LeishMANIAdb
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Pyridoxal phosphate homeostasis protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Pyridoxal phosphate homeostasis protein
Gene product:
alanine racemase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ICU4_LEIDO
TriTrypDb:
LdBPK_231880.1 , LdCL_230026000 , LDHU3_23.2470
Length:
245

Annotations

Annotations by Jardim et al.

Amino acid metabolism, alanine racemase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8ICU4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICU4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0005488 binding 1 12
GO:0016853 isomerase activity 2 5
GO:0019842 vitamin binding 3 12
GO:0030170 pyridoxal phosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0070279 vitamin B6 binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 121 123 PF00675 0.469
CLV_NRD_NRD_1 33 35 PF00675 0.494
CLV_PCSK_KEX2_1 33 35 PF00082 0.494
CLV_PCSK_SKI1_1 33 37 PF00082 0.435
CLV_PCSK_SKI1_1 93 97 PF00082 0.415
DEG_APCC_DBOX_1 33 41 PF00400 0.520
DOC_CDC14_PxL_1 96 104 PF14671 0.484
DOC_CYCLIN_RxL_1 90 97 PF00134 0.415
DOC_MAPK_gen_1 122 132 PF00069 0.408
DOC_MAPK_gen_1 168 175 PF00069 0.332
DOC_MAPK_gen_1 33 40 PF00069 0.520
DOC_MAPK_MEF2A_6 125 134 PF00069 0.399
DOC_MAPK_MEF2A_6 168 177 PF00069 0.454
DOC_USP7_MATH_1 27 31 PF00917 0.491
DOC_WW_Pin1_4 42 47 PF00397 0.408
LIG_14-3-3_CanoR_1 223 231 PF00244 0.443
LIG_14-3-3_CanoR_1 33 38 PF00244 0.484
LIG_Actin_WH2_2 88 105 PF00022 0.469
LIG_BIR_II_1 1 5 PF00653 0.679
LIG_deltaCOP1_diTrp_1 77 83 PF00928 0.403
LIG_FHA_1 12 18 PF00498 0.515
LIG_FHA_1 151 157 PF00498 0.426
LIG_FHA_1 226 232 PF00498 0.442
LIG_FHA_2 136 142 PF00498 0.399
LIG_LIR_Gen_1 78 87 PF02991 0.399
LIG_LIR_Nem_3 131 136 PF02991 0.415
LIG_LIR_Nem_3 185 190 PF02991 0.400
LIG_LIR_Nem_3 78 84 PF02991 0.387
LIG_SH2_CRK 19 23 PF00017 0.450
LIG_SH2_GRB2like 218 221 PF00017 0.484
LIG_SH2_NCK_1 4 8 PF00017 0.710
LIG_SH2_PTP2 133 136 PF00017 0.415
LIG_SH2_SRC 218 221 PF00017 0.520
LIG_SH2_SRC 4 7 PF00017 0.778
LIG_SH2_STAT5 133 136 PF00017 0.396
LIG_SH2_STAT5 159 162 PF00017 0.456
LIG_SH2_STAT5 180 183 PF00017 0.410
LIG_SH2_STAT5 218 221 PF00017 0.484
LIG_SH2_STAT5 64 67 PF00017 0.386
LIG_SUMO_SIM_par_1 36 41 PF11976 0.361
LIG_TRAF2_1 139 142 PF00917 0.415
LIG_TYR_ITIM 17 22 PF00017 0.546
LIG_UBA3_1 166 170 PF00899 0.545
MOD_CK1_1 8 14 PF00069 0.753
MOD_CK2_1 135 141 PF00069 0.399
MOD_CK2_1 142 148 PF00069 0.399
MOD_CK2_1 179 185 PF00069 0.415
MOD_GlcNHglycan 138 141 PF01048 0.401
MOD_GlcNHglycan 144 147 PF01048 0.378
MOD_GlcNHglycan 214 217 PF01048 0.450
MOD_GlcNHglycan 29 32 PF01048 0.416
MOD_GSK3_1 136 143 PF00069 0.415
MOD_GSK3_1 208 215 PF00069 0.413
MOD_GSK3_1 38 45 PF00069 0.419
MOD_N-GLC_1 136 141 PF02516 0.399
MOD_NEK2_1 208 213 PF00069 0.397
MOD_NEK2_1 224 229 PF00069 0.413
MOD_NEK2_2 225 230 PF00069 0.461
MOD_PKA_1 33 39 PF00069 0.546
MOD_PKA_2 22 28 PF00069 0.553
MOD_PKA_2 33 39 PF00069 0.504
MOD_Plk_1 150 156 PF00069 0.520
MOD_Plk_1 208 214 PF00069 0.443
MOD_Plk_1 76 82 PF00069 0.510
MOD_Plk_4 231 237 PF00069 0.422
MOD_Plk_4 33 39 PF00069 0.484
MOD_Plk_4 76 82 PF00069 0.532
MOD_ProDKin_1 42 48 PF00069 0.408
MOD_SUMO_rev_2 139 145 PF00179 0.415
TRG_AP2beta_CARGO_1 185 194 PF09066 0.400
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.517
TRG_ENDOCYTIC_2 133 136 PF00928 0.399
TRG_ENDOCYTIC_2 19 22 PF00928 0.411
TRG_ER_diArg_1 33 35 PF00400 0.498
TRG_Pf-PMV_PEXEL_1 73 77 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 93 97 PF00026 0.434

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P624 Leptomonas seymouri 80% 99%
A0A0S4JPZ2 Bodo saltans 49% 96%
A0A1X0NWM6 Trypanosomatidae 68% 99%
A0A422NJG5 Trypanosoma rangeli 67% 100%
A4HD32 Leishmania braziliensis 91% 100%
A4I0L9 Leishmania infantum 100% 100%
C9ZNR1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 95%
E9AWI0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O24748 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 34% 100%
O25156 Helicobacter pylori (strain ATCC 700392 / 26695) 37% 100%
O31727 Bacillus subtilis (strain 168) 33% 100%
O66631 Aquifex aeolicus (strain VF5) 41% 100%
O94903 Homo sapiens 47% 89%
P24562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 39% 100%
P38197 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 95%
P44506 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 41% 100%
P52055 Vibrio alginolyticus 43% 100%
P52056 Synechocystis sp. (strain PCC 6803 / Kazusa) 36% 100%
P52057 Caenorhabditis elegans 44% 100%
P57614 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 31% 100%
P67080 Escherichia coli (strain K12) 38% 100%
P67081 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 38% 100%
P67082 Escherichia coli O157:H7 38% 100%
P67084 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 29% 95%
P9WFQ6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 29% 95%
P9WFQ7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 29% 95%
Q1ZXI6 Dictyostelium discoideum 39% 96%
Q3T0G5 Bos taurus 43% 90%
Q4QAZ0 Leishmania major 97% 100%
Q5R4Z1 Pongo abelii 48% 89%
Q89A48 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 30% 100%
Q8K929 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 33% 100%
Q9CCE2 Mycobacterium leprae (strain TN) 31% 95%
Q9CPD5 Pasteurella multocida (strain Pm70) 43% 100%
Q9KUQ4 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 43% 100%
Q9P6Q1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 100%
Q9RUL6 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 32% 100%
Q9Z2Y8 Mus musculus 44% 89%
Q9ZKF2 Helicobacter pylori (strain J99 / ATCC 700824) 38% 100%
V5B6R2 Trypanosoma cruzi 67% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS