Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICW8_LEIDO

TriTrypDb:

LdBPK_320360.1 , LdCL_320008500 , LDHU3_32.0450

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8ICW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.583
CLV_NRD_NRD_1	100	102	PF00675	0.520
CLV_NRD_NRD_1	126	128	PF00675	0.494
CLV_NRD_NRD_1	83	85	PF00675	0.633
CLV_PCSK_KEX2_1	126	128	PF00082	0.494
CLV_PCSK_KEX2_1	436	438	PF00082	0.589
CLV_PCSK_KEX2_1	450	452	PF00082	0.449
CLV_PCSK_KEX2_1	82	84	PF00082	0.640
CLV_PCSK_KEX2_1	99	101	PF00082	0.532
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.567
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.583
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.629
CLV_PCSK_SKI1_1	126	130	PF00082	0.615
CLV_PCSK_SKI1_1	369	373	PF00082	0.694
CLV_PCSK_SKI1_1	384	388	PF00082	0.593
CLV_PCSK_SKI1_1	459	463	PF00082	0.573
CLV_PCSK_SKI1_1	59	63	PF00082	0.543
CLV_PCSK_SKI1_1	84	88	PF00082	0.512
DEG_APCC_DBOX_1	100	108	PF00400	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.468
DOC_MAPK_gen_1	123	131	PF00069	0.526
DOC_MAPK_gen_1	378	388	PF00069	0.726
DOC_MAPK_gen_1	82	91	PF00069	0.615
DOC_MAPK_gen_1	99	110	PF00069	0.483
DOC_USP7_MATH_1	140	144	PF00917	0.762
DOC_USP7_MATH_1	193	197	PF00917	0.680
DOC_USP7_MATH_1	250	254	PF00917	0.673
DOC_USP7_MATH_1	26	30	PF00917	0.614
DOC_USP7_MATH_1	291	295	PF00917	0.722
DOC_USP7_MATH_1	316	320	PF00917	0.657
DOC_USP7_MATH_1	40	44	PF00917	0.400
DOC_USP7_MATH_1	457	461	PF00917	0.663
DOC_USP7_UBL2_3	446	450	PF12436	0.586
DOC_USP7_UBL2_3	66	70	PF12436	0.549
DOC_WW_Pin1_4	142	147	PF00397	0.746
DOC_WW_Pin1_4	164	169	PF00397	0.719
DOC_WW_Pin1_4	246	251	PF00397	0.670
DOC_WW_Pin1_4	369	374	PF00397	0.712
LIG_14-3-3_CanoR_1	11	15	PF00244	0.560
LIG_14-3-3_CanoR_1	160	168	PF00244	0.747
LIG_14-3-3_CanoR_1	171	178	PF00244	0.624
LIG_14-3-3_CanoR_1	299	304	PF00244	0.639
LIG_14-3-3_CanoR_1	334	340	PF00244	0.720
LIG_BRCT_BRCA1_1	279	283	PF00533	0.616
LIG_BRCT_BRCA1_1	331	335	PF00533	0.717
LIG_Clathr_ClatBox_1	107	111	PF01394	0.456
LIG_eIF4E_1	206	212	PF01652	0.512
LIG_FHA_1	257	263	PF00498	0.666
LIG_FHA_1	308	314	PF00498	0.674
LIG_FHA_1	357	363	PF00498	0.673
LIG_FHA_1	383	389	PF00498	0.743
LIG_FHA_2	273	279	PF00498	0.594
LIG_FHA_2	425	431	PF00498	0.541
LIG_LIR_Gen_1	29	37	PF02991	0.518
LIG_LIR_Nem_3	358	363	PF02991	0.601
LIG_PAM2_1	22	34	PF00658	0.531
LIG_PDZ_Class_2	461	466	PF00595	0.566
LIG_Pex14_2	335	339	PF04695	0.720
LIG_SH2_STAP1	417	421	PF00017	0.603
LIG_SH2_STAP1	453	457	PF00017	0.510
LIG_SH2_STAT3	14	17	PF00017	0.583
LIG_SH2_STAT5	14	17	PF00017	0.447
LIG_SH2_STAT5	9	12	PF00017	0.443
LIG_SH3_3	259	265	PF00018	0.623
LIG_SH3_3	310	316	PF00018	0.582
LIG_SH3_3	409	415	PF00018	0.725
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.458
LIG_SUMO_SIM_par_1	106	111	PF11976	0.458
LIG_TRAF2_1	132	135	PF00917	0.593
LIG_TRAF2_1	348	351	PF00917	0.679
MOD_CDK_SPxxK_3	164	171	PF00069	0.754
MOD_CK1_1	145	151	PF00069	0.724
MOD_CK1_1	153	159	PF00069	0.818
MOD_CK1_1	170	176	PF00069	0.505
MOD_CK1_1	298	304	PF00069	0.750
MOD_CK1_1	393	399	PF00069	0.680
MOD_CK2_1	149	155	PF00069	0.751
MOD_CK2_1	389	395	PF00069	0.809
MOD_CK2_1	40	46	PF00069	0.440
MOD_Cter_Amidation	294	297	PF01082	0.614
MOD_GlcNHglycan	138	141	PF01048	0.744
MOD_GlcNHglycan	162	165	PF01048	0.673
MOD_GlcNHglycan	172	175	PF01048	0.480
MOD_GlcNHglycan	246	249	PF01048	0.677
MOD_GlcNHglycan	278	282	PF01048	0.693
MOD_GlcNHglycan	293	296	PF01048	0.637
MOD_GlcNHglycan	323	326	PF01048	0.735
MOD_GlcNHglycan	344	347	PF01048	0.733
MOD_GlcNHglycan	419	422	PF01048	0.608
MOD_GlcNHglycan	459	462	PF01048	0.543
MOD_GSK3_1	136	143	PF00069	0.797
MOD_GSK3_1	145	152	PF00069	0.659
MOD_GSK3_1	160	167	PF00069	0.708
MOD_GSK3_1	194	201	PF00069	0.614
MOD_GSK3_1	246	253	PF00069	0.624
MOD_GSK3_1	26	33	PF00069	0.495
MOD_GSK3_1	291	298	PF00069	0.646
MOD_GSK3_1	389	396	PF00069	0.728
MOD_GSK3_1	413	420	PF00069	0.616
MOD_GSK3_1	453	460	PF00069	0.597
MOD_GSK3_1	48	55	PF00069	0.474
MOD_N-GLC_1	283	288	PF02516	0.724
MOD_N-GLC_1	393	398	PF02516	0.695
MOD_NEK2_1	211	216	PF00069	0.577
MOD_NEK2_1	283	288	PF00069	0.675
MOD_NEK2_1	335	340	PF00069	0.639
MOD_NEK2_1	423	428	PF00069	0.555
MOD_NEK2_1	52	57	PF00069	0.472
MOD_NEK2_1	61	66	PF00069	0.456
MOD_NEK2_1	77	82	PF00069	0.515
MOD_NEK2_2	382	387	PF00069	0.662
MOD_NEK2_2	48	53	PF00069	0.552
MOD_PIKK_1	211	217	PF00454	0.588
MOD_PIKK_1	272	278	PF00454	0.749
MOD_PIKK_1	394	400	PF00454	0.724
MOD_PKA_1	216	222	PF00069	0.576
MOD_PKA_2	10	16	PF00069	0.558
MOD_PKA_2	149	155	PF00069	0.683
MOD_PKA_2	159	165	PF00069	0.754
MOD_PKA_2	170	176	PF00069	0.649
MOD_PKA_2	298	304	PF00069	0.698
MOD_PKA_2	335	341	PF00069	0.704
MOD_Plk_1	20	26	PF00069	0.671
MOD_Plk_1	283	289	PF00069	0.605
MOD_Plk_4	26	32	PF00069	0.580
MOD_ProDKin_1	142	148	PF00069	0.746
MOD_ProDKin_1	164	170	PF00069	0.715
MOD_ProDKin_1	246	252	PF00069	0.672
MOD_ProDKin_1	369	375	PF00069	0.712
MOD_SUMO_rev_2	397	407	PF00179	0.720
MOD_SUMO_rev_2	430	438	PF00179	0.629
MOD_SUMO_rev_2	79	89	PF00179	0.623
TRG_ER_diArg_1	98	101	PF00400	0.531
TRG_NLS_MonoExtC_3	215	220	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE29	Leptomonas seymouri	67%	98%
A0A1X0P7K1	Trypanosomatidae	37%	100%
A0A3R7NTG2	Trypanosoma rangeli	36%	100%
A4HK15	Leishmania braziliensis	83%	100%
A4I7J9	Leishmania infantum	100%	100%
D0A0A1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q5Q0	Leishmania major	96%	100%
V5BS76	Trypanosoma cruzi	33%	100%