Hypothetical_protein_conserved

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ICY6_LEIDO

TriTrypDb:

LdBPK_262090.1 , LdCL_260026500 , LDHU3_26.2750

Length:

113

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 103

Expansion

Sequence features

A0A3Q8ICY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.513
CLV_C14_Caspase3-7	87	91	PF00656	0.509
CLV_NRD_NRD_1	99	101	PF00675	0.537
CLV_PCSK_KEX2_1	99	101	PF00082	0.541
DEG_Nend_UBRbox_3	1	3	PF02207	0.802
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.571
DOC_MAPK_MEF2A_6	72	81	PF00069	0.546
DOC_PP2B_LxvP_1	71	74	PF13499	0.597
DOC_USP7_MATH_1	48	52	PF00917	0.610
DOC_WW_Pin1_4	34	39	PF00397	0.554
LIG_FHA_2	47	53	PF00498	0.642
LIG_IRF3_LxIS_1	75	82	PF10401	0.483
LIG_LIR_Gen_1	25	33	PF02991	0.546
LIG_LIR_Gen_1	65	76	PF02991	0.560
LIG_LIR_Gen_1	91	101	PF02991	0.527
LIG_LIR_Nem_3	25	30	PF02991	0.541
LIG_LIR_Nem_3	65	71	PF02991	0.587
LIG_LIR_Nem_3	82	86	PF02991	0.363
LIG_LIR_Nem_3	91	97	PF02991	0.455
LIG_MYND_1	42	46	PF01753	0.635
LIG_Pex14_2	84	88	PF04695	0.495
LIG_SH2_CRK	27	31	PF00017	0.538
LIG_SH2_CRK	94	98	PF00017	0.535
LIG_SH2_NCK_1	94	98	PF00017	0.491
LIG_SH2_STAT5	83	86	PF00017	0.502
LIG_SH3_3	35	41	PF00018	0.595
LIG_SH3_3	70	76	PF00018	0.580
LIG_TYR_ITIM	81	86	PF00017	0.462
MOD_CDK_SPxK_1	34	40	PF00069	0.559
MOD_CK1_1	105	111	PF00069	0.566
MOD_CK1_1	63	69	PF00069	0.626
MOD_CK1_1	82	88	PF00069	0.325
MOD_CK2_1	46	52	PF00069	0.631
MOD_CK2_1	63	69	PF00069	0.464
MOD_GlcNHglycan	62	65	PF01048	0.617
MOD_GlcNHglycan	90	93	PF01048	0.505
MOD_GSK3_1	12	19	PF00069	0.592
MOD_N-GLC_1	53	58	PF02516	0.530
MOD_NEK2_1	79	84	PF00069	0.517
MOD_PIKK_1	102	108	PF00454	0.567
MOD_PKA_2	88	94	PF00069	0.507
MOD_Plk_1	100	106	PF00069	0.551
MOD_Plk_4	12	18	PF00069	0.577
MOD_ProDKin_1	34	40	PF00069	0.559
TRG_ENDOCYTIC_2	27	30	PF00928	0.535
TRG_ENDOCYTIC_2	68	71	PF00928	0.630
TRG_ENDOCYTIC_2	83	86	PF00928	0.371
TRG_ENDOCYTIC_2	94	97	PF00928	0.455
TRG_ER_diLys_1	110	113	PF00400	0.585
TRG_NES_CRM1_1	12	25	PF08389	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HF53	Leishmania braziliensis	70%	100%
A4I2D7	Leishmania infantum	100%	100%
E9AYI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q8Y3	Leishmania major	96%	100%