Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICW0_LEIDO

TriTrypDb:

LdBPK_241150.1 , LdCL_240016600 , LDHU3_24.1360

Length:

802

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.505
CLV_C14_Caspase3-7	3	7	PF00656	0.502
CLV_C14_Caspase3-7	324	328	PF00656	0.558
CLV_C14_Caspase3-7	691	695	PF00656	0.450
CLV_NRD_NRD_1	191	193	PF00675	0.735
CLV_NRD_NRD_1	219	221	PF00675	0.721
CLV_NRD_NRD_1	293	295	PF00675	0.759
CLV_NRD_NRD_1	311	313	PF00675	0.660
CLV_NRD_NRD_1	57	59	PF00675	0.760
CLV_NRD_NRD_1	67	69	PF00675	0.703
CLV_PCSK_KEX2_1	191	193	PF00082	0.735
CLV_PCSK_KEX2_1	292	294	PF00082	0.760
CLV_PCSK_KEX2_1	311	313	PF00082	0.670
CLV_PCSK_KEX2_1	57	59	PF00082	0.760
CLV_PCSK_KEX2_1	67	69	PF00082	0.703
CLV_PCSK_KEX2_1	727	729	PF00082	0.675
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.679
CLV_PCSK_PC7_1	63	69	PF00082	0.735
DEG_SCF_FBW7_1	732	738	PF00400	0.448
DEG_SPOP_SBC_1	328	332	PF00917	0.531
DOC_CKS1_1	369	374	PF01111	0.509
DOC_CKS1_1	732	737	PF01111	0.447
DOC_CKS1_1	99	104	PF01111	0.544
DOC_CYCLIN_yCln2_LP_2	516	522	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	787	793	PF00134	0.649
DOC_MAPK_DCC_7	67	76	PF00069	0.436
DOC_MAPK_gen_1	292	303	PF00069	0.496
DOC_MAPK_gen_1	389	396	PF00069	0.519
DOC_MAPK_gen_1	473	480	PF00069	0.454
DOC_MAPK_MEF2A_6	786	795	PF00069	0.650
DOC_PP2B_LxvP_1	90	93	PF13499	0.532
DOC_PP4_FxxP_1	350	353	PF00568	0.523
DOC_USP7_MATH_1	158	162	PF00917	0.529
DOC_USP7_MATH_1	180	184	PF00917	0.543
DOC_USP7_MATH_1	187	191	PF00917	0.637
DOC_USP7_MATH_1	328	332	PF00917	0.509
DOC_USP7_MATH_1	357	361	PF00917	0.483
DOC_USP7_MATH_1	418	422	PF00917	0.500
DOC_USP7_MATH_1	617	621	PF00917	0.460
DOC_USP7_MATH_1	636	640	PF00917	0.451
DOC_USP7_MATH_1	735	739	PF00917	0.461
DOC_WW_Pin1_4	19	24	PF00397	0.604
DOC_WW_Pin1_4	278	283	PF00397	0.542
DOC_WW_Pin1_4	28	33	PF00397	0.529
DOC_WW_Pin1_4	286	291	PF00397	0.478
DOC_WW_Pin1_4	368	373	PF00397	0.515
DOC_WW_Pin1_4	384	389	PF00397	0.487
DOC_WW_Pin1_4	396	401	PF00397	0.444
DOC_WW_Pin1_4	432	437	PF00397	0.521
DOC_WW_Pin1_4	515	520	PF00397	0.434
DOC_WW_Pin1_4	581	586	PF00397	0.462
DOC_WW_Pin1_4	587	592	PF00397	0.447
DOC_WW_Pin1_4	731	736	PF00397	0.496
DOC_WW_Pin1_4	742	747	PF00397	0.423
DOC_WW_Pin1_4	77	82	PF00397	0.478
DOC_WW_Pin1_4	95	100	PF00397	0.489
LIG_14-3-3_CanoR_1	218	224	PF00244	0.462
LIG_14-3-3_CanoR_1	559	565	PF00244	0.598
LIG_14-3-3_CanoR_1	82	90	PF00244	0.522
LIG_14-3-3_CanoR_1	94	99	PF00244	0.533
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_BRCT_BRCA1_1	749	753	PF00533	0.477
LIG_FHA_1	174	180	PF00498	0.518
LIG_FHA_1	368	374	PF00498	0.463
LIG_FHA_1	654	660	PF00498	0.411
LIG_FHA_1	700	706	PF00498	0.416
LIG_FHA_2	129	135	PF00498	0.534
LIG_FHA_2	268	274	PF00498	0.502
LIG_FHA_2	319	325	PF00498	0.463
LIG_FHA_2	385	391	PF00498	0.566
LIG_FHA_2	689	695	PF00498	0.457
LIG_FHA_2	83	89	PF00498	0.586
LIG_Integrin_isoDGR_2	422	424	PF01839	0.644
LIG_Integrin_RGD_1	271	273	PF01839	0.715
LIG_LIR_Apic_2	276	282	PF02991	0.539
LIG_LIR_Gen_1	399	408	PF02991	0.516
LIG_LIR_Gen_1	598	607	PF02991	0.514
LIG_LIR_Gen_1	87	96	PF02991	0.500
LIG_LIR_Nem_3	245	251	PF02991	0.426
LIG_LIR_Nem_3	31	37	PF02991	0.472
LIG_LIR_Nem_3	399	404	PF02991	0.519
LIG_LIR_Nem_3	506	511	PF02991	0.458
LIG_LIR_Nem_3	575	579	PF02991	0.429
LIG_LIR_Nem_3	598	604	PF02991	0.514
LIG_LIR_Nem_3	750	755	PF02991	0.423
LIG_LIR_Nem_3	87	92	PF02991	0.517
LIG_LYPXL_yS_3	789	792	PF13949	0.710
LIG_MYND_1	23	27	PF01753	0.615
LIG_MYND_1	282	286	PF01753	0.541
LIG_MYND_1	362	366	PF01753	0.457
LIG_Pex14_1	545	549	PF04695	0.451
LIG_PTB_Apo_2	600	607	PF02174	0.478
LIG_SH2_CRK	248	252	PF00017	0.498
LIG_SH2_CRK	279	283	PF00017	0.543
LIG_SH2_CRK	601	605	PF00017	0.516
LIG_SH2_CRK	685	689	PF00017	0.488
LIG_SH2_GRB2like	601	604	PF00017	0.481
LIG_SH2_NCK_1	522	526	PF00017	0.401
LIG_SH2_NCK_1	601	605	PF00017	0.479
LIG_SH2_SRC	515	518	PF00017	0.490
LIG_SH2_STAP1	701	705	PF00017	0.376
LIG_SH2_STAT5	241	244	PF00017	0.437
LIG_SH2_STAT5	255	258	PF00017	0.398
LIG_SH2_STAT5	401	404	PF00017	0.464
LIG_SH2_STAT5	413	416	PF00017	0.467
LIG_SH2_STAT5	487	490	PF00017	0.448
LIG_SH2_STAT5	509	512	PF00017	0.455
LIG_SH2_STAT5	515	518	PF00017	0.447
LIG_SH2_STAT5	549	552	PF00017	0.459
LIG_SH2_STAT5	646	649	PF00017	0.500
LIG_SH2_STAT5	653	656	PF00017	0.436
LIG_SH2_STAT5	701	704	PF00017	0.447
LIG_SH3_1	279	285	PF00018	0.604
LIG_SH3_1	359	365	PF00018	0.498
LIG_SH3_1	67	73	PF00018	0.569
LIG_SH3_2	282	287	PF14604	0.610
LIG_SH3_2	372	377	PF14604	0.533
LIG_SH3_3	248	254	PF00018	0.425
LIG_SH3_3	26	32	PF00018	0.554
LIG_SH3_3	279	285	PF00018	0.609
LIG_SH3_3	298	304	PF00018	0.525
LIG_SH3_3	359	365	PF00018	0.496
LIG_SH3_3	366	372	PF00018	0.493
LIG_SH3_3	579	585	PF00018	0.524
LIG_SH3_3	67	73	PF00018	0.569
LIG_SH3_3	790	796	PF00018	0.649
LIG_SH3_3	96	102	PF00018	0.563
LIG_SH3_CIN85_PxpxPR_1	372	377	PF14604	0.496
LIG_SUMO_SIM_anti_2	313	327	PF11976	0.482
LIG_SUMO_SIM_par_1	789	794	PF11976	0.674
LIG_TRFH_1	685	689	PF08558	0.515
LIG_TYR_ITIM	787	792	PF00017	0.641
LIG_WRC_WIRS_1	573	578	PF05994	0.532
LIG_WW_2	362	365	PF00397	0.563
LIG_WW_3	284	288	PF00397	0.726
LIG_WW_3	374	378	PF00397	0.649
MOD_CDC14_SPxK_1	289	292	PF00782	0.682
MOD_CDK_SPK_2	278	283	PF00069	0.685
MOD_CDK_SPK_2	384	389	PF00069	0.671
MOD_CDK_SPK_2	587	592	PF00069	0.495
MOD_CDK_SPK_2	77	82	PF00069	0.592
MOD_CDK_SPK_2	95	100	PF00069	0.587
MOD_CDK_SPxK_1	286	292	PF00069	0.681
MOD_CDK_SPxxK_3	286	293	PF00069	0.681
MOD_CDK_SPxxK_3	384	391	PF00069	0.668
MOD_CDK_SPxxK_3	77	84	PF00069	0.585
MOD_CK1_1	108	114	PF00069	0.591
MOD_CK1_1	153	159	PF00069	0.724
MOD_CK1_1	183	189	PF00069	0.728
MOD_CK1_1	208	214	PF00069	0.575
MOD_CK1_1	219	225	PF00069	0.665
MOD_CK1_1	313	319	PF00069	0.643
MOD_CK1_1	330	336	PF00069	0.670
MOD_CK1_1	340	346	PF00069	0.791
MOD_CK1_1	432	438	PF00069	0.679
MOD_CK1_1	584	590	PF00069	0.531
MOD_CK1_1	624	630	PF00069	0.573
MOD_CK1_1	745	751	PF00069	0.538
MOD_CK1_1	98	104	PF00069	0.660
MOD_CK2_1	128	134	PF00069	0.655
MOD_CK2_1	311	317	PF00069	0.619
MOD_CK2_1	33	39	PF00069	0.722
MOD_CK2_1	384	390	PF00069	0.722
MOD_CK2_1	735	741	PF00069	0.563
MOD_GlcNHglycan	107	110	PF01048	0.647
MOD_GlcNHglycan	153	156	PF01048	0.647
MOD_GlcNHglycan	160	163	PF01048	0.686
MOD_GlcNHglycan	168	171	PF01048	0.719
MOD_GlcNHglycan	185	188	PF01048	0.679
MOD_GlcNHglycan	207	210	PF01048	0.651
MOD_GlcNHglycan	608	611	PF01048	0.585
MOD_GlcNHglycan	619	622	PF01048	0.582
MOD_GlcNHglycan	721	724	PF01048	0.618
MOD_GlcNHglycan	729	732	PF01048	0.587
MOD_GSK3_1	183	190	PF00069	0.758
MOD_GSK3_1	19	26	PF00069	0.640
MOD_GSK3_1	201	208	PF00069	0.622
MOD_GSK3_1	243	250	PF00069	0.524
MOD_GSK3_1	274	281	PF00069	0.701
MOD_GSK3_1	295	302	PF00069	0.648
MOD_GSK3_1	311	318	PF00069	0.689
MOD_GSK3_1	353	360	PF00069	0.581
MOD_GSK3_1	396	403	PF00069	0.647
MOD_GSK3_1	533	540	PF00069	0.577
MOD_GSK3_1	606	613	PF00069	0.665
MOD_GSK3_1	617	624	PF00069	0.545
MOD_GSK3_1	706	713	PF00069	0.579
MOD_GSK3_1	727	734	PF00069	0.615
MOD_GSK3_1	94	101	PF00069	0.675
MOD_LATS_1	309	315	PF00433	0.685
MOD_N-GLC_1	4	9	PF02516	0.663
MOD_N-GLC_1	41	46	PF02516	0.523
MOD_N-GLC_1	77	82	PF02516	0.664
MOD_NEK2_1	136	141	PF00069	0.612
MOD_NEK2_1	242	247	PF00069	0.514
MOD_NEK2_1	507	512	PF00069	0.564
MOD_NEK2_1	606	611	PF00069	0.572
MOD_NEK2_1	753	758	PF00069	0.326
MOD_NEK2_2	180	185	PF00069	0.690
MOD_NEK2_2	274	279	PF00069	0.681
MOD_NEK2_2	572	577	PF00069	0.533
MOD_OFUCOSY	629	635	PF10250	0.586
MOD_OFUCOSY	661	668	PF10250	0.478
MOD_OFUCOSY	703	710	PF10250	0.457
MOD_PIKK_1	108	114	PF00454	0.597
MOD_PIKK_1	173	179	PF00454	0.671
MOD_PIKK_1	337	343	PF00454	0.738
MOD_PIKK_1	537	543	PF00454	0.711
MOD_PK_1	299	305	PF00069	0.591
MOD_PKA_1	293	299	PF00069	0.604
MOD_PKA_1	311	317	PF00069	0.614
MOD_PKA_1	727	733	PF00069	0.507
MOD_PKA_2	150	156	PF00069	0.817
MOD_PKA_2	219	225	PF00069	0.710
MOD_PKA_2	267	273	PF00069	0.673
MOD_PKA_2	293	299	PF00069	0.817
MOD_PKA_2	310	316	PF00069	0.566
MOD_PKA_2	558	564	PF00069	0.765
MOD_PKA_2	610	616	PF00069	0.611
MOD_PKA_2	727	733	PF00069	0.507
MOD_PKB_1	149	157	PF00069	0.675
MOD_Plk_1	243	249	PF00069	0.521
MOD_Plk_1	274	280	PF00069	0.681
MOD_Plk_1	357	363	PF00069	0.579
MOD_Plk_2-3	118	124	PF00069	0.688
MOD_Plk_4	243	249	PF00069	0.606
MOD_Plk_4	274	280	PF00069	0.681
MOD_Plk_4	584	590	PF00069	0.531
MOD_ProDKin_1	19	25	PF00069	0.772
MOD_ProDKin_1	278	284	PF00069	0.685
MOD_ProDKin_1	28	34	PF00069	0.671
MOD_ProDKin_1	286	292	PF00069	0.597
MOD_ProDKin_1	368	374	PF00069	0.648
MOD_ProDKin_1	384	390	PF00069	0.608
MOD_ProDKin_1	396	402	PF00069	0.549
MOD_ProDKin_1	432	438	PF00069	0.654
MOD_ProDKin_1	515	521	PF00069	0.534
MOD_ProDKin_1	581	587	PF00069	0.573
MOD_ProDKin_1	731	737	PF00069	0.621
MOD_ProDKin_1	742	748	PF00069	0.515
MOD_ProDKin_1	77	83	PF00069	0.594
MOD_ProDKin_1	95	101	PF00069	0.613
MOD_SUMO_for_1	336	339	PF00179	0.656
TRG_DiLeu_BaEn_1	474	479	PF01217	0.559
TRG_DiLeu_BaLyEn_6	675	680	PF01217	0.469
TRG_ENDOCYTIC_2	248	251	PF00928	0.538
TRG_ENDOCYTIC_2	401	404	PF00928	0.577
TRG_ENDOCYTIC_2	508	511	PF00928	0.573
TRG_ENDOCYTIC_2	601	604	PF00928	0.566
TRG_ENDOCYTIC_2	685	688	PF00928	0.610
TRG_ENDOCYTIC_2	789	792	PF00928	0.640
TRG_ER_diArg_1	140	143	PF00400	0.640
TRG_ER_diArg_1	191	194	PF00400	0.685
TRG_ER_diArg_1	217	220	PF00400	0.583
TRG_ER_diArg_1	291	294	PF00400	0.680
TRG_ER_diArg_1	483	486	PF00400	0.587
TRG_ER_diArg_1	57	59	PF00400	0.747
TRG_ER_diArg_1	67	69	PF00400	0.673
TRG_ER_diArg_1	81	84	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	678	683	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I7	Leptomonas seymouri	34%	88%
A4HDG9	Leishmania braziliensis	64%	100%
A4I0V0	Leishmania infantum	99%	100%
E9AWV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAM0	Leishmania major	89%	100%