EF-hand domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

centrin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICY9_LEIDO

TriTrypDb:

LdBPK_320690.1 , LdCL_320012400 , LDHU3_32.0850

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICY9

Function

Biological processes
Term	Name	Level	Count
GO:0000278	mitotic cell cycle	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007049	cell cycle	2	1
GO:0007099	centriole replication	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0031023	microtubule organizing center organization	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0098534	centriole assembly	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003779	actin binding	4	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.513
CLV_PCSK_KEX2_1	204	206	PF00082	0.541
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.580
CLV_PCSK_SKI1_1	130	134	PF00082	0.503
CLV_PCSK_SKI1_1	15	19	PF00082	0.700
CLV_PCSK_SKI1_1	189	193	PF00082	0.630
CLV_PCSK_SKI1_1	201	205	PF00082	0.507
CLV_PCSK_SKI1_1	56	60	PF00082	0.434
DOC_CKS1_1	176	181	PF01111	0.484
DOC_CKS1_1	38	43	PF01111	0.668
DOC_MAPK_gen_1	137	145	PF00069	0.574
DOC_PP2B_LxvP_1	45	48	PF13499	0.659
DOC_USP7_MATH_1	17	21	PF00917	0.634
DOC_USP7_UBL2_3	118	122	PF12436	0.541
DOC_WW_Pin1_4	175	180	PF00397	0.473
DOC_WW_Pin1_4	34	39	PF00397	0.660
LIG_14-3-3_CanoR_1	149	157	PF00244	0.369
LIG_Actin_WH2_2	40	58	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_BRCT_BRCA1_1	104	108	PF00533	0.544
LIG_BRCT_BRCA1_1	35	39	PF00533	0.584
LIG_FHA_1	124	130	PF00498	0.566
LIG_FHA_1	195	201	PF00498	0.501
LIG_FHA_2	158	164	PF00498	0.452
LIG_FHA_2	41	47	PF00498	0.595
LIG_LIR_Apic_2	173	179	PF02991	0.635
LIG_LIR_Gen_1	105	116	PF02991	0.387
LIG_LIR_Gen_1	196	206	PF02991	0.429
LIG_LIR_Nem_3	105	111	PF02991	0.390
LIG_LIR_Nem_3	139	145	PF02991	0.443
LIG_LIR_Nem_3	196	202	PF02991	0.415
LIG_NRBOX	90	96	PF00104	0.412
LIG_SH2_CRK	112	116	PF00017	0.395
LIG_SH2_CRK	176	180	PF00017	0.697
LIG_SH2_PTP2	142	145	PF00017	0.427
LIG_SH2_STAT3	51	54	PF00017	0.570
LIG_SH2_STAT5	142	145	PF00017	0.408
LIG_SH2_STAT5	199	202	PF00017	0.520
LIG_SH3_3	35	41	PF00018	0.640
LIG_SUMO_SIM_par_1	190	198	PF11976	0.436
LIG_WW_1	48	51	PF00397	0.553
MOD_CK1_1	37	43	PF00069	0.663
MOD_CK2_1	117	123	PF00069	0.467
MOD_CK2_1	157	163	PF00069	0.450
MOD_CK2_1	192	198	PF00069	0.444
MOD_CK2_1	40	46	PF00069	0.604
MOD_GlcNHglycan	15	18	PF01048	0.647
MOD_GlcNHglycan	63	67	PF01048	0.604
MOD_GlcNHglycan	87	90	PF01048	0.539
MOD_GSK3_1	117	124	PF00069	0.544
MOD_GSK3_1	13	20	PF00069	0.672
MOD_GSK3_1	147	154	PF00069	0.511
MOD_GSK3_1	30	37	PF00069	0.476
MOD_N-GLC_1	13	18	PF02516	0.666
MOD_N-GLC_1	157	162	PF02516	0.565
MOD_NEK2_1	117	122	PF00069	0.572
MOD_NEK2_1	151	156	PF00069	0.597
MOD_NEK2_1	170	175	PF00069	0.422
MOD_NEK2_1	62	67	PF00069	0.596
MOD_PK_1	125	131	PF00069	0.583
MOD_PKA_1	121	127	PF00069	0.570
MOD_Plk_2-3	147	153	PF00069	0.455
MOD_Plk_4	17	23	PF00069	0.652
MOD_Plk_4	40	46	PF00069	0.623
MOD_ProDKin_1	175	181	PF00069	0.476
MOD_ProDKin_1	34	40	PF00069	0.657
MOD_SUMO_rev_2	120	126	PF00179	0.519
TRG_DiLeu_BaEn_1	198	203	PF01217	0.449
TRG_DiLeu_BaEn_1	90	95	PF01217	0.404
