LeishMANIAdb
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Nucleobase transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleobase transporter
Gene product:
nucleobase transporter
Species:
Leishmania donovani
UniProt:
A0A3Q8ICX7_LEIDO
TriTrypDb:
LdBPK_131110.1 * , LdCL_130016400 , LDHU3_13.1370
Length:
501

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

A0A3Q8ICX7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICX7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 54
GO:0005337 nucleoside transmembrane transporter activity 4 54
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 54
GO:0022857 transmembrane transporter activity 2 54
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 54
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 317 321 PF00656 0.504
CLV_NRD_NRD_1 289 291 PF00675 0.502
CLV_NRD_NRD_1 86 88 PF00675 0.291
CLV_PCSK_KEX2_1 230 232 PF00082 0.249
CLV_PCSK_KEX2_1 289 291 PF00082 0.562
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.206
CLV_PCSK_SKI1_1 227 231 PF00082 0.244
CLV_PCSK_SKI1_1 326 330 PF00082 0.354
CLV_PCSK_SKI1_1 416 420 PF00082 0.298
CLV_PCSK_SKI1_1 43 47 PF00082 0.467
DEG_Nend_Nbox_1 1 3 PF02207 0.580
DEG_SPOP_SBC_1 168 172 PF00917 0.306
DOC_ANK_TNKS_1 288 295 PF00023 0.575
DOC_CDC14_PxL_1 361 369 PF14671 0.422
DOC_CKS1_1 81 86 PF01111 0.341
DOC_CYCLIN_yClb1_LxF_4 60 66 PF00134 0.301
DOC_MAPK_gen_1 336 345 PF00069 0.461
DOC_MAPK_gen_1 373 383 PF00069 0.337
DOC_MAPK_gen_1 87 93 PF00069 0.503
DOC_MAPK_HePTP_8 91 103 PF00069 0.476
DOC_MAPK_MEF2A_6 336 345 PF00069 0.418
DOC_MAPK_MEF2A_6 376 385 PF00069 0.352
DOC_MAPK_MEF2A_6 416 424 PF00069 0.322
DOC_MAPK_MEF2A_6 94 103 PF00069 0.309
DOC_MAPK_NFAT4_5 94 102 PF00069 0.400
DOC_PP2B_LxvP_1 110 113 PF13499 0.298
DOC_PP2B_LxvP_1 362 365 PF13499 0.303
DOC_PP2B_LxvP_1 367 370 PF13499 0.222
DOC_PP4_FxxP_1 345 348 PF00568 0.541
DOC_PP4_FxxP_1 401 404 PF00568 0.533
DOC_USP7_MATH_1 295 299 PF00917 0.764
DOC_USP7_MATH_1 30 34 PF00917 0.349
DOC_USP7_MATH_1 484 488 PF00917 0.349
DOC_USP7_UBL2_3 287 291 PF12436 0.753
DOC_WW_Pin1_4 52 57 PF00397 0.424
DOC_WW_Pin1_4 80 85 PF00397 0.380
LIG_14-3-3_CanoR_1 214 219 PF00244 0.473
LIG_14-3-3_CanoR_1 326 334 PF00244 0.541
LIG_14-3-3_CanoR_1 394 400 PF00244 0.298
LIG_14-3-3_CanoR_1 464 473 PF00244 0.492
LIG_14-3-3_CanoR_1 87 92 PF00244 0.466
LIG_Actin_WH2_2 174 192 PF00022 0.454
LIG_BIR_III_4 390 394 PF00653 0.271
LIG_BRCT_BRCA1_1 211 215 PF00533 0.431
LIG_BRCT_BRCA1_1 397 401 PF00533 0.448
LIG_BRCT_BRCA1_1 454 458 PF00533 0.405
LIG_BRCT_BRCA1_1 54 58 PF00533 0.395
LIG_BRCT_BRCA1_1 89 93 PF00533 0.494
LIG_Clathr_ClatBox_1 101 105 PF01394 0.345
LIG_EH1_1 356 364 PF00400 0.392
LIG_eIF4E_1 14 20 PF01652 0.313
LIG_eIF4E_1 438 444 PF01652 0.317
LIG_FHA_1 14 20 PF00498 0.306
