DnaJ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICT2_LEIDO

TriTrypDb:

LdBPK_261180.1 , LdCL_260017400 , LDHU3_26.1460

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 7
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8ICT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.408
CLV_C14_Caspase3-7	561	565	PF00656	0.388
CLV_NRD_NRD_1	192	194	PF00675	0.699
CLV_NRD_NRD_1	254	256	PF00675	0.630
CLV_NRD_NRD_1	261	263	PF00675	0.639
CLV_NRD_NRD_1	339	341	PF00675	0.437
CLV_NRD_NRD_1	433	435	PF00675	0.608
CLV_NRD_NRD_1	491	493	PF00675	0.704
CLV_NRD_NRD_1	547	549	PF00675	0.555
CLV_NRD_NRD_1	605	607	PF00675	0.552
CLV_NRD_NRD_1	7	9	PF00675	0.585
CLV_NRD_NRD_1	86	88	PF00675	0.600
CLV_NRD_NRD_1	89	91	PF00675	0.611
CLV_PCSK_FUR_1	87	91	PF00082	0.640
CLV_PCSK_KEX2_1	192	194	PF00082	0.699
CLV_PCSK_KEX2_1	250	252	PF00082	0.609
CLV_PCSK_KEX2_1	254	256	PF00082	0.611
CLV_PCSK_KEX2_1	261	263	PF00082	0.624
CLV_PCSK_KEX2_1	338	340	PF00082	0.437
CLV_PCSK_KEX2_1	357	359	PF00082	0.587
CLV_PCSK_KEX2_1	441	443	PF00082	0.730
CLV_PCSK_KEX2_1	480	482	PF00082	0.605
CLV_PCSK_KEX2_1	490	492	PF00082	0.707
CLV_PCSK_KEX2_1	547	549	PF00082	0.552
CLV_PCSK_KEX2_1	604	606	PF00082	0.535
CLV_PCSK_KEX2_1	7	9	PF00082	0.585
CLV_PCSK_KEX2_1	86	88	PF00082	0.612
CLV_PCSK_KEX2_1	89	91	PF00082	0.623
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.628
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.620
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.447
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.526
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.730
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.595
CLV_PCSK_PC7_1	3	9	PF00082	0.641
CLV_PCSK_PC7_1	543	549	PF00082	0.622
CLV_PCSK_SKI1_1	106	110	PF00082	0.542
CLV_PCSK_SKI1_1	247	251	PF00082	0.636
CLV_PCSK_SKI1_1	262	266	PF00082	0.596
CLV_PCSK_SKI1_1	296	300	PF00082	0.448
CLV_PCSK_SKI1_1	362	366	PF00082	0.552
CLV_PCSK_SKI1_1	469	473	PF00082	0.501
CLV_PCSK_SKI1_1	560	564	PF00082	0.622
CLV_PCSK_SKI1_1	606	610	PF00082	0.563
CLV_PCSK_SKI1_1	8	12	PF00082	0.580
CLV_PCSK_SKI1_1	97	101	PF00082	0.626
DEG_APCC_DBOX_1	105	113	PF00400	0.435
DEG_APCC_DBOX_1	230	238	PF00400	0.438
DEG_APCC_DBOX_1	605	613	PF00400	0.323
DEG_APCC_DBOX_1	7	15	PF00400	0.490
DEG_SPOP_SBC_1	45	49	PF00917	0.570
DEG_SPOP_SBC_1	64	68	PF00917	0.472
DOC_CKS1_1	182	187	PF01111	0.456
DOC_CKS1_1	225	230	PF01111	0.452
DOC_CYCLIN_RxL_1	356	369	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	522	528	PF00134	0.304
DOC_MAPK_DCC_7	520	529	PF00069	0.377
DOC_MAPK_MEF2A_6	451	459	PF00069	0.453
DOC_MAPK_MEF2A_6	520	529	PF00069	0.426
DOC_PP1_RVXF_1	531	537	PF00149	0.383
DOC_PP2B_LxvP_1	287	290	PF13499	0.291
DOC_PP2B_LxvP_1	522	525	PF13499	0.317
DOC_PP4_FxxP_1	221	224	PF00568	0.508
DOC_USP7_MATH_1	104	108	PF00917	0.354
DOC_USP7_MATH_1	196	200	PF00917	0.539
DOC_USP7_MATH_1	25	29	PF00917	0.496
DOC_USP7_MATH_1	270	274	PF00917	0.420
DOC_USP7_MATH_1	41	45	PF00917	0.543
DOC_USP7_MATH_1	424	428	PF00917	0.473
DOC_USP7_MATH_1	430	434	PF00917	0.467
DOC_USP7_MATH_1	46	50	PF00917	0.512
DOC_USP7_MATH_1	493	497	PF00917	0.515
DOC_USP7_MATH_1	626	630	PF00917	0.455
DOC_USP7_MATH_1	69	73	PF00917	0.480
DOC_USP7_MATH_1	93	97	PF00917	0.489
DOC_USP7_UBL2_3	257	261	PF12436	0.453
DOC_USP7_UBL2_3	265	269	PF12436	0.483
DOC_USP7_UBL2_3	533	537	PF12436	0.482
DOC_USP7_UBL2_3	624	628	PF12436	0.375
DOC_WW_Pin1_4	123	128	PF00397	0.289
DOC_WW_Pin1_4	181	186	PF00397	0.451
DOC_WW_Pin1_4	224	229	PF00397	0.457
DOC_WW_Pin1_4	313	318	PF00397	0.339
DOC_WW_Pin1_4	332	337	PF00397	0.240
DOC_WW_Pin1_4	504	509	PF00397	0.608
LIG_14-3-3_CanoR_1	210	215	PF00244	0.547
LIG_14-3-3_CanoR_1	331	336	PF00244	0.240
LIG_14-3-3_CanoR_1	558	563	PF00244	0.384
LIG_APCC_ABBA_1	235	240	PF00400	0.524
LIG_APCC_ABBA_1	307	312	PF00400	0.237
LIG_BIR_II_1	1	5	PF00653	0.514
LIG_BRCT_BRCA1_1	522	526	PF00533	0.358
LIG_BRCT_BRCA1_1	70	74	PF00533	0.477
LIG_FHA_1	273	279	PF00498	0.537
LIG_FHA_1	345	351	PF00498	0.407
LIG_FHA_1	584	590	PF00498	0.365
LIG_FHA_1	613	619	PF00498	0.375
LIG_FHA_2	251	257	PF00498	0.523
LIG_FHA_2	391	397	PF00498	0.387
LIG_FHA_2	559	565	PF00498	0.390
LIG_FHA_2	76	82	PF00498	0.390
LIG_GBD_Chelix_1	455	463	PF00786	0.626
LIG_LIR_Apic_2	145	151	PF02991	0.400
LIG_LIR_Gen_1	523	534	PF02991	0.442
LIG_LIR_Gen_1	71	82	PF02991	0.474
LIG_LIR_Nem_3	176	182	PF02991	0.451
LIG_LIR_Nem_3	184	190	PF02991	0.408
LIG_LIR_Nem_3	213	217	PF02991	0.406
LIG_LIR_Nem_3	280	286	PF02991	0.262
LIG_LIR_Nem_3	327	333	PF02991	0.250
LIG_LIR_Nem_3	478	482	PF02991	0.269
LIG_LIR_Nem_3	523	529	PF02991	0.454
LIG_LIR_Nem_3	614	619	PF02991	0.324
LIG_LIR_Nem_3	71	77	PF02991	0.495
LIG_PCNA_PIPBox_1	172	181	PF02747	0.375
LIG_Pex14_1	157	161	PF04695	0.274
LIG_Pex14_2	378	382	PF04695	0.445
LIG_Rb_pABgroove_1	587	595	PF01858	0.445
