Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP76

Species:

Leishmania donovani

UniProt:

A0A3Q8ICZ9_LEIDO

TriTrypDb:

LdBPK_242050.1 , LdCL_240026200 , LDHU3_24.2500

Length:

756

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0044612	nuclear pore linkers	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8ICZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICZ9

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.401
CLV_C14_Caspase3-7	570	574	PF00656	0.511
CLV_C14_Caspase3-7	590	594	PF00656	0.362
CLV_NRD_NRD_1	116	118	PF00675	0.436
CLV_NRD_NRD_1	180	182	PF00675	0.551
CLV_NRD_NRD_1	386	388	PF00675	0.604
CLV_NRD_NRD_1	44	46	PF00675	0.475
CLV_NRD_NRD_1	526	528	PF00675	0.462
CLV_NRD_NRD_1	674	676	PF00675	0.606
CLV_NRD_NRD_1	685	687	PF00675	0.463
CLV_NRD_NRD_1	695	697	PF00675	0.419
CLV_NRD_NRD_1	729	731	PF00675	0.550
CLV_NRD_NRD_1	742	744	PF00675	0.492
CLV_PCSK_FUR_1	693	697	PF00082	0.441
CLV_PCSK_KEX2_1	116	118	PF00082	0.460
CLV_PCSK_KEX2_1	180	182	PF00082	0.542
CLV_PCSK_KEX2_1	386	388	PF00082	0.559
CLV_PCSK_KEX2_1	525	527	PF00082	0.469
CLV_PCSK_KEX2_1	674	676	PF00082	0.554
CLV_PCSK_KEX2_1	685	687	PF00082	0.406
CLV_PCSK_KEX2_1	693	695	PF00082	0.304
CLV_PCSK_KEX2_1	729	731	PF00082	0.533
CLV_PCSK_PC7_1	522	528	PF00082	0.395
CLV_PCSK_SKI1_1	108	112	PF00082	0.412
CLV_PCSK_SKI1_1	181	185	PF00082	0.450
CLV_PCSK_SKI1_1	19	23	PF00082	0.484
CLV_PCSK_SKI1_1	217	221	PF00082	0.651
CLV_PCSK_SKI1_1	611	615	PF00082	0.407
CLV_PCSK_SKI1_1	743	747	PF00082	0.445
CLV_Separin_Metazoa	383	387	PF03568	0.508
DEG_APCC_DBOX_1	180	188	PF00400	0.417
DEG_APCC_DBOX_1	653	661	PF00400	0.420
DEG_COP1_1	581	589	PF00400	0.433
DEG_Nend_UBRbox_1	1	4	PF02207	0.438
DEG_ODPH_VHL_1	484	497	PF01847	0.476
DOC_MAPK_gen_1	116	124	PF00069	0.455
DOC_MAPK_gen_1	541	550	PF00069	0.608
DOC_MAPK_MEF2A_6	117	126	PF00069	0.449
DOC_MAPK_MEF2A_6	461	470	PF00069	0.493
DOC_MAPK_MEF2A_6	543	552	PF00069	0.564
DOC_MAPK_MEF2A_6	598	606	PF00069	0.424
DOC_PP1_RVXF_1	106	112	PF00149	0.419
DOC_PP2B_LxvP_1	134	137	PF13499	0.484
DOC_PP2B_LxvP_1	565	568	PF13499	0.387
DOC_USP7_MATH_1	201	205	PF00917	0.758
DOC_USP7_MATH_1	297	301	PF00917	0.701
DOC_USP7_MATH_1	336	340	PF00917	0.446
DOC_USP7_MATH_1	444	448	PF00917	0.458
DOC_USP7_MATH_1	480	484	PF00917	0.695
DOC_USP7_MATH_1	51	55	PF00917	0.551
DOC_USP7_MATH_1	587	591	PF00917	0.598
DOC_USP7_MATH_1	60	64	PF00917	0.549
DOC_USP7_MATH_1	663	667	PF00917	0.502
DOC_USP7_MATH_1	84	88	PF00917	0.718
DOC_USP7_MATH_1	89	93	PF00917	0.723
DOC_USP7_MATH_2	75	81	PF00917	0.547
DOC_WW_Pin1_4	100	105	PF00397	0.474
DOC_WW_Pin1_4	199	204	PF00397	0.739
DOC_WW_Pin1_4	30	35	PF00397	0.503
DOC_WW_Pin1_4	337	342	PF00397	0.355
DOC_WW_Pin1_4	390	395	PF00397	0.537
DOC_WW_Pin1_4	462	467	PF00397	0.618
DOC_WW_Pin1_4	558	563	PF00397	0.564
DOC_WW_Pin1_4	90	95	PF00397	0.568
LIG_14-3-3_CanoR_1	190	199	PF00244	0.430
LIG_14-3-3_CanoR_1	481	485	PF00244	0.610
LIG_14-3-3_CanoR_1	700	705	PF00244	0.496
LIG_14-3-3_CanoR_1	743	749	PF00244	0.435
LIG_14-3-3_CanoR_1	97	104	PF00244	0.404
LIG_Actin_WH2_2	169	187	PF00022	0.466
LIG_Actin_WH2_2	597	613	PF00022	0.466
LIG_Actin_WH2_2	642	660	PF00022	0.413
LIG_BIR_III_2	556	560	PF00653	0.472
LIG_BRCT_BRCA1_1	28	32	PF00533	0.491
LIG_BRCT_BRCA1_1	282	286	PF00533	0.541
LIG_FHA_1	16	22	PF00498	0.421
LIG_FHA_1	239	245	PF00498	0.775
LIG_FHA_1	252	258	PF00498	0.733
LIG_FHA_1	321	327	PF00498	0.644
LIG_FHA_1	338	344	PF00498	0.329
LIG_FHA_1	427	433	PF00498	0.407
LIG_FHA_1	45	51	PF00498	0.576
LIG_FHA_1	469	475	PF00498	0.490
LIG_FHA_1	490	496	PF00498	0.477
LIG_FHA_1	512	518	PF00498	0.513
LIG_FHA_1	579	585	PF00498	0.365
LIG_FHA_1	630	636	PF00498	0.594
LIG_FHA_1	667	673	PF00498	0.397
LIG_FHA_1	74	80	PF00498	0.717
LIG_FHA_2	161	167	PF00498	0.394
LIG_FHA_2	218	224	PF00498	0.636
LIG_FHA_2	251	257	PF00498	0.614
LIG_FHA_2	377	383	PF00498	0.581
LIG_GBD_Chelix_1	602	610	PF00786	0.461
LIG_IRF3_LxIS_1	153	159	PF10401	0.356
LIG_LIR_Apic_2	330	335	PF02991	0.396
LIG_LIR_Gen_1	142	153	PF02991	0.408
LIG_LIR_Gen_1	398	407	PF02991	0.476
LIG_LIR_Nem_3	142	148	PF02991	0.375
LIG_LIR_Nem_3	168	174	PF02991	0.417
LIG_LIR_Nem_3	398	403	PF02991	0.459
LIG_LIR_Nem_3	717	721	PF02991	0.431
LIG_PCNA_yPIPBox_3	634	646	PF02747	0.552
LIG_PCNA_yPIPBox_3	736	746	PF02747	0.466
LIG_Pex14_2	28	32	PF04695	0.491
LIG_Pex14_2	516	520	PF04695	0.399
LIG_PTB_Apo_2	8	15	PF02174	0.383
LIG_RPA_C_Fungi	690	702	PF08784	0.376
LIG_SH2_CRK	332	336	PF00017	0.446
LIG_SH2_CRK	400	404	PF00017	0.449
LIG_SH2_NCK_1	332	336	PF00017	0.446
LIG_SH2_SRC	65	68	PF00017	0.580
LIG_SH2_STAP1	354	358	PF00017	0.443
LIG_SH2_STAP1	65	69	PF00017	0.599
LIG_SH2_STAT5	120	123	PF00017	0.361
LIG_SH2_STAT5	171	174	PF00017	0.601
LIG_SH3_1	243	249	PF00018	0.540
LIG_SH3_3	171	177	PF00018	0.508
LIG_SH3_3	243	249	PF00018	0.798
LIG_SH3_3	310	316	PF00018	0.736
LIG_SH3_3	36	42	PF00018	0.560
LIG_SH3_3	443	449	PF00018	0.448
LIG_SH3_3	460	466	PF00018	0.592
LIG_SH3_3	483	489	PF00018	0.586
LIG_SH3_3	545	551	PF00018	0.506
LIG_SH3_3	556	562	PF00018	0.446
LIG_SH3_3	581	587	PF00018	0.310
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.416
LIG_SUMO_SIM_anti_2	323	330	PF11976	0.561
LIG_SUMO_SIM_anti_2	337	346	PF11976	0.380
LIG_SUMO_SIM_anti_2	581	588	PF11976	0.422
LIG_SUMO_SIM_par_1	120	125	PF11976	0.338
LIG_SUMO_SIM_par_1	342	350	PF11976	0.397
LIG_SUMO_SIM_par_1	393	398	PF11976	0.477
LIG_SUMO_SIM_par_1	581	588	PF11976	0.373
LIG_SUMO_SIM_par_1	600	605	PF11976	0.495
LIG_TRAF2_1	379	382	PF00917	0.687
LIG_TRFH_1	332	336	PF08558	0.446
MOD_CDK_SPxxK_3	90	97	PF00069	0.543
MOD_CK1_1	204	210	PF00069	0.644
MOD_CK1_1	227	233	PF00069	0.757
MOD_CK1_1	30	36	PF00069	0.437
MOD_CK1_1	44	50	PF00069	0.310
MOD_CK1_1	666	672	PF00069	0.473
MOD_CK2_1	190	196	PF00069	0.552
MOD_CK2_1	250	256	PF00069	0.738
MOD_CK2_1	297	303	PF00069	0.697
MOD_CK2_1	30	36	PF00069	0.587
MOD_CK2_1	376	382	PF00069	0.657
MOD_CK2_1	77	83	PF00069	0.665
MOD_CMANNOS	530	533	PF00535	0.377
MOD_GlcNHglycan	158	161	PF01048	0.401
MOD_GlcNHglycan	299	302	PF01048	0.803
MOD_GlcNHglycan	349	352	PF01048	0.406
MOD_GlcNHglycan	403	406	PF01048	0.430
MOD_GlcNHglycan	474	477	PF01048	0.541
MOD_GlcNHglycan	507	510	PF01048	0.524
MOD_GlcNHglycan	611	614	PF01048	0.454
MOD_GlcNHglycan	625	628	PF01048	0.618
MOD_GlcNHglycan	664	668	PF01048	0.472
MOD_GlcNHglycan	67	70	PF01048	0.642
MOD_GlcNHglycan	679	682	PF01048	0.538
MOD_GlcNHglycan	86	89	PF01048	0.725
MOD_GlcNHglycan	98	101	PF01048	0.529
MOD_GSK3_1	15	22	PF00069	0.384
MOD_GSK3_1	156	163	PF00069	0.502
MOD_GSK3_1	201	208	PF00069	0.760
MOD_GSK3_1	26	33	PF00069	0.414
MOD_GSK3_1	280	287	PF00069	0.710
MOD_GSK3_1	365	372	PF00069	0.681
MOD_GSK3_1	401	408	PF00069	0.461
MOD_GSK3_1	468	475	PF00069	0.444
MOD_GSK3_1	487	494	PF00069	0.548
MOD_GSK3_1	568	575	PF00069	0.517
MOD_GSK3_1	73	80	PF00069	0.689
MOD_GSK3_1	96	103	PF00069	0.417
MOD_N-GLC_2	467	469	PF02516	0.301
MOD_N-GLC_2	502	504	PF02516	0.414
MOD_NEK2_1	26	31	PF00069	0.383
MOD_NEK2_1	345	350	PF00069	0.440
MOD_NEK2_1	433	438	PF00069	0.342
MOD_NEK2_1	472	477	PF00069	0.471
MOD_NEK2_1	497	502	PF00069	0.480
MOD_NEK2_1	602	607	PF00069	0.416
MOD_NEK2_1	96	101	PF00069	0.466
MOD_NEK2_2	160	165	PF00069	0.397
MOD_PIKK_1	224	230	PF00454	0.808
MOD_PIKK_1	321	327	PF00454	0.588
MOD_PIKK_1	497	503	PF00454	0.480
MOD_PK_1	572	578	PF00069	0.454
MOD_PKA_2	239	245	PF00069	0.588
MOD_PKA_2	44	50	PF00069	0.565
MOD_PKA_2	480	486	PF00069	0.655
MOD_PKA_2	96	102	PF00069	0.403
MOD_Plk_1	122	128	PF00069	0.515
MOD_Plk_1	160	166	PF00069	0.398
MOD_Plk_1	167	173	PF00069	0.585
MOD_Plk_1	188	194	PF00069	0.510
MOD_Plk_1	572	578	PF00069	0.461
MOD_Plk_1	587	593	PF00069	0.484
MOD_Plk_1	60	66	PF00069	0.475
MOD_Plk_1	77	83	PF00069	0.514
MOD_Plk_2-3	588	594	PF00069	0.597
MOD_Plk_2-3	77	83	PF00069	0.548
MOD_Plk_4	160	166	PF00069	0.373
MOD_Plk_4	167	173	PF00069	0.445
MOD_ProDKin_1	100	106	PF00069	0.470
MOD_ProDKin_1	199	205	PF00069	0.744
MOD_ProDKin_1	30	36	PF00069	0.505
MOD_ProDKin_1	337	343	PF00069	0.348
MOD_ProDKin_1	390	396	PF00069	0.532
MOD_ProDKin_1	462	468	PF00069	0.606
MOD_ProDKin_1	558	564	PF00069	0.568
MOD_ProDKin_1	90	96	PF00069	0.557
TRG_DiLeu_BaEn_1	398	403	PF01217	0.480
TRG_DiLeu_BaLyEn_6	548	553	PF01217	0.512
TRG_ENDOCYTIC_2	171	174	PF00928	0.601
TRG_ENDOCYTIC_2	400	403	PF00928	0.449
TRG_ER_diArg_1	115	117	PF00400	0.453
TRG_ER_diArg_1	180	182	PF00400	0.592
TRG_ER_diArg_1	377	380	PF00400	0.568
TRG_ER_diArg_1	385	387	PF00400	0.532
TRG_ER_diArg_1	454	457	PF00400	0.531
TRG_ER_diArg_1	525	527	PF00400	0.469
TRG_ER_diArg_1	62	65	PF00400	0.616
TRG_ER_diArg_1	673	675	PF00400	0.614
TRG_ER_diArg_1	693	696	PF00400	0.290
TRG_NLS_MonoExtN_4	42	49	PF00514	0.506
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	674	678	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	695	699	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIR5	Leptomonas seymouri	47%	93%
A0A1X0NVW3	Trypanosomatidae	27%	97%
A0A3R7NQB0	Trypanosoma rangeli	30%	100%
A4HDQ9	Leishmania braziliensis	72%	100%
A4I105	Leishmania infantum	99%	100%
C9ZWA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AX43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAD3	Leishmania major	93%	100%