Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ICU2_LEIDO

TriTrypDb:

LdBPK_313110.1 , LdCL_310039400 , LDHU3_31.5320

Length:

936

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	640	644	PF00656	0.416
CLV_C14_Caspase3-7	783	787	PF00656	0.442
CLV_NRD_NRD_1	157	159	PF00675	0.544
CLV_NRD_NRD_1	269	271	PF00675	0.522
CLV_NRD_NRD_1	322	324	PF00675	0.598
CLV_NRD_NRD_1	429	431	PF00675	0.651
CLV_NRD_NRD_1	456	458	PF00675	0.603
CLV_NRD_NRD_1	499	501	PF00675	0.577
CLV_NRD_NRD_1	544	546	PF00675	0.469
CLV_NRD_NRD_1	576	578	PF00675	0.505
CLV_NRD_NRD_1	658	660	PF00675	0.545
CLV_NRD_NRD_1	681	683	PF00675	0.544
CLV_NRD_NRD_1	751	753	PF00675	0.450
CLV_NRD_NRD_1	770	772	PF00675	0.627
CLV_NRD_NRD_1	80	82	PF00675	0.546
CLV_NRD_NRD_1	890	892	PF00675	0.454
CLV_NRD_NRD_1	90	92	PF00675	0.419
CLV_NRD_NRD_1	919	921	PF00675	0.483
CLV_PCSK_KEX2_1	157	159	PF00082	0.544
CLV_PCSK_KEX2_1	177	179	PF00082	0.515
CLV_PCSK_KEX2_1	269	271	PF00082	0.522
CLV_PCSK_KEX2_1	321	323	PF00082	0.583
CLV_PCSK_KEX2_1	429	431	PF00082	0.651
CLV_PCSK_KEX2_1	456	458	PF00082	0.603
CLV_PCSK_KEX2_1	546	548	PF00082	0.450
CLV_PCSK_KEX2_1	578	580	PF00082	0.560
CLV_PCSK_KEX2_1	653	655	PF00082	0.536
CLV_PCSK_KEX2_1	658	660	PF00082	0.503
CLV_PCSK_KEX2_1	681	683	PF00082	0.544
CLV_PCSK_KEX2_1	729	731	PF00082	0.548
CLV_PCSK_KEX2_1	751	753	PF00082	0.450
CLV_PCSK_KEX2_1	770	772	PF00082	0.466
CLV_PCSK_KEX2_1	80	82	PF00082	0.546
CLV_PCSK_KEX2_1	890	892	PF00082	0.454
CLV_PCSK_KEX2_1	90	92	PF00082	0.419
CLV_PCSK_KEX2_1	919	921	PF00082	0.483
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.509
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.519
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.560
CLV_PCSK_PC1ET2_1	653	655	PF00082	0.536
CLV_PCSK_PC1ET2_1	729	731	PF00082	0.513
CLV_PCSK_PC7_1	654	660	PF00082	0.539
CLV_PCSK_PC7_1	86	92	PF00082	0.436
CLV_PCSK_SKI1_1	189	193	PF00082	0.378
CLV_PCSK_SKI1_1	362	366	PF00082	0.625
CLV_PCSK_SKI1_1	554	558	PF00082	0.419
CLV_PCSK_SKI1_1	579	583	PF00082	0.487
CLV_PCSK_SKI1_1	645	649	PF00082	0.563
CLV_PCSK_SKI1_1	654	658	PF00082	0.538
CLV_PCSK_SKI1_1	735	739	PF00082	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.491
DEG_SCF_FBW7_2	565	571	PF00400	0.554
DOC_CKS1_1	399	404	PF01111	0.674
DOC_CKS1_1	479	484	PF01111	0.566
DOC_CKS1_1	565	570	PF01111	0.554
DOC_CYCLIN_RxL_1	184	195	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	275	281	PF00134	0.409
DOC_MAPK_gen_1	177	183	PF00069	0.493
DOC_MAPK_gen_1	5	15	PF00069	0.418
DOC_MAPK_gen_1	575	583	PF00069	0.563
DOC_MAPK_gen_1	890	898	PF00069	0.445
DOC_MAPK_HePTP_8	888	900	PF00069	0.534
DOC_MAPK_MEF2A_6	891	900	PF00069	0.488
DOC_PP1_RVXF_1	69	75	PF00149	0.406
DOC_PP1_SILK_1	669	674	PF00149	0.406
DOC_PP2B_LxvP_1	331	334	PF13499	0.655
DOC_USP7_MATH_1	124	128	PF00917	0.523
DOC_USP7_MATH_1	161	165	PF00917	0.733
DOC_USP7_MATH_1	226	230	PF00917	0.522
DOC_USP7_MATH_1	285	289	PF00917	0.507
DOC_USP7_MATH_1	327	331	PF00917	0.664
DOC_USP7_MATH_1	336	340	PF00917	0.576
DOC_USP7_MATH_1	409	413	PF00917	0.816
DOC_USP7_MATH_1	463	467	PF00917	0.647
DOC_USP7_MATH_1	817	821	PF00917	0.636
DOC_USP7_MATH_1	918	922	PF00917	0.542
DOC_USP7_UBL2_3	193	197	PF12436	0.419
DOC_WW_Pin1_4	344	349	PF00397	0.654
DOC_WW_Pin1_4	395	400	PF00397	0.716
DOC_WW_Pin1_4	431	436	PF00397	0.606
DOC_WW_Pin1_4	447	452	PF00397	0.631
DOC_WW_Pin1_4	478	483	PF00397	0.611
DOC_WW_Pin1_4	564	569	PF00397	0.672
LIG_14-3-3_CanoR_1	125	135	PF00244	0.459
LIG_14-3-3_CanoR_1	178	182	PF00244	0.383
LIG_14-3-3_CanoR_1	184	192	PF00244	0.406
LIG_14-3-3_CanoR_1	382	387	PF00244	0.631
LIG_14-3-3_CanoR_1	408	414	PF00244	0.789
LIG_14-3-3_CanoR_1	456	463	PF00244	0.804
LIG_14-3-3_CanoR_1	522	529	PF00244	0.481
LIG_14-3-3_CanoR_1	598	604	PF00244	0.574
LIG_14-3-3_CanoR_1	906	911	PF00244	0.480
LIG_14-3-3_CanoR_1	919	925	PF00244	0.515
LIG_Actin_WH2_2	418	434	PF00022	0.642
LIG_Actin_WH2_2	704	720	PF00022	0.482
LIG_AP2alpha_2	413	415	PF02296	0.660
LIG_AP2alpha_2	45	47	PF02296	0.418
LIG_APCC_ABBA_1	558	563	PF00400	0.529
LIG_BRCT_BRCA1_1	362	366	PF00533	0.630
LIG_BRCT_BRCA1_1	411	415	PF00533	0.663
LIG_BRCT_BRCA1_1	43	47	PF00533	0.428
LIG_Clathr_ClatBox_1	871	875	PF01394	0.449
LIG_deltaCOP1_diTrp_1	592	600	PF00928	0.452
LIG_FHA_1	23	29	PF00498	0.449
LIG_FHA_1	368	374	PF00498	0.564
LIG_FHA_1	555	561	PF00498	0.445
LIG_FHA_1	588	594	PF00498	0.536
LIG_FHA_1	632	638	PF00498	0.564
LIG_FHA_1	655	661	PF00498	0.535
LIG_FHA_1	866	872	PF00498	0.461
LIG_FHA_1	90	96	PF00498	0.428
LIG_FHA_2	164	170	PF00498	0.601
LIG_FHA_2	228	234	PF00498	0.521
LIG_FHA_2	255	261	PF00498	0.392
LIG_FHA_2	719	725	PF00498	0.499
LIG_FHA_2	781	787	PF00498	0.494
LIG_Integrin_isoDGR_2	520	522	PF01839	0.484
LIG_LIR_Apic_2	11	17	PF02991	0.353
LIG_LIR_Gen_1	105	115	PF02991	0.388
LIG_LIR_Gen_1	129	138	PF02991	0.342
LIG_LIR_Gen_1	239	248	PF02991	0.290
LIG_LIR_Gen_1	363	374	PF02991	0.567
LIG_LIR_Gen_1	412	422	PF02991	0.674
LIG_LIR_Gen_1	618	628	PF02991	0.488
LIG_LIR_Gen_1	897	908	PF02991	0.590
LIG_LIR_Gen_1	909	918	PF02991	0.488
LIG_LIR_Nem_3	105	111	PF02991	0.392
LIG_LIR_Nem_3	129	134	PF02991	0.360
LIG_LIR_Nem_3	239	245	PF02991	0.292
LIG_LIR_Nem_3	412	418	PF02991	0.683
LIG_LIR_Nem_3	51	57	PF02991	0.423
LIG_LIR_Nem_3	625	630	PF02991	0.483
LIG_LIR_Nem_3	84	88	PF02991	0.533
LIG_LIR_Nem_3	897	903	PF02991	0.591
LIG_LIR_Nem_3	909	913	PF02991	0.488
LIG_LYPXL_SIV_4	629	637	PF13949	0.481
LIG_MLH1_MIPbox_1	362	366	PF16413	0.553
LIG_MYND_1	281	285	PF01753	0.367
LIG_PCNA_PIPBox_1	649	658	PF02747	0.525
LIG_PTB_Apo_2	56	63	PF02174	0.359
LIG_PTB_Phospho_1	56	62	PF10480	0.359
LIG_REV1ctd_RIR_1	363	372	PF16727	0.545
LIG_SH2_CRK	108	112	PF00017	0.332
LIG_SH2_GRB2like	630	633	PF00017	0.477
LIG_SH2_NCK_1	131	135	PF00017	0.338
LIG_SH2_PTP2	14	17	PF00017	0.367
LIG_SH2_SRC	14	17	PF00017	0.422
LIG_SH2_SRC	223	226	PF00017	0.444
LIG_SH2_SRC	630	633	PF00017	0.477
LIG_SH2_SRC	743	746	PF00017	0.395
LIG_SH2_STAP1	131	135	PF00017	0.338
LIG_SH2_STAP1	552	556	PF00017	0.444
LIG_SH2_STAP1	62	66	PF00017	0.331
LIG_SH2_STAP1	638	642	PF00017	0.486
LIG_SH2_STAP1	679	683	PF00017	0.482
LIG_SH2_STAP1	743	747	PF00017	0.395
LIG_SH2_STAT3	638	641	PF00017	0.498
LIG_SH2_STAT5	14	17	PF00017	0.367
LIG_SH2_STAT5	620	623	PF00017	0.471
LIG_SH2_STAT5	627	630	PF00017	0.397
LIG_SH2_STAT5	638	641	PF00017	0.364
LIG_SH2_STAT5	655	658	PF00017	0.521
LIG_SH3_1	400	406	PF00018	0.600
LIG_SH3_2	403	408	PF14604	0.598
LIG_SH3_3	219	225	PF00018	0.410
LIG_SH3_3	275	281	PF00018	0.422
LIG_SH3_3	388	394	PF00018	0.617
LIG_SH3_3	396	402	PF00018	0.641
LIG_SH3_3	476	482	PF00018	0.765
LIG_SH3_3	50	56	PF00018	0.350
LIG_Sin3_3	508	515	PF02671	0.556
LIG_SUMO_SIM_anti_2	290	296	PF11976	0.343
LIG_SUMO_SIM_par_1	22	29	PF11976	0.441
LIG_SUMO_SIM_par_1	868	876	PF11976	0.446
LIG_TRAF2_1	114	117	PF00917	0.291
LIG_TRAF2_1	867	870	PF00917	0.515
LIG_TRFH_1	242	246	PF08558	0.324
LIG_UBA3_1	646	653	PF00899	0.516
MOD_CDK_SPK_2	395	400	PF00069	0.605
MOD_CDK_SPxK_1	344	350	PF00069	0.576
MOD_CDK_SPxxK_3	431	438	PF00069	0.653
MOD_CDK_SPxxK_3	478	485	PF00069	0.648
MOD_CK1_1	160	166	PF00069	0.633
MOD_CK1_1	254	260	PF00069	0.389
MOD_CK1_1	385	391	PF00069	0.660
MOD_CK1_1	395	401	PF00069	0.815
MOD_CK1_1	404	410	PF00069	0.615
MOD_CK1_1	450	456	PF00069	0.691
MOD_CK1_1	466	472	PF00069	0.640
MOD_CK1_1	490	496	PF00069	0.670
MOD_CK1_1	606	612	PF00069	0.500
MOD_CK1_1	746	752	PF00069	0.504
MOD_CK1_1	842	848	PF00069	0.571
MOD_CK1_1	923	929	PF00069	0.656
MOD_CK2_1	126	132	PF00069	0.430
MOD_CK2_1	163	169	PF00069	0.629
MOD_CK2_1	254	260	PF00069	0.389
MOD_CK2_1	501	507	PF00069	0.575
MOD_CK2_1	832	838	PF00069	0.691
MOD_GlcNHglycan	128	131	PF01048	0.454
MOD_GlcNHglycan	159	162	PF01048	0.642
MOD_GlcNHglycan	163	166	PF01048	0.608
MOD_GlcNHglycan	185	188	PF01048	0.474
MOD_GlcNHglycan	28	31	PF01048	0.512
MOD_GlcNHglycan	298	301	PF01048	0.423
MOD_GlcNHglycan	338	341	PF01048	0.583
MOD_GlcNHglycan	362	365	PF01048	0.630
MOD_GlcNHglycan	394	397	PF01048	0.765
MOD_GlcNHglycan	403	406	PF01048	0.753
MOD_GlcNHglycan	459	462	PF01048	0.675
MOD_GlcNHglycan	465	468	PF01048	0.610
MOD_GlcNHglycan	507	511	PF01048	0.599
MOD_GlcNHglycan	524	527	PF01048	0.453
MOD_GlcNHglycan	530	534	PF01048	0.529
MOD_GlcNHglycan	616	620	PF01048	0.575
MOD_GlcNHglycan	75	78	PF01048	0.429
MOD_GlcNHglycan	820	823	PF01048	0.593
MOD_GlcNHglycan	834	837	PF01048	0.576
MOD_GlcNHglycan	920	923	PF01048	0.671
MOD_GSK3_1	157	164	PF00069	0.659
MOD_GSK3_1	22	29	PF00069	0.432
MOD_GSK3_1	240	247	PF00069	0.341
MOD_GSK3_1	251	258	PF00069	0.419
MOD_GSK3_1	323	330	PF00069	0.635
MOD_GSK3_1	336	343	PF00069	0.569
MOD_GSK3_1	373	380	PF00069	0.562
MOD_GSK3_1	382	389	PF00069	0.625
MOD_GSK3_1	394	401	PF00069	0.648
MOD_GSK3_1	443	450	PF00069	0.736
MOD_GSK3_1	462	469	PF00069	0.592
MOD_GSK3_1	487	494	PF00069	0.671
MOD_GSK3_1	599	606	PF00069	0.499
MOD_GSK3_1	654	661	PF00069	0.535
MOD_GSK3_1	702	709	PF00069	0.437
MOD_GSK3_1	828	835	PF00069	0.571
MOD_GSK3_1	923	930	PF00069	0.629
MOD_N-GLC_1	340	345	PF02516	0.658
MOD_N-GLC_1	382	387	PF02516	0.658
MOD_N-GLC_1	487	492	PF02516	0.669
MOD_N-GLC_1	631	636	PF02516	0.481
MOD_NEK2_1	183	188	PF00069	0.463
MOD_NEK2_1	191	196	PF00069	0.342
MOD_NEK2_1	373	378	PF00069	0.532
MOD_NEK2_1	529	534	PF00069	0.572
MOD_NEK2_1	57	62	PF00069	0.350
MOD_NEK2_1	593	598	PF00069	0.529
MOD_NEK2_1	623	628	PF00069	0.554
MOD_NEK2_1	702	707	PF00069	0.480
MOD_NEK2_1	841	846	PF00069	0.584
MOD_NEK2_1	925	930	PF00069	0.640
MOD_NEK2_2	556	561	PF00069	0.521
MOD_NEK2_2	894	899	PF00069	0.473
MOD_OFUCOSY	291	297	PF10250	0.379
MOD_PIKK_1	124	130	PF00454	0.506
MOD_PIKK_1	386	392	PF00454	0.671
MOD_PIKK_1	927	933	PF00454	0.595
MOD_PK_1	177	183	PF00069	0.393
MOD_PK_1	658	664	PF00069	0.526
MOD_PKA_1	157	163	PF00069	0.552
MOD_PKA_1	177	183	PF00069	0.439
MOD_PKA_1	658	664	PF00069	0.526
MOD_PKA_1	90	96	PF00069	0.373
MOD_PKA_2	124	130	PF00069	0.475
MOD_PKA_2	157	163	PF00069	0.780
MOD_PKA_2	177	183	PF00069	0.302
MOD_PKA_2	226	232	PF00069	0.463
MOD_PKA_2	367	373	PF00069	0.642
MOD_PKA_2	407	413	PF00069	0.763
MOD_PKA_2	455	461	PF00069	0.719
MOD_PKA_2	658	664	PF00069	0.529
MOD_PKA_2	717	723	PF00069	0.523
MOD_PKA_2	780	786	PF00069	0.468
MOD_PKA_2	89	95	PF00069	0.385
MOD_PKA_2	918	924	PF00069	0.467
MOD_PKB_1	321	329	PF00069	0.621
MOD_Plk_1	22	28	PF00069	0.489
MOD_Plk_1	382	388	PF00069	0.659
MOD_Plk_1	418	424	PF00069	0.580
MOD_Plk_1	506	512	PF00069	0.564
MOD_Plk_1	554	560	PF00069	0.443
MOD_Plk_1	615	621	PF00069	0.510
MOD_Plk_1	702	708	PF00069	0.428
MOD_Plk_1	743	749	PF00069	0.439
MOD_Plk_1	842	848	PF00069	0.571
MOD_Plk_1	894	900	PF00069	0.474
MOD_Plk_4	103	109	PF00069	0.344
MOD_Plk_4	290	296	PF00069	0.331
MOD_Plk_4	437	443	PF00069	0.789
MOD_Plk_4	57	63	PF00069	0.368
MOD_Plk_4	623	629	PF00069	0.453
MOD_Plk_4	743	749	PF00069	0.495
MOD_Plk_4	90	96	PF00069	0.373
MOD_Plk_4	906	912	PF00069	0.500
MOD_Plk_4	920	926	PF00069	0.569
MOD_ProDKin_1	344	350	PF00069	0.656
MOD_ProDKin_1	395	401	PF00069	0.718
MOD_ProDKin_1	431	437	PF00069	0.609
MOD_ProDKin_1	447	453	PF00069	0.632
MOD_ProDKin_1	478	484	PF00069	0.613
MOD_ProDKin_1	564	570	PF00069	0.675
MOD_SUMO_rev_2	539	544	PF00179	0.472
MOD_SUMO_rev_2	640	647	PF00179	0.424
MOD_SUMO_rev_2	722	731	PF00179	0.613
TRG_DiLeu_BaEn_1	507	512	PF01217	0.560
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.408
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.641
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.633
TRG_ENDOCYTIC_2	108	111	PF00928	0.332
TRG_ENDOCYTIC_2	131	134	PF00928	0.302
TRG_ENDOCYTIC_2	620	623	PF00928	0.490
TRG_ER_diArg_1	321	323	PF00400	0.591
TRG_ER_diArg_1	428	430	PF00400	0.651
TRG_ER_diArg_1	544	547	PF00400	0.527
TRG_ER_diArg_1	610	613	PF00400	0.477
TRG_ER_diArg_1	658	660	PF00400	0.545
TRG_ER_diArg_1	672	675	PF00400	0.365
TRG_ER_diArg_1	681	683	PF00400	0.506
TRG_ER_diArg_1	750	752	PF00400	0.450
TRG_ER_diArg_1	889	891	PF00400	0.461
TRG_ER_diArg_1	89	91	PF00400	0.473
TRG_NES_CRM1_1	855	870	PF08389	0.526
TRG_NLS_MonoExtC_3	544	549	PF00514	0.523
TRG_NLS_MonoExtN_4	543	549	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	536	541	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	723	727	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	738	742	PF00026	0.414
TRG_PTS1	933	936	PF00515	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I347	Leptomonas seymouri	42%	100%
A4I7A5	Leishmania infantum	99%	100%
Q4Q5V8	Leishmania major	86%	99%