Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICV2_LEIDO

TriTrypDb:

LdBPK_241140.1 , LdCL_240016500 , LDHU3_24.1350

Length:

921

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.591
CLV_C14_Caspase3-7	482	486	PF00656	0.621
CLV_C14_Caspase3-7	637	641	PF00656	0.443
CLV_C14_Caspase3-7	826	830	PF00656	0.609
CLV_MEL_PAP_1	840	846	PF00089	0.603
CLV_NRD_NRD_1	209	211	PF00675	0.490
CLV_NRD_NRD_1	363	365	PF00675	0.660
CLV_NRD_NRD_1	384	386	PF00675	0.515
CLV_NRD_NRD_1	539	541	PF00675	0.709
CLV_NRD_NRD_1	680	682	PF00675	0.477
CLV_NRD_NRD_1	723	725	PF00675	0.492
CLV_NRD_NRD_1	784	786	PF00675	0.645
CLV_NRD_NRD_1	80	82	PF00675	0.602
CLV_NRD_NRD_1	852	854	PF00675	0.795
CLV_PCSK_KEX2_1	208	210	PF00082	0.500
CLV_PCSK_KEX2_1	363	365	PF00082	0.466
CLV_PCSK_KEX2_1	383	385	PF00082	0.573
CLV_PCSK_KEX2_1	410	412	PF00082	0.692
CLV_PCSK_KEX2_1	539	541	PF00082	0.709
CLV_PCSK_KEX2_1	680	682	PF00082	0.477
CLV_PCSK_KEX2_1	725	727	PF00082	0.584
CLV_PCSK_KEX2_1	784	786	PF00082	0.569
CLV_PCSK_KEX2_1	80	82	PF00082	0.618
CLV_PCSK_KEX2_1	852	854	PF00082	0.705
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.512
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.573
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.692
CLV_PCSK_PC1ET2_1	725	727	PF00082	0.584
CLV_PCSK_SKI1_1	23	27	PF00082	0.611
CLV_PCSK_SKI1_1	327	331	PF00082	0.511
CLV_PCSK_SKI1_1	384	388	PF00082	0.620
CLV_PCSK_SKI1_1	442	446	PF00082	0.470
CLV_PCSK_SKI1_1	631	635	PF00082	0.411
CLV_PCSK_SKI1_1	98	102	PF00082	0.507
CLV_Separin_Metazoa	24	28	PF03568	0.522
DEG_APCC_DBOX_1	209	217	PF00400	0.552
DEG_APCC_DBOX_1	422	430	PF00400	0.373
DEG_APCC_DBOX_1	441	449	PF00400	0.471
DEG_COP1_1	131	139	PF00400	0.495
DEG_SCF_FBW7_1	591	597	PF00400	0.635
DEG_SCF_FBW7_2	854	859	PF00400	0.526
DEG_SPOP_SBC_1	49	53	PF00917	0.505
DOC_ANK_TNKS_1	224	231	PF00023	0.559
DOC_CKS1_1	270	275	PF01111	0.622
DOC_CKS1_1	310	315	PF01111	0.525
DOC_CKS1_1	591	596	PF01111	0.691
DOC_CKS1_1	68	73	PF01111	0.622
DOC_CYCLIN_RxL_1	439	447	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.474
DOC_MAPK_MEF2A_6	631	638	PF00069	0.400
DOC_PP2B_LxvP_1	177	180	PF13499	0.581
DOC_PP2B_LxvP_1	300	303	PF13499	0.568
DOC_PP4_FxxP_1	283	286	PF00568	0.604
DOC_USP7_MATH_1	10	14	PF00917	0.681
DOC_USP7_MATH_1	158	162	PF00917	0.614
DOC_USP7_MATH_1	166	170	PF00917	0.641
DOC_USP7_MATH_1	457	461	PF00917	0.566
DOC_USP7_MATH_1	49	53	PF00917	0.664
DOC_USP7_MATH_1	492	496	PF00917	0.538
DOC_USP7_MATH_1	524	528	PF00917	0.621
DOC_USP7_MATH_1	600	604	PF00917	0.658
DOC_USP7_MATH_1	737	741	PF00917	0.520
DOC_USP7_MATH_1	824	828	PF00917	0.695
DOC_USP7_UBL2_3	393	397	PF12436	0.640
DOC_USP7_UBL2_3	398	402	PF12436	0.619
DOC_USP7_UBL2_3	721	725	PF12436	0.490
DOC_WW_Pin1_4	103	108	PF00397	0.567
DOC_WW_Pin1_4	154	159	PF00397	0.494
DOC_WW_Pin1_4	259	264	PF00397	0.659
DOC_WW_Pin1_4	26	31	PF00397	0.590
DOC_WW_Pin1_4	269	274	PF00397	0.674
DOC_WW_Pin1_4	3	8	PF00397	0.623
DOC_WW_Pin1_4	309	314	PF00397	0.545
DOC_WW_Pin1_4	50	55	PF00397	0.612
DOC_WW_Pin1_4	558	563	PF00397	0.594
DOC_WW_Pin1_4	569	574	PF00397	0.545
DOC_WW_Pin1_4	587	592	PF00397	0.802
DOC_WW_Pin1_4	67	72	PF00397	0.589
DOC_WW_Pin1_4	738	743	PF00397	0.532
DOC_WW_Pin1_4	804	809	PF00397	0.706
DOC_WW_Pin1_4	820	825	PF00397	0.658
DOC_WW_Pin1_4	852	857	PF00397	0.812
DOC_WW_Pin1_4	862	867	PF00397	0.599
LIG_14-3-3_CanoR_1	129	137	PF00244	0.629
LIG_14-3-3_CanoR_1	182	190	PF00244	0.500
LIG_14-3-3_CanoR_1	238	248	PF00244	0.520
LIG_14-3-3_CanoR_1	363	367	PF00244	0.551
LIG_14-3-3_CanoR_1	384	389	PF00244	0.707
LIG_14-3-3_CanoR_1	423	427	PF00244	0.455
LIG_14-3-3_CanoR_1	479	489	PF00244	0.484
LIG_14-3-3_CanoR_1	555	561	PF00244	0.651
LIG_14-3-3_CanoR_1	749	757	PF00244	0.399
LIG_14-3-3_CanoR_1	796	803	PF00244	0.668
LIG_14-3-3_CanoR_1	80	84	PF00244	0.539
LIG_14-3-3_CanoR_1	843	850	PF00244	0.615
LIG_Actin_WH2_2	167	184	PF00022	0.572
LIG_AP2alpha_1	338	342	PF02296	0.356
LIG_AP2alpha_2	62	64	PF02296	0.562
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_BIR_III_4	829	833	PF00653	0.566
LIG_BRCT_BRCA1_1	279	283	PF00533	0.535
LIG_BRCT_BRCA1_1	446	450	PF00533	0.400
LIG_BRCT_BRCA1_1	60	64	PF00533	0.587
LIG_BRCT_BRCA1_1	704	708	PF00533	0.429
LIG_CaM_IQ_9	319	335	PF13499	0.520
LIG_CSL_BTD_1	775	778	PF09270	0.361
LIG_CtBP_PxDLS_1	75	79	PF00389	0.548
LIG_eIF4E_1	83	89	PF01652	0.476
LIG_EVH1_2	556	560	PF00568	0.497
LIG_FHA_1	139	145	PF00498	0.642
LIG_FHA_1	160	166	PF00498	0.551
LIG_FHA_1	184	190	PF00498	0.485
LIG_FHA_1	422	428	PF00498	0.432
LIG_FHA_1	485	491	PF00498	0.612
LIG_FHA_1	591	597	PF00498	0.783
LIG_FHA_1	649	655	PF00498	0.422
LIG_FHA_1	83	89	PF00498	0.521
LIG_FHA_2	310	316	PF00498	0.470
LIG_FHA_2	711	717	PF00498	0.465
LIG_FHA_2	837	843	PF00498	0.597
LIG_FHA_2	915	921	PF00498	0.596
LIG_Integrin_isoDGR_2	782	784	PF01839	0.509
LIG_LIR_Apic_2	280	286	PF02991	0.536
LIG_LIR_Gen_1	61	71	PF02991	0.532
LIG_LIR_Gen_1	658	665	PF02991	0.386
LIG_LIR_Gen_1	705	712	PF02991	0.375
LIG_LIR_Gen_1	754	762	PF02991	0.435
LIG_LIR_Gen_1	917	921	PF02991	0.550
LIG_LIR_LC3C_4	650	655	PF02991	0.311
LIG_LIR_Nem_3	468	474	PF02991	0.419
LIG_LIR_Nem_3	558	563	PF02991	0.666
LIG_LIR_Nem_3	61	67	PF02991	0.524
LIG_LIR_Nem_3	658	663	PF02991	0.374
LIG_LIR_Nem_3	705	711	PF02991	0.375
LIG_LIR_Nem_3	754	758	PF02991	0.448
LIG_LIR_Nem_3	86	92	PF02991	0.457
LIG_LIR_Nem_3	917	921	PF02991	0.550
LIG_NRBOX	440	446	PF00104	0.461
LIG_NRBOX	641	647	PF00104	0.365
LIG_PCNA_yPIPBox_3	877	885	PF02747	0.512
LIG_Pex14_2	338	342	PF04695	0.370
LIG_Pex14_2	758	762	PF04695	0.349
LIG_Pex14_2	772	776	PF04695	0.351
LIG_PTAP_UEV_1	272	277	PF05743	0.563
LIG_Rb_LxCxE_1	424	439	PF01857	0.478
LIG_SH2_NCK_1	68	72	PF00017	0.559
LIG_SH2_PTP2	178	181	PF00017	0.574
LIG_SH2_SRC	472	475	PF00017	0.337
LIG_SH2_STAT5	178	181	PF00017	0.679
LIG_SH2_STAT5	222	225	PF00017	0.622
LIG_SH2_STAT5	232	235	PF00017	0.526
LIG_SH2_STAT5	472	475	PF00017	0.337
LIG_SH2_STAT5	670	673	PF00017	0.392
LIG_SH2_STAT5	719	722	PF00017	0.465
LIG_SH3_2	273	278	PF14604	0.567
LIG_SH3_3	1	7	PF00018	0.642
LIG_SH3_3	177	183	PF00018	0.629
LIG_SH3_3	270	276	PF00018	0.607
LIG_SH3_3	51	57	PF00018	0.586
LIG_SH3_3	567	573	PF00018	0.594
LIG_SH3_3	588	594	PF00018	0.691
LIG_SH3_3	772	778	PF00018	0.445
LIG_SH3_3	818	824	PF00018	0.658
LIG_SUMO_SIM_anti_2	266	272	PF11976	0.577
LIG_SUMO_SIM_anti_2	424	430	PF11976	0.379
LIG_SUMO_SIM_anti_2	801	807	PF11976	0.492
LIG_SUMO_SIM_anti_2	865	871	PF11976	0.566
LIG_SUMO_SIM_anti_2	902	911	PF11976	0.607
LIG_SUMO_SIM_par_1	161	169	PF11976	0.519
LIG_SUMO_SIM_par_1	487	495	PF11976	0.522
LIG_SUMO_SIM_par_1	632	637	PF11976	0.389
LIG_SUMO_SIM_par_1	661	666	PF11976	0.433
LIG_SxIP_EBH_1	736	749	PF03271	0.481
LIG_TRAF2_1	312	315	PF00917	0.589
LIG_TRAF2_1	689	692	PF00917	0.520
LIG_TRAF2_1	712	715	PF00917	0.401
LIG_TRAF2_2	183	188	PF00917	0.557
LIG_UBA3_1	470	476	PF00899	0.401
LIG_WRC_WIRS_1	190	195	PF05994	0.550
MOD_CDK_SPK_2	587	592	PF00069	0.693
MOD_CK1_1	138	144	PF00069	0.613
MOD_CK1_1	169	175	PF00069	0.588
MOD_CK1_1	192	198	PF00069	0.594
MOD_CK1_1	301	307	PF00069	0.552
MOD_CK1_1	460	466	PF00069	0.360
MOD_CK1_1	495	501	PF00069	0.664
MOD_CK1_1	529	535	PF00069	0.629
MOD_CK1_1	558	564	PF00069	0.690
MOD_CK1_1	566	572	PF00069	0.610
MOD_CK1_1	583	589	PF00069	0.657
MOD_CK1_1	595	601	PF00069	0.626
MOD_CK1_1	648	654	PF00069	0.407
MOD_CK1_1	798	804	PF00069	0.578
MOD_CK1_1	823	829	PF00069	0.726
MOD_CK1_1	845	851	PF00069	0.627
MOD_CK1_1	914	920	PF00069	0.673
MOD_CK2_1	309	315	PF00069	0.477
MOD_CK2_1	600	606	PF00069	0.671
MOD_CK2_1	66	72	PF00069	0.572
MOD_CK2_1	685	691	PF00069	0.531
MOD_CK2_1	710	716	PF00069	0.460
MOD_CK2_1	862	868	PF00069	0.626
MOD_Cter_Amidation	395	398	PF01082	0.586
MOD_Cter_Amidation	782	785	PF01082	0.518
MOD_GlcNHglycan	168	171	PF01048	0.665
MOD_GlcNHglycan	18	21	PF01048	0.632
MOD_GlcNHglycan	251	254	PF01048	0.716
MOD_GlcNHglycan	291	294	PF01048	0.695
MOD_GlcNHglycan	300	303	PF01048	0.662
MOD_GlcNHglycan	459	462	PF01048	0.478
MOD_GlcNHglycan	500	503	PF01048	0.601
MOD_GlcNHglycan	585	588	PF01048	0.661
MOD_GlcNHglycan	686	690	PF01048	0.535
MOD_GlcNHglycan	844	847	PF01048	0.650
MOD_GlcNHglycan	913	916	PF01048	0.584
MOD_GSK3_1	154	161	PF00069	0.490
MOD_GSK3_1	166	173	PF00069	0.651
MOD_GSK3_1	188	195	PF00069	0.563
MOD_GSK3_1	239	246	PF00069	0.556
MOD_GSK3_1	259	266	PF00069	0.611
MOD_GSK3_1	277	284	PF00069	0.668
MOD_GSK3_1	289	296	PF00069	0.563
MOD_GSK3_1	384	391	PF00069	0.720
MOD_GSK3_1	451	458	PF00069	0.587
MOD_GSK3_1	475	482	PF00069	0.493
MOD_GSK3_1	494	501	PF00069	0.516
MOD_GSK3_1	524	531	PF00069	0.641
MOD_GSK3_1	551	558	PF00069	0.742
MOD_GSK3_1	583	590	PF00069	0.699
MOD_GSK3_1	595	602	PF00069	0.604
MOD_GSK3_1	702	709	PF00069	0.336
MOD_GSK3_1	743	750	PF00069	0.474
MOD_GSK3_1	810	817	PF00069	0.592
MOD_GSK3_1	820	827	PF00069	0.710
MOD_GSK3_1	902	909	PF00069	0.668
MOD_N-GLC_1	16	21	PF02516	0.602
MOD_N-GLC_1	566	571	PF02516	0.788
MOD_N-GLC_1	862	867	PF02516	0.606
MOD_NEK2_1	148	153	PF00069	0.608
MOD_NEK2_1	248	253	PF00069	0.544
MOD_NEK2_1	264	269	PF00069	0.515
MOD_NEK2_1	373	378	PF00069	0.543
MOD_NEK2_1	422	427	PF00069	0.407
MOD_NEK2_1	444	449	PF00069	0.427
MOD_NEK2_1	455	460	PF00069	0.517
MOD_NEK2_1	516	521	PF00069	0.622
MOD_NEK2_1	528	533	PF00069	0.704
MOD_NEK2_1	563	568	PF00069	0.597
MOD_NEK2_1	580	585	PF00069	0.717
MOD_NEK2_1	66	71	PF00069	0.687
MOD_NEK2_1	720	725	PF00069	0.398
MOD_NEK2_1	748	753	PF00069	0.420
MOD_NEK2_1	844	849	PF00069	0.594
MOD_NEK2_2	84	89	PF00069	0.459
MOD_PIKK_1	10	16	PF00454	0.632
MOD_PIKK_1	183	189	PF00454	0.633
MOD_PIKK_1	192	198	PF00454	0.544
MOD_PIKK_1	671	677	PF00454	0.401
MOD_PIKK_1	845	851	PF00454	0.681
MOD_PKA_1	384	390	PF00069	0.567
MOD_PKA_1	398	404	PF00069	0.686
MOD_PKA_1	784	790	PF00069	0.589
MOD_PKA_2	128	134	PF00069	0.773
MOD_PKA_2	277	283	PF00069	0.600
MOD_PKA_2	289	295	PF00069	0.582
MOD_PKA_2	355	361	PF00069	0.550
MOD_PKA_2	362	368	PF00069	0.470
MOD_PKA_2	384	390	PF00069	0.596
MOD_PKA_2	422	428	PF00069	0.459
MOD_PKA_2	529	535	PF00069	0.633
MOD_PKA_2	748	754	PF00069	0.417
MOD_PKA_2	784	790	PF00069	0.609
MOD_PKA_2	79	85	PF00069	0.537
MOD_PKA_2	795	801	PF00069	0.486
MOD_PKA_2	842	848	PF00069	0.560
MOD_PKB_1	553	561	PF00069	0.538
MOD_Plk_1	158	164	PF00069	0.561
MOD_Plk_1	566	572	PF00069	0.787
MOD_Plk_1	836	842	PF00069	0.604
MOD_Plk_2-3	355	361	PF00069	0.415
MOD_Plk_4	170	176	PF00069	0.727
MOD_Plk_4	304	310	PF00069	0.505
MOD_Plk_4	422	428	PF00069	0.417
MOD_Plk_4	566	572	PF00069	0.723
MOD_Plk_4	696	702	PF00069	0.382
MOD_Plk_4	743	749	PF00069	0.463
MOD_Plk_4	801	807	PF00069	0.510
MOD_Plk_4	815	821	PF00069	0.643
MOD_Plk_4	84	90	PF00069	0.460
MOD_Plk_4	902	908	PF00069	0.542
MOD_ProDKin_1	103	109	PF00069	0.565
MOD_ProDKin_1	154	160	PF00069	0.496
MOD_ProDKin_1	259	265	PF00069	0.660
MOD_ProDKin_1	26	32	PF00069	0.591
MOD_ProDKin_1	269	275	PF00069	0.674
MOD_ProDKin_1	3	9	PF00069	0.626
MOD_ProDKin_1	309	315	PF00069	0.542
MOD_ProDKin_1	50	56	PF00069	0.611
MOD_ProDKin_1	558	564	PF00069	0.597
MOD_ProDKin_1	569	575	PF00069	0.547
MOD_ProDKin_1	587	593	PF00069	0.801
MOD_ProDKin_1	67	73	PF00069	0.586
MOD_ProDKin_1	738	744	PF00069	0.531
MOD_ProDKin_1	804	810	PF00069	0.701
MOD_ProDKin_1	820	826	PF00069	0.661
MOD_ProDKin_1	852	858	PF00069	0.811
MOD_ProDKin_1	862	868	PF00069	0.597
MOD_SUMO_for_1	409	412	PF00179	0.669
MOD_SUMO_rev_2	131	136	PF00179	0.523
MOD_SUMO_rev_2	648	654	PF00179	0.407
TRG_DiLeu_BaEn_1	244	249	PF01217	0.500
TRG_DiLeu_BaEn_4	715	721	PF01217	0.409
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.503
TRG_DiLeu_BaLyEn_6	775	780	PF01217	0.367
TRG_ENDOCYTIC_2	178	181	PF00928	0.628
TRG_ENDOCYTIC_2	755	758	PF00928	0.444
TRG_ENDOCYTIC_2	91	94	PF00928	0.482
TRG_ENDOCYTIC_2	97	100	PF00928	0.458
TRG_ER_diArg_1	384	386	PF00400	0.496
TRG_ER_diArg_1	553	556	PF00400	0.513
TRG_ER_diArg_1	679	681	PF00400	0.527
TRG_ER_diArg_1	852	854	PF00400	0.677
TRG_NES_CRM1_1	332	346	PF08389	0.374
TRG_NES_CRM1_1	643	658	PF08389	0.303
TRG_NLS_Bipartite_1	383	403	PF00514	0.575
TRG_NLS_MonoCore_2	396	401	PF00514	0.596
TRG_NLS_MonoCore_2	723	728	PF00514	0.575
TRG_NLS_MonoExtC_3	397	402	PF00514	0.603
TRG_NLS_MonoExtC_3	723	728	PF00514	0.509
TRG_NLS_MonoExtN_4	397	403	PF00514	0.584
TRG_NLS_MonoExtN_4	721	728	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	882	887	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX7	Leptomonas seymouri	38%	98%
A4HDG8	Leishmania braziliensis	65%	100%
E9AWV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAM1	Leishmania major	85%	98%