Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICW4_LEIDO

TriTrypDb:

LdBPK_272320.1 , LdCL_270031600 , LDHU3_27.3550

Length:

153

Annotations

LeishMANIAdb annotations

Unique but conserved family

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8ICW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.564
CLV_NRD_NRD_1	24	26	PF00675	0.432
CLV_NRD_NRD_1	47	49	PF00675	0.342
CLV_NRD_NRD_1	65	67	PF00675	0.331
CLV_NRD_NRD_1	68	70	PF00675	0.325
CLV_PCSK_KEX2_1	118	120	PF00082	0.569
CLV_PCSK_KEX2_1	2	4	PF00082	0.462
CLV_PCSK_KEX2_1	24	26	PF00082	0.432
CLV_PCSK_KEX2_1	47	49	PF00082	0.342
CLV_PCSK_KEX2_1	65	67	PF00082	0.331
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.623
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.434
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.331
CLV_PCSK_SKI1_1	120	124	PF00082	0.552
CLV_PCSK_SKI1_1	131	135	PF00082	0.519
CLV_PCSK_SKI1_1	147	151	PF00082	0.533
DEG_Nend_UBRbox_1	1	4	PF02207	0.638
DOC_MAPK_gen_1	118	126	PF00069	0.339
DOC_MAPK_gen_1	65	77	PF00069	0.448
DOC_MAPK_MEF2A_6	70	79	PF00069	0.368
DOC_PP1_RVXF_1	67	74	PF00149	0.449
DOC_WW_Pin1_4	33	38	PF00397	0.676
LIG_14-3-3_CanoR_1	69	74	PF00244	0.448
LIG_14-3-3_CanoR_1	99	105	PF00244	0.421
LIG_FHA_1	79	85	PF00498	0.409
LIG_FHA_2	139	145	PF00498	0.420
LIG_LIR_Gen_1	23	30	PF02991	0.667
LIG_LIR_Gen_1	94	105	PF02991	0.286
LIG_LIR_Nem_3	23	29	PF02991	0.643
LIG_LIR_Nem_3	94	100	PF02991	0.369
LIG_MYND_1	50	54	PF01753	0.531
LIG_NRP_CendR_1	150	153	PF00754	0.662
LIG_Pex14_1	76	80	PF04695	0.289
LIG_SH2_CRK	97	101	PF00017	0.398
LIG_SH2_STAP1	101	105	PF00017	0.336
LIG_SH2_STAP1	22	26	PF00017	0.620
LIG_SH2_STAT5	104	107	PF00017	0.419
LIG_SH2_STAT5	55	58	PF00017	0.533
LIG_SH3_1	3	9	PF00018	0.621
LIG_SH3_3	3	9	PF00018	0.621
LIG_TYR_ITIM	95	100	PF00017	0.339
MOD_CDK_SPxxK_3	33	40	PF00069	0.664
MOD_NEK2_1	100	105	PF00069	0.427
MOD_NEK2_1	20	25	PF00069	0.624
MOD_PKA_1	69	75	PF00069	0.448
MOD_PKA_2	138	144	PF00069	0.442
MOD_Plk_4	100	106	PF00069	0.406
MOD_Plk_4	69	75	PF00069	0.551
MOD_ProDKin_1	33	39	PF00069	0.672
MOD_SUMO_rev_2	144	149	PF00179	0.409
TRG_ENDOCYTIC_2	97	100	PF00928	0.369
TRG_ER_diArg_1	24	26	PF00400	0.650
TRG_NES_CRM1_1	51	63	PF08389	0.528
TRG_NLS_Bipartite_1	47	69	PF00514	0.531
TRG_NLS_MonoCore_2	117	122	PF00514	0.417
TRG_NLS_MonoExtC_3	64	69	PF00514	0.539
TRG_NLS_MonoExtN_4	65	70	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE08	Leptomonas seymouri	85%	100%
A0A0S4J669	Bodo saltans	65%	100%
A0A1X0NFB4	Trypanosomatidae	69%	100%
A0A422NE01	Trypanosoma rangeli	72%	100%
A4HG17	Leishmania braziliensis	95%	100%
A4I339	Leishmania infantum	100%	100%
C9ZJL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9ACV7	Leishmania major	97%	100%
E9AZE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5B6L7	Trypanosoma cruzi	76%	100%