3	58	62	PF12436	0.464
LIG_14-3-3_CanoR_1	42	47	PF00244	0.464
LIG_FHA_1	50	56	PF00498	0.334
LIG_FHA_2	51	57	PF00498	0.464
LIG_LIR_Gen_1	31	39	PF02991	0.344
LIG_LIR_Nem_3	31	36	PF02991	0.344
LIG_LIR_Nem_3	7	13	PF02991	0.470
LIG_LYPXL_yS_3	10	13	PF13949	0.468
LIG_SH2_NCK_1	48	52	PF00017	0.344
LIG_SH2_STAT5	32	35	PF00017	0.344
LIG_SH3_3	23	29	PF00018	0.477
LIG_SH3_3	33	39	PF00018	0.344
LIG_TYR_ITIM	8	13	PF00017	0.470
MOD_CK1_1	49	55	PF00069	0.334
MOD_CK1_1	9	15	PF00069	0.484
MOD_CK2_1	50	56	PF00069	0.464
MOD_GSK3_1	42	49	PF00069	0.319
MOD_NEK2_1	34	39	PF00069	0.464
MOD_PKA_2	65	71	PF00069	0.344
MOD_PKB_1	40	48	PF00069	0.464
MOD_Plk_1	6	12	PF00069	0.473
MOD_Plk_4	28	34	PF00069	0.344
MOD_Plk_4	42	48	PF00069	0.344
TRG_ENDOCYTIC_2	10	13	PF00928	0.468
TRG_ER_diArg_1	22	24	PF00400	0.491
TRG_ER_diArg_1	39	42	PF00400	0.330
TRG_ER_diArg_1	80	82	PF00400	0.437
TRG_NLS_MonoCore_2	20	25	PF00514	0.489
TRG_NLS_MonoExtN_4	19	25	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1D8PTI7	Candida albicans (strain SC5314 / ATCC MYA-2876)	56%	100%
A0A381MWU3	Leishmania infantum	100%	100%
A4H9G9	Leishmania braziliensis	99%	100%
D0A8H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9ATF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O64650	Arabidopsis thaliana	54%	100%
O74330	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	56%	100%
P24051	Rattus norvegicus	62%	100%
P35997	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	58%	100%
P38654	Entamoeba histolytica	42%	100%
P38711	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	58%	100%
P42677	Homo sapiens	62%	100%
P47903	Chlamydomonas reinhardtii	54%	100%
P47904	Xenopus laevis	64%	100%
P55833	Homarus americanus	54%	100%
Q2KHT7	Bos taurus	62%	100%
Q3T0B7	Bos taurus	62%	100%
Q4Q140	Leishmania major	100%	100%
Q5RBK1	Pongo abelii	61%	100%
Q6ZWU9	Mus musculus	62%	100%
Q6ZWY3	Mus musculus	62%	100%
Q71TY3	Rattus norvegicus	62%	100%
Q71UM5	Homo sapiens	62%	100%
Q7RVN2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	54%	100%
Q8L953	Arabidopsis thaliana	54%	100%
Q8T1V4	Dictyostelium discoideum	49%	100%
Q96564	Hordeum vulgare	57%	100%
Q973F9	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	43%	100%
Q97Z80	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	41%	100%
Q9M2F1	Arabidopsis thaliana	56%	100%
Q9TXP0	Caenorhabditis elegans	54%	100%
V5BWH4	Trypanosoma cruzi	77%	100%