Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICT4_LEIDO

TriTrypDb:

LdBPK_231690.1 , LdCL_230024000 , LDHU3_23.2250

Length:

321

Annotations

LeishMANIAdb annotations

Related to other eukaryotic ZDHHC palmitoyltransferases, especially animal ZDHHC2.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8ICT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICT4

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016409	palmitoyltransferase activity	5	13
GO:0016417	S-acyltransferase activity	5	13
GO:0016740	transferase activity	2	13
GO:0016746	acyltransferase activity	3	13
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	13
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	13
GO:0019707	protein-cysteine S-acyltransferase activity	3	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.636
CLV_NRD_NRD_1	263	265	PF00675	0.427
CLV_NRD_NRD_1	299	301	PF00675	0.391
CLV_NRD_NRD_1	307	309	PF00675	0.373
CLV_NRD_NRD_1	47	49	PF00675	0.590
CLV_PCSK_KEX2_1	265	267	PF00082	0.390
CLV_PCSK_KEX2_1	299	301	PF00082	0.408
CLV_PCSK_KEX2_1	307	309	PF00082	0.385
CLV_PCSK_KEX2_1	47	49	PF00082	0.590
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.435
CLV_PCSK_SKI1_1	131	135	PF00082	0.315
CLV_PCSK_SKI1_1	168	172	PF00082	0.296
CLV_PCSK_SKI1_1	287	291	PF00082	0.354
DEG_Nend_UBRbox_4	1	3	PF02207	0.632
DOC_MAPK_FxFP_2	194	197	PF00069	0.354
DOC_MAPK_gen_1	284	292	PF00069	0.546
DOC_MAPK_MEF2A_6	284	292	PF00069	0.561
DOC_PP4_FxxP_1	194	197	PF00568	0.354
DOC_PP4_FxxP_1	317	320	PF00568	0.667
DOC_PP4_FxxP_1	86	89	PF00568	0.555
DOC_WW_Pin1_4	316	321	PF00397	0.635
LIG_14-3-3_CanoR_1	10	17	PF00244	0.587
LIG_14-3-3_CanoR_1	106	115	PF00244	0.582
LIG_14-3-3_CanoR_1	125	130	PF00244	0.511
LIG_14-3-3_CanoR_1	242	248	PF00244	0.509
LIG_Actin_WH2_2	36	52	PF00022	0.486
LIG_APCC_ABBA_1	69	74	PF00400	0.234
LIG_BRCT_BRCA1_1	166	170	PF00533	0.554
LIG_BRCT_BRCA1_1	190	194	PF00533	0.448
LIG_BRCT_BRCA1_1	217	221	PF00533	0.368
LIG_deltaCOP1_diTrp_1	282	292	PF00928	0.553
LIG_EH1_1	64	72	PF00400	0.416
LIG_IBAR_NPY_1	111	113	PF08397	0.587
LIG_LIR_Apic_2	191	197	PF02991	0.296
LIG_LIR_Apic_2	314	320	PF02991	0.661
LIG_LIR_Gen_1	110	121	PF02991	0.581
LIG_LIR_Gen_1	15	25	PF02991	0.549
LIG_LIR_Gen_1	167	178	PF02991	0.530
LIG_LIR_Gen_1	187	197	PF02991	0.118
LIG_LIR_Gen_1	218	229	PF02991	0.359
LIG_LIR_Gen_1	282	292	PF02991	0.456
LIG_LIR_Nem_3	110	116	PF02991	0.576
LIG_LIR_Nem_3	15	20	PF02991	0.607
LIG_LIR_Nem_3	167	173	PF02991	0.503
LIG_LIR_Nem_3	187	193	PF02991	0.118
LIG_LIR_Nem_3	218	224	PF02991	0.359
LIG_LIR_Nem_3	270	276	PF02991	0.546
LIG_LIR_Nem_3	59	65	PF02991	0.253
LIG_MLH1_MIPbox_1	166	170	PF16413	0.554
LIG_PCNA_yPIPBox_3	242	251	PF02747	0.538
LIG_PDZ_Class_1	316	321	PF00595	0.701
LIG_Pex14_2	129	133	PF04695	0.538
LIG_Pex14_2	169	173	PF04695	0.394
LIG_Pex14_2	190	194	PF04695	0.402
LIG_Pex14_2	196	200	PF04695	0.297
LIG_Pex14_2	232	236	PF04695	0.347
LIG_PTB_Apo_2	54	61	PF02174	0.421
LIG_SH2_CRK	65	69	PF00017	0.394
LIG_SH2_PTP2	176	179	PF00017	0.313
LIG_SH2_SRC	176	179	PF00017	0.376
LIG_SH2_STAP1	305	309	PF00017	0.583
LIG_SH2_STAT3	241	244	PF00017	0.538
LIG_SH2_STAT5	126	129	PF00017	0.468
LIG_SH2_STAT5	176	179	PF00017	0.328
LIG_SH2_STAT5	24	27	PF00017	0.320
LIG_SH2_STAT5	65	68	PF00017	0.350
LIG_SH3_3	288	294	PF00018	0.530
LIG_SH3_3	90	96	PF00018	0.520
LIG_SUMO_SIM_anti_2	212	218	PF11976	0.321
LIG_SUMO_SIM_par_1	212	218	PF11976	0.299
LIG_SUMO_SIM_par_1	81	87	PF11976	0.437
LIG_TYR_ITIM	174	179	PF00017	0.303
LIG_WRC_WIRS_1	126	131	PF05994	0.554
MOD_CK1_1	188	194	PF00069	0.422
MOD_CK1_1	5	11	PF00069	0.561
MOD_GlcNHglycan	14	17	PF01048	0.365
MOD_GlcNHglycan	311	314	PF01048	0.425
MOD_GSK3_1	184	191	PF00069	0.332
MOD_GSK3_1	205	212	PF00069	0.282
MOD_GSK3_1	215	222	PF00069	0.371
MOD_N-GLC_1	56	61	PF02516	0.562
MOD_N-GLC_2	159	161	PF02516	0.247
MOD_NEK2_1	20	25	PF00069	0.359
MOD_NEK2_1	250	255	PF00069	0.581
MOD_NEK2_2	2	7	PF00069	0.609
MOD_PKB_1	10	18	PF00069	0.537
MOD_PKB_1	123	131	PF00069	0.498
MOD_Plk_1	205	211	PF00069	0.308
MOD_Plk_1	56	62	PF00069	0.363
MOD_Plk_4	185	191	PF00069	0.362
MOD_Plk_4	20	26	PF00069	0.361
MOD_Plk_4	205	211	PF00069	0.118
MOD_Plk_4	215	221	PF00069	0.371
MOD_Plk_4	56	62	PF00069	0.317
TRG_ENDOCYTIC_2	113	116	PF00928	0.560
TRG_ENDOCYTIC_2	126	129	PF00928	0.468
TRG_ENDOCYTIC_2	176	179	PF00928	0.327
TRG_ENDOCYTIC_2	64	67	PF00928	0.349
TRG_ENDOCYTIC_2	78	81	PF00928	0.332
TRG_ER_diArg_1	123	126	PF00400	0.531
TRG_ER_diArg_1	298	300	PF00400	0.606
TRG_ER_diArg_1	307	309	PF00400	0.585
TRG_ER_diArg_1	46	48	PF00400	0.398
TRG_ER_diArg_1	9	12	PF00400	0.594
TRG_NLS_Bipartite_1	254	268	PF00514	0.654
TRG_NLS_MonoExtC_3	263	269	PF00514	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I542	Leptomonas seymouri	24%	100%
A0A0N1IMN2	Leptomonas seymouri	22%	73%
A0A0N1PEH3	Leptomonas seymouri	76%	100%
A0A0R4IF99	Danio rerio	24%	84%
A0A0S4IYT3	Bodo saltans	31%	100%
A0A0S4J1K8	Bodo saltans	30%	70%
A0A0S4JCH4	Bodo saltans	25%	87%
A0A0S4KLP7	Bodo saltans	27%	79%
A0A1X0NUX2	Trypanosomatidae	25%	87%
A0A1X0NY23	Trypanosomatidae	46%	100%
A0A3R7MRW9	Trypanosoma rangeli	35%	100%
A0A422NXW5	Trypanosoma rangeli	47%	100%
A2VDT6	Bos taurus	27%	100%
A4HD15	Leishmania braziliensis	78%	100%
A4I0K1	Leishmania infantum	100%	100%
A4I3R5	Leishmania infantum	25%	70%
B8A4F0	Danio rerio	25%	83%
C9ZVD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AWG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AWG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	71%
O60069	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	90%
P59267	Mus musculus	31%	88%
Q03289	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	86%
Q06551	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	89%
Q4QB09	Leishmania major	94%	100%
Q4R7E2	Macaca fascicularis	25%	85%
Q4WC37	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	75%
Q555N7	Dictyostelium discoideum	26%	90%
Q58CU4	Bos taurus	25%	85%
Q5M757	Arabidopsis thaliana	28%	100%
Q5PNZ1	Arabidopsis thaliana	24%	78%
Q5RB84	Pongo abelii	25%	100%
Q5REH2	Pongo abelii	27%	78%
Q6C4W5	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	80%
Q6CQB5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	90%
Q8IVQ6	Homo sapiens	25%	100%
Q8VYP5	Arabidopsis thaliana	25%	100%
Q94C49	Arabidopsis thaliana	29%	100%
Q969W1	Homo sapiens	25%	85%
Q9D270	Mus musculus	26%	100%
Q9ESG8	Mus musculus	25%	89%
Q9H6R6	Homo sapiens	27%	78%
Q9JKR5	Rattus norvegicus	31%	88%
Q9NYG2	Homo sapiens	28%	100%
Q9UIJ5	Homo sapiens	31%	87%
V5B7I7	Trypanosoma cruzi	28%	100%
V5BJ88	Trypanosoma cruzi	43%	100%
V5DFI9	Trypanosoma cruzi	30%	100%