Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICY8_LEIDO

TriTrypDb:

LdBPK_241900.1 , LdCL_240024600 , LDHU3_24.2330

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.532
CLV_NRD_NRD_1	166	168	PF00675	0.571
CLV_NRD_NRD_1	225	227	PF00675	0.580
CLV_PCSK_KEX2_1	145	147	PF00082	0.534
CLV_PCSK_KEX2_1	225	227	PF00082	0.604
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.569
CLV_PCSK_SKI1_1	145	149	PF00082	0.522
CLV_PCSK_SKI1_1	62	66	PF00082	0.636
DEG_APCC_KENBOX_2	200	204	PF00400	0.591
DEG_Nend_UBRbox_1	1	4	PF02207	0.737
DEG_SCF_FBW7_2	83	88	PF00400	0.542
DOC_MAPK_gen_1	120	129	PF00069	0.541
DOC_MAPK_gen_1	145	154	PF00069	0.577
DOC_MAPK_MEF2A_6	120	129	PF00069	0.550
DOC_PP2B_LxvP_1	83	86	PF13499	0.526
DOC_PP4_FxxP_1	89	92	PF00568	0.550
DOC_USP7_MATH_2	130	136	PF00917	0.556
DOC_WW_Pin1_4	1	6	PF00397	0.616
DOC_WW_Pin1_4	49	54	PF00397	0.641
DOC_WW_Pin1_4	81	86	PF00397	0.533
LIG_14-3-3_CanoR_1	112	118	PF00244	0.486
LIG_14-3-3_CanoR_1	7	15	PF00244	0.699
LIG_deltaCOP1_diTrp_1	88	95	PF00928	0.562
LIG_EVH1_2	85	89	PF00568	0.544
LIG_FHA_1	14	20	PF00498	0.662
LIG_FHA_1	189	195	PF00498	0.414
LIG_FHA_1	65	71	PF00498	0.572
LIG_FHA_2	63	69	PF00498	0.562
LIG_LIR_Apic_2	88	92	PF02991	0.537
LIG_PTB_Apo_2	155	162	PF02174	0.673
LIG_PTB_Phospho_1	155	161	PF10480	0.673
LIG_SH2_GRB2like	151	154	PF00017	0.531
LIG_SH2_PTP2	151	154	PF00017	0.591
LIG_SH2_STAP1	123	127	PF00017	0.544
LIG_SH2_STAP1	46	50	PF00017	0.573
LIG_SH2_STAT3	175	178	PF00017	0.608
LIG_SH2_STAT3	46	49	PF00017	0.511
LIG_SH2_STAT5	151	154	PF00017	0.591
LIG_SH2_STAT5	161	164	PF00017	0.622
LIG_SH2_STAT5	189	192	PF00017	0.519
LIG_SH3_3	124	130	PF00018	0.616
LIG_TRAF2_1	116	119	PF00917	0.435
LIG_TRAF2_1	99	102	PF00917	0.517
MOD_CDK_SPxK_1	1	7	PF00069	0.612
MOD_CDK_SPxxK_3	49	56	PF00069	0.652
MOD_CK2_1	113	119	PF00069	0.488
MOD_CK2_1	62	68	PF00069	0.568
MOD_GlcNHglycan	22	25	PF01048	0.606
MOD_GlcNHglycan	8	11	PF01048	0.681
MOD_N-GLC_1	13	18	PF02516	0.504
MOD_N-GLC_1	211	216	PF02516	0.530
MOD_NEK2_1	13	18	PF00069	0.516
MOD_NEK2_1	20	25	PF00069	0.555
MOD_NEK2_1	6	11	PF00069	0.606
MOD_PKA_2	178	184	PF00069	0.610
MOD_PKA_2	6	12	PF00069	0.658
MOD_Plk_1	118	124	PF00069	0.532
MOD_Plk_1	13	19	PF00069	0.498
MOD_Plk_1	171	177	PF00069	0.621
MOD_Plk_4	14	20	PF00069	0.720
MOD_ProDKin_1	1	7	PF00069	0.616
MOD_ProDKin_1	49	55	PF00069	0.646
MOD_ProDKin_1	81	87	PF00069	0.540
MOD_SUMO_rev_2	116	121	PF00179	0.488
TRG_ENDOCYTIC_2	151	154	PF00928	0.531
TRG_ENDOCYTIC_2	27	30	PF00928	0.531
TRG_ER_diArg_1	164	167	PF00400	0.609
TRG_ER_diArg_1	225	227	PF00400	0.604
TRG_NLS_MonoExtN_4	142	149	PF00514	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P367	Leptomonas seymouri	84%	85%
A0A0S4J5N9	Bodo saltans	62%	100%
A0A1X0NVV7	Trypanosomatidae	76%	100%
A4HDP4	Leishmania braziliensis	98%	100%
C9ZWB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AH90	Leishmania infantum	100%	100%
E9AX28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QAE8	Leishmania major	99%	100%