LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

DnaJ domain containing protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DnaJ domain containing protein, putative
Gene product:
DnaJ domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ICU0_LEIDO
TriTrypDb:
LdBPK_261390.1 * , LdCL_260019500 , LDHU3_26.1700
Length:
536

Annotations

LeishMANIAdb annotations

These kinetoplastid-specific proteins contain a conserved DnaJ domain at their C-termini and a completely unique structure before and after that.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3Q8ICU0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICU0

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
GO:0061077 chaperone-mediated protein folding 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0044183 protein folding chaperone 1 1
GO:0051082 unfolded protein binding 3 1
GO:0051087 protein-folding chaperone binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 460 464 PF00656 0.558
CLV_NRD_NRD_1 329 331 PF00675 0.424
CLV_NRD_NRD_1 375 377 PF00675 0.482
CLV_NRD_NRD_1 474 476 PF00675 0.423
CLV_PCSK_FUR_1 247 251 PF00082 0.471
CLV_PCSK_KEX2_1 249 251 PF00082 0.425
CLV_PCSK_KEX2_1 329 331 PF00082 0.424
CLV_PCSK_KEX2_1 342 344 PF00082 0.407
CLV_PCSK_KEX2_1 375 377 PF00082 0.482
CLV_PCSK_KEX2_1 466 468 PF00082 0.282
CLV_PCSK_KEX2_1 474 476 PF00082 0.414
CLV_PCSK_KEX2_1 484 486 PF00082 0.413
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.453
CLV_PCSK_PC1ET2_1 342 344 PF00082 0.485
CLV_PCSK_PC1ET2_1 466 468 PF00082 0.313
CLV_PCSK_PC1ET2_1 484 486 PF00082 0.444
CLV_PCSK_SKI1_1 255 259 PF00082 0.341
CLV_PCSK_SKI1_1 324 328 PF00082 0.423
CLV_PCSK_SKI1_1 428 432 PF00082 0.336
CLV_PCSK_SKI1_1 5 9 PF00082 0.365
CLV_PCSK_SKI1_1 70 74 PF00082 0.602
DEG_APCC_DBOX_1 27 35 PF00400 0.342
DEG_APCC_DBOX_1 301 309 PF00400 0.362
DEG_Nend_Nbox_1 1 3 PF02207 0.702
DOC_CYCLIN_RxL_1 422 435 PF00134 0.586
DOC_PP1_RVXF_1 115 122 PF00149 0.491
DOC_PP1_RVXF_1 3 10 PF00149 0.637
DOC_PP1_RVXF_1 68 74 PF00149 0.373
DOC_PP4_FxxP_1 9 12 PF00568 0.441
DOC_USP7_MATH_1 186 190 PF00917 0.459
DOC_USP7_MATH_1 265 269 PF00917 0.491
DOC_USP7_MATH_1 364 368 PF00917 0.701
DOC_USP7_MATH_1 369 373 PF00917 0.732
DOC_USP7_UBL2_3 413 417 PF12436 0.363
DOC_WD40_RPTOR_TOS_1 32 38 PF00400 0.381
DOC_WW_Pin1_4 162 167 PF00397 0.544
DOC_WW_Pin1_4 306 311 PF00397 0.355
DOC_WW_Pin1_4 52 57 PF00397 0.318
LIG_14-3-3_CanoR_1 149 155 PF00244 0.568
LIG_14-3-3_CanoR_1 167 175 PF00244 0.362
LIG_14-3-3_CanoR_1 247 257 PF00244 0.576
LIG_14-3-3_CanoR_1 28 32 PF00244 0.458
LIG_14-3-3_CanoR_1 302 306 PF00244 0.356
LIG_14-3-3_CanoR_1 330 336 PF00244 0.640
LIG_14-3-3_CanoR_1 448 458 PF00244 0.557
LIG_14-3-3_CanoR_1 474 483 PF00244 0.726
LIG_14-3-3_CanoR_1 523 528 PF00244 0.466
LIG_14-3-3_CanoR_1 65 73 PF00244 0.394
LIG_Actin_WH2_2 118 134 PF00022 0.446
LIG_Actin_WH2_2 14 30 PF00022 0.305
LIG_APCC_ABBA_1 83 88 PF00400 0.433
LIG_BRCT_BRCA1_1 28 32 PF00533 0.360
LIG_Clathr_ClatBox_1 174 178 PF01394 0.401
LIG_Clathr_ClatBox_1 31 35 PF01394 0.438
LIG_DLG_GKlike_1 485 493 PF00625 0.546
LIG_eIF4E_1 26 32 PF01652 0.435
LIG_eIF4E_1 425 431 PF01652 0.586
LIG_FHA_1 114 120 PF00498 0.419
LIG_FHA_1 145 151 PF00498 0.490
LIG_FHA_1 217 223 PF00498 0.313
LIG_FHA_1 22 28 PF00498 0.463
LIG_FHA_1 228 234 PF00498 0.284
LIG_FHA_1 269 275 PF00498 0.278
LIG_FHA_1 302 308 PF00498 0.340
LIG_FHA_1 489 495 PF00498 0.613
LIG_FHA_1 497 503 PF00498 0.328
LIG_FHA_2 332 338 PF00498 0.587
LIG_FHA_2 458 464 PF00498 0.553
LIG_LIR_Gen_1 404 414 PF02991 0.500
LIG_LIR_Gen_1 456 462 PF02991 0.562
LIG_LIR_Gen_1 519 527 PF02991 0.423
LIG_LIR_Gen_1 61 71 PF02991 0.436
LIG_LIR_Nem_3 107 113 PF02991 0.405
LIG_LIR_Nem_3 251 257 PF02991 0.552
LIG_LIR_Nem_3 404 410 PF02991 0.480
LIG_LIR_Nem_3 456 461 PF02991 0.562
LIG_LIR_Nem_3 512 517 PF02991 0.546
LIG_LIR_Nem_3 61 66 PF02991 0.438
LIG_LIR_Nem_3 69 75 PF02991 0.380
LIG_LYPXL_S_1 101 105 PF13949 0.587
LIG_LYPXL_yS_3 102 105 PF13949 0.391
LIG_NRBOX 17 23 PF00104 0.378
LIG_NRBOX 279 285 PF00104 0.351
LIG_Pex14_1 239 243 PF04695 0.527
LIG_Pex14_1 46 50 PF04695 0.471
LIG_Pex14_2 221 225 PF04695 0.367
LIG_Pex14_2 50 54 PF04695 0.467
LIG_REV1ctd_RIR_1 47 55 PF16727 0.451
LIG_REV1ctd_RIR_1 70 78 PF16727 0.309
LIG_SH2_CRK 182 186 PF00017 0.470
LIG_SH2_CRK 458 462 PF00017 0.562
LIG_SH2_CRK 63 67 PF00017 0.413
LIG_SH2_PTP2 100 103 PF00017 0.409
LIG_SH2_SRC 100 103 PF00017 0.365
LIG_SH2_STAP1 218 222 PF00017 0.391
LIG_SH2_STAP1 275 279 PF00017 0.452
LIG_SH2_STAP1 458 462 PF00017 0.562
LIG_SH2_STAP1 63 67 PF00017 0.423
LIG_SH2_STAT3 242 245 PF00017 0.598
LIG_SH2_STAT5 100 103 PF00017 0.346
LIG_SH2_STAT5 208 211 PF00017 0.356
LIG_SH2_STAT5 218 221 PF00017 0.378
LIG_SH2_STAT5 242 245 PF00017 0.625
LIG_SH2_STAT5 26 29 PF00017 0.340
LIG_SH2_STAT5 260 263 PF00017 0.418
LIG_SH2_STAT5 517 520 PF00017 0.434
LIG_SH3_1 182 188 PF00018 0.473
LIG_SH3_2 185 190 PF14604 0.478
LIG_SH3_3 182 188 PF00018 0.473
LIG_SUMO_SIM_anti_2 228 235 PF11976 0.266
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.284
LIG_SUMO_SIM_anti_2 498 504 PF11976 0.422
LIG_SUMO_SIM_par_1 172 178 PF11976 0.410
LIG_SUMO_SIM_par_1 228 235 PF11976 0.266
LIG_SUMO_SIM_par_1 303 309 PF11976 0.411
LIG_SUMO_SIM_par_1 493 499 PF11976 0.301
LIG_SUMO_SIM_par_1 530 536 PF11976 0.541
LIG_TRAF2_1 200 203 PF00917 0.389
LIG_TYR_ITSM 402 409 PF00017 0.402
LIG_WRC_WIRS_1 59 64 PF05994 0.572
LIG_WW_3 184 188 PF00397 0.586
MOD_CDK_SPK_2 162 167 PF00069 0.623
MOD_CK1_1 139 145 PF00069 0.732
MOD_CK1_1 148 154 PF00069 0.731
MOD_CK1_1 160 166 PF00069 0.663
MOD_CK1_1 268 274 PF00069 0.440
MOD_CK1_1 488 494 PF00069 0.555
MOD_CK1_1 52 58 PF00069 0.577
MOD_CK1_1 61 67 PF00069 0.585
MOD_GlcNHglycan 138 141 PF01048 0.729
MOD_GlcNHglycan 144 147 PF01048 0.731
MOD_GlcNHglycan 159 162 PF01048 0.635
MOD_GlcNHglycan 171 174 PF01048 0.608
MOD_GlcNHglycan 222 225 PF01048 0.355
MOD_GlcNHglycan 371 374 PF01048 0.612
MOD_GlcNHglycan 451 454 PF01048 0.402
MOD_GlcNHglycan 51 54 PF01048 0.528
MOD_GlcNHglycan 511 514 PF01048 0.630
MOD_GSK3_1 138 145 PF00069 0.732
MOD_GSK3_1 153 160 PF00069 0.655
MOD_GSK3_1 216 223 PF00069 0.367
MOD_GSK3_1 227 234 PF00069 0.281
MOD_GSK3_1 265 272 PF00069 0.342
MOD_GSK3_1 286 293 PF00069 0.469
MOD_GSK3_1 45 52 PF00069 0.553
MOD_GSK3_1 457 464 PF00069 0.480
MOD_GSK3_1 54 61 PF00069 0.550
MOD_NEK2_1 113 118 PF00069 0.504
MOD_NEK2_1 131 136 PF00069 0.458
MOD_NEK2_1 138 143 PF00069 0.633
MOD_NEK2_1 169 174 PF00069 0.487
MOD_NEK2_1 27 32 PF00069 0.470
MOD_NEK2_1 363 368 PF00069 0.644
MOD_NEK2_1 49 54 PF00069 0.544
MOD_NEK2_2 216 221 PF00069 0.463
MOD_NEK2_2 45 50 PF00069 0.546
MOD_PIKK_1 167 173 PF00454 0.641
MOD_PKA_1 249 255 PF00069 0.512
MOD_PKA_1 474 480 PF00069 0.574
MOD_PKA_2 131 137 PF00069 0.694
MOD_PKA_2 148 154 PF00069 0.754
MOD_PKA_2 186 192 PF00069 0.619
MOD_PKA_2 249 255 PF00069 0.542
MOD_PKA_2 27 33 PF00069 0.585
MOD_PKA_2 301 307 PF00069 0.408
MOD_PKA_2 474 480 PF00069 0.574
MOD_PKA_2 522 528 PF00069 0.618
MOD_Plk_1 227 233 PF00069 0.415
MOD_Plk_4 126 132 PF00069 0.629
MOD_Plk_4 216 222 PF00069 0.434
MOD_Plk_4 227 233 PF00069 0.368
MOD_Plk_4 238 244 PF00069 0.462
MOD_Plk_4 269 275 PF00069 0.372
MOD_Plk_4 27 33 PF00069 0.502
MOD_Plk_4 301 307 PF00069 0.410
MOD_Plk_4 313 319 PF00069 0.369
MOD_Plk_4 457 463 PF00069 0.457
MOD_Plk_4 496 502 PF00069 0.394
MOD_Plk_4 516 522 PF00069 0.446
MOD_Plk_4 55 61 PF00069 0.559
MOD_Plk_4 78 84 PF00069 0.385
MOD_ProDKin_1 162 168 PF00069 0.700
MOD_ProDKin_1 306 312 PF00069 0.355
MOD_ProDKin_1 52 58 PF00069 0.382
MOD_SUMO_rev_2 336 344 PF00179 0.607
MOD_SUMO_rev_2 416 424 PF00179 0.339
TRG_DiLeu_BaEn_1 17 22 PF01217 0.447
TRG_DiLeu_BaEn_1 301 306 PF01217 0.355
TRG_DiLeu_BaEn_2 477 483 PF01217 0.507
TRG_DiLeu_BaLyEn_6 114 119 PF01217 0.636
TRG_DiLeu_BaLyEn_6 62 67 PF01217 0.486
TRG_DiLeu_BaLyEn_6 71 76 PF01217 0.484
TRG_ENDOCYTIC_2 102 105 PF00928 0.513
TRG_ENDOCYTIC_2 110 113 PF00928 0.423
TRG_ENDOCYTIC_2 218 221 PF00928 0.378
TRG_ENDOCYTIC_2 406 409 PF00928 0.338
TRG_ENDOCYTIC_2 458 461 PF00928 0.335
TRG_ENDOCYTIC_2 470 473 PF00928 0.475
TRG_ENDOCYTIC_2 517 520 PF00928 0.549
TRG_ENDOCYTIC_2 63 66 PF00928 0.519
TRG_ER_diArg_1 473 475 PF00400 0.547
TRG_NES_CRM1_1 25 38 PF08389 0.552
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.538

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4K7 Leptomonas seymouri 58% 100%
A0A1X0NST5 Trypanosomatidae 31% 100%
A0A3R7KCJ4 Trypanosoma rangeli 31% 100%
A4HEZ6 Leishmania braziliensis 78% 100%
A4I270 Leishmania infantum 99% 100%
C9ZRS7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AYC0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q953 Leishmania major 92% 100%
V5DAA3 Trypanosoma cruzi 32% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS