Rab-GTPase-TBC domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICU1_LEIDO

TriTrypDb:

LdBPK_271910.1 , LdCL_270026300 , LDHU3_27.2890

Length:

1025

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICU1

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.839
CLV_C14_Caspase3-7	797	801	PF00656	0.448
CLV_C14_Caspase3-7	935	939	PF00656	0.734
CLV_NRD_NRD_1	1018	1020	PF00675	0.605
CLV_NRD_NRD_1	123	125	PF00675	0.665
CLV_NRD_NRD_1	136	138	PF00675	0.663
CLV_NRD_NRD_1	24	26	PF00675	0.765
CLV_NRD_NRD_1	273	275	PF00675	0.769
CLV_NRD_NRD_1	40	42	PF00675	0.674
CLV_NRD_NRD_1	429	431	PF00675	0.532
CLV_NRD_NRD_1	432	434	PF00675	0.521
CLV_NRD_NRD_1	612	614	PF00675	0.715
CLV_NRD_NRD_1	774	776	PF00675	0.372
CLV_PCSK_FUR_1	22	26	PF00082	0.727
CLV_PCSK_FUR_1	430	434	PF00082	0.522
CLV_PCSK_KEX2_1	123	125	PF00082	0.665
CLV_PCSK_KEX2_1	136	138	PF00082	0.663
CLV_PCSK_KEX2_1	24	26	PF00082	0.765
CLV_PCSK_KEX2_1	273	275	PF00082	0.769
CLV_PCSK_KEX2_1	40	42	PF00082	0.674
CLV_PCSK_KEX2_1	431	433	PF00082	0.518
CLV_PCSK_KEX2_1	612	614	PF00082	0.637
CLV_PCSK_KEX2_1	774	776	PF00082	0.372
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.518
CLV_PCSK_PC7_1	119	125	PF00082	0.598
CLV_PCSK_SKI1_1	40	44	PF00082	0.665
CLV_PCSK_SKI1_1	401	405	PF00082	0.526
CLV_PCSK_SKI1_1	521	525	PF00082	0.513
CLV_PCSK_SKI1_1	550	554	PF00082	0.411
CLV_Separin_Metazoa	54	58	PF03568	0.796
DEG_APCC_DBOX_1	520	528	PF00400	0.513
DEG_Nend_UBRbox_2	1	3	PF02207	0.686
DEG_SCF_TRCP1_1	373	379	PF00400	0.636
DEG_SPOP_SBC_1	196	200	PF00917	0.625
DEG_SPOP_SBC_1	507	511	PF00917	0.666
DEG_SPOP_SBC_1	846	850	PF00917	0.779
DOC_ANK_TNKS_1	15	22	PF00023	0.704
DOC_ANK_TNKS_1	23	30	PF00023	0.722
DOC_CDC14_PxL_1	150	158	PF14671	0.643
DOC_CKS1_1	181	186	PF01111	0.727
DOC_CKS1_1	258	263	PF01111	0.810
DOC_CKS1_1	687	692	PF01111	0.731
DOC_CKS1_1	696	701	PF01111	0.473
DOC_CYCLIN_RxL_1	37	47	PF00134	0.665
DOC_CYCLIN_RxL_1	547	556	PF00134	0.411
DOC_CYCLIN_RxL_1	750	760	PF00134	0.411
DOC_CYCLIN_yClb5_NLxxxL_5	881	887	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	687	693	PF00134	0.738
DOC_CYCLIN_yCln2_LP_2	814	820	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	960	966	PF00134	0.595
DOC_MAPK_DCC_7	812	820	PF00069	0.513
DOC_MAPK_gen_1	295	303	PF00069	0.601
DOC_MAPK_gen_1	654	664	PF00069	0.676
DOC_MAPK_MEF2A_6	246	255	PF00069	0.695
DOC_MAPK_MEF2A_6	345	352	PF00069	0.726
DOC_MAPK_MEF2A_6	657	664	PF00069	0.628
DOC_MAPK_MEF2A_6	812	820	PF00069	0.411
DOC_MAPK_NFAT4_5	657	665	PF00069	0.629
DOC_PP1_RVXF_1	143	149	PF00149	0.532
DOC_PP1_RVXF_1	391	398	PF00149	0.556
DOC_PP1_RVXF_1	404	411	PF00149	0.384
DOC_PP1_SILK_1	767	772	PF00149	0.411
DOC_PP2B_LxvP_1	529	532	PF13499	0.411
DOC_PP2B_LxvP_1	814	817	PF13499	0.513
DOC_PP2B_LxvP_1	897	900	PF13499	0.593
DOC_PP4_FxxP_1	182	185	PF00568	0.745
DOC_USP7_MATH_1	196	200	PF00917	0.671
DOC_USP7_MATH_1	240	244	PF00917	0.804
DOC_USP7_MATH_1	286	290	PF00917	0.758
DOC_USP7_MATH_1	31	35	PF00917	0.688
DOC_USP7_MATH_1	311	315	PF00917	0.704
DOC_USP7_MATH_1	333	337	PF00917	0.768
DOC_USP7_MATH_1	353	357	PF00917	0.683
DOC_USP7_MATH_1	371	375	PF00917	0.406
DOC_USP7_MATH_1	512	516	PF00917	0.588
DOC_USP7_MATH_1	541	545	PF00917	0.411
DOC_USP7_MATH_1	588	592	PF00917	0.637
DOC_USP7_MATH_1	80	84	PF00917	0.698
DOC_USP7_MATH_1	841	845	PF00917	0.816
DOC_USP7_MATH_1	858	862	PF00917	0.629
DOC_USP7_MATH_1	901	905	PF00917	0.687
DOC_USP7_MATH_1	932	936	PF00917	0.696
DOC_USP7_MATH_1	940	944	PF00917	0.725
DOC_WW_Pin1_4	180	185	PF00397	0.708
DOC_WW_Pin1_4	191	196	PF00397	0.693
DOC_WW_Pin1_4	257	262	PF00397	0.762
DOC_WW_Pin1_4	267	272	PF00397	0.686
DOC_WW_Pin1_4	451	456	PF00397	0.668
DOC_WW_Pin1_4	514	519	PF00397	0.400
DOC_WW_Pin1_4	533	538	PF00397	0.411
DOC_WW_Pin1_4	680	685	PF00397	0.711
DOC_WW_Pin1_4	686	691	PF00397	0.715
DOC_WW_Pin1_4	695	700	PF00397	0.513
DOC_WW_Pin1_4	707	712	PF00397	0.664
DOC_WW_Pin1_4	721	726	PF00397	0.568
LIG_14-3-3_CanoR_1	145	149	PF00244	0.706
LIG_14-3-3_CanoR_1	235	245	PF00244	0.760
LIG_14-3-3_CanoR_1	273	277	PF00244	0.689
LIG_14-3-3_CanoR_1	297	302	PF00244	0.735
LIG_14-3-3_CanoR_1	331	341	PF00244	0.732
LIG_14-3-3_CanoR_1	411	418	PF00244	0.476
LIG_14-3-3_CanoR_1	440	449	PF00244	0.668
LIG_14-3-3_CanoR_1	612	617	PF00244	0.550
LIG_14-3-3_CanoR_1	661	671	PF00244	0.682
LIG_14-3-3_CanoR_1	673	677	PF00244	0.672
LIG_14-3-3_CanoR_1	702	711	PF00244	0.637
LIG_14-3-3_CanoR_1	73	79	PF00244	0.688
LIG_14-3-3_CanoR_1	753	758	PF00244	0.353
LIG_14-3-3_CanoR_1	996	1001	PF00244	0.636
LIG_Actin_WH2_2	142	159	PF00022	0.745
LIG_BRCT_BRCA1_1	178	182	PF00533	0.759
LIG_BRCT_BRCA1_1	187	191	PF00533	0.654
LIG_BRCT_BRCA1_1	535	539	PF00533	0.411
LIG_DLG_GKlike_1	297	304	PF00625	0.737
LIG_FHA_1	296	302	PF00498	0.774
LIG_FHA_1	337	343	PF00498	0.697
LIG_FHA_1	377	383	PF00498	0.578
LIG_FHA_1	508	514	PF00498	0.748
LIG_FHA_1	654	660	PF00498	0.648
LIG_FHA_1	74	80	PF00498	0.598