TRG_ENDOCYTIC_2	112	115	PF00928	0.391
TRG_ENDOCYTIC_2	142	145	PF00928	0.402
TRG_ENDOCYTIC_2	199	202	PF00928	0.520
TRG_NES_CRM1_1	146	161	PF08389	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N1	Leptomonas seymouri	66%	100%
A0A0N0P8Y6	Leptomonas seymouri	28%	100%
A0A0N1PB14	Leptomonas seymouri	27%	99%
A0A0S4ILD1	Bodo saltans	28%	100%
A0A0S4INC8	Bodo saltans	30%	100%
A0A0S4J7U6	Bodo saltans	36%	100%
A0A0S4KIF8	Bodo saltans	47%	100%
A0A1X0NEW2	Trypanosomatidae	33%	100%
A0A1X0NVB5	Trypanosomatidae	51%	100%
A0A1X0P9X3	Trypanosomatidae	28%	100%
A0A3Q8IHK5	Leishmania donovani	31%	100%
A0A3Q8IW81	Leishmania donovani	29%	100%
A0A3R7NPA6	Trypanosoma rangeli	50%	100%
A0A3S7WPW7	Leishmania donovani	32%	100%
A0A3S7WXD9	Leishmania donovani	32%	100%
A0A422N5Z1	Trypanosoma rangeli	30%	100%
A0A422P0I1	Trypanosoma rangeli	31%	100%
A4H522	Leishmania braziliensis	33%	97%
A4H5R9	Leishmania braziliensis	34%	100%
A4HAV0	Leishmania braziliensis	30%	100%
A4HCI2	Leishmania braziliensis	32%	100%
A4HK46	Leishmania braziliensis	84%	100%
A4HPN5	Leishmania braziliensis	28%	100%
A4HT95	Leishmania infantum	32%	94%
A4HU13	Leishmania infantum	34%	100%
A4I000	Leishmania infantum	32%	100%
A4I7L6	Leishmania infantum	100%	100%
A4IA04	Leishmania infantum	31%	100%
A4ID29	Leishmania infantum	29%	100%
B1PSN3	Leishmania donovani	34%	100%
C9ZUM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A3W9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A9T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D2DGW3	Tyrophagus putrescentiae	35%	100%
E9AL84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	94%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AVX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B2I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B525	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O74435	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O82659	Arabidopsis thaliana	29%	100%
P05434	Chlamydomonas reinhardtii	34%	100%
P15159	Tachypleus tridentatus	32%	100%
P15845	Schistosoma mansoni	28%	100%
P41208	Homo sapiens	38%	100%
P41209	Mus musculus	36%	100%
P41210	Atriplex nummularia	29%	100%
P43645	Spermatozopsis similis	33%	100%
P43646	Tetraselmis striata	33%	100%
P53441	Naegleria gruberi	35%	100%
P54213	Dunaliella salina	35%	100%
P57796	Homo sapiens	29%	76%
Q06827	Scherffelia dubia	33%	100%
Q11083	Caenorhabditis elegans	27%	91%
Q12798	Homo sapiens	37%	100%
Q24956	Giardia intestinalis	37%	100%
Q2TBN3	Bos taurus	37%	100%
Q32LE3	Bos taurus	38%	100%
Q338P8	Oryza sativa subsp. japonica	31%	100%
Q4Q148	Leishmania major	29%	100%
Q4Q2W1	Leishmania major	31%	100%
Q4Q5L7	Leishmania major	94%	100%
Q4QBK6	Leishmania major	32%	100%
Q4QHT2	Leishmania major	34%	100%
Q4QIM0	Leishmania major	32%	94%
Q7F0J0	Oryza sativa subsp. japonica	31%	100%
Q84MN0	Oryza sativa subsp. japonica	30%	100%
Q8K4K1	Mus musculus	34%	100%
Q94726	Paramecium tetraurelia	30%	100%
Q948R0	Oryza sativa subsp. japonica	28%	100%
Q9JLK4	Mus musculus	27%	97%
Q9LIK5	Arabidopsis thaliana	30%	100%
Q9NPB3	Homo sapiens	26%	95%
Q9R1K9	Mus musculus	37%	100%
V5BNS7	Trypanosoma cruzi	25%	100%
V5DQ66	Trypanosoma cruzi	32%	100%