Fatty acyl-CoA reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Male sterility protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICX8_LEIDO

TriTrypDb:

LdBPK_241710.1 , LdCL_240022200 , LDHU3_24.2100

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8ICX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICX8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006637	acyl-CoA metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035336	long-chain fatty-acyl-CoA metabolic process	6	1
GO:0035337	fatty-acyl-CoA metabolic process	5	1
GO:0035383	thioester metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901568	fatty acid derivative metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4	12
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	12
GO:0080019	alcohol-forming very long-chain fatty acyl-CoA reductase activity	5	12
GO:0102965	alcohol-forming long-chain fatty acyl-CoA reductase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	172	174	PF00675	0.404
CLV_NRD_NRD_1	318	320	PF00675	0.533
CLV_NRD_NRD_1	490	492	PF00675	0.374
CLV_NRD_NRD_1	51	53	PF00675	0.305
CLV_NRD_NRD_1	525	527	PF00675	0.387
CLV_PCSK_FUR_1	426	430	PF00082	0.530
CLV_PCSK_FUR_1	46	50	PF00082	0.374
CLV_PCSK_KEX2_1	172	174	PF00082	0.421
CLV_PCSK_KEX2_1	196	198	PF00082	0.419
CLV_PCSK_KEX2_1	318	320	PF00082	0.499
CLV_PCSK_KEX2_1	39	41	PF00082	0.339
CLV_PCSK_KEX2_1	428	430	PF00082	0.410
CLV_PCSK_KEX2_1	48	50	PF00082	0.298
CLV_PCSK_KEX2_1	490	492	PF00082	0.369
CLV_PCSK_KEX2_1	51	53	PF00082	0.270
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.419
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.343
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.410
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.334
CLV_PCSK_SKI1_1	12	16	PF00082	0.329
CLV_PCSK_SKI1_1	176	180	PF00082	0.156
CLV_PCSK_SKI1_1	196	200	PF00082	0.281
CLV_PCSK_SKI1_1	25	29	PF00082	0.301
CLV_PCSK_SKI1_1	282	286	PF00082	0.407
CLV_PCSK_SKI1_1	30	34	PF00082	0.301
CLV_PCSK_SKI1_1	306	310	PF00082	0.320
CLV_PCSK_SKI1_1	51	55	PF00082	0.335
CLV_Separin_Metazoa	74	78	PF03568	0.421
DEG_APCC_DBOX_1	61	69	PF00400	0.421
DEG_SPOP_SBC_1	369	373	PF00917	0.666
DEG_SPOP_SBC_1	403	407	PF00917	0.408
DOC_CYCLIN_RxL_1	303	311	PF00134	0.328
DOC_MAPK_DCC_7	236	246	PF00069	0.421
DOC_MAPK_gen_1	236	245	PF00069	0.320
DOC_MAPK_gen_1	428	439	PF00069	0.485
DOC_MAPK_HePTP_8	233	245	PF00069	0.386
DOC_MAPK_MEF2A_6	133	140	PF00069	0.362
DOC_MAPK_MEF2A_6	236	245	PF00069	0.360
DOC_MAPK_MEF2A_6	342	350	PF00069	0.721
DOC_MAPK_MEF2A_6	432	441	PF00069	0.502
DOC_MAPK_MEF2A_6	456	463	PF00069	0.486
DOC_MAPK_NFAT4_5	133	141	PF00069	0.350
DOC_MAPK_RevD_3	160	173	PF00069	0.421
DOC_PP2B_LxvP_1	469	472	PF13499	0.488
DOC_PP4_FxxP_1	560	563	PF00568	0.425
DOC_USP7_MATH_1	200	204	PF00917	0.234
DOC_USP7_MATH_1	207	211	PF00917	0.417
DOC_USP7_MATH_1	324	328	PF00917	0.595
DOC_USP7_MATH_1	340	344	PF00917	0.390
DOC_USP7_MATH_1	369	373	PF00917	0.718
DOC_USP7_MATH_1	403	407	PF00917	0.406
DOC_USP7_MATH_1	462	466	PF00917	0.436
DOC_USP7_UBL2_3	306	310	PF12436	0.322
DOC_USP7_UBL2_3	428	432	PF12436	0.467
DOC_WW_Pin1_4	329	334	PF00397	0.670
DOC_WW_Pin1_4	376	381	PF00397	0.684
DOC_WW_Pin1_4	472	477	PF00397	0.541
DOC_WW_Pin1_4	67	72	PF00397	0.335
LIG_14-3-3_CanoR_1	111	115	PF00244	0.324
LIG_14-3-3_CanoR_1	342	350	PF00244	0.643
LIG_14-3-3_CanoR_1	411	415	PF00244	0.510
LIG_14-3-3_CanoR_1	416	422	PF00244	0.495
LIG_14-3-3_CanoR_1	526	532	PF00244	0.375
LIG_14-3-3_CterR_2	575	579	PF00244	0.475
LIG_AP2alpha_2	257	259	PF02296	0.421
LIG_BIR_II_1	1	5	PF00653	0.437
LIG_BRCT_BRCA1_1	69	73	PF00533	0.316
LIG_CaM_IQ_9	308	323	PF13499	0.442
LIG_CaM_NSCaTE_8	262	269	PF13499	0.299
LIG_deltaCOP1_diTrp_1	506	511	PF00928	0.293
LIG_EH1_1	298	306	PF00400	0.312
LIG_FHA_1	11	17	PF00498	0.395
LIG_FHA_1	164	170	PF00498	0.301
LIG_FHA_1	18	24	PF00498	0.345
LIG_FHA_1	273	279	PF00498	0.316
LIG_FHA_1	369	375	PF00498	0.726
LIG_FHA_1	380	386	PF00498	0.698
LIG_FHA_1	417	423	PF00498	0.481
LIG_FHA_2	389	395	PF00498	0.593
LIG_FHA_2	501	507	PF00498	0.335
LIG_GBD_Chelix_1	300	308	PF00786	0.316
LIG_LIR_Apic_2	254	258	PF02991	0.335
LIG_LIR_Apic_2	557	563	PF02991	0.425
LIG_LIR_Gen_1	496	504	PF02991	0.406
LIG_LIR_Gen_1	506	517	PF02991	0.353
LIG_LIR_Gen_1	82	92	PF02991	0.400
LIG_LIR_Nem_3	165	171	PF02991	0.316
LIG_LIR_Nem_3	34	38	PF02991	0.312
LIG_LIR_Nem_3	413	417	PF02991	0.415
LIG_LIR_Nem_3	496	502	PF02991	0.406
LIG_LIR_Nem_3	506	512	PF02991	0.353
LIG_LIR_Nem_3	528	534	PF02991	0.404
LIG_LIR_Nem_3	535	541	PF02991	0.362
LIG_LIR_Nem_3	70	76	PF02991	0.324
LIG_LIR_Nem_3	82	88	PF02991	0.301
LIG_MYND_1	563	567	PF01753	0.505
LIG_PCNA_yPIPBox_3	302	316	PF02747	0.386
LIG_PDZ_Class_1	574	579	PF00595	0.486
LIG_Pex14_1	507	511	PF04695	0.370
LIG_SH2_CRK	29	33	PF00017	0.421
LIG_SH2_CRK	509	513	PF00017	0.425
LIG_SH2_CRK	541	545	PF00017	0.386
LIG_SH2_GRB2like	168	171	PF00017	0.301
LIG_SH2_GRB2like	56	59	PF00017	0.386
LIG_SH2_NCK_1	541	545	PF00017	0.335
LIG_SH2_PTP2	460	463	PF00017	0.509
LIG_SH2_SRC	545	548	PF00017	0.363
LIG_SH2_SRC	56	59	PF00017	0.413
LIG_SH2_STAP1	534	538	PF00017	0.335
LIG_SH2_STAP1	541	545	PF00017	0.306
LIG_SH2_STAT5	168	171	PF00017	0.301
LIG_SH2_STAT5	223	226	PF00017	0.296
LIG_SH2_STAT5	255	258	PF00017	0.331
LIG_SH2_STAT5	299	302	PF00017	0.462
LIG_SH2_STAT5	42	45	PF00017	0.302
LIG_SH2_STAT5	453	456	PF00017	0.473
LIG_SH2_STAT5	460	463	PF00017	0.422
LIG_SH2_STAT5	541	544	PF00017	0.354
LIG_SH2_STAT5	56	59	PF00017	0.305
LIG_SH3_3	374	380	PF00018	0.734
LIG_SH3_3	560	566	PF00018	0.416
LIG_SUMO_SIM_anti_2	370	379	PF11976	0.666
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.448
LIG_SUMO_SIM_par_1	272	277	PF11976	0.362
LIG_SUMO_SIM_par_1	346	351	PF11976	0.676
LIG_SUMO_SIM_par_1	370	379	PF11976	0.666
LIG_TYR_ITAM	444	463	PF00017	0.402
LIG_TYR_ITIM	27	32	PF00017	0.404
LIG_TYR_ITIM	450	455	PF00017	0.498
LIG_UBA3_1	27	33	PF00899	0.301
LIG_UBA3_1	304	310	PF00899	0.313
MOD_CDC14_SPxK_1	475	478	PF00782	0.548
MOD_CDK_SPK_2	472	477	PF00069	0.536
MOD_CDK_SPxK_1	472	478	PF00069	0.541
MOD_CK1_1	10	16	PF00069	0.361
MOD_CK1_1	372	378	PF00069	0.658
MOD_CK1_1	379	385	PF00069	0.651
MOD_CK1_1	388	394	PF00069	0.648
MOD_CK1_1	525	531	PF00069	0.409
MOD_CK2_1	372	378	PF00069	0.681
MOD_CK2_1	403	409	PF00069	0.524
MOD_CK2_1	500	506	PF00069	0.335
MOD_CK2_1	565	571	PF00069	0.514
MOD_Cter_Amidation	426	429	PF01082	0.476
MOD_Cter_Amidation	46	49	PF01082	0.386
MOD_GlcNHglycan	209	212	PF01048	0.389
MOD_GlcNHglycan	326	329	PF01048	0.633
MOD_GlcNHglycan	343	346	PF01048	0.642
MOD_GlcNHglycan	364	367	PF01048	0.715
MOD_GlcNHglycan	387	390	PF01048	0.680
MOD_GlcNHglycan	567	570	PF01048	0.537
MOD_GSK3_1	10	17	PF00069	0.355
MOD_GSK3_1	219	226	PF00069	0.301
MOD_GSK3_1	368	375	PF00069	0.608
MOD_GSK3_1	433	440	PF00069	0.547
MOD_LATS_1	430	436	PF00433	0.481
MOD_N-GLC_1	10	15	PF02516	0.467
MOD_N-GLC_1	512	517	PF02516	0.370
MOD_NEK2_1	124	129	PF00069	0.325
MOD_NEK2_1	151	156	PF00069	0.415
MOD_NEK2_1	272	277	PF00069	0.287
MOD_NEK2_1	308	313	PF00069	0.341
MOD_NEK2_1	385	390	PF00069	0.704
MOD_NEK2_1	437	442	PF00069	0.456
MOD_NEK2_1	500	505	PF00069	0.382
MOD_NEK2_2	433	438	PF00069	0.495
MOD_PIKK_1	308	314	PF00454	0.365
MOD_PIKK_1	539	545	PF00454	0.362
MOD_PKA_2	110	116	PF00069	0.368
MOD_PKA_2	246	252	PF00069	0.310
MOD_PKA_2	341	347	PF00069	0.724
MOD_PKA_2	410	416	PF00069	0.495
MOD_PKA_2	525	531	PF00069	0.444
MOD_PKA_2	554	560	PF00069	0.461
MOD_Plk_1	10	16	PF00069	0.459
MOD_Plk_1	369	375	PF00069	0.665
MOD_Plk_1	500	506	PF00069	0.421
MOD_Plk_1	512	518	PF00069	0.421
MOD_Plk_1	97	103	PF00069	0.417
MOD_Plk_2-3	493	499	PF00069	0.448
MOD_Plk_2-3	532	538	PF00069	0.136
MOD_Plk_4	246	252	PF00069	0.306
MOD_Plk_4	372	378	PF00069	0.747
MOD_Plk_4	417	423	PF00069	0.516
MOD_ProDKin_1	329	335	PF00069	0.674
MOD_ProDKin_1	376	382	PF00069	0.684
MOD_ProDKin_1	472	478	PF00069	0.541
MOD_ProDKin_1	67	73	PF00069	0.335
MOD_SUMO_rev_2	34	41	PF00179	0.405
MOD_SUMO_rev_2	349	354	PF00179	0.614
TRG_DiLeu_BaEn_1	209	214	PF01217	0.368
TRG_DiLeu_BaEn_2	394	400	PF01217	0.550
TRG_ENDOCYTIC_2	29	32	PF00928	0.348
TRG_ENDOCYTIC_2	42	45	PF00928	0.232
TRG_ENDOCYTIC_2	447	450	PF00928	0.470
TRG_ENDOCYTIC_2	452	455	PF00928	0.480
TRG_ENDOCYTIC_2	460	463	PF00928	0.213
TRG_ENDOCYTIC_2	509	512	PF00928	0.425
TRG_ENDOCYTIC_2	541	544	PF00928	0.386
TRG_ENDOCYTIC_2	547	550	PF00928	0.386
TRG_ER_diArg_1	171	173	PF00400	0.421
TRG_ER_diArg_1	318	321	PF00400	0.516
TRG_ER_diArg_1	448	451	PF00400	0.503
TRG_ER_diArg_1	489	491	PF00400	0.359
TRG_ER_diArg_1	49	52	PF00400	0.332
TRG_NES_CRM1_1	493	506	PF08389	0.387
TRG_NLS_MonoExtC_3	47	52	PF00514	0.361
TRG_NLS_MonoExtN_4	172	177	PF00514	0.448
TRG_NLS_MonoExtN_4	46	52	PF00514	0.360
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I721	Leptomonas seymouri	72%	100%
A0A0S4ILT5	Bodo saltans	42%	100%
A0A1X0NVR7	Trypanosomatidae	49%	100%
A0A422N8G4	Trypanosoma rangeli	48%	98%
A4HDM4	Leishmania braziliensis	86%	100%
C9ZWE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	93%
E9AH71	Leishmania infantum	100%	100%
E9AX09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAG7	Leishmania major	95%	100%
Q9LXN3	Arabidopsis thaliana	28%	100%
V5AVK6	Trypanosoma cruzi	50%	98%