Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICU5_LEIDO

TriTrypDb:

LdBPK_240940.1 , LdCL_240014400 , LDHU3_24.1110

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.534
CLV_C14_Caspase3-7	380	384	PF00656	0.528
CLV_NRD_NRD_1	107	109	PF00675	0.448
CLV_NRD_NRD_1	199	201	PF00675	0.521
CLV_PCSK_KEX2_1	107	109	PF00082	0.420
CLV_PCSK_KEX2_1	199	201	PF00082	0.521
CLV_PCSK_KEX2_1	229	231	PF00082	0.638
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.638
CLV_PCSK_SKI1_1	131	135	PF00082	0.504
CLV_PCSK_SKI1_1	389	393	PF00082	0.382
CLV_PCSK_SKI1_1	56	60	PF00082	0.554
DOC_CKS1_1	157	162	PF01111	0.598
DOC_MAPK_gen_1	288	296	PF00069	0.433
DOC_MAPK_MEF2A_6	158	165	PF00069	0.572
DOC_PP1_RVXF_1	384	391	PF00149	0.496
DOC_USP7_MATH_1	18	22	PF00917	0.741
DOC_USP7_MATH_1	190	194	PF00917	0.507
DOC_USP7_MATH_1	209	213	PF00917	0.308
DOC_USP7_MATH_1	25	29	PF00917	0.705
DOC_USP7_MATH_1	258	262	PF00917	0.681
DOC_USP7_MATH_1	290	294	PF00917	0.467
DOC_USP7_MATH_1	70	74	PF00917	0.694
DOC_USP7_UBL2_3	395	399	PF12436	0.401
DOC_WW_Pin1_4	156	161	PF00397	0.620
DOC_WW_Pin1_4	235	240	PF00397	0.743
DOC_WW_Pin1_4	242	247	PF00397	0.705
DOC_WW_Pin1_4	438	443	PF00397	0.552
DOC_WW_Pin1_4	81	86	PF00397	0.657
LIG_14-3-3_CanoR_1	126	130	PF00244	0.549
LIG_14-3-3_CanoR_1	136	146	PF00244	0.468
LIG_14-3-3_CanoR_1	216	221	PF00244	0.369
LIG_14-3-3_CanoR_1	291	295	PF00244	0.463
LIG_14-3-3_CanoR_1	353	358	PF00244	0.466
LIG_BIR_III_4	153	157	PF00653	0.657
LIG_Dynein_DLC8_1	458	464	PF01221	0.503
LIG_eIF4E_1	215	221	PF01652	0.542
LIG_EVH1_1	243	247	PF00568	0.620
LIG_FHA_1	170	176	PF00498	0.382
LIG_FHA_1	356	362	PF00498	0.510
LIG_FHA_2	330	336	PF00498	0.539
LIG_FHA_2	372	378	PF00498	0.491
LIG_GBD_Chelix_1	321	329	PF00786	0.527
LIG_LIR_Gen_1	111	118	PF02991	0.524
LIG_LIR_Gen_1	159	168	PF02991	0.550
LIG_LIR_Gen_1	39	48	PF02991	0.477
LIG_LIR_LC3C_4	293	296	PF02991	0.453
LIG_LIR_Nem_3	104	109	PF02991	0.409
LIG_LIR_Nem_3	111	116	PF02991	0.395
LIG_LIR_Nem_3	159	165	PF02991	0.575
LIG_LIR_Nem_3	212	218	PF02991	0.530
LIG_LIR_Nem_3	39	43	PF02991	0.486
LIG_MYND_1	14	18	PF01753	0.588
LIG_NRBOX	324	330	PF00104	0.436
LIG_PCNA_PIPBox_1	55	64	PF02747	0.515
LIG_PCNA_yPIPBox_3	53	62	PF02747	0.503
LIG_Pex14_1	299	303	PF04695	0.360
LIG_Pex14_2	367	371	PF04695	0.397
LIG_REV1ctd_RIR_1	389	399	PF16727	0.529
LIG_SH2_CRK	113	117	PF00017	0.404
LIG_SH2_CRK	215	219	PF00017	0.522
LIG_SH2_STAP1	113	117	PF00017	0.388
LIG_SH2_STAP1	191	195	PF00017	0.431
LIG_SH2_STAP1	357	361	PF00017	0.520
LIG_SH2_STAT5	303	306	PF00017	0.387
LIG_SH2_STAT5	357	360	PF00017	0.527
LIG_SH3_1	439	445	PF00018	0.582
LIG_SH3_2	442	447	PF14604	0.636
LIG_SH3_3	241	247	PF00018	0.699
LIG_SH3_3	439	445	PF00018	0.582
LIG_SH3_3	82	88	PF00018	0.640
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.528
LIG_SUMO_SIM_par_1	337	343	PF11976	0.367
LIG_WRC_WIRS_1	95	100	PF05994	0.502
MOD_CDK_SPxK_1	81	87	PF00069	0.654
MOD_CK1_1	193	199	PF00069	0.533
MOD_CK1_1	237	243	PF00069	0.734
MOD_CK1_1	256	262	PF00069	0.641
MOD_CK1_1	355	361	PF00069	0.562
MOD_CK1_1	60	66	PF00069	0.612
MOD_CK2_1	371	377	PF00069	0.474
MOD_CK2_1	438	444	PF00069	0.624
MOD_CMANNOS	433	436	PF00535	0.401
MOD_GlcNHglycan	19	23	PF01048	0.768
MOD_GlcNHglycan	207	210	PF01048	0.497
MOD_GlcNHglycan	211	214	PF01048	0.543
MOD_GlcNHglycan	225	228	PF01048	0.594
MOD_GlcNHglycan	260	263	PF01048	0.658
MOD_GlcNHglycan	347	350	PF01048	0.554
MOD_GlcNHglycan	406	409	PF01048	0.764
MOD_GlcNHglycan	419	422	PF01048	0.630
MOD_GlcNHglycan	50	53	PF01048	0.565
MOD_GlcNHglycan	62	65	PF01048	0.610
MOD_GSK3_1	205	212	PF00069	0.416
MOD_GSK3_1	25	32	PF00069	0.743
MOD_GSK3_1	317	324	PF00069	0.528
MOD_GSK3_1	345	352	PF00069	0.530
MOD_GSK3_1	367	374	PF00069	0.470
MOD_GSK3_1	427	434	PF00069	0.361
MOD_GSK3_1	446	453	PF00069	0.577
MOD_GSK3_1	459	466	PF00069	0.484
MOD_GSK3_1	62	69	PF00069	0.612
MOD_GSK3_1	72	79	PF00069	0.666
MOD_GSK3_1	90	97	PF00069	0.618
MOD_LATS_1	214	220	PF00433	0.372
MOD_N-GLC_1	120	125	PF02516	0.513
MOD_N-GLC_1	345	350	PF02516	0.484
MOD_NEK2_1	1	6	PF00069	0.763
MOD_NEK2_1	202	207	PF00069	0.489
MOD_NEK2_1	284	289	PF00069	0.471
MOD_NEK2_1	329	334	PF00069	0.404
MOD_NEK2_1	365	370	PF00069	0.481
MOD_NEK2_1	427	432	PF00069	0.453
MOD_NEK2_1	450	455	PF00069	0.728
MOD_PIKK_1	282	288	PF00454	0.549
MOD_PIKK_1	355	361	PF00454	0.536
MOD_PIKK_1	459	465	PF00454	0.509
MOD_PKA_2	125	131	PF00069	0.543
MOD_PKA_2	290	296	PF00069	0.461
MOD_PKA_2	352	358	PF00069	0.598
MOD_PKA_2	446	452	PF00069	0.650
MOD_PKA_2	459	465	PF00069	0.480
MOD_Plk_1	120	126	PF00069	0.446
MOD_Plk_1	193	199	PF00069	0.522
MOD_Plk_4	125	131	PF00069	0.451
MOD_Plk_4	174	180	PF00069	0.389
MOD_Plk_4	193	199	PF00069	0.519
MOD_Plk_4	216	222	PF00069	0.526
MOD_Plk_4	290	296	PF00069	0.383
MOD_Plk_4	299	305	PF00069	0.332
MOD_Plk_4	317	323	PF00069	0.383
MOD_Plk_4	57	63	PF00069	0.576
MOD_Plk_4	90	96	PF00069	0.617
MOD_ProDKin_1	156	162	PF00069	0.608
MOD_ProDKin_1	235	241	PF00069	0.741
MOD_ProDKin_1	242	248	PF00069	0.694
MOD_ProDKin_1	438	444	PF00069	0.565
MOD_ProDKin_1	81	87	PF00069	0.654
MOD_SUMO_for_1	5	8	PF00179	0.792
MOD_SUMO_rev_2	375	380	PF00179	0.522
MOD_SUMO_rev_2	51	61	PF00179	0.589
TRG_ENDOCYTIC_2	106	109	PF00928	0.416
TRG_ENDOCYTIC_2	113	116	PF00928	0.389
TRG_ENDOCYTIC_2	215	218	PF00928	0.522
TRG_ER_diArg_1	106	108	PF00400	0.447
TRG_ER_diArg_1	198	200	PF00400	0.525
TRG_NLS_MonoCore_2	11	16	PF00514	0.715
TRG_NLS_MonoExtC_3	11	17	PF00514	0.783
TRG_NLS_MonoExtN_4	9	16	PF00514	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYW2	Leptomonas seymouri	57%	100%
A0A0S4IXA1	Bodo saltans	35%	100%
A0A1X0NVG3	Trypanosomatidae	30%	91%
A0A3R7KEJ9	Trypanosoma rangeli	44%	100%
A4HDE8	Leishmania braziliensis	76%	100%
A4I0T1	Leishmania infantum	100%	100%
D0A760	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AWT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAP1	Leishmania major	92%	100%
V5BVT1	Trypanosoma cruzi	43%	100%