LIG_FHA_1	847	853	PF00498	0.607
LIG_FHA_1	892	898	PF00498	0.691
LIG_FHA_2	258	264	PF00498	0.814
LIG_FHA_2	320	326	PF00498	0.814
LIG_FHA_2	739	745	PF00498	0.389
LIG_FHA_2	795	801	PF00498	0.448
LIG_FHA_2	922	928	PF00498	0.733
LIG_LIR_Apic_2	179	185	PF02991	0.751
LIG_LIR_Gen_1	800	811	PF02991	0.387
LIG_LIR_Gen_1	824	831	PF02991	0.381
LIG_LIR_Nem_3	800	806	PF02991	0.387
LIG_LIR_Nem_3	824	829	PF02991	0.381
LIG_LIR_Nem_3	965	971	PF02991	0.530
LIG_LYPXL_SIV_4	31	39	PF13949	0.674
LIG_NRBOX	145	151	PF00104	0.639
LIG_NRBOX	38	44	PF00104	0.766
LIG_NRBOX	805	811	PF00104	0.411
LIG_OCRL_FandH_1	802	814	PF00620	0.411
LIG_Pex14_2	575	579	PF04695	0.513
LIG_Pex14_2	964	968	PF04695	0.495
LIG_SH2_NCK_1	416	420	PF00017	0.511
LIG_SH2_SRC	416	419	PF00017	0.499
LIG_SH2_STAP1	438	442	PF00017	0.523
LIG_SH2_STAP1	519	523	PF00017	0.513
LIG_SH2_STAT3	438	441	PF00017	0.521
LIG_SH2_STAT3	739	742	PF00017	0.476
LIG_SH2_STAT5	1015	1018	PF00017	0.459
LIG_SH2_STAT5	169	172	PF00017	0.713
LIG_SH2_STAT5	244	247	PF00017	0.721
LIG_SH2_STAT5	438	441	PF00017	0.521
LIG_SH2_STAT5	442	445	PF00017	0.547
LIG_SH2_STAT5	564	567	PF00017	0.411
LIG_SH2_STAT5	69	72	PF00017	0.598
LIG_SH2_STAT5	712	715	PF00017	0.581
LIG_SH2_STAT5	739	742	PF00017	0.476
LIG_SH2_STAT5	826	829	PF00017	0.411
LIG_SH3_3	155	161	PF00018	0.643
LIG_SH3_3	171	177	PF00018	0.719
LIG_SH3_3	178	184	PF00018	0.815
LIG_SH3_3	190	196	PF00018	0.596
LIG_SH3_3	761	767	PF00018	0.513
LIG_SUMO_SIM_anti_2	714	724	PF11976	0.671
LIG_SUMO_SIM_par_1	346	351	PF11976	0.629
LIG_SUMO_SIM_par_1	447	454	PF11976	0.623
LIG_TRAF2_1	140	143	PF00917	0.744
LIG_TRAF2_1	260	263	PF00917	0.712
LIG_TRAF2_1	82	85	PF00917	0.814
LIG_TRAF2_1	864	867	PF00917	0.576
LIG_TRAF2_1	924	927	PF00917	0.741
LIG_TRAF2_1	974	977	PF00917	0.616
LIG_WW_3	270	274	PF00397	0.724
MOD_CDK_SPxK_1	267	273	PF00069	0.840
MOD_CDK_SPxxK_3	267	274	PF00069	0.748
MOD_CDK_SPxxK_3	514	521	PF00069	0.411
MOD_CDK_SPxxK_3	695	702	PF00069	0.688
MOD_CK1_1	115	121	PF00069	0.751
MOD_CK1_1	144	150	PF00069	0.623
MOD_CK1_1	213	219	PF00069	0.776
MOD_CK1_1	318	324	PF00069	0.765
MOD_CK1_1	336	342	PF00069	0.528
MOD_CK1_1	444	450	PF00069	0.592
MOD_CK1_1	454	460	PF00069	0.671
MOD_CK1_1	508	514	PF00069	0.621
MOD_CK1_1	665	671	PF00069	0.766
MOD_CK1_1	675	681	PF00069	0.762
MOD_CK1_1	682	688	PF00069	0.586
MOD_CK1_1	738	744	PF00069	0.552
MOD_CK1_1	861	867	PF00069	0.644
MOD_CK1_1	891	897	PF00069	0.666
MOD_CK1_1	921	927	PF00069	0.712
MOD_CK1_1	943	949	PF00069	0.783
MOD_CK2_1	257	263	PF00069	0.705
MOD_CK2_1	311	317	PF00069	0.765
MOD_CK2_1	319	325	PF00069	0.732
MOD_CK2_1	382	388	PF00069	0.631
MOD_CK2_1	447	453	PF00069	0.721
MOD_CK2_1	514	520	PF00069	0.411
MOD_CK2_1	738	744	PF00069	0.451
MOD_CK2_1	861	867	PF00069	0.644
MOD_CK2_1	921	927	PF00069	0.695
MOD_CK2_1	944	950	PF00069	0.683
MOD_GlcNHglycan	199	202	PF01048	0.800
MOD_GlcNHglycan	212	215	PF01048	0.634
MOD_GlcNHglycan	288	291	PF01048	0.715
MOD_GlcNHglycan	33	36	PF01048	0.686
MOD_GlcNHglycan	355	358	PF01048	0.721
MOD_GlcNHglycan	373	376	PF01048	0.459
MOD_GlcNHglycan	443	446	PF01048	0.549
MOD_GlcNHglycan	503	506	PF01048	0.705
MOD_GlcNHglycan	510	513	PF01048	0.628
MOD_GlcNHglycan	590	593	PF01048	0.587
MOD_GlcNHglycan	624	627	PF01048	0.781
MOD_GlcNHglycan	640	643	PF01048	0.746
MOD_GlcNHglycan	667	670	PF01048	0.697
MOD_GlcNHglycan	843	846	PF01048	0.759
MOD_GlcNHglycan	861	864	PF01048	0.623
MOD_GlcNHglycan	903	906	PF01048	0.629
MOD_GlcNHglycan	929	932	PF01048	0.733
MOD_GlcNHglycan	934	937	PF01048	0.722
MOD_GlcNHglycan	942	945	PF01048	0.744
MOD_GlcNHglycan	972	975	PF01048	0.707
MOD_GSK3_1	113	120	PF00069	0.795
MOD_GSK3_1	172	179	PF00069	0.788
MOD_GSK3_1	187	194	PF00069	0.627
MOD_GSK3_1	206	213	PF00069	0.544
MOD_GSK3_1	236	243	PF00069	0.738
MOD_GSK3_1	27	34	PF00069	0.705
MOD_GSK3_1	278	285	PF00069	0.820
MOD_GSK3_1	302	309	PF00069	0.743
MOD_GSK3_1	311	318	PF00069	0.667
MOD_GSK3_1	332	339	PF00069	0.817
MOD_GSK3_1	447	454	PF00069	0.644
MOD_GSK3_1	501	508	PF00069	0.788
MOD_GSK3_1	598	605	PF00069	0.605
MOD_GSK3_1	663	670	PF00069	0.756
MOD_GSK3_1	671	678	PF00069	0.676
MOD_GSK3_1	682	689	PF00069	0.524
MOD_GSK3_1	691	698	PF00069	0.585
MOD_GSK3_1	707	714	PF00069	0.413
MOD_GSK3_1	837	844	PF00069	0.682
MOD_GSK3_1	848	855	PF00069	0.692
MOD_GSK3_1	888	895	PF00069	0.612
MOD_GSK3_1	940	947	PF00069	0.721
MOD_N-GLC_1	185	190	PF02516	0.675
MOD_N-GLC_1	307	312	PF02516	0.723
MOD_N-GLC_1	889	894	PF02516	0.633
MOD_NEK2_1	303	308	PF00069	0.734
MOD_NEK2_1	319	324	PF00069	0.604
MOD_NEK2_1	376	381	PF00069	0.604
MOD_NEK2_1	464	469	PF00069	0.588
MOD_NEK2_1	501	506	PF00069	0.719
MOD_NEK2_1	553	558	PF00069	0.411
MOD_NEK2_1	662	667	PF00069	0.661
MOD_NEK2_1	852	857	PF00069	0.554
MOD_NEK2_1	888	893	PF00069	0.545
MOD_PIKK_1	100	106	PF00454	0.839
MOD_PIKK_1	117	123	PF00454	0.496
MOD_PIKK_1	206	212	PF00454	0.744
MOD_PIKK_1	553	559	PF00454	0.411
MOD_PIKK_1	738	744	PF00454	0.451
MOD_PIKK_1	889	895	PF00454	0.671
MOD_PK_1	612	618	PF00069	0.522
MOD_PKA_1	612	618	PF00069	0.638
MOD_PKA_2	125	131	PF00069	0.626
MOD_PKA_2	144	150	PF00069	0.728
MOD_PKA_2	225	231	PF00069	0.669
MOD_PKA_2	272	278	PF00069	0.763
MOD_PKA_2	296	302	PF00069	0.638
MOD_PKA_2	336	342	PF00069	0.749
MOD_PKA_2	588	594	PF00069	0.651
MOD_PKA_2	598	604	PF00069	0.590
MOD_PKA_2	611	617	PF00069	0.640
MOD_PKA_2	672	678	PF00069	0.811
MOD_PKA_2	701	707	PF00069	0.720
MOD_PKA_2	72	78	PF00069	0.729
MOD_PKA_2	921	927	PF00069	0.688
MOD_PKB_1	994	1002	PF00069	0.548
MOD_Plk_2-3	624	630	PF00069	0.794
MOD_Plk_4	125	131	PF00069	0.671
MOD_Plk_4	144	150	PF00069	0.495
MOD_Plk_4	240	246	PF00069	0.724
MOD_Plk_4	315	321	PF00069	0.708
MOD_Plk_4	444	450	PF00069	0.592
MOD_Plk_4	457	463	PF00069	0.683
MOD_Plk_4	735	741	PF00069	0.537
MOD_Plk_4	744	750	PF00069	0.361
MOD_Plk_4	753	759	PF00069	0.272
MOD_Plk_4	783	789	PF00069	0.445
MOD_Plk_4	794	800	PF00069	0.374
MOD_Plk_4	911	917	PF00069	0.742
MOD_ProDKin_1	180	186	PF00069	0.710
MOD_ProDKin_1	191	197	PF00069	0.694
MOD_ProDKin_1	257	263	PF00069	0.765
MOD_ProDKin_1	267	273	PF00069	0.689
MOD_ProDKin_1	451	457	PF00069	0.670
MOD_ProDKin_1	514	520	PF00069	0.400
MOD_ProDKin_1	533	539	PF00069	0.411
MOD_ProDKin_1	680	686	PF00069	0.709
MOD_ProDKin_1	695	701	PF00069	0.674
MOD_ProDKin_1	707	713	PF00069	0.653
MOD_ProDKin_1	721	727	PF00069	0.563
MOD_SUMO_for_1	974	977	PF00179	0.532
MOD_SUMO_rev_2	106	116	PF00179	0.828
MOD_SUMO_rev_2	631	640	PF00179	0.725
TRG_DiLeu_BaEn_4	262	268	PF01217	0.836
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.646
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.766
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.452
TRG_DiLeu_BaLyEn_6	658	663	PF01217	0.648
TRG_DiLeu_BaLyEn_6	814	819	PF01217	0.513
TRG_ENDOCYTIC_2	576	579	PF00928	0.411
TRG_ENDOCYTIC_2	826	829	PF00928	0.411
TRG_ER_diArg_1	136	138	PF00400	0.641
TRG_ER_diArg_1	22	25	PF00400	0.759
TRG_ER_diArg_1	272	274	PF00400	0.849
TRG_ER_diArg_1	39	41	PF00400	0.676
TRG_ER_diArg_1	430	433	PF00400	0.525
TRG_ER_diArg_1	773	775	PF00400	0.375
TRG_NLS_MonoCore_2	429	434	PF00514	0.526
TRG_NLS_MonoExtC_3	430	436	PF00514	0.512
TRG_NLS_MonoExtN_4	430	435	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE32	Leptomonas seymouri	43%	96%
A4HFX6	Leishmania braziliensis	70%	100%
A4I306	Leishmania infantum	99%	100%
E9ADH9	Leishmania major	89%	100%
E9AZA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%