Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICY2_LEIDO

TriTrypDb:

LdBPK_280220.1 , LdCL_280007100 , LDHU3_28.0300

Length:

355

Annotations

LeishMANIAdb annotations

Related to many other eukaryotic palmitoyltransferases (e.g. mammalian ZDHHC4/9/14/24)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3Q8ICY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICY2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0016409	palmitoyltransferase activity	5	20
GO:0016417	S-acyltransferase activity	5	20
GO:0016740	transferase activity	2	20
GO:0016746	acyltransferase activity	3	20
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	20
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	20
GO:0019707	protein-cysteine S-acyltransferase activity	3	20
GO:0140096	catalytic activity, acting on a protein	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.491
CLV_NRD_NRD_1	150	152	PF00675	0.387
CLV_NRD_NRD_1	172	174	PF00675	0.206
CLV_NRD_NRD_1	261	263	PF00675	0.512
CLV_NRD_NRD_1	307	309	PF00675	0.210
CLV_NRD_NRD_1	311	313	PF00675	0.210
CLV_NRD_NRD_1	324	326	PF00675	0.314
CLV_NRD_NRD_1	64	66	PF00675	0.412
CLV_NRD_NRD_1	77	79	PF00675	0.304
CLV_PCSK_FUR_1	148	152	PF00082	0.350
CLV_PCSK_KEX2_1	150	152	PF00082	0.387
CLV_PCSK_KEX2_1	172	174	PF00082	0.208
CLV_PCSK_KEX2_1	261	263	PF00082	0.509
CLV_PCSK_KEX2_1	307	309	PF00082	0.211
CLV_PCSK_KEX2_1	324	326	PF00082	0.378
CLV_PCSK_KEX2_1	63	65	PF00082	0.407
CLV_PCSK_KEX2_1	76	78	PF00082	0.335
CLV_PCSK_SKI1_1	207	211	PF00082	0.229
CLV_PCSK_SKI1_1	229	233	PF00082	0.472
CLV_PCSK_SKI1_1	331	335	PF00082	0.384
CLV_PCSK_SKI1_1	78	82	PF00082	0.421
DEG_APCC_DBOX_1	76	84	PF00400	0.468
DEG_SCF_FBW7_1	249	256	PF00400	0.195
DEG_SCF_FBW7_2	235	241	PF00400	0.189
DOC_ANK_TNKS_1	15	22	PF00023	0.588
DOC_CKS1_1	235	240	PF01111	0.211
DOC_CKS1_1	250	255	PF01111	0.200
DOC_CYCLIN_RxL_1	226	234	PF00134	0.373
DOC_CYCLIN_RxL_1	45	57	PF00134	0.529
DOC_MAPK_gen_1	204	213	PF00069	0.404
DOC_MAPK_gen_1	312	319	PF00069	0.656
DOC_MAPK_gen_1	45	53	PF00069	0.539
DOC_MAPK_gen_1	76	85	PF00069	0.602
DOC_MAPK_JIP1_4	47	53	PF00069	0.543
DOC_MAPK_MEF2A_6	312	321	PF00069	0.540
DOC_MAPK_MEF2A_6	78	87	PF00069	0.429
DOC_PP1_RVXF_1	202	209	PF00149	0.419
DOC_PP1_RVXF_1	47	54	PF00149	0.535
DOC_PP1_RVXF_1	82	88	PF00149	0.530
DOC_PP2B_LxvP_1	334	337	PF13499	0.576
DOC_USP7_UBL2_3	45	49	PF12436	0.687
DOC_WW_Pin1_4	234	239	PF00397	0.301
DOC_WW_Pin1_4	249	254	PF00397	0.283
DOC_WW_Pin1_4	332	337	PF00397	0.600
DOC_WW_Pin1_4	40	45	PF00397	0.690
LIG_14-3-3_CanoR_1	207	212	PF00244	0.434
LIG_14-3-3_CanoR_1	261	265	PF00244	0.360
LIG_14-3-3_CanoR_1	28	36	PF00244	0.729
LIG_14-3-3_CanoR_1	312	318	PF00244	0.640
LIG_Actin_WH2_2	134	152	PF00022	0.312
LIG_AP2alpha_1	232	236	PF02296	0.200
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BIR_III_4	18	22	PF00653	0.591
LIG_BRCT_BRCA1_1	87	91	PF00533	0.544
LIG_eIF4E_1	121	127	PF01652	0.305
LIG_eIF4E_1	230	236	PF01652	0.222
LIG_FHA_1	136	142	PF00498	0.401
LIG_FHA_1	208	214	PF00498	0.345
LIG_FHA_1	99	105	PF00498	0.255
LIG_FHA_2	137	143	PF00498	0.375
LIG_FHA_2	304	310	PF00498	0.437
LIG_GBD_Chelix_1	274	282	PF00786	0.479
LIG_GBD_Chelix_1	285	293	PF00786	0.289
LIG_LIR_Gen_1	120	129	PF02991	0.268
LIG_LIR_Nem_3	120	126	PF02991	0.285
LIG_LIR_Nem_3	228	233	PF02991	0.322
LIG_LIR_Nem_3	50	56	PF02991	0.607
LIG_LYPXL_S_1	145	149	PF13949	0.247
LIG_LYPXL_yS_3	146	149	PF13949	0.452
LIG_LYPXL_yS_3	254	257	PF13949	0.200
LIG_MYND_1	40	44	PF01753	0.550
LIG_NRBOX	277	283	PF00104	0.376
LIG_NRBOX	316	322	PF00104	0.514
LIG_PDZ_Class_1	350	355	PF00595	0.649
LIG_Pex14_1	208	212	PF04695	0.232
LIG_Pex14_1	226	230	PF04695	0.259
LIG_Pex14_2	132	136	PF04695	0.280
LIG_Pex14_2	232	236	PF04695	0.296
LIG_Pex14_2	87	91	PF04695	0.483
LIG_SH2_STAT5	121	124	PF00017	0.361
LIG_SH2_STAT5	212	215	PF00017	0.229
LIG_SH2_STAT5	230	233	PF00017	0.352
LIG_SH2_STAT5	297	300	PF00017	0.289
LIG_SH2_STAT5	86	89	PF00017	0.484
LIG_SH3_2	23	28	PF14604	0.608
LIG_SH3_3	17	23	PF00018	0.589
LIG_SH3_3	330	336	PF00018	0.497
LIG_SH3_4	45	52	PF00018	0.677
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.290
LIG_SUMO_SIM_anti_2	283	289	PF11976	0.287
LIG_SUMO_SIM_par_1	124	131	PF11976	0.364
LIG_SUMO_SIM_par_1	277	283	PF11976	0.332
LIG_TRAF2_1	347	350	PF00917	0.578
LIG_UBA3_1	80	84	PF00899	0.472
LIG_WRC_WIRS_1	72	77	PF05994	0.423
LIG_WW_3	173	177	PF00397	0.465
MOD_CDK_SPK_2	40	45	PF00069	0.581
MOD_CDK_SPxxK_3	40	47	PF00069	0.593
MOD_CK1_1	215	221	PF00069	0.273
MOD_CK1_1	24	30	PF00069	0.719
MOD_CK1_1	303	309	PF00069	0.444
MOD_CK2_1	303	309	PF00069	0.453
MOD_Cter_Amidation	259	262	PF01082	0.509
MOD_GlcNHglycan	1	4	PF01048	0.491
MOD_GlcNHglycan	29	32	PF01048	0.534
MOD_GlcNHglycan	67	70	PF01048	0.424
MOD_GlcNHglycan	87	90	PF01048	0.200
MOD_GSK3_1	127	134	PF00069	0.274
MOD_GSK3_1	212	219	PF00069	0.348
MOD_GSK3_1	249	256	PF00069	0.265
MOD_GSK3_1	298	305	PF00069	0.302
MOD_GSK3_1	332	339	PF00069	0.511
MOD_N-GLC_1	242	247	PF02516	0.446
MOD_N-GLC_2	184	186	PF02516	0.227
MOD_NEK2_1	127	132	PF00069	0.304
MOD_NEK2_1	136	141	PF00069	0.281
MOD_NEK2_1	298	303	PF00069	0.307
MOD_NEK2_1	98	103	PF00069	0.400
MOD_NEK2_2	71	76	PF00069	0.496
MOD_PKA_1	307	313	PF00069	0.443
MOD_PKA_2	260	266	PF00069	0.289
MOD_PKA_2	27	33	PF00069	0.736
MOD_PKA_2	307	313	PF00069	0.470
MOD_PKB_1	63	71	PF00069	0.434
MOD_Plk_1	349	355	PF00069	0.544
MOD_Plk_4	192	198	PF00069	0.509
MOD_Plk_4	217	223	PF00069	0.421
MOD_Plk_4	336	342	PF00069	0.470
MOD_Plk_4	56	62	PF00069	0.534
MOD_ProDKin_1	234	240	PF00069	0.301
MOD_ProDKin_1	249	255	PF00069	0.293
MOD_ProDKin_1	332	338	PF00069	0.604
MOD_ProDKin_1	40	46	PF00069	0.690
TRG_DiLeu_BaEn_1	350	355	PF01217	0.593
TRG_ENDOCYTIC_2	146	149	PF00928	0.451
TRG_ENDOCYTIC_2	233	236	PF00928	0.316
TRG_ENDOCYTIC_2	254	257	PF00928	0.332
TRG_ENDOCYTIC_2	297	300	PF00928	0.278
TRG_ER_diArg_1	147	150	PF00400	0.498
TRG_ER_diArg_1	171	173	PF00400	0.406
TRG_ER_diArg_1	323	325	PF00400	0.612
TRG_ER_diArg_1	62	65	PF00400	0.628
TRG_ER_diArg_1	75	78	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P729	Leptomonas seymouri	34%	100%
A0A0N1HZ19	Leptomonas seymouri	64%	100%
A0A0N1IMN2	Leptomonas seymouri	25%	81%
A0A0S4IT15	Bodo saltans	38%	100%
A0A0S4IXZ6	Bodo saltans	29%	100%
A0A0S4JRL4	Bodo saltans	38%	99%
A0A1X0NX08	Trypanosomatidae	41%	100%
A0A1X0NY30	Trypanosomatidae	26%	100%
A0A3Q8IIC8	Leishmania donovani	28%	100%
A0A3R7N519	Trypanosoma rangeli	39%	100%
A0A3S7WZD9	Leishmania donovani	20%	100%
A4HG63	Leishmania braziliensis	71%	100%
A4HMS9	Leishmania braziliensis	31%	100%
A4I1S8	Leishmania infantum	20%	100%
A4I395	Leishmania infantum	99%	100%
A4IBG8	Leishmania infantum	28%	100%
B3DN87	Arabidopsis thaliana	27%	100%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AF82	Leishmania major	28%	100%
E9AZI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B6D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O74384	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O80685	Arabidopsis thaliana	26%	86%
Q0WQK2	Arabidopsis thaliana	25%	80%
Q4Q8P8	Leishmania major	92%	100%
Q4Q9K8	Leishmania major	23%	100%
Q5PNZ1	Arabidopsis thaliana	26%	86%
Q5REH2	Pongo abelii	25%	86%
Q6CUB5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	94%
Q8VYS8	Arabidopsis thaliana	23%	87%
Q9CPV7	Mus musculus	26%	86%
Q9FLM3	Arabidopsis thaliana	26%	87%
Q9H6R6	Homo sapiens	25%	86%
Q9NXF8	Homo sapiens	22%	100%
Q9NYG2	Homo sapiens	23%	100%
Q9SB58	Arabidopsis thaliana	23%	87%
V5BC02	Trypanosoma cruzi	42%	100%