LeishMANIAdb
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NPK1-related protein kinase-like

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NPK1-related protein kinase-like
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ICW9_LEIDO
TriTrypDb:
LdBPK_241500.1 * , LdCL_240020200 , LDHU3_24.1830
Length:
602

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICW9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICW9

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016310 phosphorylation 5 7
GO:0019538 protein metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:0007165 signal transduction 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0004672 protein kinase activity 3 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016301 kinase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140096 catalytic activity, acting on a protein 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 148 152 PF00656 0.663
CLV_NRD_NRD_1 134 136 PF00675 0.750
CLV_NRD_NRD_1 162 164 PF00675 0.708
CLV_NRD_NRD_1 239 241 PF00675 0.671
CLV_NRD_NRD_1 323 325 PF00675 0.483
CLV_NRD_NRD_1 357 359 PF00675 0.353
CLV_NRD_NRD_1 36 38 PF00675 0.674
CLV_NRD_NRD_1 482 484 PF00675 0.385
CLV_NRD_NRD_1 51 53 PF00675 0.557
CLV_PCSK_KEX2_1 133 135 PF00082 0.651
CLV_PCSK_KEX2_1 161 163 PF00082 0.709
CLV_PCSK_KEX2_1 239 241 PF00082 0.662
CLV_PCSK_KEX2_1 36 38 PF00082 0.528
CLV_PCSK_KEX2_1 482 484 PF00082 0.385
CLV_PCSK_KEX2_1 584 586 PF00082 0.385
CLV_PCSK_KEX2_1 97 99 PF00082 0.787
CLV_PCSK_PC1ET2_1 133 135 PF00082 0.680
CLV_PCSK_PC1ET2_1 584 586 PF00082 0.385
CLV_PCSK_PC1ET2_1 97 99 PF00082 0.791
CLV_PCSK_PC7_1 32 38 PF00082 0.536
CLV_PCSK_PC7_1 580 586 PF00082 0.385
CLV_PCSK_SKI1_1 420 424 PF00082 0.385
CLV_PCSK_SKI1_1 452 456 PF00082 0.481
CLV_PCSK_SKI1_1 482 486 PF00082 0.385
DEG_APCC_DBOX_1 187 195 PF00400 0.592
DEG_SPOP_SBC_1 194 198 PF00917 0.729
DOC_ANK_TNKS_1 75 82 PF00023 0.576
DOC_CKS1_1 129 134 PF01111 0.801
DOC_CKS1_1 495 500 PF01111 0.385
DOC_MAPK_gen_1 452 461 PF00069 0.385
DOC_PP1_RVXF_1 390 397 PF00149 0.409
DOC_PP1_RVXF_1 472 479 PF00149 0.385
DOC_PP2B_PxIxI_1 594 600 PF00149 0.351
DOC_PP4_FxxP_1 120 123 PF00568 0.694
DOC_USP7_MATH_1 181 185 PF00917 0.731
DOC_USP7_MATH_1 269 273 PF00917 0.801
DOC_USP7_MATH_1 282 286 PF00917 0.594
DOC_USP7_MATH_1 343 347 PF00917 0.385
DOC_USP7_MATH_1 424 428 PF00917 0.273
DOC_USP7_MATH_1 468 472 PF00917 0.363
DOC_USP7_MATH_1 59 63 PF00917 0.681
DOC_USP7_MATH_1 65 69 PF00917 0.703
DOC_USP7_MATH_2 123 129 PF00917 0.797
DOC_USP7_UBL2_3 470 474 PF12436 0.273
DOC_USP7_UBL2_3 53 57 PF12436 0.781
DOC_USP7_UBL2_3 93 97 PF12436 0.782
DOC_WW_Pin1_4 128 133 PF00397 0.761
DOC_WW_Pin1_4 300 305 PF00397 0.603
DOC_WW_Pin1_4 494 499 PF00397 0.385
DOC_WW_Pin1_4 564 569 PF00397 0.385
LIG_14-3-3_CanoR_1 134 139 PF00244 0.729
LIG_14-3-3_CanoR_1 166 172 PF00244 0.672
LIG_14-3-3_CanoR_1 226 232 PF00244 0.688
LIG_14-3-3_CanoR_1 244 253 PF00244 0.619
LIG_14-3-3_CanoR_1 386 392 PF00244 0.375
LIG_14-3-3_CanoR_1 431 438 PF00244 0.487
LIG_APCC_ABBA_1 403 408 PF00400 0.385
LIG_BRCT_BRCA1_1 25 29 PF00533 0.600
LIG_EVH1_2 227 231 PF00568 0.732
LIG_FHA_1 228 234 PF00498 0.809
LIG_FHA_1 295 301 PF00498 0.510
LIG_FHA_1 432 438 PF00498 0.385
LIG_FHA_1 483 489 PF00498 0.487
LIG_FHA_2 153 159 PF00498 0.680
LIG_FHA_2 461 467 PF00498 0.385
LIG_FHA_2 525 531 PF00498 0.385
LIG_LIR_Apic_2 119 123 PF02991 0.693
LIG_LIR_Apic_2 497 503 PF02991 0.385
LIG_LIR_Gen_1 20 29 PF02991 0.432
LIG_LIR_Gen_1 297 307 PF02991 0.550
LIG_LIR_Gen_1 344 355 PF02991 0.487
LIG_LIR_Nem_3 20 25 PF02991 0.425
LIG_LIR_Nem_3 297 302 PF02991 0.587
LIG_LIR_Nem_3 333 337 PF02991 0.364
LIG_LIR_Nem_3 344 350 PF02991 0.385
LIG_LIR_Nem_3 390 394 PF02991 0.385
LIG_SH2_CRK 334 338 PF00017 0.385
LIG_SH2_SRC 443 446 PF00017 0.487
LIG_SH2_STAP1 296 300 PF00017 0.556
LIG_SH2_STAP1 515 519 PF00017 0.385
LIG_SH2_STAT5 171 174 PF00017 0.594
LIG_SH2_STAT5 296 299 PF00017 0.671
LIG_SH2_STAT5 338 341 PF00017 0.385
LIG_SH2_STAT5 395 398 PF00017 0.451
LIG_SH2_STAT5 409 412 PF00017 0.320
LIG_SH2_STAT5 443 446 PF00017 0.385
LIG_SH3_2 536 541 PF14604 0.385
LIG_SH3_3 102 108 PF00018 0.795
LIG_SH3_3 215 221 PF00018 0.810
LIG_SH3_3 533 539 PF00018 0.385
LIG_SH3_3 58 64 PF00018 0.741
LIG_SH3_3 71 77 PF00018 0.635
LIG_SH3_4 53 60 PF00018 0.670
LIG_SUMO_SIM_anti_2 234 239 PF11976 0.675
LIG_SUMO_SIM_par_1 369 374 PF11976 0.395
LIG_SUMO_SIM_par_1 504 509 PF11976 0.176
LIG_TRAF2_1 198 201 PF00917 0.684
LIG_TRAF2_1 289 292 PF00917 0.559
LIG_TRAF2_1 562 565 PF00917 0.385
LIG_WRC_WIRS_1 388 393 PF05994 0.385
MOD_CDK_SPK_2 128 133 PF00069 0.699
MOD_CDK_SPxK_1 128 134 PF00069 0.677
MOD_CDK_SPxxK_3 128 135 PF00069 0.802
MOD_CK1_1 124 130 PF00069 0.656
MOD_CK1_1 137 143 PF00069 0.594
MOD_CK1_1 257 263 PF00069 0.685
MOD_CK1_1 315 321 PF00069 0.486
MOD_CK1_1 489 495 PF00069 0.385
MOD_CK1_1 513 519 PF00069 0.402
MOD_CK2_1 113 119 PF00069 0.669
MOD_CK2_1 195 201 PF00069 0.699
MOD_CK2_1 286 292 PF00069 0.571
MOD_CK2_1 524 530 PF00069 0.385
MOD_GlcNHglycan 112 116 PF01048 0.708
MOD_GlcNHglycan 147 150 PF01048 0.659
MOD_GlcNHglycan 25 28 PF01048 0.650
MOD_GlcNHglycan 288 291 PF01048 0.553
MOD_GlcNHglycan 399 402 PF01048 0.393
MOD_GlcNHglycan 415 418 PF01048 0.316
MOD_GlcNHglycan 438 441 PF01048 0.487
MOD_GlcNHglycan 507 511 PF01048 0.385
MOD_GlcNHglycan 512 515 PF01048 0.385
MOD_GlcNHglycan 542 545 PF01048 0.385
MOD_GlcNHglycan 552 555 PF01048 0.385
MOD_GlcNHglycan 67 70 PF01048 0.700
MOD_GlcNHglycan 99 102 PF01048 0.803
MOD_GSK3_1 121 128 PF00069 0.744
MOD_GSK3_1 150 157 PF00069 0.715
MOD_GSK3_1 227 234 PF00069 0.614
MOD_GSK3_1 282 289 PF00069 0.664
MOD_GSK3_1 294 301 PF00069 0.572
MOD_GSK3_1 311 318 PF00069 0.403
MOD_GSK3_1 425 432 PF00069 0.487
MOD_GSK3_1 482 489 PF00069 0.385
MOD_GSK3_1 490 497 PF00069 0.385
MOD_GSK3_1 506 513 PF00069 0.385
MOD_GSK3_1 520 527 PF00069 0.351
MOD_GSK3_1 552 559 PF00069 0.385
MOD_GSK3_1 97 104 PF00069 0.788
MOD_N-GLC_1 315 320 PF02516 0.507
MOD_N-GLC_2 387 389 PF02516 0.385
MOD_NEK2_1 1 6 PF00069 0.577
MOD_NEK2_1 195 200 PF00069 0.742
MOD_NEK2_1 311 316 PF00069 0.493
MOD_NEK2_1 460 465 PF00069 0.385
MOD_NEK2_1 550 555 PF00069 0.385
MOD_NEK2_2 282 287 PF00069 0.684
MOD_NEK2_2 343 348 PF00069 0.385
MOD_NEK2_2 82 87 PF00069 0.630
MOD_PIKK_1 196 202 PF00454 0.626
MOD_PIKK_1 431 437 PF00454 0.445
MOD_PIKK_1 443 449 PF00454 0.307
MOD_PIKK_1 468 474 PF00454 0.382
MOD_PIKK_1 486 492 PF00454 0.341
MOD_PK_1 254 260 PF00069 0.620
MOD_PKA_1 134 140 PF00069 0.717
MOD_PKA_1 324 330 PF00069 0.321
MOD_PKA_1 482 488 PF00069 0.385
MOD_PKA_1 584 590 PF00069 0.385
MOD_PKA_1 97 103 PF00069 0.804
MOD_PKA_2 134 140 PF00069 0.795
MOD_PKA_2 165 171 PF00069 0.758
MOD_PKA_2 286 292 PF00069 0.643
MOD_PKA_2 330 336 PF00069 0.376
MOD_PKA_2 482 488 PF00069 0.385
MOD_PKA_2 584 590 PF00069 0.385
MOD_PKA_2 97 103 PF00069 0.797
MOD_Plk_1 124 130 PF00069 0.778
MOD_Plk_1 150 156 PF00069 0.715
MOD_Plk_1 213 219 PF00069 0.777
MOD_Plk_4 324 330 PF00069 0.374
MOD_Plk_4 333 339 PF00069 0.402
MOD_Plk_4 425 431 PF00069 0.439
MOD_Plk_4 490 496 PF00069 0.385
MOD_ProDKin_1 128 134 PF00069 0.761
MOD_ProDKin_1 300 306 PF00069 0.601
MOD_ProDKin_1 494 500 PF00069 0.385
MOD_ProDKin_1 564 570 PF00069 0.385
MOD_SUMO_for_1 599 602 PF00179 0.507
MOD_SUMO_rev_2 249 256 PF00179 0.624
TRG_ENDOCYTIC_2 334 337 PF00928 0.374
TRG_ENDOCYTIC_2 338 341 PF00928 0.385
TRG_ER_diArg_1 161 163 PF00400 0.705
TRG_ER_diArg_1 238 240 PF00400 0.707
TRG_ER_diArg_1 383 386 PF00400 0.388
TRG_ER_diArg_1 482 484 PF00400 0.385
TRG_NES_CRM1_1 363 376 PF08389 0.385
TRG_NLS_Bipartite_1 36 56 PF00514 0.623
TRG_NLS_MonoCore_2 51 56 PF00514 0.660
TRG_NLS_MonoExtC_3 419 424 PF00514 0.385
TRG_NLS_MonoExtC_3 51 56 PF00514 0.660
TRG_NLS_MonoExtN_4 132 137 PF00514 0.719
TRG_Pf-PMV_PEXEL_1 482 486 PF00026 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HTF0 Leptomonas seymouri 59% 95%
A0A3Q8ITZ9 Leishmania donovani 25% 100%
A4H459 Leishmania braziliensis 26% 100%
A4H601 Leishmania braziliensis 22% 100%
A4HDJ5 Leishmania braziliensis 80% 100%
A4HFA1 Leishmania braziliensis 25% 100%
A4HLJ9 Leishmania braziliensis 24% 100%
A4HSE2 Leishmania infantum 26% 100%
A4I0Y4 Leishmania infantum 100% 100%
A4I910 Leishmania infantum 25% 100%
E9AWZ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B3X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
Q4Q449 Leishmania major 25% 100%
Q4QAI6 Leishmania major 92% 99%
Q6F3A6 Oryza sativa subsp. japonica 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS