Str_synth domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ICT3_LEIDO

TriTrypDb:

LdBPK_170690.1 , LdCL_170012300 , LdCL_170012400 , LDHU3_17.1010

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICT3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	234	236	PF00675	0.544
CLV_PCSK_KEX2_1	234	236	PF00082	0.544
CLV_PCSK_KEX2_1	99	101	PF00082	0.470
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.470
CLV_PCSK_SKI1_1	138	142	PF00082	0.466
CLV_PCSK_SKI1_1	28	32	PF00082	0.551
CLV_PCSK_SKI1_1	313	317	PF00082	0.479
CLV_PCSK_SKI1_1	376	380	PF00082	0.496
CLV_Separin_Metazoa	383	387	PF03568	0.431
DEG_APCC_DBOX_1	233	241	PF00400	0.692
DEG_APCC_DBOX_1	375	383	PF00400	0.436
DEG_SPOP_SBC_1	243	247	PF00917	0.619
DOC_CYCLIN_RxL_1	25	33	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.511
DOC_MAPK_gen_1	194	203	PF00069	0.523
DOC_MAPK_MEF2A_6	194	203	PF00069	0.523
DOC_PP1_RVXF_1	136	143	PF00149	0.470
DOC_PP2B_LxvP_1	226	229	PF13499	0.518
DOC_PP4_FxxP_1	116	119	PF00568	0.707
DOC_SPAK_OSR1_1	196	200	PF12202	0.522
DOC_USP7_MATH_1	181	185	PF00917	0.604
DOC_USP7_MATH_1	243	247	PF00917	0.711
DOC_USP7_UBL2_3	215	219	PF12436	0.504
DOC_USP7_UBL2_3	363	367	PF12436	0.504
LIG_14-3-3_CanoR_1	182	186	PF00244	0.497
LIG_14-3-3_CanoR_1	296	302	PF00244	0.566
LIG_APCC_ABBA_1	6	11	PF00400	0.500
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BIR_III_4	287	291	PF00653	0.526
LIG_BIR_III_4	81	85	PF00653	0.544
LIG_deltaCOP1_diTrp_1	78	85	PF00928	0.562
LIG_FHA_1	155	161	PF00498	0.564
LIG_FHA_1	31	37	PF00498	0.539
LIG_FHA_1	364	370	PF00498	0.552
LIG_FHA_2	175	181	PF00498	0.499
LIG_FHA_2	200	206	PF00498	0.409
LIG_FHA_2	257	263	PF00498	0.443
LIG_FHA_2	378	384	PF00498	0.405
LIG_Integrin_isoDGR_2	136	138	PF01839	0.504
LIG_Integrin_RGD_1	21	23	PF01839	0.579
LIG_Integrin_RGD_1	284	286	PF01839	0.572
LIG_LIR_Apic_2	113	119	PF02991	0.696
LIG_LYPXL_yS_3	121	124	PF13949	0.472
LIG_REV1ctd_RIR_1	139	149	PF16727	0.517
LIG_REV1ctd_RIR_1	209	216	PF16727	0.524
LIG_SH2_CRK	348	352	PF00017	0.480
LIG_SH2_STAT3	230	233	PF00017	0.549
LIG_SH2_STAT5	231	234	PF00017	0.539
LIG_SH2_STAT5	278	281	PF00017	0.400
LIG_SH2_STAT5	350	353	PF00017	0.470
LIG_SH3_3	116	122	PF00018	0.617
LIG_SH3_3	248	254	PF00018	0.606
LIG_SH3_3	84	90	PF00018	0.520
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.555
LIG_SUMO_SIM_anti_2	266	276	PF11976	0.395
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.410
LIG_SUMO_SIM_par_1	256	262	PF11976	0.555
LIG_TRAF2_1	177	180	PF00917	0.634
LIG_UBA3_1	210	219	PF00899	0.474
MOD_CK2_1	174	180	PF00069	0.626
MOD_CK2_1	181	187	PF00069	0.545
MOD_CK2_1	199	205	PF00069	0.374
MOD_CK2_1	243	249	PF00069	0.697
MOD_CK2_1	377	383	PF00069	0.409
MOD_GlcNHglycan	23	27	PF01048	0.551
MOD_GlcNHglycan	304	307	PF01048	0.511
MOD_GlcNHglycan	44	48	PF01048	0.553
MOD_GSK3_1	101	108	PF00069	0.548
MOD_GSK3_1	22	29	PF00069	0.574
MOD_GSK3_1	238	245	PF00069	0.653
MOD_N-GLC_1	243	248	PF02516	0.603
MOD_NEK2_1	124	129	PF00069	0.537
MOD_NEK2_1	13	18	PF00069	0.476
MOD_NEK2_1	30	35	PF00069	0.539
MOD_NEK2_1	43	48	PF00069	0.350
MOD_NEK2_2	26	31	PF00069	0.527
MOD_PKA_2	110	116	PF00069	0.637
MOD_PKA_2	181	187	PF00069	0.501
MOD_Plk_1	13	19	PF00069	0.534
MOD_Plk_1	43	49	PF00069	0.549
MOD_Plk_2-3	174	180	PF00069	0.565
MOD_Plk_2-3	187	193	PF00069	0.583
MOD_Plk_4	181	187	PF00069	0.591
MOD_Plk_4	253	259	PF00069	0.579
MOD_Plk_4	26	32	PF00069	0.554
MOD_SUMO_rev_2	248	257	PF00179	0.541
MOD_SUMO_rev_2	44	54	PF00179	0.430
TRG_DiLeu_BaEn_1	266	271	PF01217	0.513
TRG_DiLeu_BaEn_1	312	317	PF01217	0.491
TRG_DiLeu_LyEn_5	159	164	PF01217	0.537
TRG_ENDOCYTIC_2	121	124	PF00928	0.472
TRG_ENDOCYTIC_2	348	351	PF00928	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJF2	Leishmania donovani	100%	100%
A4H906	Leishmania braziliensis	76%	100%
A4HXD7	Leishmania infantum	99%	100%
E9AR32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
N4WEA4	Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T)	30%	82%
Q4QED1	Leishmania major	94%	100%