LeishMANIAdb
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Semialdehyde dehydrogenase, NAD binding domain/NADH(P)-binding/3-beta hydroxysteroid dehydrogenase/isomerase family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Semialdehyde dehydrogenase, NAD binding domain/NADH(P)-binding/3-beta hydroxysteroid dehydrogenase/isomerase family, putative
Gene product:
3-beta hydroxysteroid dehydrogenase/isomerase family, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ICY3_LEIDO
TriTrypDb:
LdBPK_180080.1 , LdCL_180005700 , LDHU3_18.0090
Length:
479

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3Q8ICY3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICY3

Function

Biological processes
TermNameLevelCount
GO:0006629 lipid metabolic process 3 11
GO:0006694 steroid biosynthetic process 5 11
GO:0006743 ubiquinone metabolic process 5 1
GO:0006744 ubiquinone biosynthetic process 6 1
GO:0008152 metabolic process 1 11
GO:0008202 steroid metabolic process 4 11
GO:0008610 lipid biosynthetic process 4 11
GO:0009058 biosynthetic process 2 11
GO:0009987 cellular process 1 1
GO:0042180 cellular ketone metabolic process 3 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 11
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity 5 11
GO:0005488 binding 1 1
GO:0016229 steroid dehydrogenase activity 3 11
GO:0016491 oxidoreductase activity 2 11
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 11
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 11
GO:0016853 isomerase activity 2 2
GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 11
GO:0044877 protein-containing complex binding 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 130 134 PF00656 0.317
CLV_NRD_NRD_1 35 37 PF00675 0.522
CLV_NRD_NRD_1 361 363 PF00675 0.445
CLV_NRD_NRD_1 392 394 PF00675 0.552
CLV_NRD_NRD_1 80 82 PF00675 0.545
CLV_PCSK_KEX2_1 319 321 PF00082 0.524
CLV_PCSK_KEX2_1 361 363 PF00082 0.445
CLV_PCSK_KEX2_1 79 81 PF00082 0.559
CLV_PCSK_KEX2_1 88 90 PF00082 0.403
CLV_PCSK_PC1ET2_1 319 321 PF00082 0.508
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PDT9 Leptomonas seymouri 91% 100%
A0A0S4JJB1 Bodo saltans 76% 100%
A0A1X0P6V3 Trypanosomatidae 85% 100%
A4H9B3 Leishmania braziliensis 94% 100%
A4HXN4 Leishmania infantum 100% 100%
D0A011 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 87% 99%
E9ARE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QE34 Leishmania major 98% 100%
V5B9X0 Trypanosoma cruzi 83% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS