LeishMANIAdb
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Vacuolar protein sorting complex subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Vacuolar protein sorting complex subunit
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8ICU6_LEIDO
TriTrypDb:
LdBPK_240950.1 , LdCL_240014500 , LDHU3_24.1120
Length:
941

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3Q8ICU6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICU6

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 596 600 PF00656 0.667
CLV_C14_Caspase3-7 879 883 PF00656 0.778
CLV_C14_Caspase3-7 885 889 PF00656 0.650
CLV_MEL_PAP_1 910 916 PF00089 0.623
CLV_NRD_NRD_1 247 249 PF00675 0.412
CLV_NRD_NRD_1 301 303 PF00675 0.762
CLV_NRD_NRD_1 433 435 PF00675 0.538
CLV_NRD_NRD_1 487 489 PF00675 0.541
CLV_NRD_NRD_1 65 67 PF00675 0.721
CLV_NRD_NRD_1 761 763 PF00675 0.706
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I5F2 Leptomonas seymouri 42% 91%
A4HDE9 Leishmania braziliensis 73% 100%
A4I0T2 Leishmania infantum 100% 100%
E9AWT4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 98%
Q4QAP0 Leishmania major 93% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS