Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICZ4_LEIDO

TriTrypDb:

LdBPK_241720.1 , LdCL_240022800 , LDHU3_24.2130

Length:

535

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.550
CLV_C14_Caspase3-7	361	365	PF00656	0.493
CLV_MEL_PAP_1	337	343	PF00089	0.481
CLV_NRD_NRD_1	14	16	PF00675	0.693
CLV_NRD_NRD_1	153	155	PF00675	0.515
CLV_NRD_NRD_1	232	234	PF00675	0.412
CLV_NRD_NRD_1	272	274	PF00675	0.487
CLV_NRD_NRD_1	303	305	PF00675	0.433
CLV_NRD_NRD_1	324	326	PF00675	0.501
CLV_NRD_NRD_1	64	66	PF00675	0.673
CLV_PCSK_FUR_1	270	274	PF00082	0.481
CLV_PCSK_KEX2_1	153	155	PF00082	0.515
CLV_PCSK_KEX2_1	272	274	PF00082	0.522
CLV_PCSK_KEX2_1	303	305	PF00082	0.429
CLV_PCSK_KEX2_1	323	325	PF00082	0.351
CLV_PCSK_PC7_1	299	305	PF00082	0.555
CLV_PCSK_SKI1_1	110	114	PF00082	0.597
CLV_PCSK_SKI1_1	16	20	PF00082	0.638
CLV_PCSK_SKI1_1	233	237	PF00082	0.521
CLV_PCSK_SKI1_1	388	392	PF00082	0.577
CLV_PCSK_SKI1_1	500	504	PF00082	0.472
CLV_Separin_Metazoa	165	169	PF03568	0.532
DEG_APCC_DBOX_1	380	388	PF00400	0.492
DEG_ODPH_VHL_1	35	46	PF01847	0.635
DEG_SCF_TRCP1_1	445	451	PF00400	0.614
DEG_SPOP_SBC_1	431	435	PF00917	0.523
DEG_SPOP_SBC_1	474	478	PF00917	0.768
DOC_MAPK_gen_1	233	240	PF00069	0.418
DOC_MAPK_gen_1	323	334	PF00069	0.580
DOC_MAPK_gen_1	498	507	PF00069	0.458
DOC_PP1_RVXF_1	501	508	PF00149	0.462
DOC_PP2B_LxvP_1	35	38	PF13499	0.658
DOC_USP7_MATH_1	28	32	PF00917	0.700
DOC_USP7_MATH_1	38	42	PF00917	0.717
DOC_USP7_MATH_1	396	400	PF00917	0.580
DOC_USP7_MATH_1	431	435	PF00917	0.663
DOC_USP7_MATH_1	473	477	PF00917	0.707
DOC_USP7_UBL2_3	329	333	PF12436	0.484
DOC_USP7_UBL2_3	496	500	PF12436	0.584
DOC_WW_Pin1_4	469	474	PF00397	0.717
DOC_WW_Pin1_4	475	480	PF00397	0.543
DOC_WW_Pin1_4	515	520	PF00397	0.665
DOC_WW_Pin1_4	524	529	PF00397	0.657
LIG_14-3-3_CanoR_1	15	21	PF00244	0.730
LIG_14-3-3_CanoR_1	176	181	PF00244	0.531
LIG_14-3-3_CanoR_1	263	268	PF00244	0.509
LIG_14-3-3_CanoR_1	374	378	PF00244	0.502
LIG_14-3-3_CanoR_1	388	395	PF00244	0.463
LIG_14-3-3_CanoR_1	457	465	PF00244	0.628
LIG_14-3-3_CanoR_1	68	77	PF00244	0.656
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BRCT_BRCA1_1	485	489	PF00533	0.720
LIG_BRCT_BRCA1_1	503	507	PF00533	0.509
LIG_Clathr_ClatBox_1	237	241	PF01394	0.416
LIG_EH1_1	282	290	PF00400	0.568
LIG_FHA_1	144	150	PF00498	0.544
LIG_FHA_1	179	185	PF00498	0.503
LIG_FHA_1	200	206	PF00498	0.550
LIG_FHA_1	269	275	PF00498	0.514
LIG_FHA_1	280	286	PF00498	0.342
LIG_FHA_1	290	296	PF00498	0.450
LIG_FHA_1	389	395	PF00498	0.610
LIG_FHA_1	5	11	PF00498	0.751
LIG_FHA_2	291	297	PF00498	0.535
LIG_FHA_2	457	463	PF00498	0.757
LIG_FHA_2	69	75	PF00498	0.683
LIG_GBD_Chelix_1	123	131	PF00786	0.452
LIG_LIR_Gen_1	247	256	PF02991	0.549
LIG_LIR_Gen_1	261	268	PF02991	0.495
LIG_LIR_LC3C_4	213	217	PF02991	0.528
LIG_LIR_Nem_3	247	251	PF02991	0.551
LIG_LIR_Nem_3	261	267	PF02991	0.493
LIG_LIR_Nem_3	93	99	PF02991	0.550
LIG_PCNA_TLS_4	398	405	PF02747	0.459
LIG_PCNA_yPIPBox_3	209	221	PF02747	0.530
LIG_PTB_Apo_2	507	514	PF02174	0.614
LIG_PTB_Phospho_1	507	513	PF10480	0.608
LIG_SH2_CRK	177	181	PF00017	0.431
LIG_SH2_GRB2like	95	98	PF00017	0.496
LIG_SH2_NCK_1	177	181	PF00017	0.546
LIG_SH2_STAT3	194	197	PF00017	0.563
LIG_SH2_STAT3	95	98	PF00017	0.608
LIG_SH2_STAT5	194	197	PF00017	0.546
LIG_SH3_3	467	473	PF00018	0.630
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.633
LIG_SUMO_SIM_par_1	236	241	PF11976	0.417
LIG_TRAF2_1	155	158	PF00917	0.549
LIG_TRAF2_1	259	262	PF00917	0.541
LIG_TRAF2_1	459	462	PF00917	0.697
LIG_UBA3_1	237	242	PF00899	0.519
MOD_CDK_SPK_2	524	529	PF00069	0.641
MOD_CK1_1	179	185	PF00069	0.511
MOD_CK1_1	372	378	PF00069	0.575
MOD_CK1_1	430	436	PF00069	0.743
MOD_CK1_1	456	462	PF00069	0.758
MOD_CK1_1	478	484	PF00069	0.622
MOD_CK1_1	69	75	PF00069	0.664
MOD_CK2_1	263	269	PF00069	0.590
MOD_CK2_1	396	402	PF00069	0.481
MOD_CK2_1	456	462	PF00069	0.764
MOD_CK2_1	524	530	PF00069	0.610
MOD_CK2_1	68	74	PF00069	0.714
MOD_GlcNHglycan	1	4	PF01048	0.696
MOD_GlcNHglycan	20	23	PF01048	0.754
MOD_GlcNHglycan	32	35	PF01048	0.704
MOD_GlcNHglycan	418	422	PF01048	0.719
MOD_GlcNHglycan	429	432	PF01048	0.583
MOD_GlcNHglycan	445	448	PF01048	0.716
MOD_GlcNHglycan	485	488	PF01048	0.666
MOD_GlcNHglycan	57	60	PF01048	0.718
MOD_GlcNHglycan	68	71	PF01048	0.579
MOD_GSK3_1	10	17	PF00069	0.733
MOD_GSK3_1	133	140	PF00069	0.489
MOD_GSK3_1	369	376	PF00069	0.646
MOD_GSK3_1	419	426	PF00069	0.658
MOD_GSK3_1	427	434	PF00069	0.637
MOD_GSK3_1	469	476	PF00069	0.708
MOD_GSK3_1	479	486	PF00069	0.719
MOD_GSK3_1	51	58	PF00069	0.751
MOD_GSK3_1	515	522	PF00069	0.680
MOD_GSK3_1	60	67	PF00069	0.664
MOD_GSK3_1	76	83	PF00069	0.635
MOD_N-GLC_1	39	44	PF02516	0.521
MOD_NEK2_1	126	131	PF00069	0.593
MOD_NEK2_1	14	19	PF00069	0.733
MOD_NEK2_1	240	245	PF00069	0.460
MOD_NEK2_1	268	273	PF00069	0.606
MOD_NEK2_1	370	375	PF00069	0.514
MOD_NEK2_1	404	409	PF00069	0.602
MOD_NEK2_1	419	424	PF00069	0.725
MOD_NEK2_1	483	488	PF00069	0.752
MOD_NEK2_1	64	69	PF00069	0.738
MOD_NEK2_1	76	81	PF00069	0.617
MOD_NEK2_1	85	90	PF00069	0.484
MOD_NEK2_2	479	484	PF00069	0.624
MOD_PIKK_1	143	149	PF00454	0.570
MOD_PK_1	176	182	PF00069	0.531
MOD_PK_1	263	269	PF00069	0.437
MOD_PKA_2	14	20	PF00069	0.758
MOD_PKA_2	28	34	PF00069	0.656
MOD_PKA_2	373	379	PF00069	0.529
MOD_PKA_2	456	462	PF00069	0.768
MOD_PKA_2	64	70	PF00069	0.689
MOD_PKB_1	386	394	PF00069	0.531
MOD_Plk_1	199	205	PF00069	0.557
MOD_Plk_1	240	246	PF00069	0.459
MOD_Plk_1	39	45	PF00069	0.522
MOD_Plk_1	491	497	PF00069	0.463
MOD_Plk_2-3	491	497	PF00069	0.517
MOD_Plk_4	263	269	PF00069	0.558
MOD_Plk_4	501	507	PF00069	0.533
MOD_Plk_4	76	82	PF00069	0.653
MOD_ProDKin_1	469	475	PF00069	0.710
MOD_ProDKin_1	515	521	PF00069	0.659
MOD_ProDKin_1	524	530	PF00069	0.655
MOD_SUMO_rev_2	275	280	PF00179	0.558
MOD_SUMO_rev_2	328	334	PF00179	0.484
MOD_SUMO_rev_2	364	373	PF00179	0.568
TRG_DiLeu_BaEn_1	247	252	PF01217	0.462
TRG_ENDOCYTIC_2	163	166	PF00928	0.435
TRG_ENDOCYTIC_2	177	180	PF00928	0.402
TRG_ER_diArg_1	270	273	PF00400	0.533
TRG_ER_diArg_1	302	304	PF00400	0.439
TRG_ER_diArg_1	323	325	PF00400	0.438
TRG_NES_CRM1_1	206	220	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	132	137	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEM1	Leptomonas seymouri	54%	100%
A0A1X0NPU9	Trypanosomatidae	36%	88%
A0A422NJA6	Trypanosoma rangeli	25%	92%
A0A422NQP6	Trypanosoma rangeli	34%	96%
A4HDM5	Leishmania braziliensis	78%	100%
D0A6S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	95%
E9AH72	Leishmania infantum	100%	100%
E9AX10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4QAG6	Leishmania major	94%	100%
V5BJY8	Trypanosoma cruzi	37%	95%