LIG_FHA_1 378 384 PF00498 0.327
LIG_FHA_1 71 77 PF00498 0.308
LIG_FHA_2 315 321 PF00498 0.463
LIG_FHA_2 327 333 PF00498 0.474
LIG_LIR_Apic_2 398 404 PF02991 0.545
LIG_LIR_Gen_1 105 114 PF02991 0.319
LIG_LIR_Gen_1 143 153 PF02991 0.451
LIG_LIR_Gen_1 182 193 PF02991 0.263
LIG_LIR_Gen_1 352 362 PF02991 0.247
LIG_LIR_Gen_1 375 386 PF02991 0.311
LIG_LIR_Gen_1 423 432 PF02991 0.364
LIG_LIR_Nem_3 105 110 PF02991 0.256
LIG_LIR_Nem_3 143 148 PF02991 0.481
LIG_LIR_Nem_3 182 188 PF02991 0.271
LIG_LIR_Nem_3 212 218 PF02991 0.378
LIG_LIR_Nem_3 225 229 PF02991 0.415
LIG_LIR_Nem_3 275 280 PF02991 0.741
LIG_LIR_Nem_3 337 343 PF02991 0.497
LIG_LIR_Nem_3 352 357 PF02991 0.249
LIG_LIR_Nem_3 375 381 PF02991 0.270
LIG_LIR_Nem_3 423 427 PF02991 0.341
LIG_LIR_Nem_3 455 461 PF02991 0.257
LIG_LIR_Nem_3 64 68 PF02991 0.263
LIG_LIR_Nem_3 90 96 PF02991 0.488
LIG_Pex14_2 161 165 PF04695 0.313
LIG_Pex14_2 354 358 PF04695 0.251
LIG_Pex14_2 424 428 PF04695 0.326
LIG_PTB_Apo_2 445 452 PF02174 0.300
LIG_SH2_CRK 145 149 PF00017 0.510
LIG_SH2_CRK 185 189 PF00017 0.287
LIG_SH2_NCK_1 145 149 PF00017 0.489
LIG_SH2_NCK_1 66 70 PF00017 0.369
LIG_SH2_SRC 12 15 PF00017 0.396
LIG_SH2_SRC 139 142 PF00017 0.354
LIG_SH2_SRC 430 433 PF00017 0.288
LIG_SH2_STAP1 14 18 PF00017 0.322
LIG_SH2_STAP1 185 189 PF00017 0.250
LIG_SH2_STAT5 12 15 PF00017 0.307
LIG_SH2_STAT5 139 142 PF00017 0.329
LIG_SH2_STAT5 193 196 PF00017 0.264
LIG_SH2_STAT5 430 433 PF00017 0.266
LIG_SH2_STAT5 438 441 PF00017 0.311
LIG_SH3_1 429 435 PF00018 0.146
LIG_SH3_3 429 435 PF00018 0.259
LIG_SH3_3 454 460 PF00018 0.373
LIG_SH3_3 495 501 PF00018 0.483
LIG_SH3_3 50 56 PF00018 0.289
LIG_SH3_3 78 84 PF00018 0.313
LIG_SUMO_SIM_anti_2 360 366 PF11976 0.422
LIG_SUMO_SIM_anti_2 380 385 PF11976 0.286
LIG_SUMO_SIM_par_1 347 352 PF11976 0.373
LIG_SUMO_SIM_par_1 360 366 PF11976 0.351
LIG_TRAF2_1 247 250 PF00917 0.477
LIG_TYR_ITSM 141 148 PF00017 0.447
LIG_WRC_WIRS_1 62 67 PF05994 0.251
MOD_CDK_SPxxK_3 80 87 PF00069 0.376
MOD_CK1_1 70 76 PF00069 0.292
MOD_CK2_1 135 141 PF00069 0.358
MOD_CK2_1 326 332 PF00069 0.491
MOD_CK2_1 4 10 PF00069 0.506
MOD_GlcNHglycan 156 159 PF01048 0.277
MOD_GlcNHglycan 165 168 PF01048 0.300
MOD_GlcNHglycan 32 35 PF01048 0.525
MOD_GlcNHglycan 488 491 PF01048 0.287
MOD_GSK3_1 163 170 PF00069 0.279
MOD_GSK3_1 177 184 PF00069 0.255
MOD_GSK3_1 252 259 PF00069 0.483
MOD_GSK3_1 295 302 PF00069 0.760
MOD_GSK3_1 314 321 PF00069 0.428
MOD_N-GLC_1 252 257 PF02516 0.361
MOD_N-GLC_1 3 8 PF02516 0.253
MOD_N-GLC_1 326 331 PF02516 0.261
MOD_NEK2_1 127 132 PF00069 0.353
MOD_NEK2_1 140 145 PF00069 0.462
MOD_NEK2_1 147 152 PF00069 0.438
MOD_NEK2_1 194 199 PF00069 0.315
MOD_NEK2_1 20 25 PF00069 0.286
MOD_NEK2_1 209 214 PF00069 0.174
MOD_NEK2_1 252 257 PF00069 0.533
MOD_NEK2_1 3 8 PF00069 0.517
MOD_NEK2_1 334 339 PF00069 0.466
MOD_NEK2_1 349 354 PF00069 0.268
MOD_NEK2_1 357 362 PF00069 0.330
MOD_NEK2_1 444 449 PF00069 0.370
MOD_NEK2_1 89 94 PF00069 0.476
MOD_NEK2_1 97 102 PF00069 0.267
MOD_NEK2_2 395 400 PF00069 0.194
MOD_PIKK_1 115 121 PF00454 0.338
MOD_PIKK_1 70 76 PF00454 0.238
MOD_PKA_1 87 93 PF00069 0.466
MOD_Plk_1 140 146 PF00069 0.473
MOD_Plk_1 181 187 PF00069 0.190
MOD_Plk_1 252 258 PF00069 0.500
MOD_Plk_1 3 9 PF00069 0.620
MOD_Plk_2-3 299 305 PF00069 0.520
MOD_Plk_4 135 141 PF00069 0.353
MOD_Plk_4 184 190 PF00069 0.251
MOD_Plk_4 20 26 PF00069 0.314
MOD_Plk_4 357 363 PF00069 0.279
MOD_Plk_4 420 426 PF00069 0.298
MOD_Plk_4 61 67 PF00069 0.267
MOD_Plk_4 77 83 PF00069 0.274
MOD_Plk_4 97 103 PF00069 0.209
MOD_ProDKin_1 52 58 PF00069 0.417
MOD_ProDKin_1 80 86 PF00069 0.375
TRG_ENDOCYTIC_2 145 148 PF00928 0.474
TRG_ENDOCYTIC_2 185 188 PF00928 0.273
TRG_ENDOCYTIC_2 193 196 PF00928 0.251
TRG_ENDOCYTIC_2 277 280 PF00928 0.743
TRG_ENDOCYTIC_2 438 441 PF00928 0.342

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 38% 100%
A0A0N0P6Z5 Leptomonas seymouri 31% 100%
A0A0N1I1J0 Leptomonas seymouri 33% 100%
A0A0N1I8E8 Leptomonas seymouri 28% 100%
A0A0N1PBQ1 Leptomonas seymouri 68% 99%
A0A0S4JBS4 Bodo saltans 33% 100%
A0A1X0NN91 Trypanosomatidae 52% 100%
A0A1X0NPL0 Trypanosomatidae 55% 100%
A0A1X0NV38 Trypanosomatidae 36% 100%
A0A1X0NWJ5 Trypanosomatidae 37% 100%
A0A3R7NQR3 Trypanosoma rangeli 54% 100%
A0A3S7WTL0 Leishmania donovani 33% 100%
A0A3S7XAS5 Leishmania donovani 33% 100%
A0A422MQ08 Trypanosoma rangeli 34% 100%
A0A422N8M2 Trypanosoma rangeli 29% 100%
A0A422NHH9 Trypanosoma rangeli 30% 100%
A0A422NR81 Trypanosoma rangeli 33% 100%
A1L272 Danio rerio 22% 97%
A4H6I0 Leishmania braziliensis 35% 100%
A4H7A5 Leishmania braziliensis 80% 100%
A4HG96 Leishmania braziliensis 27% 97%
A4HP60 Leishmania braziliensis 34% 98%
A4HUW2 Leishmania infantum 37% 100%
A4HVP9 Leishmania infantum 99% 100%
A4HWK9 Leishmania infantum 33% 100%
A4IDG6 Leishmania infantum 33% 98%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AGM5 Leishmania infantum 33% 100%
E9AGM6 Leishmania infantum 33% 100%
E9AGM7 Leishmania infantum 33% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 99%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 99%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 99%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 98%
O76343 Leishmania donovani 33% 100%
Q4Q1M9 Leishmania major 33% 98%
Q4QF58 Leishmania major 32% 100%
Q4QF59 Leishmania major 33% 100%
Q4QG33 Leishmania major 92% 100%
Q4QH25 Leishmania major 37% 100%
Q7RTT9 Homo sapiens 23% 95%
Q8R139 Mus musculus 22% 95%
V5BGB1 Trypanosoma cruzi 56% 100%
V5BRM5 Trypanosoma cruzi 36% 100%
V5DSF4 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS