J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICV4_LEIDO

TriTrypDb:

LdBPK_240070.1 , LdCL_240005600 , LDHU3_24.0090

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8ICV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.457
CLV_C14_Caspase3-7	396	400	PF00656	0.634
CLV_C14_Caspase3-7	76	80	PF00656	0.415
CLV_NRD_NRD_1	154	156	PF00675	0.564
CLV_NRD_NRD_1	227	229	PF00675	0.804
CLV_NRD_NRD_1	31	33	PF00675	0.604
CLV_NRD_NRD_1	384	386	PF00675	0.411
CLV_NRD_NRD_1	392	394	PF00675	0.414
CLV_NRD_NRD_1	74	76	PF00675	0.559
CLV_PCSK_FUR_1	342	346	PF00082	0.467
CLV_PCSK_KEX2_1	154	156	PF00082	0.564
CLV_PCSK_KEX2_1	227	229	PF00082	0.799
CLV_PCSK_KEX2_1	344	346	PF00082	0.410
CLV_PCSK_KEX2_1	377	379	PF00082	0.407
CLV_PCSK_KEX2_1	392	394	PF00082	0.418
CLV_PCSK_KEX2_1	411	413	PF00082	0.377
CLV_PCSK_KEX2_1	74	76	PF00082	0.572
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.410
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.407
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.455
CLV_PCSK_PC7_1	388	394	PF00082	0.408
CLV_PCSK_SKI1_1	188	192	PF00082	0.684
CLV_PCSK_SKI1_1	214	218	PF00082	0.756
CLV_PCSK_SKI1_1	246	250	PF00082	0.791
CLV_PCSK_SKI1_1	300	304	PF00082	0.600
CLV_PCSK_SKI1_1	313	317	PF00082	0.652
CLV_PCSK_SKI1_1	377	381	PF00082	0.408
CLV_PCSK_SKI1_1	38	42	PF00082	0.651
CLV_PCSK_SKI1_1	417	421	PF00082	0.445
CLV_PCSK_SKI1_1	68	72	PF00082	0.528
DEG_Nend_UBRbox_1	1	4	PF02207	0.510
DEG_SPOP_SBC_1	230	234	PF00917	0.469
DOC_CYCLIN_RxL_1	211	222	PF00134	0.494
DOC_MAPK_gen_1	411	418	PF00069	0.585
DOC_MAPK_MEF2A_6	411	418	PF00069	0.587
DOC_MAPK_MEF2A_6	57	64	PF00069	0.340
DOC_MAPK_NFAT4_5	411	419	PF00069	0.602
DOC_MAPK_RevD_3	60	75	PF00069	0.351
DOC_SPAK_OSR1_1	5	9	PF12202	0.376
DOC_USP7_MATH_1	129	133	PF00917	0.494
DOC_USP7_MATH_1	272	276	PF00917	0.422
DOC_USP7_MATH_1	387	391	PF00917	0.609
DOC_USP7_MATH_1	402	406	PF00917	0.680
DOC_USP7_UBL2_3	23	27	PF12436	0.434
LIG_14-3-3_CanoR_1	130	139	PF00244	0.464
LIG_14-3-3_CanoR_1	201	208	PF00244	0.528
LIG_14-3-3_CanoR_1	345	354	PF00244	0.666
LIG_14-3-3_CanoR_1	388	394	PF00244	0.601
LIG_14-3-3_CanoR_1	74	78	PF00244	0.368
LIG_14-3-3_CanoR_1	89	93	PF00244	0.250
LIG_Actin_WH2_2	175	190	PF00022	0.414
LIG_APCC_ABBA_1	333	338	PF00400	0.346
LIG_BIR_III_4	79	83	PF00653	0.427
LIG_FHA_1	17	23	PF00498	0.457
LIG_FHA_1	187	193	PF00498	0.429
LIG_FHA_1	236	242	PF00498	0.578
LIG_FHA_1	307	313	PF00498	0.428
LIG_FHA_2	139	145	PF00498	0.402
LIG_FHA_2	232	238	PF00498	0.585
LIG_FHA_2	266	272	PF00498	0.561
LIG_FHA_2	285	291	PF00498	0.409
LIG_FHA_2	299	305	PF00498	0.373
LIG_FHA_2	394	400	PF00498	0.626
LIG_FHA_2	408	414	PF00498	0.561
LIG_FHA_2	74	80	PF00498	0.377
LIG_LIR_Gen_1	24	29	PF02991	0.451
LIG_LIR_Gen_1	320	330	PF02991	0.346
LIG_LIR_Gen_1	331	341	PF02991	0.346
LIG_LIR_Gen_1	84	94	PF02991	0.339
LIG_LIR_Nem_3	134	139	PF02991	0.435
LIG_LIR_Nem_3	24	28	PF02991	0.413
LIG_LIR_Nem_3	320	326	PF02991	0.346
LIG_LIR_Nem_3	331	337	PF02991	0.346
LIG_LIR_Nem_3	43	47	PF02991	0.279
LIG_LIR_Nem_3	84	90	PF02991	0.353
LIG_LIR_Nem_3	91	97	PF02991	0.316
LIG_NRBOX	66	72	PF00104	0.333
LIG_Pex14_2	380	384	PF04695	0.607
LIG_SH2_PTP2	136	139	PF00017	0.476
LIG_SH2_PTP2	334	337	PF00017	0.330
LIG_SH2_SRC	126	129	PF00017	0.404
LIG_SH2_SRC	136	139	PF00017	0.420
LIG_SH2_SRC	334	337	PF00017	0.281
LIG_SH2_SRC	94	97	PF00017	0.331
LIG_SH2_STAP1	372	376	PF00017	0.606
LIG_SH2_STAT3	372	375	PF00017	0.596
LIG_SH2_STAT5	126	129	PF00017	0.412
LIG_SH2_STAT5	136	139	PF00017	0.420
LIG_SH2_STAT5	323	326	PF00017	0.333
LIG_SH2_STAT5	334	337	PF00017	0.311
LIG_SH2_STAT5	69	72	PF00017	0.329
LIG_SH3_2	254	259	PF14604	0.421
LIG_SH3_3	251	257	PF00018	0.476
LIG_SH3_3	55	61	PF00018	0.350
LIG_SUMO_SIM_par_1	60	65	PF11976	0.365
LIG_TRAF2_1	264	267	PF00917	0.520
LIG_TYR_ITIM	332	337	PF00017	0.330
LIG_TYR_ITIM	49	54	PF00017	0.328
LIG_TYR_ITIM	92	97	PF00017	0.332
LIG_WRC_WIRS_1	394	399	PF05994	0.542
MOD_CK1_1	132	138	PF00069	0.482
MOD_CK1_1	328	334	PF00069	0.356
MOD_CK2_1	137	143	PF00069	0.439
MOD_CK2_1	231	237	PF00069	0.583
MOD_CK2_1	261	267	PF00069	0.590
MOD_CK2_1	298	304	PF00069	0.415
MOD_CK2_1	346	352	PF00069	0.662
MOD_CK2_1	402	408	PF00069	0.608
MOD_GlcNHglycan	242	245	PF01048	0.764
MOD_GlcNHglycan	249	252	PF01048	0.750
MOD_GlcNHglycan	263	266	PF01048	0.647
MOD_GSK3_1	158	165	PF00069	0.455
MOD_GSK3_1	182	189	PF00069	0.465
MOD_GSK3_1	229	236	PF00069	0.558
MOD_GSK3_1	261	268	PF00069	0.533
MOD_GSK3_1	346	353	PF00069	0.696
MOD_N-GLC_1	306	311	PF02516	0.621
MOD_NEK2_1	1	6	PF00069	0.446
MOD_NEK2_1	182	187	PF00069	0.489
MOD_NEK2_1	317	322	PF00069	0.290
MOD_NEK2_1	325	330	PF00069	0.346
MOD_NEK2_1	62	67	PF00069	0.351
MOD_NEK2_1	88	93	PF00069	0.344
MOD_NEK2_2	186	191	PF00069	0.426
MOD_NEK2_2	265	270	PF00069	0.387
MOD_PIKK_1	27	33	PF00454	0.393
MOD_PIKK_1	371	377	PF00454	0.611
MOD_PKA_2	1	7	PF00069	0.501
MOD_PKA_2	129	135	PF00069	0.467
MOD_PKA_2	200	206	PF00069	0.521
MOD_PKA_2	387	393	PF00069	0.613
MOD_PKA_2	402	408	PF00069	0.687
MOD_PKA_2	73	79	PF00069	0.368
MOD_PKA_2	88	94	PF00069	0.251
MOD_Plk_1	265	271	PF00069	0.598
MOD_Plk_1	317	323	PF00069	0.281
MOD_Plk_2-3	284	290	PF00069	0.463
MOD_Plk_4	132	138	PF00069	0.422
MOD_Plk_4	317	323	PF00069	0.272
MOD_Plk_4	325	331	PF00069	0.321
MOD_Plk_4	358	364	PF00069	0.634
MOD_Plk_4	83	89	PF00069	0.449
MOD_SUMO_for_1	315	318	PF00179	0.444
MOD_SUMO_for_1	40	43	PF00179	0.451
MOD_SUMO_rev_2	104	111	PF00179	0.408
MOD_SUMO_rev_2	196	200	PF00179	0.476
MOD_SUMO_rev_2	310	315	PF00179	0.434
MOD_SUMO_rev_2	409	419	PF00179	0.640
TRG_DiLeu_BaEn_1	170	175	PF01217	0.399
TRG_DiLeu_BaEn_2	212	218	PF01217	0.554
TRG_ENDOCYTIC_2	136	139	PF00928	0.476
TRG_ENDOCYTIC_2	25	28	PF00928	0.401
TRG_ENDOCYTIC_2	323	326	PF00928	0.334
TRG_ENDOCYTIC_2	334	337	PF00928	0.307
TRG_ENDOCYTIC_2	51	54	PF00928	0.330
TRG_ENDOCYTIC_2	94	97	PF00928	0.331
TRG_ER_diArg_1	154	156	PF00400	0.446
TRG_ER_diArg_1	227	229	PF00400	0.564
TRG_ER_diArg_1	392	394	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N9	Leptomonas seymouri	76%	99%
A0A0S4IV95	Bodo saltans	54%	100%
A0A1X0NKJ2	Trypanosomatidae	64%	99%
A4HD65	Leishmania braziliensis	81%	100%
A4I0N0	Leishmania infantum	98%	100%
D0A6X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
E9AWJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAX3	Leishmania major	93%	100%
V5BW05	Trypanosoma cruzi	64%	94%