LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8ICV5_LEIDO
TriTrypDb:
LdBPK_272080.1 , LdCL_270028100 , LDHU3_27.3190
Length:
376

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICV5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICV5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.667
CLV_NRD_NRD_1 23 25 PF00675 0.627
CLV_NRD_NRD_1 346 348 PF00675 0.511
CLV_PCSK_KEX2_1 2 4 PF00082 0.667
CLV_PCSK_KEX2_1 346 348 PF00082 0.533
CLV_PCSK_SKI1_1 27 31 PF00082 0.562
DEG_COP1_1 238 246 PF00400 0.376
DEG_Nend_UBRbox_1 1 4 PF02207 0.627
DOC_CKS1_1 150 155 PF01111 0.425
DOC_CYCLIN_yClb5_NLxxxL_5 310 317 PF00134 0.392
DOC_CYCLIN_yCln2_LP_2 317 323 PF00134 0.482
DOC_MAPK_gen_1 235 243 PF00069 0.434
DOC_USP7_MATH_1 236 240 PF00917 0.550
DOC_WW_Pin1_4 149 154 PF00397 0.317
DOC_WW_Pin1_4 84 89 PF00397 0.365
LIG_14-3-3_CanoR_1 142 147 PF00244 0.343
LIG_14-3-3_CanoR_1 2 6 PF00244 0.630
LIG_14-3-3_CanoR_1 27 36 PF00244 0.632
LIG_Actin_WH2_2 59 75 PF00022 0.369
LIG_APCC_ABBA_1 16 21 PF00400 0.571
LIG_BIR_III_2 251 255 PF00653 0.330
LIG_BRCT_BRCA1_1 106 110 PF00533 0.430
LIG_BRCT_BRCA1_1 89 93 PF00533 0.438
LIG_DLG_GKlike_1 142 150 PF00625 0.357
LIG_FHA_1 150 156 PF00498 0.334
LIG_FHA_1 61 67 PF00498 0.518
LIG_FHA_1 84 90 PF00498 0.439
LIG_FHA_2 261 267 PF00498 0.490
LIG_LIR_Apic_2 101 106 PF02991 0.471
LIG_LIR_Gen_1 90 99 PF02991 0.355
LIG_LIR_Nem_3 148 154 PF02991 0.323
LIG_LIR_Nem_3 203 209 PF02991 0.310
LIG_LIR_Nem_3 266 270 PF02991 0.467
LIG_LIR_Nem_3 90 96 PF02991 0.351
LIG_MYND_1 244 248 PF01753 0.313
LIG_MYND_3 253 257 PF01753 0.379
LIG_Pex14_2 201 205 PF04695 0.448
LIG_Pex14_2 348 352 PF04695 0.446
LIG_REV1ctd_RIR_1 203 211 PF16727 0.441
LIG_REV1ctd_RIR_1 231 241 PF16727 0.409
LIG_REV1ctd_RIR_1 285 294 PF16727 0.486
LIG_REV1ctd_RIR_1 326 335 PF16727 0.354
LIG_SH2_CRK 103 107 PF00017 0.482
LIG_SH2_CRK 57 61 PF00017 0.481
LIG_SH2_NCK_1 103 107 PF00017 0.482
LIG_SH2_STAT5 151 154 PF00017 0.317
LIG_SH2_STAT5 157 160 PF00017 0.293
LIG_SH2_STAT5 186 189 PF00017 0.412
LIG_SH2_STAT5 242 245 PF00017 0.533
LIG_SH2_STAT5 344 347 PF00017 0.391
LIG_SH3_3 147 153 PF00018 0.449
LIG_SH3_3 74 80 PF00018 0.381
LIG_SUMO_SIM_par_1 335 341 PF11976 0.411
LIG_TRAF2_1 145 148 PF00917 0.377
MOD_CK1_1 149 155 PF00069 0.312
MOD_CK1_1 260 266 PF00069 0.474
MOD_CK1_1 87 93 PF00069 0.366
MOD_CK2_1 142 148 PF00069 0.488
MOD_CK2_1 260 266 PF00069 0.468
MOD_CK2_1 283 289 PF00069 0.382
MOD_GlcNHglycan 127 130 PF01048 0.466
MOD_GlcNHglycan 177 182 PF01048 0.494
MOD_GlcNHglycan 89 92 PF01048 0.441
MOD_GSK3_1 138 145 PF00069 0.348
MOD_GSK3_1 185 192 PF00069 0.426
MOD_GSK3_1 268 275 PF00069 0.417
MOD_GSK3_1 27 34 PF00069 0.618
MOD_GSK3_1 83 90 PF00069 0.326
MOD_N-GLC_1 257 262 PF02516 0.391
MOD_N-GLC_1 43 48 PF02516 0.371
MOD_NEK2_1 1 6 PF00069 0.621
MOD_NEK2_1 125 130 PF00069 0.428
MOD_NEK2_1 146 151 PF00069 0.357
MOD_NEK2_1 159 164 PF00069 0.379
MOD_NEK2_1 283 288 PF00069 0.457
MOD_NEK2_1 62 67 PF00069 0.569
MOD_NEK2_1 72 77 PF00069 0.394
MOD_PIKK_1 213 219 PF00454 0.461
MOD_PKA_1 38 44 PF00069 0.425
MOD_PKA_2 1 7 PF00069 0.635
MOD_PKA_2 19 25 PF00069 0.438
MOD_PKA_2 72 78 PF00069 0.459
MOD_Plk_1 146 152 PF00069 0.358
MOD_Plk_4 146 152 PF00069 0.453
MOD_Plk_4 242 248 PF00069 0.342
MOD_Plk_4 260 266 PF00069 0.343
MOD_Plk_4 31 37 PF00069 0.419
MOD_ProDKin_1 149 155 PF00069 0.314
MOD_ProDKin_1 84 90 PF00069 0.371
TRG_DiLeu_BaEn_1 366 371 PF01217 0.545
TRG_DiLeu_BaEn_2 120 126 PF01217 0.412
TRG_DiLeu_BaEn_4 178 184 PF01217 0.578
TRG_DiLeu_LyEn_5 366 371 PF01217 0.635
TRG_ENDOCYTIC_2 267 270 PF00928 0.461
TRG_ENDOCYTIC_2 57 60 PF00928 0.502
TRG_ER_diArg_1 1 3 PF00400 0.672
TRG_ER_diArg_1 345 347 PF00400 0.477
TRG_NLS_MonoCore_2 23 28 PF00514 0.572
TRG_Pf-PMV_PEXEL_1 369 374 PF00026 0.594

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2W1 Leptomonas seymouri 74% 100%
A0A0S4ISK5 Bodo saltans 46% 100%
A0A1X0NRI0 Trypanosomatidae 54% 100%
A4HFZ3 Leishmania braziliensis 89% 100%
A4I312 Leishmania infantum 100% 100%
C9ZJH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9ADJ6 Leishmania major 97% 100%
E9AZC2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BNB6 Trypanosoma cruzi 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS