LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8ICW6_LEIDO
TriTrypDb:
LdBPK_130920.1 * , LdCL_130014600 , LDHU3_13.1140
Length:
366

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICW6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICW6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 130 134 PF00656 0.584
CLV_C14_Caspase3-7 272 276 PF00656 0.531
CLV_MEL_PAP_1 324 330 PF00089 0.486
CLV_PCSK_KEX2_1 265 267 PF00082 0.566
CLV_PCSK_PC1ET2_1 265 267 PF00082 0.566
CLV_PCSK_SKI1_1 124 128 PF00082 0.527
CLV_PCSK_SKI1_1 186 190 PF00082 0.590
CLV_PCSK_SKI1_1 227 231 PF00082 0.403
CLV_Separin_Metazoa 221 225 PF03568 0.351
DEG_Nend_UBRbox_1 1 4 PF02207 0.587
DEG_SPOP_SBC_1 125 129 PF00917 0.634
DEG_SPOP_SBC_1 16 20 PF00917 0.641
DEG_SPOP_SBC_1 170 174 PF00917 0.535
DEG_SPOP_SBC_1 270 274 PF00917 0.502
DOC_CDC14_PxL_1 253 261 PF14671 0.451
DOC_CKS1_1 244 249 PF01111 0.502
DOC_PP1_RVXF_1 263 270 PF00149 0.501
DOC_PP1_RVXF_1 83 90 PF00149 0.439
DOC_PP2B_LxvP_1 168 171 PF13499 0.543
DOC_PP2B_LxvP_1 323 326 PF13499 0.567
DOC_USP7_MATH_1 125 129 PF00917 0.610
DOC_USP7_MATH_1 199 203 PF00917 0.569
DOC_USP7_MATH_1 229 233 PF00917 0.448
DOC_USP7_MATH_1 271 275 PF00917 0.554
DOC_USP7_MATH_1 296 300 PF00917 0.631
DOC_USP7_MATH_1 326 330 PF00917 0.580
DOC_USP7_MATH_2 295 301 PF00917 0.567
DOC_WW_Pin1_4 172 177 PF00397 0.642
DOC_WW_Pin1_4 243 248 PF00397 0.560
DOC_WW_Pin1_4 55 60 PF00397 0.582
LIG_14-3-3_CanoR_1 124 132 PF00244 0.649
LIG_14-3-3_CanoR_1 169 179 PF00244 0.542
LIG_14-3-3_CanoR_1 25 31 PF00244 0.564
LIG_14-3-3_CanoR_1 327 331 PF00244 0.541
LIG_14-3-3_CanoR_1 33 39 PF00244 0.372
LIG_CtBP_PxDLS_1 295 299 PF00389 0.550
LIG_FHA_1 173 179 PF00498 0.569
LIG_FHA_1 25 31 PF00498 0.570
LIG_FHA_1 262 268 PF00498 0.556
LIG_FHA_1 317 323 PF00498 0.566
LIG_FHA_1 330 336 PF00498 0.485
LIG_FHA_1 5 11 PF00498 0.658
LIG_FHA_1 99 105 PF00498 0.398
LIG_FHA_2 223 229 PF00498 0.393
LIG_HP1_1 326 330 PF01393 0.523
LIG_LIR_Gen_1 228 237 PF02991 0.380
LIG_LIR_Gen_1 258 267 PF02991 0.481
LIG_LIR_Gen_1 306 315 PF02991 0.634
LIG_LIR_Nem_3 228 233 PF02991 0.478
LIG_LIR_Nem_3 258 263 PF02991 0.465
LIG_LIR_Nem_3 306 311 PF02991 0.640
LIG_PDZ_Class_2 361 366 PF00595 0.463
LIG_Pex14_1 156 160 PF04695 0.417
LIG_SH2_CRK 260 264 PF00017 0.479
LIG_SH2_NCK_1 260 264 PF00017 0.678
LIG_SH2_NCK_1 308 312 PF00017 0.591
LIG_SH2_STAP1 17 21 PF00017 0.762
LIG_SH2_STAP1 308 312 PF00017 0.594
LIG_SH2_STAT5 245 248 PF00017 0.556
LIG_SH3_1 289 295 PF00018 0.672
LIG_SH3_3 289 295 PF00018 0.698
LIG_Sin3_3 318 325 PF02671 0.510
LIG_SUMO_SIM_anti_2 143 150 PF11976 0.444
LIG_SUMO_SIM_anti_2 319 325 PF11976 0.497
LIG_SUMO_SIM_anti_2 361 366 PF11976 0.406
LIG_SUMO_SIM_par_1 143 150 PF11976 0.372
LIG_TRAF2_1 237 240 PF00917 0.490
MOD_CK1_1 172 178 PF00069 0.695
MOD_CK1_1 24 30 PF00069 0.649
MOD_CK1_1 3 9 PF00069 0.608
MOD_CK1_1 306 312 PF00069 0.642
MOD_CK1_1 329 335 PF00069 0.498
MOD_CK1_1 356 362 PF00069 0.486
MOD_CK1_1 68 74 PF00069 0.607
MOD_CK1_1 94 100 PF00069 0.423
MOD_CK2_1 178 184 PF00069 0.489
MOD_CK2_1 222 228 PF00069 0.397
MOD_GlcNHglycan 11 14 PF01048 0.602
MOD_GlcNHglycan 151 154 PF01048 0.591
MOD_GlcNHglycan 180 183 PF01048 0.559
MOD_GlcNHglycan 206 209 PF01048 0.662
MOD_GlcNHglycan 59 62 PF01048 0.609
MOD_GlcNHglycan 71 74 PF01048 0.573
MOD_GlcNHglycan 79 82 PF01048 0.540
MOD_GSK3_1 16 23 PF00069 0.669
MOD_GSK3_1 25 32 PF00069 0.532
MOD_GSK3_1 271 278 PF00069 0.563
MOD_GSK3_1 356 363 PF00069 0.506
MOD_GSK3_1 65 72 PF00069 0.540
MOD_GSK3_1 94 101 PF00069 0.395
MOD_NEK2_1 1 6 PF00069 0.662
MOD_NEK2_1 222 227 PF00069 0.396
MOD_NEK2_1 298 303 PF00069 0.562
MOD_NEK2_1 345 350 PF00069 0.725
MOD_NEK2_1 360 365 PF00069 0.542
MOD_NEK2_1 66 71 PF00069 0.564
MOD_NEK2_1 98 103 PF00069 0.518
MOD_NEK2_2 17 22 PF00069 0.685
MOD_PIKK_1 88 94 PF00454 0.429
MOD_PKA_2 21 27 PF00069 0.610
MOD_PKA_2 326 332 PF00069 0.483
MOD_PKA_2 4 10 PF00069 0.619
MOD_Plk_1 356 362 PF00069 0.553
MOD_Plk_1 94 100 PF00069 0.352
MOD_Plk_4 26 32 PF00069 0.541
MOD_Plk_4 298 304 PF00069 0.693
MOD_Plk_4 326 332 PF00069 0.594
MOD_Plk_4 360 366 PF00069 0.503
MOD_Plk_4 94 100 PF00069 0.352
MOD_ProDKin_1 172 178 PF00069 0.641
MOD_ProDKin_1 243 249 PF00069 0.558
MOD_ProDKin_1 55 61 PF00069 0.581
TRG_DiLeu_BaEn_4 239 245 PF01217 0.482
TRG_DiLeu_BaLyEn_6 100 105 PF01217 0.330
TRG_ENDOCYTIC_2 260 263 PF00928 0.534
TRG_ENDOCYTIC_2 308 311 PF00928 0.633

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P893 Leptomonas seymouri 35% 96%
A0A3R7KDT1 Trypanosoma rangeli 25% 100%
A4H791 Leishmania braziliensis 66% 100%
A4HVN1 Leishmania infantum 99% 100%
D0A6L6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9APC7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%
Q4QG51 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS