DNAJ-domain protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICX0_LEIDO

TriTrypDb:

LdBPK_241330.1 , LdCL_240018400 , LDHU3_24.1590

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	492	496	PF00656	0.605
CLV_C14_Caspase3-7	653	657	PF00656	0.577
CLV_C14_Caspase3-7	747	751	PF00656	0.539
CLV_C14_Caspase3-7	775	779	PF00656	0.441
CLV_NRD_NRD_1	163	165	PF00675	0.497
CLV_NRD_NRD_1	215	217	PF00675	0.505
CLV_NRD_NRD_1	222	224	PF00675	0.465
CLV_NRD_NRD_1	273	275	PF00675	0.718
CLV_NRD_NRD_1	3	5	PF00675	0.700
CLV_NRD_NRD_1	747	749	PF00675	0.602
CLV_NRD_NRD_1	85	87	PF00675	0.781
CLV_PCSK_KEX2_1	163	165	PF00082	0.497
CLV_PCSK_KEX2_1	215	217	PF00082	0.582
CLV_PCSK_KEX2_1	221	223	PF00082	0.547
CLV_PCSK_KEX2_1	273	275	PF00082	0.718
CLV_PCSK_KEX2_1	3	5	PF00082	0.700
CLV_PCSK_KEX2_1	548	550	PF00082	0.508
CLV_PCSK_KEX2_1	558	560	PF00082	0.552
CLV_PCSK_KEX2_1	85	87	PF00082	0.781
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.386
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.385
CLV_PCSK_PC7_1	544	550	PF00082	0.457
CLV_PCSK_SKI1_1	14	18	PF00082	0.412
CLV_PCSK_SKI1_1	216	220	PF00082	0.537
CLV_PCSK_SKI1_1	514	518	PF00082	0.450
CLV_PCSK_SKI1_1	544	548	PF00082	0.488
CLV_PCSK_SKI1_1	559	563	PF00082	0.561
CLV_PCSK_SKI1_1	67	71	PF00082	0.415
CLV_PCSK_SKI1_1	743	747	PF00082	0.492
CLV_PCSK_SKI1_1	9	13	PF00082	0.474
DEG_APCC_DBOX_1	13	21	PF00400	0.436
DEG_APCC_DBOX_1	543	551	PF00400	0.455
DEG_APCC_DBOX_1	66	74	PF00400	0.434
DEG_Nend_Nbox_1	1	3	PF02207	0.587
DEG_SCF_FBW7_1	122	128	PF00400	0.540
DEG_SCF_TRCP1_1	402	407	PF00400	0.497
DEG_SPOP_SBC_1	125	129	PF00917	0.606
DOC_CKS1_1	10	15	PF01111	0.572
DOC_CKS1_1	122	127	PF01111	0.537
DOC_CKS1_1	143	148	PF01111	0.588
DOC_CKS1_1	435	440	PF01111	0.452
DOC_CYCLIN_RxL_1	14	25	PF00134	0.341
DOC_CYCLIN_yClb1_LxF_4	727	733	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	683	689	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	782	788	PF00134	0.363
DOC_MAPK_gen_1	333	340	PF00069	0.432
DOC_MAPK_MEF2A_6	205	214	PF00069	0.466
DOC_MAPK_MEF2A_6	333	340	PF00069	0.382
DOC_MAPK_NFAT4_5	333	341	PF00069	0.386
DOC_PP2B_LxvP_1	782	785	PF13499	0.349
DOC_PP4_FxxP_1	143	146	PF00568	0.551
DOC_PP4_FxxP_1	263	266	PF00568	0.505
DOC_USP7_MATH_1	101	105	PF00917	0.636
DOC_USP7_MATH_1	125	129	PF00917	0.656
DOC_USP7_MATH_1	281	285	PF00917	0.569
DOC_USP7_MATH_1	312	316	PF00917	0.448
DOC_USP7_MATH_1	400	404	PF00917	0.497
DOC_USP7_MATH_1	431	435	PF00917	0.535
DOC_USP7_MATH_1	800	804	PF00917	0.665
DOC_USP7_UBL2_3	501	505	PF12436	0.664
DOC_WW_Pin1_4	121	126	PF00397	0.636
DOC_WW_Pin1_4	142	147	PF00397	0.486
DOC_WW_Pin1_4	20	25	PF00397	0.287
DOC_WW_Pin1_4	26	31	PF00397	0.245
DOC_WW_Pin1_4	434	439	PF00397	0.468
DOC_WW_Pin1_4	504	509	PF00397	0.638
DOC_WW_Pin1_4	585	590	PF00397	0.656
DOC_WW_Pin1_4	756	761	PF00397	0.488
DOC_WW_Pin1_4	767	772	PF00397	0.474
DOC_WW_Pin1_4	9	14	PF00397	0.483
LIG_14-3-3_CanoR_1	114	122	PF00244	0.658
LIG_14-3-3_CanoR_1	163	169	PF00244	0.516
LIG_14-3-3_CanoR_1	18	23	PF00244	0.325
LIG_14-3-3_CanoR_1	3	7	PF00244	0.609
LIG_14-3-3_CanoR_1	301	309	PF00244	0.554
LIG_14-3-3_CanoR_1	345	353	PF00244	0.395
LIG_14-3-3_CanoR_1	39	43	PF00244	0.296
LIG_14-3-3_CanoR_1	60	68	PF00244	0.274
LIG_14-3-3_CanoR_1	651	656	PF00244	0.641
LIG_14-3-3_CanoR_1	85	95	PF00244	0.735
LIG_Actin_WH2_2	529	546	PF00022	0.389
LIG_APCC_ABBA_1	617	622	PF00400	0.554
LIG_APCC_ABBA_1	634	639	PF00400	0.407
LIG_BIR_III_4	656	660	PF00653	0.519
LIG_BRCT_BRCA1_1	62	66	PF00533	0.380
LIG_FHA_1	143	149	PF00498	0.637
LIG_FHA_1	191	197	PF00498	0.539
LIG_FHA_1	23	29	PF00498	0.350
LIG_FHA_1	318	324	PF00498	0.407
LIG_FHA_1	435	441	PF00498	0.579
LIG_FHA_1	466	472	PF00498	0.483
LIG_FHA_1	531	537	PF00498	0.459
LIG_FHA_1	688	694	PF00498	0.564
LIG_FHA_1	704	710	PF00498	0.575
LIG_FHA_2	145	151	PF00498	0.630
LIG_FHA_2	558	564	PF00498	0.466
LIG_FHA_2	605	611	PF00498	0.397
LIG_FHA_2	679	685	PF00498	0.385
LIG_FHA_2	757	763	PF00498	0.424
LIG_FHA_2	793	799	PF00498	0.433
LIG_HP1_1	254	258	PF01393	0.523
LIG_LIR_Apic_2	129	135	PF02991	0.633
LIG_LIR_Gen_1	226	236	PF02991	0.559
LIG_LIR_Gen_1	330	339	PF02991	0.374
LIG_LIR_Gen_1	560	567	PF02991	0.352
LIG_LIR_Gen_1	574	580	PF02991	0.494
LIG_LIR_Nem_3	226	232	PF02991	0.549
LIG_LIR_Nem_3	330	334	PF02991	0.368
LIG_LIR_Nem_3	462	466	PF02991	0.428
LIG_LIR_Nem_3	522	528	PF02991	0.441
LIG_LIR_Nem_3	560	565	PF02991	0.550
LIG_LIR_Nem_3	57	62	PF02991	0.276
LIG_LIR_Nem_3	574	579	PF02991	0.581
LIG_LYPXL_L_2	310	319	PF13949	0.462
LIG_MYND_1	46	50	PF01753	0.273
LIG_NRBOX	792	798	PF00104	0.435
LIG_PDZ_Class_2	803	808	PF00595	0.612
LIG_Pex14_1	614	618	PF04695	0.438
LIG_Pex14_2	637	641	PF04695	0.546
LIG_Pex14_2	732	736	PF04695	0.326
LIG_REV1ctd_RIR_1	188	198	PF16727	0.491
LIG_SH2_CRK	592	596	PF00017	0.494
LIG_SH2_PTP2	787	790	PF00017	0.386
LIG_SH2_SRC	195	198	PF00017	0.472
LIG_SH2_SRC	787	790	PF00017	0.386
LIG_SH2_STAT3	37	40	PF00017	0.292
LIG_SH2_STAT3	96	99	PF00017	0.540
LIG_SH2_STAT5	195	198	PF00017	0.472
LIG_SH2_STAT5	224	227	PF00017	0.489
LIG_SH2_STAT5	229	232	PF00017	0.517
LIG_SH2_STAT5	37	40	PF00017	0.273
LIG_SH2_STAT5	618	621	PF00017	0.407
LIG_SH2_STAT5	623	626	PF00017	0.385
LIG_SH2_STAT5	717	720	PF00017	0.358
LIG_SH2_STAT5	729	732	PF00017	0.329
LIG_SH2_STAT5	787	790	PF00017	0.386
LIG_SH3_3	119	125	PF00018	0.561
LIG_SH3_3	47	53	PF00018	0.292
LIG_SH3_3	503	509	PF00018	0.693
LIG_SH3_3	639	645	PF00018	0.554
LIG_SH3_3	7	13	PF00018	0.616
LIG_SH3_3	719	725	PF00018	0.382
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.445
LIG_SUMO_SIM_par_1	18	23	PF11976	0.341
LIG_SUMO_SIM_par_1	792	799	PF11976	0.448
LIG_TRFH_1	562	566	PF08558	0.459
LIG_UBA3_1	540	548	PF00899	0.386
LIG_WRC_WIRS_1	165	170	PF05994	0.574
LIG_WRC_WIRS_1	729	734	PF05994	0.329
MOD_CDC14_SPxK_1	588	591	PF00782	0.502
MOD_CDC14_SPxK_1	770	773	PF00782	0.466
MOD_CDK_SPK_2	9	14	PF00069	0.466
MOD_CDK_SPxK_1	585	591	PF00069	0.517
MOD_CDK_SPxK_1	767	773	PF00069	0.442
MOD_CK1_1	123	129	PF00069	0.729
MOD_CK1_1	288	294	PF00069	0.697
MOD_CK1_1	359	365	PF00069	0.621
MOD_CK1_1	373	379	PF00069	0.326
MOD_CK1_1	419	425	PF00069	0.455
MOD_CK1_1	434	440	PF00069	0.458
MOD_CK1_1	557	563	PF00069	0.350
MOD_CK1_1	87	93	PF00069	0.738
MOD_CK2_1	516	522	PF00069	0.543
MOD_CK2_1	557	563	PF00069	0.365
MOD_CK2_1	604	610	PF00069	0.404
MOD_Cter_Amidation	83	86	PF01082	0.663
MOD_DYRK1A_RPxSP_1	9	13	PF00069	0.509
MOD_GlcNHglycan	180	183	PF01048	0.545
MOD_GlcNHglycan	199	202	PF01048	0.325
MOD_GlcNHglycan	283	286	PF01048	0.739
MOD_GlcNHglycan	347	350	PF01048	0.397
MOD_GlcNHglycan	355	361	PF01048	0.561
MOD_GlcNHglycan	374	378	PF01048	0.306
MOD_GlcNHglycan	402	405	PF01048	0.574
MOD_GlcNHglycan	421	425	PF01048	0.493
MOD_GlcNHglycan	495	498	PF01048	0.728
MOD_GlcNHglycan	666	669	PF01048	0.498
MOD_GlcNHglycan	80	83	PF01048	0.721
MOD_GlcNHglycan	89	92	PF01048	0.695
MOD_GSK3_1	116	123	PF00069	0.731
MOD_GSK3_1	18	25	PF00069	0.304
MOD_GSK3_1	281	288	PF00069	0.644
MOD_GSK3_1	355	362	PF00069	0.615
MOD_GSK3_1	400	407	PF00069	0.593
MOD_GSK3_1	416	423	PF00069	0.625
MOD_GSK3_1	489	496	PF00069	0.725
MOD_GSK3_1	516	523	PF00069	0.481
MOD_GSK3_1	524	531	PF00069	0.388
MOD_GSK3_1	550	557	PF00069	0.516
MOD_GSK3_1	574	581	PF00069	0.670
MOD_N-GLC_1	554	559	PF02516	0.444
MOD_N-GLC_1	60	65	PF02516	0.424
MOD_NEK2_1	176	181	PF00069	0.610
MOD_NEK2_1	190	195	PF00069	0.454
MOD_NEK2_1	2	7	PF00069	0.601
MOD_NEK2_1	372	377	PF00069	0.540
MOD_NEK2_1	516	521	PF00069	0.477
MOD_NEK2_1	524	529	PF00069	0.365
MOD_NEK2_1	567	572	PF00069	0.406
MOD_NEK2_1	736	741	PF00069	0.445
MOD_NEK2_2	101	106	PF00069	0.628
MOD_PIKK_1	489	495	PF00454	0.645
MOD_PIKK_1	678	684	PF00454	0.418
MOD_PIKK_1	800	806	PF00454	0.464
MOD_PKA_1	85	91	PF00069	0.609
MOD_PKA_2	2	8	PF00069	0.614
MOD_PKA_2	300	306	PF00069	0.459
MOD_PKA_2	38	44	PF00069	0.296
MOD_PKA_2	567	573	PF00069	0.577
MOD_PKA_2	650	656	PF00069	0.655
MOD_PKA_2	703	709	PF00069	0.533
MOD_PKA_2	84	90	PF00069	0.656
MOD_Plk_1	149	155	PF00069	0.571
MOD_Plk_1	574	580	PF00069	0.545
MOD_Plk_1	697	703	PF00069	0.372
MOD_Plk_2-3	327	333	PF00069	0.399
MOD_Plk_4	520	526	PF00069	0.574
MOD_Plk_4	567	573	PF00069	0.442
MOD_Plk_4	728	734	PF00069	0.332
MOD_Plk_4	792	798	PF00069	0.424
MOD_ProDKin_1	121	127	PF00069	0.638
MOD_ProDKin_1	142	148	PF00069	0.485
MOD_ProDKin_1	20	26	PF00069	0.287
MOD_ProDKin_1	434	440	PF00069	0.458
MOD_ProDKin_1	504	510	PF00069	0.620
MOD_ProDKin_1	585	591	PF00069	0.657
MOD_ProDKin_1	756	762	PF00069	0.486
MOD_ProDKin_1	767	773	PF00069	0.484
MOD_ProDKin_1	9	15	PF00069	0.478
MOD_SUMO_for_1	334	337	PF00179	0.438
MOD_SUMO_for_1	572	575	PF00179	0.508
MOD_SUMO_rev_2	299	309	PF00179	0.419
TRG_DiLeu_BaEn_1	436	441	PF01217	0.443
TRG_ENDOCYTIC_2	229	232	PF00928	0.560
TRG_ENDOCYTIC_2	638	641	PF00928	0.562
TRG_ENDOCYTIC_2	729	732	PF00928	0.348
TRG_ER_diArg_1	162	164	PF00400	0.517
TRG_ER_diArg_1	2	4	PF00400	0.695
TRG_ER_diArg_1	214	216	PF00400	0.584
TRG_ER_diArg_1	221	223	PF00400	0.541
TRG_ER_diArg_1	541	544	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	559	563	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JIX4	Bodo saltans	28%	75%
A0A1X0NVN0	Trypanosomatidae	41%	97%
A0A422NQ56	Trypanosoma rangeli	42%	96%
A4HDL7	Leishmania braziliensis	88%	100%
A4I0W8	Leishmania infantum	100%	100%
D0A799	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9AWX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QAK2	Leishmania major	96%	100%
V5BAJ1	Trypanosoma cruzi	39%	96%