Thioesterase-like superfamily/Thioesterase superfamily, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioesterase-like superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICX4_LEIDO

TriTrypDb:

LdBPK_261940.1 , LdCL_260025000 , LDHU3_26.2540

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.472
CLV_NRD_NRD_1	197	199	PF00675	0.325
CLV_NRD_NRD_1	222	224	PF00675	0.631
CLV_NRD_NRD_1	268	270	PF00675	0.595
CLV_NRD_NRD_1	71	73	PF00675	0.591
CLV_PCSK_KEX2_1	183	185	PF00082	0.410
CLV_PCSK_KEX2_1	222	224	PF00082	0.631
CLV_PCSK_KEX2_1	71	73	PF00082	0.587
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.410
CLV_PCSK_SKI1_1	135	139	PF00082	0.420
CLV_PCSK_SKI1_1	162	166	PF00082	0.407
CLV_PCSK_SKI1_1	269	273	PF00082	0.508
DEG_APCC_DBOX_1	59	67	PF00400	0.525
DEG_SPOP_SBC_1	166	170	PF00917	0.511
DOC_CKS1_1	278	283	PF01111	0.652
DOC_CKS1_1	56	61	PF01111	0.694
DOC_CYCLIN_yCln2_LP_2	164	167	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.570
DOC_MAPK_DCC_7	60	68	PF00069	0.525
DOC_MAPK_gen_1	118	127	PF00069	0.504
DOC_MAPK_gen_1	149	159	PF00069	0.504
DOC_MAPK_gen_1	198	206	PF00069	0.454
DOC_MAPK_gen_1	8	17	PF00069	0.557
DOC_MAPK_MEF2A_6	60	68	PF00069	0.525
DOC_PP1_RVXF_1	118	125	PF00149	0.481
DOC_PP1_RVXF_1	133	139	PF00149	0.294
DOC_PP2B_LxvP_1	164	167	PF13499	0.504
DOC_PP2B_LxvP_1	31	34	PF13499	0.603
DOC_PP2B_LxvP_1	66	69	PF13499	0.516
DOC_PP4_FxxP_1	172	175	PF00568	0.449
DOC_USP7_MATH_1	38	42	PF00917	0.641
DOC_USP7_UBL2_3	195	199	PF12436	0.504
DOC_WW_Pin1_4	175	180	PF00397	0.454
DOC_WW_Pin1_4	277	282	PF00397	0.644
DOC_WW_Pin1_4	328	333	PF00397	0.793
DOC_WW_Pin1_4	55	60	PF00397	0.694
LIG_14-3-3_CanoR_1	120	125	PF00244	0.481
LIG_14-3-3_CanoR_1	156	166	PF00244	0.447
LIG_14-3-3_CanoR_1	245	251	PF00244	0.550
LIG_14-3-3_CanoR_1	314	323	PF00244	0.617
LIG_14-3-3_CanoR_1	324	329	PF00244	0.731
LIG_APCC_ABBAyCdc20_2	183	189	PF00400	0.504
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BIR_III_3	1	5	PF00653	0.566
LIG_BRCT_BRCA1_1	168	172	PF00533	0.504
LIG_eIF4E_1	93	99	PF01652	0.561
LIG_FHA_1	159	165	PF00498	0.404
LIG_FHA_1	278	284	PF00498	0.736
LIG_FHA_1	28	34	PF00498	0.555
LIG_FHA_1	324	330	PF00498	0.668
LIG_LIR_Apic_2	169	175	PF02991	0.444
LIG_LIR_Gen_1	77	88	PF02991	0.447
LIG_LIR_Nem_3	100	105	PF02991	0.424
LIG_LIR_Nem_3	123	127	PF02991	0.504
LIG_LIR_Nem_3	77	83	PF02991	0.476
LIG_PTB_Apo_2	104	111	PF02174	0.407
LIG_PTB_Phospho_1	104	110	PF10480	0.407
LIG_SH2_CRK	93	97	PF00017	0.569
LIG_SH2_SRC	187	190	PF00017	0.504
LIG_SH2_STAP1	216	220	PF00017	0.492
LIG_SH2_STAT5	110	113	PF00017	0.407
LIG_SH2_STAT5	187	190	PF00017	0.504
LIG_SH2_STAT5	93	96	PF00017	0.467
LIG_SH3_1	72	78	PF00018	0.543
LIG_SH3_3	233	239	PF00018	0.703
LIG_SH3_3	329	335	PF00018	0.764
LIG_SH3_3	53	59	PF00018	0.677
LIG_SH3_3	72	78	PF00018	0.543
LIG_SH3_3	81	87	PF00018	0.457
LIG_TRAF2_1	298	301	PF00917	0.723
LIG_TRAF2_1	304	307	PF00917	0.578
LIG_WW_2	61	64	PF00397	0.572
MOD_CDK_SPK_2	55	60	PF00069	0.694
MOD_CK1_1	141	147	PF00069	0.407
MOD_CK1_1	177	183	PF00069	0.371
MOD_CK1_1	327	333	PF00069	0.765
MOD_CK2_1	261	267	PF00069	0.506
MOD_Cter_Amidation	196	199	PF01082	0.504
MOD_GlcNHglycan	27	30	PF01048	0.538
MOD_GlcNHglycan	273	276	PF01048	0.647
MOD_GlcNHglycan	301	304	PF01048	0.671
MOD_GSK3_1	174	181	PF00069	0.385
MOD_GSK3_1	21	28	PF00069	0.499
MOD_GSK3_1	323	330	PF00069	0.761
MOD_NEK2_1	143	148	PF00069	0.393
MOD_NEK2_1	21	26	PF00069	0.400
MOD_NEK2_1	260	265	PF00069	0.591
MOD_NEK2_1	323	328	PF00069	0.704
MOD_PIKK_1	78	84	PF00454	0.471
MOD_PKA_2	21	27	PF00069	0.574
MOD_PKA_2	246	252	PF00069	0.496
MOD_PKA_2	307	313	PF00069	0.657
MOD_PKA_2	316	322	PF00069	0.599
MOD_PKA_2	323	329	PF00069	0.575
MOD_PKB_1	118	126	PF00069	0.504
MOD_PKB_1	243	251	PF00069	0.675
MOD_Plk_1	141	147	PF00069	0.407
MOD_Plk_1	260	266	PF00069	0.546
MOD_Plk_2-3	261	267	PF00069	0.553
MOD_Plk_4	120	126	PF00069	0.504
MOD_Plk_4	324	330	PF00069	0.671
MOD_Plk_4	38	44	PF00069	0.544
MOD_ProDKin_1	175	181	PF00069	0.454
MOD_ProDKin_1	277	283	PF00069	0.650
MOD_ProDKin_1	328	334	PF00069	0.791
MOD_ProDKin_1	55	61	PF00069	0.692
MOD_SUMO_for_1	214	217	PF00179	0.590
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.556
TRG_ENDOCYTIC_2	110	113	PF00928	0.407
TRG_ENDOCYTIC_2	93	96	PF00928	0.467
TRG_ER_diArg_1	133	136	PF00400	0.429
TRG_ER_diArg_1	184	186	PF00400	0.454
TRG_ER_diArg_1	20	23	PF00400	0.566
TRG_ER_diArg_1	222	224	PF00400	0.631
TRG_ER_diArg_1	70	72	PF00400	0.595
TRG_NES_CRM1_1	86	101	PF08389	0.460
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E3	Leptomonas seymouri	45%	96%
A4I2C2	Leishmania infantum	98%	100%
E9AYH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q8Z8	Leishmania major	91%	100%