PPR repeat/Pentatricopeptide repeat domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICT6_LEIDO

TriTrypDb:

LdBPK_260580.1 , LdCL_260011500 , LDHU3_26.0770

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8ICT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.460
CLV_C14_Caspase3-7	73	77	PF00656	0.600
CLV_NRD_NRD_1	139	141	PF00675	0.352
CLV_NRD_NRD_1	27	29	PF00675	0.584
CLV_NRD_NRD_1	271	273	PF00675	0.282
CLV_NRD_NRD_1	308	310	PF00675	0.361
CLV_NRD_NRD_1	326	328	PF00675	0.306
CLV_NRD_NRD_1	335	337	PF00675	0.317
CLV_NRD_NRD_1	37	39	PF00675	0.516
CLV_PCSK_FUR_1	269	273	PF00082	0.330
CLV_PCSK_FUR_1	306	310	PF00082	0.396
CLV_PCSK_KEX2_1	139	141	PF00082	0.364
CLV_PCSK_KEX2_1	27	29	PF00082	0.586
CLV_PCSK_KEX2_1	271	273	PF00082	0.272
CLV_PCSK_KEX2_1	308	310	PF00082	0.402
CLV_PCSK_KEX2_1	335	337	PF00082	0.328
CLV_PCSK_KEX2_1	37	39	PF00082	0.523
CLV_PCSK_SKI1_1	158	162	PF00082	0.335
CLV_PCSK_SKI1_1	38	42	PF00082	0.512
DEG_COP1_1	75	86	PF00400	0.705
DEG_Nend_Nbox_1	1	3	PF02207	0.742
DEG_SCF_FBW7_1	345	352	PF00400	0.600
DEG_SPOP_SBC_1	385	389	PF00917	0.442
DEG_SPOP_SBC_1	86	90	PF00917	0.721
DOC_CKS1_1	114	119	PF01111	0.687
DOC_CKS1_1	8	13	PF01111	0.591
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.596
DOC_MAPK_gen_1	158	167	PF00069	0.543
DOC_MAPK_gen_1	306	314	PF00069	0.552
DOC_MAPK_MEF2A_6	306	314	PF00069	0.538
DOC_USP7_MATH_1	222	226	PF00917	0.500
DOC_USP7_MATH_1	349	353	PF00917	0.609
DOC_USP7_MATH_1	36	40	PF00917	0.695
DOC_USP7_MATH_1	386	390	PF00917	0.448
DOC_USP7_MATH_1	82	86	PF00917	0.690
DOC_USP7_MATH_2	313	319	PF00917	0.565
DOC_WW_Pin1_4	113	118	PF00397	0.643
DOC_WW_Pin1_4	200	205	PF00397	0.487
DOC_WW_Pin1_4	345	350	PF00397	0.592
DOC_WW_Pin1_4	56	61	PF00397	0.747
DOC_WW_Pin1_4	7	12	PF00397	0.778
DOC_WW_Pin1_4	87	92	PF00397	0.716
LIG_14-3-3_CanoR_1	166	176	PF00244	0.512
LIG_14-3-3_CanoR_1	186	190	PF00244	0.500
LIG_14-3-3_CanoR_1	272	280	PF00244	0.542
LIG_14-3-3_CanoR_1	37	46	PF00244	0.733
LIG_Actin_WH2_2	150	168	PF00022	0.520
LIG_Actin_WH2_2	172	188	PF00022	0.484
LIG_Actin_WH2_2	356	372	PF00022	0.374
LIG_AP2alpha_2	291	293	PF02296	0.592
LIG_BRCT_BRCA1_1	351	355	PF00533	0.559
LIG_FHA_1	78	84	PF00498	0.729
LIG_FHA_1	99	105	PF00498	0.756
LIG_FHA_2	101	107	PF00498	0.674
LIG_FHA_2	114	120	PF00498	0.539
LIG_FHA_2	71	77	PF00498	0.674
LIG_LIR_Gen_1	170	180	PF02991	0.544
LIG_LIR_Gen_1	190	200	PF02991	0.471
LIG_LIR_Gen_1	225	235	PF02991	0.526
LIG_LIR_Gen_1	262	270	PF02991	0.489
LIG_LIR_Gen_1	279	288	PF02991	0.463
LIG_LIR_Gen_1	317	326	PF02991	0.490
LIG_LIR_Gen_1	342	350	PF02991	0.603
LIG_LIR_Gen_1	352	361	PF02991	0.499
LIG_LIR_Nem_3	170	175	PF02991	0.544
LIG_LIR_Nem_3	262	267	PF02991	0.513
LIG_LIR_Nem_3	279	283	PF02991	0.459
LIG_LIR_Nem_3	294	298	PF02991	0.467
LIG_LIR_Nem_3	315	319	PF02991	0.510
LIG_LIR_Nem_3	342	347	PF02991	0.521
LIG_LIR_Nem_3	352	356	PF02991	0.469
LIG_LIR_Nem_3	48	52	PF02991	0.746
LIG_LYPXL_yS_3	49	52	PF13949	0.631
LIG_PCNA_yPIPBox_3	131	142	PF02747	0.549
LIG_Pex14_1	295	299	PF04695	0.495
LIG_Pex14_2	68	72	PF04695	0.634
LIG_SH2_CRK	207	211	PF00017	0.451
LIG_SH2_CRK	280	284	PF00017	0.464
LIG_SH2_GRB2like	287	290	PF00017	0.451
LIG_SH2_SRC	141	144	PF00017	0.610
LIG_SH2_SRC	340	343	PF00017	0.529
LIG_SH2_STAP1	150	154	PF00017	0.507
LIG_SH2_STAP1	172	176	PF00017	0.543
LIG_SH2_STAP1	207	211	PF00017	0.464
LIG_SH2_STAP1	242	246	PF00017	0.451
LIG_SH2_STAP1	381	385	PF00017	0.428
LIG_SH2_STAT5	141	144	PF00017	0.555
LIG_SH2_STAT5	319	322	PF00017	0.547
LIG_SH2_STAT5	333	336	PF00017	0.505
LIG_SH2_STAT5	340	343	PF00017	0.521
LIG_SH2_STAT5	362	365	PF00017	0.340
LIG_SH2_STAT5	375	378	PF00017	0.335
LIG_SH3_3	307	313	PF00018	0.636
LIG_SH3_3	57	63	PF00018	0.753
LIG_SH3_5	146	150	PF00018	0.520
LIG_TYR_ITIM	373	378	PF00017	0.319
LIG_UBA3_1	366	370	PF00899	0.281
MOD_CDK_SPK_2	7	12	PF00069	0.570
MOD_CDK_SPxK_1	345	351	PF00069	0.598
MOD_CK1_1	168	174	PF00069	0.576
MOD_CK1_1	178	184	PF00069	0.456
MOD_CK1_1	273	279	PF00069	0.547
MOD_CK1_1	384	390	PF00069	0.462
MOD_CK1_1	39	45	PF00069	0.784
MOD_CK1_1	70	76	PF00069	0.715
MOD_CK1_1	85	91	PF00069	0.616
MOD_CK2_1	113	119	PF00069	0.596
MOD_CK2_1	167	173	PF00069	0.525
MOD_GlcNHglycan	167	170	PF01048	0.351
MOD_GlcNHglycan	180	183	PF01048	0.232
MOD_GlcNHglycan	20	23	PF01048	0.530
MOD_GlcNHglycan	249	252	PF01048	0.366
MOD_GlcNHglycan	69	72	PF01048	0.467
MOD_GlcNHglycan	84	87	PF01048	0.478
MOD_GSK3_1	174	181	PF00069	0.589
MOD_GSK3_1	32	39	PF00069	0.730
MOD_GSK3_1	345	352	PF00069	0.540
MOD_GSK3_1	380	387	PF00069	0.372
MOD_GSK3_1	41	48	PF00069	0.761
MOD_GSK3_1	50	57	PF00069	0.804
MOD_GSK3_1	82	89	PF00069	0.744
MOD_GSK3_1	94	101	PF00069	0.684
MOD_NEK2_1	124	129	PF00069	0.574
MOD_NEK2_1	165	170	PF00069	0.510
MOD_NEK2_1	175	180	PF00069	0.581
MOD_NEK2_1	18	23	PF00069	0.817
MOD_NEK2_1	244	249	PF00069	0.508
MOD_NEK2_1	40	45	PF00069	0.642
MOD_NEK2_2	222	227	PF00069	0.500
MOD_PKA_2	165	171	PF00069	0.500
MOD_PKA_2	185	191	PF00069	0.482
MOD_PKA_2	265	271	PF00069	0.498
MOD_PKA_2	273	279	PF00069	0.470
MOD_PKA_2	36	42	PF00069	0.694
MOD_Plk_1	148	154	PF00069	0.537
MOD_Plk_1	381	387	PF00069	0.472
MOD_Plk_4	175	181	PF00069	0.588
MOD_Plk_4	222	228	PF00069	0.511
MOD_Plk_4	315	321	PF00069	0.561
MOD_Plk_4	368	374	PF00069	0.396
MOD_Plk_4	388	394	PF00069	0.444
MOD_ProDKin_1	113	119	PF00069	0.639
MOD_ProDKin_1	200	206	PF00069	0.487
MOD_ProDKin_1	345	351	PF00069	0.598
MOD_ProDKin_1	56	62	PF00069	0.753
MOD_ProDKin_1	7	13	PF00069	0.780
MOD_ProDKin_1	87	93	PF00069	0.716
TRG_ENDOCYTIC_2	172	175	PF00928	0.543
TRG_ENDOCYTIC_2	192	195	PF00928	0.460
TRG_ENDOCYTIC_2	207	210	PF00928	0.424
TRG_ENDOCYTIC_2	242	245	PF00928	0.507
TRG_ENDOCYTIC_2	280	283	PF00928	0.451
TRG_ENDOCYTIC_2	287	290	PF00928	0.451
TRG_ENDOCYTIC_2	302	305	PF00928	0.497
TRG_ENDOCYTIC_2	319	322	PF00928	0.488
TRG_ENDOCYTIC_2	362	365	PF00928	0.390
TRG_ENDOCYTIC_2	375	378	PF00928	0.335
TRG_ENDOCYTIC_2	49	52	PF00928	0.728
TRG_ER_diArg_1	138	140	PF00400	0.563
TRG_ER_diArg_1	26	28	PF00400	0.774
TRG_ER_diArg_1	271	274	PF00400	0.521
TRG_ER_diArg_1	305	308	PF00400	0.527
TRG_ER_diArg_1	309	312	PF00400	0.563
TRG_ER_diArg_1	334	336	PF00400	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW81	Leptomonas seymouri	59%	100%
A0A0S4JWX5	Bodo saltans	45%	100%
A0A1X0NSQ2	Trypanosomatidae	59%	100%
A4HER6	Leishmania braziliensis	81%	100%
A4I1Z3	Leishmania infantum	100%	100%
C9ZS21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AY40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q9D3	Leishmania major	94%	100%
V5BUJ1	Trypanosoma cruzi	54%	100%