Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP48

Species:

Leishmania donovani

UniProt:

A0A3Q8ICS9_LEIDO

TriTrypDb:

LdBPK_130250.1 , LdCL_130007500 , LDHU3_13.0310

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8ICS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICS9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.754
CLV_NRD_NRD_1	120	122	PF00675	0.696
CLV_NRD_NRD_1	126	128	PF00675	0.662
CLV_NRD_NRD_1	171	173	PF00675	0.603
CLV_NRD_NRD_1	177	179	PF00675	0.571
CLV_NRD_NRD_1	466	468	PF00675	0.435
CLV_PCSK_KEX2_1	119	121	PF00082	0.690
CLV_PCSK_KEX2_1	126	128	PF00082	0.672
CLV_PCSK_KEX2_1	171	173	PF00082	0.600
CLV_PCSK_KEX2_1	177	179	PF00082	0.573
CLV_PCSK_KEX2_1	465	467	PF00082	0.451
CLV_PCSK_SKI1_1	160	164	PF00082	0.537
CLV_PCSK_SKI1_1	171	175	PF00082	0.498
CLV_PCSK_SKI1_1	246	250	PF00082	0.392
CLV_PCSK_SKI1_1	289	293	PF00082	0.489
CLV_PCSK_SKI1_1	323	327	PF00082	0.519
CLV_PCSK_SKI1_1	6	10	PF00082	0.598
CLV_Separin_Metazoa	3	7	PF03568	0.578
DEG_APCC_DBOX_1	126	134	PF00400	0.685
DEG_Nend_Nbox_1	1	3	PF02207	0.507
DEG_SPOP_SBC_1	92	96	PF00917	0.669
DOC_CKS1_1	399	404	PF01111	0.519
DOC_CYCLIN_RxL_1	169	179	PF00134	0.579
DOC_CYCLIN_RxL_1	3	12	PF00134	0.530
DOC_MAPK_HePTP_8	430	442	PF00069	0.514
DOC_MAPK_MEF2A_6	433	442	PF00069	0.507
DOC_PP1_RVXF_1	233	239	PF00149	0.451
DOC_PP1_RVXF_1	321	327	PF00149	0.524
DOC_PP2B_PxIxI_1	435	441	PF00149	0.497
DOC_PP4_FxxP_1	154	157	PF00568	0.523
DOC_USP7_MATH_1	176	180	PF00917	0.626
DOC_USP7_MATH_1	208	212	PF00917	0.498
DOC_USP7_MATH_1	264	268	PF00917	0.635
DOC_USP7_MATH_1	284	288	PF00917	0.617
DOC_USP7_MATH_1	315	319	PF00917	0.373
DOC_USP7_MATH_1	387	391	PF00917	0.609
DOC_USP7_MATH_1	393	397	PF00917	0.511
DOC_USP7_MATH_1	503	507	PF00917	0.542
DOC_WW_Pin1_4	378	383	PF00397	0.626
DOC_WW_Pin1_4	398	403	PF00397	0.218
LIG_14-3-3_CanoR_1	126	130	PF00244	0.639
LIG_14-3-3_CanoR_1	296	302	PF00244	0.462
LIG_14-3-3_CanoR_1	77	86	PF00244	0.773
LIG_BRCT_BRCA1_1	416	420	PF00533	0.501
LIG_EH_1	434	438	PF12763	0.452
LIG_FHA_1	210	216	PF00498	0.460
LIG_FHA_1	320	326	PF00498	0.504
LIG_FHA_1	339	345	PF00498	0.333
LIG_FHA_1	421	427	PF00498	0.494
LIG_FHA_1	472	478	PF00498	0.403
LIG_FHA_1	510	516	PF00498	0.539
LIG_FHA_2	112	118	PF00498	0.707
LIG_FHA_2	364	370	PF00498	0.517
LIG_FHA_2	457	463	PF00498	0.479
LIG_GBD_Chelix_1	442	450	PF00786	0.512
LIG_LIR_Apic_2	153	157	PF02991	0.571
LIG_LIR_Gen_1	195	203	PF02991	0.390
LIG_LIR_Gen_1	37	47	PF02991	0.610
LIG_LIR_Nem_3	106	112	PF02991	0.755
LIG_LIR_Nem_3	195	201	PF02991	0.480
LIG_LIR_Nem_3	35	39	PF02991	0.635
LIG_LIR_Nem_3	448	454	PF02991	0.533
LIG_LIR_Nem_3	59	63	PF02991	0.658
LIG_LYPXL_S_1	46	50	PF13949	0.620
LIG_LYPXL_yS_3	47	50	PF13949	0.616
LIG_MLH1_MIPbox_1	416	420	PF16413	0.501
LIG_MYND_1	138	142	PF01753	0.613
LIG_NBox_RRM_1	163	173	PF00076	0.513
LIG_SH2_CRK	39	43	PF00017	0.627
LIG_SH2_CRK	451	455	PF00017	0.543
LIG_SH2_STAT5	419	422	PF00017	0.444
LIG_SH3_3	330	336	PF00018	0.544
LIG_SH3_3	339	345	PF00018	0.530
LIG_SH3_3	396	402	PF00018	0.491
LIG_SUMO_SIM_anti_2	372	377	PF11976	0.432
LIG_SUMO_SIM_par_1	340	346	PF11976	0.561
LIG_TRAF2_1	202	205	PF00917	0.536
LIG_WRC_WIRS_1	504	509	PF05994	0.554
MOD_CK1_1	111	117	PF00069	0.700
MOD_CK1_1	266	272	PF00069	0.664
MOD_CK1_1	297	303	PF00069	0.547
MOD_CK1_1	381	387	PF00069	0.577
MOD_CK1_1	444	450	PF00069	0.535
MOD_CK1_1	70	76	PF00069	0.729
MOD_CK1_1	81	87	PF00069	0.750
MOD_CK2_1	363	369	PF00069	0.513
MOD_CK2_1	456	462	PF00069	0.478
MOD_CMANNOS	238	241	PF00535	0.460
MOD_Cter_Amidation	124	127	PF01082	0.628
MOD_GlcNHglycan	135	138	PF01048	0.627
MOD_GlcNHglycan	265	269	PF01048	0.598
MOD_GlcNHglycan	275	278	PF01048	0.525
MOD_GlcNHglycan	285	289	PF01048	0.529
MOD_GlcNHglycan	296	299	PF01048	0.453
MOD_GlcNHglycan	35	39	PF01048	0.584
MOD_GlcNHglycan	383	386	PF01048	0.683
MOD_GlcNHglycan	72	75	PF01048	0.766
MOD_GlcNHglycan	80	83	PF01048	0.779
MOD_GSK3_1	158	165	PF00069	0.554
MOD_GSK3_1	188	195	PF00069	0.521
MOD_GSK3_1	315	322	PF00069	0.520
MOD_GSK3_1	34	41	PF00069	0.606
MOD_GSK3_1	383	390	PF00069	0.560
MOD_GSK3_1	441	448	PF00069	0.537
MOD_GSK3_1	66	73	PF00069	0.662
MOD_GSK3_1	76	83	PF00069	0.723
MOD_N-GLC_1	66	71	PF02516	0.768
MOD_NEK2_1	133	138	PF00069	0.634
MOD_NEK2_1	263	268	PF00069	0.484
MOD_NEK2_1	299	304	PF00069	0.459
MOD_NEK2_1	363	368	PF00069	0.502
MOD_NEK2_1	420	425	PF00069	0.467
MOD_NEK2_1	445	450	PF00069	0.384
MOD_NEK2_1	461	466	PF00069	0.407
MOD_NEK2_1	93	98	PF00069	0.763
MOD_NEK2_2	158	163	PF00069	0.588
MOD_PKA_1	119	125	PF00069	0.717
MOD_PKA_2	119	125	PF00069	0.714
MOD_PKA_2	176	182	PF00069	0.548
MOD_PKA_2	185	191	PF00069	0.400
MOD_PKA_2	409	415	PF00069	0.511
MOD_PKA_2	76	82	PF00069	0.792
MOD_Plk_1	34	40	PF00069	0.613
MOD_Plk_4	192	198	PF00069	0.405
MOD_Plk_4	234	240	PF00069	0.542
MOD_Plk_4	338	344	PF00069	0.535
MOD_Plk_4	414	420	PF00069	0.489
MOD_Plk_4	441	447	PF00069	0.542
MOD_Plk_4	511	517	PF00069	0.419
MOD_ProDKin_1	378	384	PF00069	0.633
MOD_ProDKin_1	398	404	PF00069	0.217
TRG_DiLeu_BaEn_1	473	478	PF01217	0.426
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.504
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.550
TRG_ENDOCYTIC_2	196	199	PF00928	0.510
TRG_ENDOCYTIC_2	39	42	PF00928	0.600
TRG_ENDOCYTIC_2	451	454	PF00928	0.542
TRG_ENDOCYTIC_2	47	50	PF00928	0.535
TRG_ER_diArg_1	119	121	PF00400	0.707
TRG_ER_diArg_1	171	173	PF00400	0.603
TRG_ER_diArg_1	177	180	PF00400	0.577
TRG_ER_diArg_1	293	296	PF00400	0.337
TRG_ER_diArg_1	376	379	PF00400	0.528
TRG_ER_diArg_1	465	467	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I3	Leptomonas seymouri	55%	100%
A0A0S4JJV4	Bodo saltans	26%	100%
A0A1X0NPX8	Trypanosomatidae	42%	100%
A0A3R7KGG9	Trypanosoma rangeli	37%	100%
A4HHS4	Leishmania braziliensis	83%	100%
A4HVH0	Leishmania infantum	100%	100%
D0A6U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AP59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QGC9	Leishmania major	95%	100%
V5D9X2	Trypanosoma cruzi	37%	100%