Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICX1_LEIDO

TriTrypDb:

LdBPK_261070.1 , LdCL_260016300 , LDHU3_26.1350

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.414
CLV_C14_Caspase3-7	93	97	PF00656	0.682
CLV_NRD_NRD_1	262	264	PF00675	0.569
CLV_NRD_NRD_1	27	29	PF00675	0.716
CLV_NRD_NRD_1	39	41	PF00675	0.671
CLV_NRD_NRD_1	88	90	PF00675	0.770
CLV_PCSK_KEX2_1	27	29	PF00082	0.716
CLV_PCSK_KEX2_1	39	41	PF00082	0.671
CLV_PCSK_KEX2_1	88	90	PF00082	0.770
CLV_PCSK_SKI1_1	16	20	PF00082	0.600
CLV_PCSK_SKI1_1	269	273	PF00082	0.424
CLV_PCSK_SKI1_1	28	32	PF00082	0.609
CLV_PCSK_SKI1_1	383	387	PF00082	0.540
CLV_PCSK_SKI1_1	403	407	PF00082	0.439
DEG_SPOP_SBC_1	194	198	PF00917	0.637
DOC_CKS1_1	220	225	PF01111	0.606
DOC_CKS1_1	45	50	PF01111	0.798
DOC_CYCLIN_RxL_1	13	21	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	158	164	PF00134	0.528
DOC_MAPK_DCC_7	366	375	PF00069	0.407
DOC_MAPK_MEF2A_6	366	375	PF00069	0.347
DOC_PP1_RVXF_1	208	215	PF00149	0.547
DOC_PP2B_LxvP_1	183	186	PF13499	0.688
DOC_PP2B_LxvP_1	313	316	PF13499	0.534
DOC_PP4_FxxP_1	31	34	PF00568	0.706
DOC_USP7_MATH_1	133	137	PF00917	0.539
DOC_USP7_MATH_1	194	198	PF00917	0.635
DOC_USP7_MATH_1	342	346	PF00917	0.536
DOC_USP7_MATH_1	420	424	PF00917	0.552
DOC_USP7_MATH_1	56	60	PF00917	0.699
DOC_USP7_UBL2_3	29	33	PF12436	0.554
DOC_WW_Pin1_4	111	116	PF00397	0.666
DOC_WW_Pin1_4	196	201	PF00397	0.610
DOC_WW_Pin1_4	219	224	PF00397	0.625
DOC_WW_Pin1_4	245	250	PF00397	0.509
DOC_WW_Pin1_4	280	285	PF00397	0.604
DOC_WW_Pin1_4	290	295	PF00397	0.476
DOC_WW_Pin1_4	361	366	PF00397	0.512
DOC_WW_Pin1_4	44	49	PF00397	0.763
LIG_14-3-3_CanoR_1	138	143	PF00244	0.519
LIG_14-3-3_CanoR_1	238	245	PF00244	0.510
LIG_14-3-3_CanoR_1	263	267	PF00244	0.580
LIG_14-3-3_CanoR_1	298	307	PF00244	0.526
LIG_14-3-3_CanoR_1	61	71	PF00244	0.726
LIG_14-3-3_CanoR_1	72	82	PF00244	0.726
LIG_Actin_WH2_2	372	388	PF00022	0.387
LIG_APCC_ABBA_1	297	302	PF00400	0.427
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_CSL_BTD_1	42	45	PF09270	0.576
LIG_eIF4E_1	356	362	PF01652	0.473
LIG_FHA_1	127	133	PF00498	0.478
LIG_FHA_1	152	158	PF00498	0.414
LIG_FHA_1	308	314	PF00498	0.530
LIG_FHA_1	334	340	PF00498	0.517
LIG_FHA_1	374	380	PF00498	0.505
LIG_FHA_2	122	128	PF00498	0.490
LIG_FHA_2	220	226	PF00498	0.598
LIG_FHA_2	246	252	PF00498	0.626
LIG_FHA_2	342	348	PF00498	0.464
LIG_FHA_2	45	51	PF00498	0.757
LIG_FXI_DFP_1	300	304	PF00024	0.462
LIG_GBD_Chelix_1	413	421	PF00786	0.531
LIG_HP1_1	371	375	PF01393	0.437
LIG_LIR_Apic_2	199	205	PF02991	0.581
LIG_LIR_Gen_1	136	147	PF02991	0.557
LIG_LIR_Gen_1	416	422	PF02991	0.537
LIG_LIR_Nem_3	136	142	PF02991	0.558
LIG_LIR_Nem_3	312	317	PF02991	0.515
LIG_LIR_Nem_3	416	421	PF02991	0.527
LIG_LIR_Nem_3	68	74	PF02991	0.606
LIG_NRBOX	14	20	PF00104	0.645
LIG_NRBOX	287	293	PF00104	0.428
LIG_NRBOX	356	362	PF00104	0.510
LIG_Pex14_1	139	143	PF04695	0.552
LIG_Pex14_2	303	307	PF04695	0.527
LIG_PTAP_UEV_1	152	157	PF05743	0.504
LIG_SH2_CRK	112	116	PF00017	0.726
LIG_SH2_CRK	118	122	PF00017	0.581
LIG_SH2_CRK	71	75	PF00017	0.613
LIG_SH2_GRB2like	356	359	PF00017	0.546
LIG_SH2_NCK_1	118	122	PF00017	0.429
LIG_SH2_STAT3	229	232	PF00017	0.532
LIG_SH2_STAT5	130	133	PF00017	0.500
LIG_SH2_STAT5	148	151	PF00017	0.408
LIG_SH2_STAT5	356	359	PF00017	0.546
LIG_SH3_1	150	156	PF00018	0.519
LIG_SH3_3	150	156	PF00018	0.480
LIG_SH3_3	39	45	PF00018	0.763
LIG_SH3_3	46	52	PF00018	0.788
LIG_SH3_CIN85_PxpxPR_1	34	39	PF14604	0.601
LIG_SUMO_SIM_par_1	269	275	PF11976	0.390
LIG_SUMO_SIM_par_1	370	376	PF11976	0.385
LIG_UBA3_1	287	295	PF00899	0.550
MOD_CDK_SPK_2	290	295	PF00069	0.476
MOD_CDK_SPK_2	361	366	PF00069	0.434
MOD_CK1_1	196	202	PF00069	0.588
MOD_CK1_1	345	351	PF00069	0.559
MOD_CK1_1	65	71	PF00069	0.655
MOD_CK2_1	219	225	PF00069	0.576
MOD_CK2_1	280	286	PF00069	0.587
MOD_CK2_1	341	347	PF00069	0.468
MOD_GlcNHglycan	118	121	PF01048	0.589
MOD_GlcNHglycan	179	182	PF01048	0.664
MOD_GlcNHglycan	183	186	PF01048	0.678
MOD_GlcNHglycan	347	350	PF01048	0.428
MOD_GlcNHglycan	56	59	PF01048	0.665
MOD_GlcNHglycan	64	67	PF01048	0.673
MOD_GlcNHglycan	75	78	PF01048	0.629
MOD_GlcNHglycan	99	104	PF01048	0.800
MOD_GSK3_1	175	182	PF00069	0.688
MOD_GSK3_1	341	348	PF00069	0.496
MOD_GSK3_1	50	57	PF00069	0.709
MOD_GSK3_1	91	98	PF00069	0.677
MOD_N-GLC_1	10	15	PF02516	0.655
MOD_N-GLC_1	342	347	PF02516	0.581
MOD_NEK2_1	126	131	PF00069	0.524
MOD_NEK2_1	18	23	PF00069	0.631
MOD_NEK2_1	237	242	PF00069	0.505
MOD_NEK2_1	341	346	PF00069	0.557
MOD_NEK2_1	351	356	PF00069	0.407
MOD_NEK2_1	421	426	PF00069	0.578
MOD_NEK2_1	73	78	PF00069	0.680
MOD_NEK2_2	333	338	PF00069	0.467
MOD_PIKK_1	262	268	PF00454	0.610
MOD_PIKK_1	421	427	PF00454	0.579
MOD_PIKK_1	91	97	PF00454	0.682
MOD_PKA_2	237	243	PF00069	0.452
MOD_PKA_2	262	268	PF00069	0.573
MOD_Plk_1	10	16	PF00069	0.653
MOD_Plk_1	126	132	PF00069	0.617
MOD_Plk_1	342	348	PF00069	0.572
MOD_Plk_4	121	127	PF00069	0.513
MOD_Plk_4	138	144	PF00069	0.348
MOD_Plk_4	321	327	PF00069	0.461
MOD_Plk_4	352	358	PF00069	0.459
MOD_ProDKin_1	111	117	PF00069	0.657
MOD_ProDKin_1	196	202	PF00069	0.596
MOD_ProDKin_1	219	225	PF00069	0.616
MOD_ProDKin_1	245	251	PF00069	0.513
MOD_ProDKin_1	280	286	PF00069	0.602
MOD_ProDKin_1	290	296	PF00069	0.469
MOD_ProDKin_1	361	367	PF00069	0.508
MOD_ProDKin_1	44	50	PF00069	0.762
MOD_SUMO_rev_2	219	228	PF00179	0.540
TRG_DiLeu_BaEn_1	347	352	PF01217	0.450
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.501
TRG_ENDOCYTIC_2	418	421	PF00928	0.532
TRG_ENDOCYTIC_2	71	74	PF00928	0.614
TRG_ER_diArg_1	38	40	PF00400	0.734
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7E4	Leptomonas seymouri	41%	91%
A0A1X0NTZ3	Trypanosomatidae	32%	100%
A0A3R7L6E6	Trypanosoma rangeli	29%	100%
A4HEW5	Leishmania braziliensis	76%	100%
A4I238	Leishmania infantum	99%	100%
C9ZRW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AY88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q985	Leishmania major	91%	100%