G protein-coupled receptor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICY4_LEIDO

TriTrypDb:

LdBPK_131230.1 , LdCL_130017800 , LDHU3_13.1510

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8ICY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.478
CLV_C14_Caspase3-7	298	302	PF00656	0.670
CLV_MEL_PAP_1	274	280	PF00089	0.366
CLV_NRD_NRD_1	130	132	PF00675	0.442
CLV_NRD_NRD_1	146	148	PF00675	0.437
CLV_NRD_NRD_1	414	416	PF00675	0.492
CLV_PCSK_FUR_1	411	415	PF00082	0.486
CLV_PCSK_KEX2_1	130	132	PF00082	0.442
CLV_PCSK_KEX2_1	146	148	PF00082	0.437
CLV_PCSK_KEX2_1	410	412	PF00082	0.515
CLV_PCSK_KEX2_1	413	415	PF00082	0.493
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.505
CLV_PCSK_SKI1_1	188	192	PF00082	0.369
CLV_PCSK_SKI1_1	232	236	PF00082	0.601
CLV_PCSK_SKI1_1	29	33	PF00082	0.609
DEG_APCC_DBOX_1	63	71	PF00400	0.611
DEG_SCF_FBW7_1	403	409	PF00400	0.684
DEG_SPOP_SBC_1	189	193	PF00917	0.369
DEG_SPOP_SBC_1	449	453	PF00917	0.447
DOC_CKS1_1	403	408	PF01111	0.685
DOC_MAPK_gen_1	62	70	PF00069	0.609
DOC_MAPK_RevD_3	399	412	PF00069	0.693
DOC_PP4_FxxP_1	217	220	PF00568	0.398
DOC_PP4_FxxP_1	291	294	PF00568	0.670
DOC_USP7_MATH_1	126	130	PF00917	0.665
DOC_USP7_MATH_1	190	194	PF00917	0.369
DOC_USP7_MATH_1	239	243	PF00917	0.424
DOC_USP7_MATH_1	253	257	PF00917	0.398
DOC_USP7_MATH_1	311	315	PF00917	0.636
DOC_USP7_MATH_1	389	393	PF00917	0.710
DOC_USP7_MATH_1	449	453	PF00917	0.425
DOC_USP7_MATH_1	480	484	PF00917	0.449
DOC_USP7_MATH_1	9	13	PF00917	0.435
DOC_USP7_UBL2_3	104	108	PF12436	0.691
DOC_WW_Pin1_4	227	232	PF00397	0.460
DOC_WW_Pin1_4	248	253	PF00397	0.413
DOC_WW_Pin1_4	307	312	PF00397	0.659
DOC_WW_Pin1_4	324	329	PF00397	0.604
DOC_WW_Pin1_4	365	370	PF00397	0.657
DOC_WW_Pin1_4	402	407	PF00397	0.686
DOC_WW_Pin1_4	420	425	PF00397	0.564
DOC_WW_Pin1_4	450	455	PF00397	0.463
DOC_WW_Pin1_4	46	51	PF00397	0.278
LIG_14-3-3_CanoR_1	130	139	PF00244	0.742
LIG_14-3-3_CanoR_1	146	151	PF00244	0.592
LIG_14-3-3_CanoR_1	188	198	PF00244	0.475
LIG_14-3-3_CanoR_1	353	363	PF00244	0.635
LIG_BRCT_BRCA1_1	271	275	PF00533	0.513
LIG_EH1_1	330	338	PF00400	0.581
LIG_eIF4E_1	331	337	PF01652	0.577
LIG_FHA_1	190	196	PF00498	0.329
LIG_FHA_1	238	244	PF00498	0.409
LIG_FHA_1	255	261	PF00498	0.230
LIG_FHA_1	290	296	PF00498	0.629
LIG_FHA_1	403	409	PF00498	0.687
LIG_FHA_1	416	422	PF00498	0.623
LIG_FHA_1	47	53	PF00498	0.334
LIG_FHA_1	482	488	PF00498	0.455
LIG_FHA_2	468	474	PF00498	0.428
LIG_LIR_Apic_2	122	128	PF02991	0.676
LIG_LIR_Apic_2	212	216	PF02991	0.412
LIG_LIR_Gen_1	154	165	PF02991	0.709
LIG_LIR_Gen_1	200	206	PF02991	0.351
LIG_LIR_Gen_1	283	291	PF02991	0.614
LIG_LIR_Gen_1	320	331	PF02991	0.602
LIG_LIR_Nem_3	154	160	PF02991	0.708
LIG_LIR_Nem_3	200	204	PF02991	0.351
LIG_LIR_Nem_3	256	261	PF02991	0.382
LIG_LIR_Nem_3	272	278	PF02991	0.518
LIG_LIR_Nem_3	283	288	PF02991	0.599
LIG_LIR_Nem_3	320	326	PF02991	0.643
LIG_LIR_Nem_3	435	441	PF02991	0.304
LIG_LIR_Nem_3	458	464	PF02991	0.468
LIG_LIR_Nem_3	470	475	PF02991	0.391
LIG_MYND_1	338	342	PF01753	0.599
LIG_PDZ_Class_2	485	490	PF00595	0.464
LIG_Pex14_1	271	275	PF04695	0.513
LIG_SH2_CRK	157	161	PF00017	0.626
LIG_SH2_CRK	182	186	PF00017	0.472
LIG_SH2_CRK	364	368	PF00017	0.618
LIG_SH2_NCK_1	364	368	PF00017	0.618
LIG_SH2_PTP2	213	216	PF00017	0.370
LIG_SH2_STAT5	213	216	PF00017	0.370
LIG_SH2_STAT5	331	334	PF00017	0.579
LIG_SH2_STAT5	475	478	PF00017	0.453
LIG_SH3_2	338	343	PF14604	0.623
LIG_SH3_3	246	252	PF00018	0.435
LIG_SH3_3	335	341	PF00018	0.631
LIG_SH3_3	366	372	PF00018	0.731
LIG_SH3_3	383	389	PF00018	0.621
LIG_SH3_3	400	406	PF00018	0.632
LIG_SH3_3	456	462	PF00018	0.543
LIG_SUMO_SIM_anti_2	483	489	PF11976	0.397
LIG_SUMO_SIM_par_1	461	467	PF11976	0.439
LIG_SUMO_SIM_par_1	483	489	PF11976	0.373
LIG_TRAF2_1	93	96	PF00917	0.698
LIG_WRC_WIRS_1	152	157	PF05994	0.475
LIG_WRC_WIRS_1	198	203	PF05994	0.325
LIG_WRC_WIRS_1	260	265	PF05994	0.369
LIG_WW_3	340	344	PF00397	0.491
MOD_CDK_SPK_2	227	232	PF00069	0.527
MOD_CDK_SPK_2	324	329	PF00069	0.492
MOD_CDK_SPK_2	368	373	PF00069	0.573
MOD_CDK_SPK_2	455	460	PF00069	0.562
MOD_CDK_SPxxK_3	368	375	PF00069	0.624
MOD_CDK_SPxxK_3	420	427	PF00069	0.515
MOD_CK1_1	129	135	PF00069	0.580
MOD_CK1_1	197	203	PF00069	0.355
MOD_CK1_1	230	236	PF00069	0.676
MOD_CK1_1	242	248	PF00069	0.483
MOD_CK1_1	307	313	PF00069	0.515
MOD_CK1_1	368	374	PF00069	0.619
MOD_CK1_1	392	398	PF00069	0.676
MOD_CK1_1	452	458	PF00069	0.629
MOD_CK1_1	483	489	PF00069	0.526
MOD_Cter_Amidation	144	147	PF01082	0.589
MOD_GlcNHglycan	118	124	PF01048	0.591
MOD_GlcNHglycan	235	238	PF01048	0.479
MOD_GlcNHglycan	265	268	PF01048	0.327
MOD_GlcNHglycan	301	305	PF01048	0.669
MOD_GlcNHglycan	389	392	PF01048	0.797
MOD_GlcNHglycan	454	457	PF01048	0.574
MOD_GSK3_1	126	133	PF00069	0.579
MOD_GSK3_1	146	153	PF00069	0.585
MOD_GSK3_1	190	197	PF00069	0.340
MOD_GSK3_1	233	240	PF00069	0.593
MOD_GSK3_1	259	266	PF00069	0.286
MOD_GSK3_1	300	307	PF00069	0.574
MOD_GSK3_1	318	325	PF00069	0.573
MOD_GSK3_1	373	380	PF00069	0.577
MOD_GSK3_1	387	394	PF00069	0.584
MOD_GSK3_1	402	409	PF00069	0.556
MOD_GSK3_1	444	451	PF00069	0.519
MOD_N-GLC_1	254	259	PF02516	0.369
MOD_N-GLC_1	449	454	PF02516	0.565
MOD_NEK2_1	170	175	PF00069	0.503
MOD_NEK2_1	243	248	PF00069	0.628
MOD_NEK2_1	263	268	PF00069	0.183
MOD_NEK2_1	306	311	PF00069	0.566
MOD_NEK2_1	318	323	PF00069	0.559
MOD_NEK2_1	332	337	PF00069	0.378
MOD_NEK2_1	443	448	PF00069	0.488
MOD_NEK2_2	239	244	PF00069	0.512
MOD_PIKK_1	130	136	PF00454	0.585
MOD_PIKK_1	289	295	PF00454	0.521
MOD_PIKK_1	311	317	PF00454	0.560
MOD_PKA_1	130	136	PF00069	0.539
MOD_PKA_1	146	152	PF00069	0.532
MOD_PKA_2	126	132	PF00069	0.608
MOD_PKA_2	146	152	PF00069	0.464
MOD_PKA_2	352	358	PF00069	0.573
MOD_PKB_1	413	421	PF00069	0.610
MOD_Plk_1	119	125	PF00069	0.594
MOD_Plk_1	254	260	PF00069	0.369
MOD_Plk_1	434	440	PF00069	0.325
MOD_Plk_1	97	103	PF00069	0.523
MOD_Plk_4	135	141	PF00069	0.573
MOD_Plk_4	146	152	PF00069	0.542
MOD_Plk_4	197	203	PF00069	0.339
MOD_Plk_4	22	28	PF00069	0.656
MOD_Plk_4	239	245	PF00069	0.545
MOD_Plk_4	280	286	PF00069	0.478
MOD_Plk_4	318	324	PF00069	0.614
MOD_Plk_4	332	338	PF00069	0.385
MOD_Plk_4	346	352	PF00069	0.501
MOD_Plk_4	483	489	PF00069	0.482
MOD_Plk_4	9	15	PF00069	0.637
MOD_ProDKin_1	227	233	PF00069	0.561
MOD_ProDKin_1	248	254	PF00069	0.509
MOD_ProDKin_1	307	313	PF00069	0.566
MOD_ProDKin_1	324	330	PF00069	0.486
MOD_ProDKin_1	365	371	PF00069	0.567
MOD_ProDKin_1	402	408	PF00069	0.607
MOD_ProDKin_1	420	426	PF00069	0.427
MOD_ProDKin_1	450	456	PF00069	0.577
MOD_ProDKin_1	46	52	PF00069	0.278
MOD_SUMO_rev_2	25	34	PF00179	0.698
TRG_DiLeu_BaLyEn_6	416	421	PF01217	0.643
TRG_ENDOCYTIC_2	157	160	PF00928	0.719
TRG_ENDOCYTIC_2	182	185	PF00928	0.494
TRG_ENDOCYTIC_2	331	334	PF00928	0.457
TRG_ER_diArg_1	411	414	PF00400	0.624
TRG_NLS_MonoCore_2	409	414	PF00514	0.627
TRG_NLS_MonoExtC_3	409	414	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I976	Leptomonas seymouri	42%	95%
A4H7B6	Leishmania braziliensis	70%	98%
A4HVR1	Leishmania infantum	98%	100%
E9APF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QG21	Leishmania major	91%	100%