Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICW2_LEIDO

TriTrypDb:

LdBPK_260890.1 , LdCL_260014500 , LDHU3_26.1140

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.600
CLV_NRD_NRD_1	167	169	PF00675	0.696
CLV_PCSK_KEX2_1	104	106	PF00082	0.620
CLV_PCSK_KEX2_1	167	169	PF00082	0.696
CLV_PCSK_KEX2_1	26	28	PF00082	0.614
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.425
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.614
CLV_PCSK_PC7_1	100	106	PF00082	0.408
CLV_PCSK_SKI1_1	105	109	PF00082	0.504
CLV_PCSK_SKI1_1	14	18	PF00082	0.516
DEG_APCC_DBOX_1	104	112	PF00400	0.608
DOC_MAPK_gen_1	104	114	PF00069	0.483
DOC_MAPK_gen_1	26	33	PF00069	0.626
DOC_MAPK_MEF2A_6	77	85	PF00069	0.571
DOC_WW_Pin1_4	133	138	PF00397	0.628
DOC_WW_Pin1_4	77	82	PF00397	0.529
LIG_14-3-3_CanoR_1	14	24	PF00244	0.518
LIG_14-3-3_CanoR_1	46	52	PF00244	0.520
LIG_Actin_WH2_2	42	59	PF00022	0.561
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_eIF4E_1	102	108	PF01652	0.609
LIG_eIF4E_1	138	144	PF01652	0.539
LIG_FHA_1	78	84	PF00498	0.472
LIG_FHA_2	93	99	PF00498	0.471
LIG_LIR_Nem_3	10	16	PF02991	0.525
LIG_MYND_1	161	165	PF01753	0.542
LIG_Pex14_1	29	33	PF04695	0.490
LIG_Pex14_2	114	118	PF04695	0.481
LIG_SH2_STAP1	52	56	PF00017	0.583
LIG_SH2_STAT3	166	169	PF00017	0.538
LIG_SH2_STAT5	24	27	PF00017	0.476
LIG_SH2_STAT5	48	51	PF00017	0.463
LIG_SH3_3	150	156	PF00018	0.456
LIG_SH3_3	78	84	PF00018	0.555
LIG_SUMO_SIM_par_1	57	62	PF11976	0.522
LIG_WRPW_2	13	16	PF00400	0.513
MOD_CK1_1	136	142	PF00069	0.528
MOD_CK2_1	136	142	PF00069	0.648
MOD_CK2_1	17	23	PF00069	0.469
MOD_CK2_1	66	72	PF00069	0.529
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.412
MOD_GSK3_1	47	54	PF00069	0.527
MOD_NEK2_1	16	21	PF00069	0.544
MOD_NEK2_1	92	97	PF00069	0.454
MOD_PIKK_1	34	40	PF00454	0.603
MOD_Plk_2-3	98	104	PF00069	0.535
MOD_Plk_4	47	53	PF00069	0.526
MOD_ProDKin_1	133	139	PF00069	0.628
MOD_ProDKin_1	77	83	PF00069	0.531
TRG_DiLeu_BaEn_1	103	108	PF01217	0.635
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.474
TRG_DiLeu_LyEn_5	103	108	PF01217	0.610
TRG_ENDOCYTIC_2	28	31	PF00928	0.489
TRG_ER_diArg_1	105	107	PF00400	0.600
TRG_ER_diArg_1	144	147	PF00400	0.528
TRG_ER_diArg_1	166	168	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5S9	Leptomonas seymouri	81%	100%
A0A0S4II66	Bodo saltans	50%	99%
A0A1X0NSB7	Trypanosomatidae	60%	96%
A0A3R7M837	Trypanosoma rangeli	62%	99%
A4HEU7	Leishmania braziliensis	93%	100%
A4I221	Leishmania infantum	100%	100%
C9ZRY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AY70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9A2	Leishmania major	95%	100%
V5DR82	Trypanosoma cruzi	60%	100%