TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICX2_LEIDO

TriTrypDb:

LdBPK_280040.1 , LdCL_280005300 , LDHU3_28.0060

Length:

902

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	795	799	PF00656	0.498
CLV_NRD_NRD_1	194	196	PF00675	0.748
CLV_NRD_NRD_1	263	265	PF00675	0.575
CLV_NRD_NRD_1	317	319	PF00675	0.499
CLV_NRD_NRD_1	354	356	PF00675	0.500
CLV_NRD_NRD_1	371	373	PF00675	0.373
CLV_NRD_NRD_1	453	455	PF00675	0.511
CLV_NRD_NRD_1	488	490	PF00675	0.473
CLV_NRD_NRD_1	607	609	PF00675	0.432
CLV_NRD_NRD_1	760	762	PF00675	0.543
CLV_NRD_NRD_1	897	899	PF00675	0.612
CLV_PCSK_KEX2_1	262	264	PF00082	0.588
CLV_PCSK_KEX2_1	354	356	PF00082	0.496
CLV_PCSK_KEX2_1	488	490	PF00082	0.456
CLV_PCSK_KEX2_1	52	54	PF00082	0.664
CLV_PCSK_KEX2_1	760	762	PF00082	0.531
CLV_PCSK_KEX2_1	897	899	PF00082	0.604
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.655
CLV_PCSK_PC1ET2_1	897	899	PF00082	0.604
CLV_PCSK_PC7_1	350	356	PF00082	0.594
CLV_PCSK_PC7_1	484	490	PF00082	0.596
CLV_PCSK_SKI1_1	159	163	PF00082	0.625
CLV_PCSK_SKI1_1	17	21	PF00082	0.518
CLV_PCSK_SKI1_1	195	199	PF00082	0.641
CLV_PCSK_SKI1_1	263	267	PF00082	0.618
CLV_PCSK_SKI1_1	302	306	PF00082	0.544
CLV_PCSK_SKI1_1	355	359	PF00082	0.451
CLV_PCSK_SKI1_1	402	406	PF00082	0.517
CLV_PCSK_SKI1_1	422	426	PF00082	0.458
CLV_PCSK_SKI1_1	463	467	PF00082	0.470
CLV_PCSK_SKI1_1	489	493	PF00082	0.500
CLV_PCSK_SKI1_1	573	577	PF00082	0.551
CLV_PCSK_SKI1_1	608	612	PF00082	0.418
CLV_PCSK_SKI1_1	701	705	PF00082	0.484
CLV_PCSK_SKI1_1	760	764	PF00082	0.537
CLV_PCSK_SKI1_1	805	809	PF00082	0.453
CLV_Separin_Metazoa	586	590	PF03568	0.554
DEG_APCC_DBOX_1	354	362	PF00400	0.545
DEG_APCC_DBOX_1	401	409	PF00400	0.489
DEG_APCC_DBOX_1	488	496	PF00400	0.490
DEG_APCC_DBOX_1	607	615	PF00400	0.420
DEG_APCC_DBOX_1	655	663	PF00400	0.595
DEG_SCF_FBW7_1	177	184	PF00400	0.570
DEG_SCF_FBW7_2	145	152	PF00400	0.675
DOC_CKS1_1	178	183	PF01111	0.573
DOC_CKS1_1	73	78	PF01111	0.717
DOC_CYCLIN_RxL_1	14	22	PF00134	0.505
DOC_CYCLIN_RxL_1	299	309	PF00134	0.518
DOC_CYCLIN_RxL_1	350	362	PF00134	0.497
DOC_CYCLIN_RxL_1	484	496	PF00134	0.559
DOC_CYCLIN_RxL_1	698	708	PF00134	0.535
DOC_MAPK_gen_1	115	123	PF00069	0.725
DOC_MAPK_gen_1	195	205	PF00069	0.608
DOC_MAPK_gen_1	372	378	PF00069	0.527
DOC_MAPK_gen_1	396	405	PF00069	0.524
DOC_MAPK_gen_1	91	98	PF00069	0.655
DOC_MAPK_MEF2A_6	115	123	PF00069	0.706
DOC_MAPK_MEF2A_6	195	203	PF00069	0.608
DOC_MAPK_MEF2A_6	91	98	PF00069	0.607
DOC_PP1_RVXF_1	15	21	PF00149	0.521
DOC_PP1_RVXF_1	285	291	PF00149	0.686
DOC_PP1_RVXF_1	640	647	PF00149	0.522
DOC_PP2B_LxvP_1	121	124	PF13499	0.747
DOC_PP4_MxPP_1	1	4	PF00568	0.794
DOC_USP7_MATH_1	181	185	PF00917	0.668
DOC_USP7_MATH_1	221	225	PF00917	0.693
DOC_USP7_MATH_1	306	310	PF00917	0.549
DOC_USP7_MATH_1	325	329	PF00917	0.359
DOC_USP7_MATH_1	424	428	PF00917	0.550
DOC_USP7_MATH_1	459	463	PF00917	0.465
DOC_USP7_MATH_1	678	682	PF00917	0.671
DOC_USP7_MATH_1	727	731	PF00917	0.556
DOC_USP7_UBL2_3	893	897	PF12436	0.484
DOC_WD40_RPTOR_TOS_1	237	243	PF00400	0.437
DOC_WW_Pin1_4	103	108	PF00397	0.777
DOC_WW_Pin1_4	143	148	PF00397	0.661
DOC_WW_Pin1_4	177	182	PF00397	0.707
DOC_WW_Pin1_4	189	194	PF00397	0.699
DOC_WW_Pin1_4	676	681	PF00397	0.575
DOC_WW_Pin1_4	72	77	PF00397	0.710
LIG_14-3-3_CanoR_1	262	268	PF00244	0.616
LIG_14-3-3_CanoR_1	283	287	PF00244	0.481
LIG_14-3-3_CanoR_1	326	332	PF00244	0.581
LIG_14-3-3_CanoR_1	463	471	PF00244	0.540
LIG_14-3-3_CanoR_1	488	492	PF00244	0.535
LIG_14-3-3_CanoR_1	493	501	PF00244	0.556
LIG_14-3-3_CanoR_1	573	578	PF00244	0.451
LIG_14-3-3_CanoR_1	663	669	PF00244	0.553
LIG_Actin_WH2_2	574	591	PF00022	0.507
LIG_Actin_WH2_2	637	655	PF00022	0.535
LIG_APCC_ABBA_1	853	858	PF00400	0.469
LIG_CtBP_PxDLS_1	124	128	PF00389	0.770
LIG_deltaCOP1_diTrp_1	848	856	PF00928	0.508
LIG_FHA_1	178	184	PF00498	0.727
LIG_FHA_1	283	289	PF00498	0.643
LIG_FHA_1	380	386	PF00498	0.570
LIG_FHA_1	516	522	PF00498	0.543
LIG_FHA_1	525	531	PF00498	0.548
LIG_FHA_1	582	588	PF00498	0.502
LIG_FHA_1	686	692	PF00498	0.587
LIG_FHA_1	789	795	PF00498	0.478
LIG_FHA_1	799	805	PF00498	0.345
LIG_FHA_1	850	856	PF00498	0.430
LIG_FHA_1	871	877	PF00498	0.494
LIG_FHA_1	883	889	PF00498	0.403
LIG_FHA_2	103	109	PF00498	0.746
LIG_FHA_2	111	117	PF00498	0.711
LIG_FHA_2	131	137	PF00498	0.739
LIG_FHA_2	146	152	PF00498	0.626
LIG_FHA_2	213	219	PF00498	0.673
LIG_FHA_2	390	396	PF00498	0.485
LIG_FHA_2	747	753	PF00498	0.471
LIG_FHA_2	790	796	PF00498	0.539
LIG_IRF3_LxIS_1	837	842	PF10401	0.493
LIG_LIR_Gen_1	503	511	PF02991	0.421
LIG_LIR_Gen_1	666	677	PF02991	0.693
LIG_LIR_Gen_1	752	762	PF02991	0.445
LIG_LIR_Nem_3	386	391	PF02991	0.475
LIG_LIR_Nem_3	503	509	PF02991	0.419
LIG_LIR_Nem_3	553	558	PF02991	0.517
LIG_LIR_Nem_3	666	672	PF02991	0.620
LIG_PCNA_yPIPBox_3	556	568	PF02747	0.489
LIG_Pex14_2	384	388	PF04695	0.522
LIG_SH2_STAP1	39	43	PF00017	0.589
LIG_SH2_STAP1	506	510	PF00017	0.416
LIG_SH2_STAP1	685	689	PF00017	0.541
LIG_SH2_STAP1	754	758	PF00017	0.339
LIG_SH2_STAT3	39	42	PF00017	0.590
LIG_SH2_STAT5	802	805	PF00017	0.502
LIG_SH3_2	73	78	PF14604	0.747
LIG_SH3_2	99	104	PF14604	0.689
LIG_SH3_3	137	143	PF00018	0.665
LIG_SH3_3	175	181	PF00018	0.659
LIG_SH3_3	2	8	PF00018	0.740
LIG_SH3_3	70	76	PF00018	0.745
LIG_SH3_3	741	747	PF00018	0.499
LIG_SH3_3	827	833	PF00018	0.572
LIG_SH3_3	96	102	PF00018	0.679
LIG_Sin3_3	475	482	PF02671	0.462
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.516
LIG_SUMO_SIM_anti_2	730	736	PF11976	0.437
LIG_SUMO_SIM_par_1	435	441	PF11976	0.569
LIG_SUMO_SIM_par_1	94	100	PF11976	0.701
LIG_TRAF2_1	149	152	PF00917	0.739
LIG_TRAF2_1	392	395	PF00917	0.448
LIG_TRAF2_1	583	586	PF00917	0.582
LIG_WRC_WIRS_1	127	132	PF05994	0.574
LIG_WRC_WIRS_1	314	319	PF05994	0.446
MOD_CDC14_SPxK_1	192	195	PF00782	0.645
MOD_CDK_SPxK_1	103	109	PF00069	0.581
MOD_CDK_SPxK_1	189	195	PF00069	0.651
MOD_CDK_SPxK_1	72	78	PF00069	0.679
MOD_CDK_SPxxK_3	189	196	PF00069	0.650
MOD_CDK_SPxxK_3	676	683	PF00069	0.530
MOD_CK1_1	126	132	PF00069	0.673
MOD_CK1_1	138	144	PF00069	0.669
MOD_CK1_1	341	347	PF00069	0.593
MOD_CK1_1	379	385	PF00069	0.502
MOD_CK1_1	670	676	PF00069	0.663
MOD_CK1_1	679	685	PF00069	0.627
MOD_CK1_1	696	702	PF00069	0.441
MOD_CK1_1	730	736	PF00069	0.458
MOD_CK1_1	774	780	PF00069	0.517
MOD_CK1_1	842	848	PF00069	0.467
MOD_CK1_1	862	868	PF00069	0.440
MOD_CK1_1	870	876	PF00069	0.505
MOD_CK2_1	102	108	PF00069	0.735
MOD_CK2_1	110	116	PF00069	0.729
MOD_CK2_1	130	136	PF00069	0.738
MOD_CK2_1	145	151	PF00069	0.640
MOD_CK2_1	32	38	PF00069	0.699
MOD_CK2_1	389	395	PF00069	0.515
MOD_CK2_1	430	436	PF00069	0.558
MOD_CK2_1	461	467	PF00069	0.494
MOD_CK2_1	626	632	PF00069	0.549
MOD_CK2_1	789	795	PF00069	0.533
MOD_DYRK1A_RPxSP_1	72	76	PF00069	0.611
MOD_GlcNHglycan	140	143	PF01048	0.696
MOD_GlcNHglycan	183	186	PF01048	0.604
MOD_GlcNHglycan	21	24	PF01048	0.478
MOD_GlcNHglycan	223	226	PF01048	0.690
MOD_GlcNHglycan	308	311	PF01048	0.540
MOD_GlcNHglycan	327	330	PF01048	0.346
MOD_GlcNHglycan	343	346	PF01048	0.467
MOD_GlcNHglycan	378	381	PF01048	0.482
MOD_GlcNHglycan	432	435	PF01048	0.568
MOD_GlcNHglycan	467	470	PF01048	0.587
MOD_GlcNHglycan	480	483	PF01048	0.548
MOD_GlcNHglycan	694	698	PF01048	0.554
MOD_GlcNHglycan	728	732	PF01048	0.469
MOD_GlcNHglycan	80	83	PF01048	0.781
MOD_GlcNHglycan	844	847	PF01048	0.466
MOD_GlcNHglycan	864	867	PF01048	0.256
MOD_GlcNHglycan	9	12	PF01048	0.613
MOD_GSK3_1	110	117	PF00069	0.748
MOD_GSK3_1	126	133	PF00069	0.695
MOD_GSK3_1	177	184	PF00069	0.712
MOD_GSK3_1	231	238	PF00069	0.536
MOD_GSK3_1	282	289	PF00069	0.569
MOD_GSK3_1	334	341	PF00069	0.530
MOD_GSK3_1	379	386	PF00069	0.464
MOD_GSK3_1	426	433	PF00069	0.584
MOD_GSK3_1	459	466	PF00069	0.448
MOD_GSK3_1	483	490	PF00069	0.551
MOD_GSK3_1	626	633	PF00069	0.550
MOD_GSK3_1	764	771	PF00069	0.432
MOD_GSK3_1	835	842	PF00069	0.453
MOD_LATS_1	571	577	PF00433	0.531
MOD_N-GLC_1	515	520	PF02516	0.505
MOD_N-GLC_1	630	635	PF02516	0.585
MOD_N-GLC_1	764	769	PF02516	0.391
MOD_N-GLC_1	798	803	PF02516	0.516
MOD_NEK2_1	130	135	PF00069	0.687
MOD_NEK2_1	19	24	PF00069	0.539
MOD_NEK2_1	282	287	PF00069	0.628
MOD_NEK2_1	32	37	PF00069	0.630
MOD_NEK2_1	376	381	PF00069	0.458
MOD_NEK2_1	443	448	PF00069	0.466
MOD_NEK2_1	465	470	PF00069	0.550
MOD_NEK2_1	626	631	PF00069	0.561
MOD_NEK2_1	788	793	PF00069	0.519
MOD_NEK2_1	839	844	PF00069	0.449
MOD_NEK2_1	859	864	PF00069	0.369
MOD_NEK2_2	313	318	PF00069	0.476
MOD_NEK2_2	849	854	PF00069	0.474
MOD_PIKK_1	443	449	PF00454	0.567
MOD_PIKK_1	870	876	PF00454	0.449
MOD_PKA_1	263	269	PF00069	0.665
MOD_PKA_2	114	120	PF00069	0.672
MOD_PKA_2	263	269	PF00069	0.592
MOD_PKA_2	282	288	PF00069	0.486
MOD_PKA_2	325	331	PF00069	0.569
MOD_PKA_2	443	449	PF00069	0.518
MOD_PKA_2	483	489	PF00069	0.553
MOD_PKA_2	662	668	PF00069	0.563
MOD_PKA_2	670	676	PF00069	0.643
MOD_Plk_1	135	141	PF00069	0.765
MOD_Plk_1	292	298	PF00069	0.582
MOD_Plk_1	438	444	PF00069	0.469
MOD_Plk_1	501	507	PF00069	0.560
MOD_Plk_1	630	636	PF00069	0.445
MOD_Plk_1	764	770	PF00069	0.472
MOD_Plk_1	789	795	PF00069	0.535
MOD_Plk_1	798	804	PF00069	0.487
MOD_Plk_1	85	91	PF00069	0.700
MOD_Plk_2-3	790	796	PF00069	0.477
MOD_Plk_4	438	444	PF00069	0.464
MOD_Plk_4	501	507	PF00069	0.547
MOD_Plk_4	687	693	PF00069	0.641
MOD_Plk_4	720	726	PF00069	0.537
MOD_Plk_4	730	736	PF00069	0.414
MOD_Plk_4	768	774	PF00069	0.459
MOD_Plk_4	777	783	PF00069	0.410
MOD_Plk_4	798	804	PF00069	0.407
MOD_Plk_4	867	873	PF00069	0.529
MOD_ProDKin_1	103	109	PF00069	0.780
MOD_ProDKin_1	143	149	PF00069	0.661
MOD_ProDKin_1	177	183	PF00069	0.708
MOD_ProDKin_1	189	195	PF00069	0.698
MOD_ProDKin_1	676	682	PF00069	0.575
MOD_ProDKin_1	72	78	PF00069	0.714
MOD_SUMO_for_1	725	728	PF00179	0.538
MOD_SUMO_for_1	889	892	PF00179	0.604
MOD_SUMO_rev_2	151	161	PF00179	0.689
TRG_DiLeu_BaEn_4	260	266	PF01217	0.561
TRG_DiLeu_BaEn_4	394	400	PF01217	0.539
TRG_DiLeu_BaEn_4	418	424	PF01217	0.512
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.618
TRG_ENDOCYTIC_2	506	509	PF00928	0.418
TRG_ENDOCYTIC_2	754	757	PF00928	0.403
TRG_ER_diArg_1	262	264	PF00400	0.640
TRG_ER_diArg_1	353	355	PF00400	0.510
TRG_ER_diArg_1	487	489	PF00400	0.477
TRG_ER_diArg_1	760	762	PF00400	0.567
TRG_ER_diLys_1	897	902	PF00400	0.543
TRG_NES_CRM1_1	694	708	PF08389	0.545
TRG_NLS_MonoCore_2	896	901	PF00514	0.569
TRG_NLS_MonoExtC_3	194	199	PF00514	0.716
TRG_NLS_MonoExtC_3	896	901	PF00514	0.569
TRG_NLS_MonoExtN_4	193	199	PF00514	0.700
TRG_NLS_MonoExtN_4	897	902	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	489	494	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	528	533	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF72	Leptomonas seymouri	59%	98%
A0A0S4J1J7	Bodo saltans	29%	85%
A0A1X0NWQ3	Trypanosomatidae	35%	96%
A0A3R7LZ16	Trypanosoma rangeli	36%	95%
A4HG47	Leishmania braziliensis	75%	100%
A4I377	Leishmania infantum	99%	100%
D0A7Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	95%
E9AZG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8R6	Leishmania major	91%	100%
V5BBZ0	Trypanosoma cruzi	36%	95%