LIG_SH2_CRK	167	171	PF00017	0.329
LIG_SH2_CRK	179	183	PF00017	0.373
LIG_SH2_CRK	284	288	PF00017	0.248
LIG_SH2_CRK	330	334	PF00017	0.237
LIG_SH2_CRK	479	483	PF00017	0.312
LIG_SH2_CRK	574	578	PF00017	0.426
LIG_SH2_CRK	619	623	PF00017	0.383
LIG_SH2_NCK_1	167	171	PF00017	0.347
LIG_SH2_NCK_1	238	242	PF00017	0.509
LIG_SH2_NCK_1	420	424	PF00017	0.418
LIG_SH2_NCK_1	574	578	PF00017	0.336
LIG_SH2_SRC	238	241	PF00017	0.501
LIG_SH2_STAP1	420	424	PF00017	0.466
LIG_SH2_STAT3	593	596	PF00017	0.398
LIG_SH2_STAT3	641	644	PF00017	0.420
LIG_SH2_STAT5	188	191	PF00017	0.424
LIG_SH2_STAT5	392	395	PF00017	0.442
LIG_SH2_STAT5	416	419	PF00017	0.383
LIG_SH2_STAT5	535	538	PF00017	0.433
LIG_SH2_STAT5	553	556	PF00017	0.432
LIG_SH2_STAT5	574	577	PF00017	0.307
LIG_SH3_3	121	127	PF00018	0.417
LIG_SH3_3	179	185	PF00018	0.422
LIG_SH3_3	592	598	PF00018	0.428
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.488
LIG_TRAF2_1	393	396	PF00917	0.410
LIG_TRAF2_1	576	579	PF00917	0.323
LIG_TYR_ITIM	483	488	PF00017	0.350
LIG_WRC_WIRS_1	379	384	PF05994	0.430
MOD_CDC14_SPxK_1	335	338	PF00782	0.240
MOD_CDC14_SPxK_1	509	512	PF00782	0.473
MOD_CDK_SPxK_1	332	338	PF00069	0.240
MOD_CDK_SPxK_1	506	512	PF00069	0.475
MOD_CDK_SPxxK_3	224	231	PF00069	0.411
MOD_CDK_SPxxK_3	332	339	PF00069	0.240
MOD_CK1_1	142	148	PF00069	0.591
MOD_CK1_1	2	8	PF00069	0.502
MOD_CK1_1	201	207	PF00069	0.524
MOD_CK1_1	380	386	PF00069	0.410
MOD_CK1_1	44	50	PF00069	0.496
MOD_CK1_1	504	510	PF00069	0.576
MOD_CK1_1	68	74	PF00069	0.517
MOD_CK2_1	390	396	PF00069	0.389
MOD_CK2_1	573	579	PF00069	0.322
MOD_CK2_1	634	640	PF00069	0.419
MOD_CK2_1	75	81	PF00069	0.394
MOD_GlcNHglycan	141	144	PF01048	0.413
MOD_GlcNHglycan	197	201	PF01048	0.718
MOD_GlcNHglycan	266	269	PF01048	0.700
MOD_GlcNHglycan	27	30	PF01048	0.709
MOD_GlcNHglycan	272	275	PF01048	0.673
MOD_GlcNHglycan	41	44	PF01048	0.607
MOD_GlcNHglycan	442	445	PF01048	0.737
MOD_GlcNHglycan	493	496	PF01048	0.713
MOD_GlcNHglycan	503	506	PF01048	0.773
MOD_GlcNHglycan	67	70	PF01048	0.764
MOD_GSK3_1	142	149	PF00069	0.491
MOD_GSK3_1	196	203	PF00069	0.585
MOD_GSK3_1	21	28	PF00069	0.536
MOD_GSK3_1	35	42	PF00069	0.440
MOD_GSK3_1	426	433	PF00069	0.387
MOD_GSK3_1	44	51	PF00069	0.461
MOD_GSK3_1	516	523	PF00069	0.438
MOD_GSK3_1	558	565	PF00069	0.373
MOD_GSK3_1	63	70	PF00069	0.481
MOD_LATS_1	518	524	PF00433	0.383
MOD_N-GLC_1	626	631	PF02516	0.656
MOD_NEK2_1	1	6	PF00069	0.462
MOD_NEK2_1	378	383	PF00069	0.430
MOD_NEK2_1	580	585	PF00069	0.369
MOD_NEK2_1	612	617	PF00069	0.344
MOD_NEK2_1	634	639	PF00069	0.397
MOD_NEK2_2	553	558	PF00069	0.294
MOD_PIKK_1	380	386	PF00454	0.359
MOD_PKA_1	250	256	PF00069	0.405
MOD_PKA_1	440	446	PF00069	0.459
MOD_PKA_1	491	497	PF00069	0.442
MOD_PKA_2	2	8	PF00069	0.640
MOD_PKA_2	250	256	PF00069	0.405
MOD_PKA_2	324	330	PF00069	0.339
MOD_PKA_2	491	497	PF00069	0.555
MOD_PKB_1	137	145	PF00069	0.636
MOD_PKB_1	208	216	PF00069	0.414
MOD_Plk_1	626	632	PF00069	0.475
MOD_Plk_1	93	99	PF00069	0.523
MOD_Plk_4	174	180	PF00069	0.476
MOD_Plk_4	239	245	PF00069	0.508
MOD_Plk_4	50	56	PF00069	0.432
MOD_Plk_4	612	618	PF00069	0.328
MOD_ProDKin_1	123	129	PF00069	0.289
MOD_ProDKin_1	181	187	PF00069	0.455
MOD_ProDKin_1	224	230	PF00069	0.454
MOD_ProDKin_1	313	319	PF00069	0.339
MOD_ProDKin_1	332	338	PF00069	0.240
MOD_ProDKin_1	504	510	PF00069	0.606
TRG_DiLeu_BaEn_4	395	401	PF01217	0.441
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.472
TRG_ENDOCYTIC_2	153	156	PF00928	0.372
TRG_ENDOCYTIC_2	167	170	PF00928	0.272
TRG_ENDOCYTIC_2	179	182	PF00928	0.374
TRG_ENDOCYTIC_2	187	190	PF00928	0.287
TRG_ENDOCYTIC_2	283	286	PF00928	0.249
TRG_ENDOCYTIC_2	330	333	PF00928	0.237
TRG_ENDOCYTIC_2	479	482	PF00928	0.283
TRG_ENDOCYTIC_2	485	488	PF00928	0.314
TRG_ENDOCYTIC_2	574	577	PF00928	0.335
TRG_ER_diArg_1	137	140	PF00400	0.592
TRG_ER_diArg_1	192	194	PF00400	0.499
TRG_ER_diArg_1	207	210	PF00400	0.525
TRG_ER_diArg_1	490	492	PF00400	0.520
TRG_ER_diArg_1	546	548	PF00400	0.356
TRG_ER_diArg_1	557	560	PF00400	0.449
TRG_ER_diArg_1	6	8	PF00400	0.490
TRG_ER_diArg_1	604	606	PF00400	0.348
TRG_ER_diArg_1	85	87	PF00400	0.411
TRG_NLS_Bipartite_1	250	266	PF00514	0.434
TRG_NLS_MonoCore_2	337	342	PF00514	0.300
TRG_NLS_MonoExtC_3	260	265	PF00514	0.524
TRG_NLS_MonoExtC_3	337	343	PF00514	0.304
TRG_NLS_MonoExtN_4	259	266	PF00514	0.523
TRG_NLS_MonoExtN_4	336	342	PF00514	0.287
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL2	Leptomonas seymouri	63%	100%
A0A0S4JWY5	Bodo saltans	36%	100%
A0A1X0NS91	Trypanosomatidae	43%	100%
A0A422N6M1	Trypanosoma rangeli	44%	100%
A4HEX5	Leishmania braziliensis	80%	100%
A4I249	Leishmania infantum	100%	100%
C9ZRV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AY99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q974	Leishmania major	91%	99%
V5BUD6	Trypanosoma cruzi	44%	100%