LeishMANIAdb
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Palmitoyltransferase

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Palmitoyltransferase
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8ICU7_LEIDO
TriTrypDb:
LdBPK_130540.1 , LdCL_130010800 , LDHU3_13.0730
Length:
607

Annotations

Annotations by Jardim et al.

Protein pamitoylation, Palmitoyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005783 endoplasmic reticulum 5 1
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Phosphorylation

Amastigote: 172
Promastigote/Amastigote: 170

Expansion

Sequence features

A0A3Q8ICU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICU7

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 1
GO:0006605 protein targeting 5 1
GO:0006612 protein targeting to membrane 5 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0008104 protein localization 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018198 peptidyl-cysteine modification 6 1
GO:0018230 peptidyl-L-cysteine S-palmitoylation 7 1
GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 7 1
GO:0018345 protein palmitoylation 6 1
GO:0019538 protein metabolic process 3 1
GO:0033036 macromolecule localization 2 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043543 protein acylation 5 1
GO:0044238 primary metabolic process 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0071705 nitrogen compound transport 4 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016409 palmitoyltransferase activity 5 9
GO:0016417 S-acyltransferase activity 5 9
GO:0016740 transferase activity 2 9
GO:0016746 acyltransferase activity 3 9
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 9
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 9
GO:0019707 protein-cysteine S-acyltransferase activity 3 9
GO:0140096 catalytic activity, acting on a protein 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 217 221 PF00656 0.793
CLV_C14_Caspase3-7 267 271 PF00656 0.613
CLV_MEL_PAP_1 80 86 PF00089 0.464
CLV_NRD_NRD_1 167 169 PF00675 0.558
CLV_NRD_NRD_1 244 246 PF00675 0.468
CLV_NRD_NRD_1 250 252 PF00675 0.487
CLV_NRD_NRD_1 262 264 PF00675 0.419
CLV_NRD_NRD_1 275 277 PF00675 0.473
CLV_PCSK_KEX2_1 167 169 PF00082 0.558
CLV_PCSK_KEX2_1 244 246 PF00082 0.468
CLV_PCSK_KEX2_1 250 252 PF00082 0.487
CLV_PCSK_SKI1_1 20 24 PF00082 0.337
CLV_PCSK_SKI1_1 263 267 PF00082 0.416
CLV_Separin_Metazoa 118 122 PF03568 0.740
DEG_APCC_DBOX_1 249 257 PF00400 0.666
DEG_APCC_DBOX_1 262 270 PF00400 0.627
DEG_APCC_DBOX_1 313 321 PF00400 0.598
DEG_APCC_DBOX_1 500 508 PF00400 0.654
DEG_Kelch_Keap1_1 218 223 PF01344 0.745
DEG_SIAH_1 593 601 PF03145 0.763
DOC_CKS1_1 475 480 PF01111 0.715
DOC_CYCLIN_yCln2_LP_2 468 474 PF00134 0.582
DOC_MAPK_gen_1 244 255 PF00069 0.641
DOC_MAPK_gen_1 276 283 PF00069 0.684
DOC_MAPK_MEF2A_6 248 257 PF00069 0.684
DOC_MAPK_MEF2A_6 497 504 PF00069 0.692
DOC_MAPK_NFAT4_5 497 505 PF00069 0.693
DOC_PP2B_LxvP_1 468 471 PF13499 0.593
DOC_PP4_FxxP_1 283 286 PF00568 0.673
DOC_USP7_MATH_1 127 131 PF00917 0.775
DOC_USP7_MATH_1 5 9 PF00917 0.724
DOC_USP7_MATH_1 533 537 PF00917 0.776
DOC_USP7_MATH_1 555 559 PF00917 0.811
DOC_USP7_MATH_2 77 83 PF00917 0.684
DOC_WW_Pin1_4 167 172 PF00397 0.718
DOC_WW_Pin1_4 3 8 PF00397 0.717
DOC_WW_Pin1_4 444 449 PF00397 0.760
DOC_WW_Pin1_4 474 479 PF00397 0.678
DOC_WW_Pin1_4 549 554 PF00397 0.804
DOC_WW_Pin1_4 581 586 PF00397 0.761
LIG_14-3-3_CanoR_1 128 134 PF00244 0.748
LIG_14-3-3_CanoR_1 167 171 PF00244 0.752
LIG_14-3-3_CanoR_1 503 508 PF00244 0.695
LIG_14-3-3_CanoR_1 83 89 PF00244 0.628
LIG_Actin_WH2_2 152 169 PF00022 0.753
LIG_AP2alpha_1 492 496 PF02296 0.672
LIG_APCC_ABBA_1 187 192 PF00400 0.749
LIG_APCC_ABBAyCdc20_2 186 192 PF00400 0.749
LIG_BIR_II_1 1 5 PF00653 0.735
LIG_BRCT_BRCA1_1 380 384 PF00533 0.438
LIG_EH1_1 16 24 PF00400 0.633
LIG_eIF4E_1 17 23 PF01652 0.661
LIG_eIF4E_1 333 339 PF01652 0.461
LIG_eIF4E_1 340 346 PF01652 0.410
LIG_eIF4E_1 41 47 PF01652 0.552
LIG_FHA_1 160 166 PF00498 0.717
LIG_FHA_1 195 201 PF00498 0.786
LIG_FHA_1 405 411 PF00498 0.667
LIG_FHA_1 475 481 PF00498 0.707
LIG_FHA_1 578 584 PF00498 0.666
LIG_FHA_1 65 71 PF00498 0.376
LIG_FHA_2 113 119 PF00498 0.754
LIG_FHA_2 170 176 PF00498 0.735
LIG_FHA_2 270 276 PF00498 0.709
LIG_FHA_2 461 467 PF00498 0.657
LIG_GBD_Chelix_1 50 58 PF00786 0.352
LIG_LIR_Apic_2 280 286 PF02991 0.674
LIG_LIR_Gen_1 142 151 PF02991 0.734
LIG_LIR_Gen_1 29 39 PF02991 0.435
LIG_LIR_Gen_1 331 341 PF02991 0.598
LIG_LIR_Gen_1 357 366 PF02991 0.396
LIG_LIR_Gen_1 372 382 PF02991 0.284
LIG_LIR_Gen_1 383 392 PF02991 0.357
LIG_LIR_Nem_3 142 148 PF02991 0.735
LIG_LIR_Nem_3 29 34 PF02991 0.435
LIG_LIR_Nem_3 331 337 PF02991 0.598
LIG_LIR_Nem_3 357 363 PF02991 0.396
LIG_LIR_Nem_3 372 378 PF02991 0.284
LIG_LIR_Nem_3 381 387 PF02991 0.362
LIG_LIR_Nem_3 427 432 PF02991 0.723
LIG_LIR_Nem_3 60 64 PF02991 0.483
LIG_NRBOX 405 411 PF00104 0.718
LIG_NRBOX 54 60 PF00104 0.471
LIG_PCNA_PIPBox_1 347 356 PF02747 0.492
LIG_PCNA_yPIPBox_3 11 20 PF02747 0.656
LIG_Pex14_1 358 362 PF04695 0.328
LIG_Pex14_2 27 31 PF04695 0.349
LIG_Pex14_2 374 378 PF04695 0.492
LIG_Pex14_2 492 496 PF04695 0.700
LIG_Pex14_2 57 61 PF04695 0.376
LIG_PTAP_UEV_1 589 594 PF05743 0.683
LIG_PTB_Apo_2 327 334 PF02174 0.598
LIG_PTB_Phospho_1 327 333 PF10480 0.598
LIG_REV1ctd_RIR_1 360 369 PF16727 0.395
LIG_SH2_CRK 429 433 PF00017 0.695
LIG_SH2_GRB2like 328 331 PF00017 0.588
LIG_SH2_NCK_1 41 45 PF00017 0.585
LIG_SH2_SRC 328 331 PF00017 0.568
LIG_SH2_SRC 395 398 PF00017 0.560
LIG_SH2_SRC 429 432 PF00017 0.779
LIG_SH2_STAP1 360 364 PF00017 0.360
LIG_SH2_STAP1 380 384 PF00017 0.162
LIG_SH2_STAP1 41 45 PF00017 0.531
LIG_SH2_STAT5 190 193 PF00017 0.743
LIG_SH2_STAT5 334 337 PF00017 0.376
LIG_SH2_STAT5 340 343 PF00017 0.335
LIG_SH2_STAT5 354 357 PF00017 0.162
LIG_SH2_STAT5 360 363 PF00017 0.162
LIG_SH2_STAT5 375 378 PF00017 0.438
LIG_SH2_STAT5 395 398 PF00017 0.362
LIG_SH3_3 137 143 PF00018 0.754
LIG_SH3_3 475 481 PF00018 0.620
LIG_SH3_3 568 574 PF00018 0.756
LIG_SH3_3 587 593 PF00018 0.758
LIG_SH3_3 71 77 PF00018 0.514
LIG_SUMO_SIM_anti_2 254 259 PF11976 0.670
LIG_SUMO_SIM_anti_2 48 54 PF11976 0.330
LIG_SUMO_SIM_anti_2 566 573 PF11976 0.742
LIG_SUMO_SIM_par_1 254 259 PF11976 0.670
LIG_SUMO_SIM_par_1 573 578 PF11976 0.673
LIG_TRAF2_1 172 175 PF00917 0.780
LIG_TRAF2_1 440 443 PF00917 0.789
LIG_TRAF2_1 448 451 PF00917 0.716
LIG_TYR_ITIM 338 343 PF00017 0.438
LIG_WRC_WIRS_1 30 35 PF05994 0.423
LIG_WRC_WIRS_1 58 63 PF05994 0.507
LIG_WRC_WIRS_1 89 94 PF05994 0.471
MOD_CK1_1 169 175 PF00069 0.685
MOD_CK1_1 198 204 PF00069 0.809
MOD_CK1_1 29 35 PF00069 0.376
MOD_CK1_1 434 440 PF00069 0.720
MOD_CK1_1 548 554 PF00069 0.763
MOD_CK1_1 581 587 PF00069 0.734
MOD_CK1_1 6 12 PF00069 0.641
MOD_CK1_1 65 71 PF00069 0.498
MOD_CK1_1 82 88 PF00069 0.415
MOD_CK2_1 112 118 PF00069 0.712
MOD_CK2_1 169 175 PF00069 0.692
MOD_CK2_1 460 466 PF00069 0.549
MOD_GlcNHglycan 125 128 PF01048 0.598
MOD_GlcNHglycan 209 212 PF01048 0.700
MOD_GlcNHglycan 3 6 PF01048 0.729
MOD_GlcNHglycan 366 369 PF01048 0.486
MOD_GlcNHglycan 380 383 PF01048 0.348
MOD_GlcNHglycan 42 45 PF01048 0.521
MOD_GlcNHglycan 442 447 PF01048 0.731
MOD_GlcNHglycan 535 538 PF01048 0.702
MOD_GlcNHglycan 580 583 PF01048 0.711
MOD_GlcNHglycan 590 593 PF01048 0.714
MOD_GlcNHglycan 71 74 PF01048 0.525
MOD_GlcNHglycan 84 87 PF01048 0.522
MOD_GSK3_1 1 8 PF00069 0.696
MOD_GSK3_1 123 130 PF00069 0.711
MOD_GSK3_1 194 201 PF00069 0.773
MOD_GSK3_1 354 361 PF00069 0.454
MOD_GSK3_1 449 456 PF00069 0.717
MOD_GSK3_1 545 552 PF00069 0.762
MOD_GSK3_1 563 570 PF00069 0.621
MOD_GSK3_1 577 584 PF00069 0.708
MOD_GSK3_1 65 72 PF00069 0.465
MOD_N-GLC_1 128 133 PF02516 0.720
MOD_N-GLC_1 299 304 PF02516 0.492
MOD_N-GLC_2 289 291 PF02516 0.492
MOD_N-GLC_2 309 311 PF02516 0.162
MOD_NEK2_1 1 6 PF00069 0.661
MOD_NEK2_1 166 171 PF00069 0.787
MOD_NEK2_1 299 304 PF00069 0.391
MOD_NEK2_1 341 346 PF00069 0.389
MOD_NEK2_1 378 383 PF00069 0.381
MOD_NEK2_1 449 454 PF00069 0.657
MOD_NEK2_1 57 62 PF00069 0.381
MOD_NEK2_1 64 69 PF00069 0.356
MOD_NEK2_2 26 31 PF00069 0.279
MOD_NEK2_2 358 363 PF00069 0.390
MOD_PIKK_1 150 156 PF00454 0.723
MOD_PIKK_1 195 201 PF00454 0.591
MOD_PK_1 503 509 PF00069 0.625
MOD_PKA_2 127 133 PF00069 0.699
MOD_PKA_2 166 172 PF00069 0.777
MOD_PKA_2 82 88 PF00069 0.566
MOD_PKB_1 501 509 PF00069 0.627
MOD_Plk_1 434 440 PF00069 0.683
MOD_Plk_1 567 573 PF00069 0.597
MOD_Plk_2-3 512 518 PF00069 0.644
MOD_Plk_4 341 347 PF00069 0.401
MOD_Plk_4 358 364 PF00069 0.249
MOD_Plk_4 369 375 PF00069 0.354
MOD_Plk_4 567 573 PF00069 0.562
MOD_Plk_4 57 63 PF00069 0.484
MOD_Plk_4 65 71 PF00069 0.412
MOD_Plk_4 88 94 PF00069 0.535
MOD_ProDKin_1 167 173 PF00069 0.657
MOD_ProDKin_1 3 9 PF00069 0.654
MOD_ProDKin_1 444 450 PF00069 0.713
MOD_ProDKin_1 474 480 PF00069 0.616
MOD_ProDKin_1 549 555 PF00069 0.781
MOD_ProDKin_1 581 587 PF00069 0.723
MOD_SUMO_for_1 602 605 PF00179 0.711
TRG_DiLeu_BaEn_1 280 285 PF01217 0.489
TRG_DiLeu_BaEn_2 278 284 PF01217 0.607
TRG_ENDOCYTIC_2 333 336 PF00928 0.381
TRG_ENDOCYTIC_2 340 343 PF00928 0.329
TRG_ENDOCYTIC_2 360 363 PF00928 0.162
TRG_ENDOCYTIC_2 375 378 PF00928 0.438
TRG_ENDOCYTIC_2 429 432 PF00928 0.644
TRG_ER_diArg_1 166 168 PF00400 0.720
TRG_ER_diArg_1 243 245 PF00400 0.602
TRG_ER_diArg_1 249 251 PF00400 0.619
TRG_ER_diArg_1 500 503 PF00400 0.625
TRG_ER_diArg_1 556 559 PF00400 0.683
TRG_NES_CRM1_1 232 246 PF08389 0.681
TRG_NLS_MonoExtC_3 246 251 PF00514 0.602
TRG_NLS_MonoExtN_4 244 251 PF00514 0.597

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7C7 Leptomonas seymouri 50% 96%
A0A3S5IRN1 Trypanosoma rangeli 25% 100%
A4H754 Leishmania braziliensis 74% 100%
A4HVJ3 Leishmania infantum 100% 100%
E9AP89 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QG89 Leishmania major 92% 100%
V5AVF5 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS