Cytidylyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytidylyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICX3_LEIDO

TriTrypDb:

LdBPK_171450.1 , LdCL_170020700 , LDHU3_17.1970

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICX3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009435	NAD biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019359	nicotinamide nucleotide biosynthetic process	7	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019363	pyridine nucleotide biosynthetic process	6	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072525	pyridine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016779	nucleotidyltransferase activity	4	6
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	6	2
GO:0004515	nicotinate-nucleotide adenylyltransferase activity	6	2
GO:0070566	adenylyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.421
CLV_NRD_NRD_1	105	107	PF00675	0.322
CLV_NRD_NRD_1	161	163	PF00675	0.340
CLV_NRD_NRD_1	90	92	PF00675	0.353
CLV_PCSK_KEX2_1	161	163	PF00082	0.340
CLV_PCSK_KEX2_1	67	69	PF00082	0.345
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.345
CLV_PCSK_SKI1_1	106	110	PF00082	0.283
CLV_PCSK_SKI1_1	129	133	PF00082	0.352
CLV_PCSK_SKI1_1	164	168	PF00082	0.289
CLV_PCSK_SKI1_1	189	193	PF00082	0.273
CLV_PCSK_SKI1_1	278	282	PF00082	0.518
CLV_PCSK_SKI1_1	286	290	PF00082	0.419
CLV_PCSK_SKI1_1	76	80	PF00082	0.358
DOC_CYCLIN_RxL_1	186	194	PF00134	0.484
DOC_MAPK_gen_1	161	168	PF00069	0.545
DOC_PP1_RVXF_1	162	168	PF00149	0.502
DOC_PP4_FxxP_1	177	180	PF00568	0.461
DOC_PP4_FxxP_1	249	252	PF00568	0.545
DOC_PP4_FxxP_1	82	85	PF00568	0.475
DOC_SPAK_OSR1_1	101	105	PF12202	0.373
DOC_USP7_MATH_1	24	28	PF00917	0.687
DOC_USP7_MATH_1	280	284	PF00917	0.560
DOC_USP7_MATH_1	293	297	PF00917	0.398
DOC_USP7_MATH_1	66	70	PF00917	0.554
DOC_USP7_MATH_2	30	36	PF00917	0.557
DOC_WW_Pin1_4	26	31	PF00397	0.634
DOC_WW_Pin1_4	267	272	PF00397	0.461
DOC_WW_Pin1_4	81	86	PF00397	0.461
LIG_14-3-3_CanoR_1	241	247	PF00244	0.512
LIG_APCC_ABBA_1	198	203	PF00400	0.538
LIG_APCC_ABBA_1	298	303	PF00400	0.426
LIG_CSL_BTD_1	177	180	PF09270	0.504
LIG_FHA_1	11	17	PF00498	0.511
LIG_FHA_1	128	134	PF00498	0.475
LIG_FHA_1	219	225	PF00498	0.573
LIG_FHA_2	155	161	PF00498	0.500
LIG_FHA_2	226	232	PF00498	0.547
LIG_LIR_Apic_2	175	180	PF02991	0.462
LIG_LIR_Apic_2	248	252	PF02991	0.480
LIG_LIR_Apic_2	88	93	PF02991	0.552
LIG_LIR_Gen_1	100	109	PF02991	0.373
LIG_LIR_Gen_1	172	180	PF02991	0.456
LIG_LIR_Gen_1	193	200	PF02991	0.448
LIG_LIR_Gen_1	213	223	PF02991	0.552
LIG_LIR_Gen_1	243	252	PF02991	0.552
LIG_LIR_LC3C_4	194	199	PF02991	0.549
LIG_LIR_Nem_3	128	134	PF02991	0.491
LIG_LIR_Nem_3	172	177	PF02991	0.462
LIG_LIR_Nem_3	193	198	PF02991	0.517
LIG_LIR_Nem_3	213	218	PF02991	0.549
LIG_LIR_Nem_3	243	249	PF02991	0.552
LIG_LIR_Nem_3	299	304	PF02991	0.463
LIG_LIR_Nem_3	51	55	PF02991	0.484
LIG_NRBOX	187	193	PF00104	0.475
LIG_PCNA_yPIPBox_3	278	289	PF02747	0.509
LIG_Pex14_2	174	178	PF04695	0.550
LIG_SH2_CRK	90	94	PF00017	0.550
LIG_SH2_SRC	145	148	PF00017	0.480
LIG_SH2_STAP1	127	131	PF00017	0.521
LIG_SH2_STAP1	242	246	PF00017	0.517
LIG_SH2_STAT5	127	130	PF00017	0.443
LIG_SH2_STAT5	242	245	PF00017	0.550
LIG_TRAF2_1	136	139	PF00917	0.588
LIG_WRC_WIRS_1	174	179	PF05994	0.461
LIG_WRC_WIRS_1	192	197	PF05994	0.501
LIG_WRC_WIRS_1	246	251	PF05994	0.480
MOD_CK1_1	240	246	PF00069	0.504
MOD_CK2_1	26	32	PF00069	0.665
MOD_CK2_1	293	299	PF00069	0.474
MOD_GlcNHglycan	249	252	PF01048	0.304
MOD_GlcNHglycan	96	99	PF01048	0.314
MOD_GSK3_1	32	39	PF00069	0.619
MOD_NEK2_1	173	178	PF00069	0.461
MOD_NEK2_1	191	196	PF00069	0.552
MOD_NEK2_1	225	230	PF00069	0.500
MOD_NEK2_2	127	132	PF00069	0.493
MOD_PIKK_1	32	38	PF00454	0.656
MOD_PKA_2	240	246	PF00069	0.528
MOD_Plk_1	237	243	PF00069	0.516
MOD_Plk_4	173	179	PF00069	0.455
MOD_Plk_4	293	299	PF00069	0.357
MOD_ProDKin_1	26	32	PF00069	0.634
MOD_ProDKin_1	267	273	PF00069	0.467
MOD_ProDKin_1	81	87	PF00069	0.461
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.504
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.552
TRG_ENDOCYTIC_2	301	304	PF00928	0.519
TRG_ER_diArg_1	161	164	PF00400	0.538
TRG_NES_CRM1_1	190	203	PF08389	0.530
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK8	Leptomonas seymouri	56%	100%
A0A0S4J2V8	Bodo saltans	37%	100%
A0A1X0NSY4	Trypanosomatidae	37%	98%
A0A3R7KAJ0	Trypanosoma rangeli	38%	100%
A4H990	Leishmania braziliensis	80%	100%
A4HXL1	Leishmania infantum	99%	100%
E9ARA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QE56	Leishmania major	93%	100%
V5BNX9	Trypanosoma cruzi	40%	100%