Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICW3_LEIDO

TriTrypDb:

LdBPK_261760.1 , LdCL_260023200 , LDHU3_26.2200

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.687
CLV_C14_Caspase3-7	158	162	PF00656	0.657
CLV_NRD_NRD_1	210	212	PF00675	0.535
CLV_NRD_NRD_1	317	319	PF00675	0.755
CLV_NRD_NRD_1	374	376	PF00675	0.633
CLV_NRD_NRD_1	76	78	PF00675	0.640
CLV_PCSK_FUR_1	208	212	PF00082	0.538
CLV_PCSK_FUR_1	315	319	PF00082	0.634
CLV_PCSK_FUR_1	92	96	PF00082	0.568
CLV_PCSK_KEX2_1	210	212	PF00082	0.535
CLV_PCSK_KEX2_1	315	317	PF00082	0.774
CLV_PCSK_KEX2_1	374	376	PF00082	0.633
CLV_PCSK_KEX2_1	75	77	PF00082	0.639
CLV_PCSK_KEX2_1	94	96	PF00082	0.516
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.573
CLV_PCSK_PC7_1	312	318	PF00082	0.632
CLV_PCSK_SKI1_1	210	214	PF00082	0.511
DEG_SCF_TRCP1_1	253	258	PF00400	0.582
DEG_SPOP_SBC_1	137	141	PF00917	0.642
DEG_SPOP_SBC_1	299	303	PF00917	0.634
DEG_SPOP_SBC_1	36	40	PF00917	0.596
DOC_CYCLIN_RxL_1	207	217	PF00134	0.522
DOC_CYCLIN_RxL_1	218	226	PF00134	0.449
DOC_PP1_RVXF_1	219	226	PF00149	0.551
DOC_USP7_MATH_1	132	136	PF00917	0.692
DOC_USP7_MATH_1	154	158	PF00917	0.594
DOC_USP7_MATH_1	236	240	PF00917	0.662
DOC_USP7_MATH_1	26	30	PF00917	0.676
DOC_USP7_MATH_1	299	303	PF00917	0.634
DOC_USP7_MATH_1	35	39	PF00917	0.634
DOC_USP7_MATH_1	55	59	PF00917	0.499
DOC_WW_Pin1_4	12	17	PF00397	0.677
DOC_WW_Pin1_4	139	144	PF00397	0.673
DOC_WW_Pin1_4	214	219	PF00397	0.622
DOC_WW_Pin1_4	27	32	PF00397	0.559
DOC_WW_Pin1_4	295	300	PF00397	0.639
DOC_WW_Pin1_4	359	364	PF00397	0.534
LIG_14-3-3_CanoR_1	210	220	PF00244	0.517
LIG_14-3-3_CanoR_1	317	323	PF00244	0.637
LIG_14-3-3_CanoR_1	79	88	PF00244	0.624
LIG_BIR_II_1	1	5	PF00653	0.736
LIG_BIR_III_4	83	87	PF00653	0.614
LIG_Clathr_ClatBox_1	222	226	PF01394	0.522
LIG_CSL_BTD_1	191	194	PF09270	0.546
LIG_FHA_1	118	124	PF00498	0.619
LIG_FHA_1	184	190	PF00498	0.569
LIG_FHA_1	52	58	PF00498	0.670
LIG_FHA_2	103	109	PF00498	0.664
LIG_FHA_2	114	120	PF00498	0.608
LIG_FHA_2	37	43	PF00498	0.651
LIG_LIR_Apic_2	338	344	PF02991	0.591
LIG_LIR_Gen_1	329	339	PF02991	0.598
LIG_LIR_Nem_3	217	223	PF02991	0.527
LIG_LIR_Nem_3	301	307	PF02991	0.601
LIG_LIR_Nem_3	329	335	PF02991	0.601
LIG_PDZ_Class_3	377	382	PF00595	0.618
LIG_Rb_LxCxE_1	174	190	PF01857	0.630
LIG_SH2_CRK	341	345	PF00017	0.570
LIG_SH2_NCK_1	341	345	PF00017	0.570
LIG_SH2_NCK_1	361	365	PF00017	0.446
LIG_SH2_STAT5	332	335	PF00017	0.525
LIG_SH2_STAT5	358	361	PF00017	0.588
LIG_SH3_3	11	17	PF00018	0.557
LIG_SH3_3	230	236	PF00018	0.682
LIG_TRAF2_1	39	42	PF00917	0.628
LIG_TRFH_1	341	345	PF08558	0.540
LIG_WW_3	15	19	PF00397	0.555
MOD_CDC14_SPxK_1	15	18	PF00782	0.671
MOD_CDK_SPK_2	27	32	PF00069	0.655
MOD_CDK_SPxK_1	12	18	PF00069	0.678
MOD_CDK_SPxxK_3	214	221	PF00069	0.481
MOD_CK1_1	139	145	PF00069	0.667
MOD_CK1_1	2	8	PF00069	0.624
MOD_CK1_1	298	304	PF00069	0.595
MOD_CK1_1	331	337	PF00069	0.600
MOD_CK1_1	362	368	PF00069	0.508
MOD_CK1_1	82	88	PF00069	0.655
MOD_CK1_1	93	99	PF00069	0.610
MOD_CK2_1	113	119	PF00069	0.638
MOD_CK2_1	132	138	PF00069	0.658
MOD_CK2_1	141	147	PF00069	0.655
MOD_CK2_1	236	242	PF00069	0.697
MOD_CK2_1	285	291	PF00069	0.587
MOD_CK2_1	318	324	PF00069	0.639
MOD_CK2_1	35	41	PF00069	0.649
MOD_GlcNHglycan	1	4	PF01048	0.682
MOD_GlcNHglycan	108	112	PF01048	0.674
MOD_GlcNHglycan	124	127	PF01048	0.547
MOD_GlcNHglycan	134	137	PF01048	0.651
MOD_GlcNHglycan	169	172	PF01048	0.603
MOD_GlcNHglycan	238	241	PF01048	0.631
MOD_GlcNHglycan	253	256	PF01048	0.554
MOD_GlcNHglycan	346	349	PF01048	0.583
MOD_GlcNHglycan	364	367	PF01048	0.456
MOD_GlcNHglycan	375	378	PF01048	0.537
MOD_GlcNHglycan	83	87	PF01048	0.680
MOD_GSK3_1	1	8	PF00069	0.619
MOD_GSK3_1	100	107	PF00069	0.595
MOD_GSK3_1	109	116	PF00069	0.517
MOD_GSK3_1	117	124	PF00069	0.567
MOD_GSK3_1	132	139	PF00069	0.604
MOD_GSK3_1	163	170	PF00069	0.661
MOD_GSK3_1	174	181	PF00069	0.611
MOD_GSK3_1	183	190	PF00069	0.581
MOD_GSK3_1	192	199	PF00069	0.492
MOD_GSK3_1	251	258	PF00069	0.605
MOD_GSK3_1	295	302	PF00069	0.623
MOD_GSK3_1	51	58	PF00069	0.580
MOD_GSK3_1	90	97	PF00069	0.683
MOD_N-GLC_1	163	168	PF02516	0.660
MOD_NEK2_1	1	6	PF00069	0.676
MOD_NEK2_1	257	262	PF00069	0.596
MOD_NEK2_1	300	305	PF00069	0.631
MOD_PIKK_1	117	123	PF00454	0.621
MOD_PIKK_1	192	198	PF00454	0.580
MOD_PK_1	100	106	PF00069	0.568
MOD_PKA_1	94	100	PF00069	0.572
MOD_PKA_2	373	379	PF00069	0.623
MOD_PKA_2	94	100	PF00069	0.649
MOD_PKB_1	316	324	PF00069	0.636
MOD_PKB_1	77	85	PF00069	0.643
MOD_Plk_1	163	169	PF00069	0.615
MOD_Plk_1	339	345	PF00069	0.583
MOD_Plk_2-3	37	43	PF00069	0.629
MOD_Plk_4	141	147	PF00069	0.632
MOD_Plk_4	187	193	PF00069	0.668
MOD_ProDKin_1	12	18	PF00069	0.678
MOD_ProDKin_1	139	145	PF00069	0.675
MOD_ProDKin_1	214	220	PF00069	0.617
MOD_ProDKin_1	27	33	PF00069	0.557
MOD_ProDKin_1	295	301	PF00069	0.639
MOD_ProDKin_1	359	365	PF00069	0.531
MOD_SUMO_rev_2	58	67	PF00179	0.557
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.594
TRG_ENDOCYTIC_2	219	222	PF00928	0.534
TRG_ENDOCYTIC_2	307	310	PF00928	0.631
TRG_ENDOCYTIC_2	332	335	PF00928	0.579
TRG_ER_diArg_1	210	212	PF00400	0.535
TRG_ER_diArg_1	314	317	PF00400	0.716
TRG_ER_diArg_1	75	77	PF00400	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I2B0	Leishmania infantum	99%	100%
E9AIQ9	Leishmania braziliensis	65%	100%
E9AYF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q915	Leishmania major	87%	100%