Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICS7_LEIDO

TriTrypDb:

LdBPK_260440.1 , LdCL_260009900 , LDHU3_26.0570

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 3
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8ICS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.487
CLV_NRD_NRD_1	106	108	PF00675	0.317
CLV_NRD_NRD_1	284	286	PF00675	0.417
CLV_NRD_NRD_1	92	94	PF00675	0.563
CLV_PCSK_KEX2_1	106	108	PF00082	0.261
CLV_PCSK_KEX2_1	92	94	PF00082	0.619
CLV_PCSK_SKI1_1	151	155	PF00082	0.474
CLV_PCSK_SKI1_1	285	289	PF00082	0.490
CLV_PCSK_SKI1_1	445	449	PF00082	0.517
DEG_APCC_DBOX_1	136	144	PF00400	0.544
DEG_APCC_DBOX_1	284	292	PF00400	0.492
DEG_APCC_DBOX_1	316	324	PF00400	0.518
DOC_CKS1_1	256	261	PF01111	0.605
DOC_CKS1_1	58	63	PF01111	0.539
DOC_MAPK_HePTP_8	8	20	PF00069	0.524
DOC_MAPK_MEF2A_6	11	20	PF00069	0.428
DOC_MAPK_MEF2A_6	233	242	PF00069	0.397
DOC_MAPK_MEF2A_6	73	82	PF00069	0.392
DOC_MAPK_RevD_3	77	93	PF00069	0.442
DOC_PP2B_LxvP_1	122	125	PF13499	0.446
DOC_PP4_FxxP_1	154	157	PF00568	0.443
DOC_USP7_MATH_1	136	140	PF00917	0.548
DOC_USP7_MATH_1	248	252	PF00917	0.532
DOC_USP7_MATH_1	384	388	PF00917	0.555
DOC_USP7_MATH_1	437	441	PF00917	0.540
DOC_WW_Pin1_4	255	260	PF00397	0.635
DOC_WW_Pin1_4	433	438	PF00397	0.558
DOC_WW_Pin1_4	57	62	PF00397	0.540
LIG_14-3-3_CanoR_1	119	123	PF00244	0.584
LIG_14-3-3_CanoR_1	137	141	PF00244	0.488
LIG_14-3-3_CanoR_1	223	230	PF00244	0.529
LIG_14-3-3_CanoR_1	279	288	PF00244	0.470
LIG_14-3-3_CanoR_1	385	389	PF00244	0.674
LIG_14-3-3_CanoR_1	55	59	PF00244	0.548
LIG_Actin_WH2_2	136	153	PF00022	0.449
LIG_BRCT_BRCA1_1	110	114	PF00533	0.349
LIG_BRCT_BRCA1_1	395	399	PF00533	0.471
LIG_BRCT_BRCA1_1	425	429	PF00533	0.530
LIG_FHA_1	276	282	PF00498	0.390
LIG_FHA_1	307	313	PF00498	0.558
LIG_FHA_1	7	13	PF00498	0.463
LIG_FHA_2	130	136	PF00498	0.540
LIG_FHA_2	182	188	PF00498	0.586
LIG_FHA_2	256	262	PF00498	0.560
LIG_FHA_2	384	390	PF00498	0.508
LIG_LIR_Apic_2	254	259	PF02991	0.573
LIG_LIR_Gen_1	161	171	PF02991	0.466
LIG_LIR_LC3C_4	236	240	PF02991	0.422
LIG_LIR_Nem_3	161	166	PF02991	0.415
LIG_LIR_Nem_3	398	404	PF02991	0.564
LIG_NRP_CendR_1	449	450	PF00754	0.498
LIG_Pex14_2	342	346	PF04695	0.577
LIG_PTAP_UEV_1	354	359	PF05743	0.483
LIG_PTB_Apo_2	177	184	PF02174	0.668
LIG_PTB_Phospho_1	177	183	PF10480	0.476
LIG_SH2_CRK	163	167	PF00017	0.523
LIG_SH2_CRK	213	217	PF00017	0.417
LIG_SH2_CRK	369	373	PF00017	0.570
LIG_SH2_STAP1	213	217	PF00017	0.417
LIG_SH2_STAP1	299	303	PF00017	0.552
LIG_SH2_STAP1	443	447	PF00017	0.499
LIG_SH2_STAT3	295	298	PF00017	0.420
LIG_SH2_STAT5	183	186	PF00017	0.539
LIG_SH2_STAT5	208	211	PF00017	0.487
LIG_SH2_STAT5	213	216	PF00017	0.491
LIG_SH2_STAT5	272	275	PF00017	0.458
LIG_SH2_STAT5	280	283	PF00017	0.414
LIG_SH2_STAT5	296	299	PF00017	0.352
LIG_SH2_STAT5	7	10	PF00017	0.573
LIG_SH3_2	355	360	PF14604	0.482
LIG_SH3_3	167	173	PF00018	0.504
LIG_SH3_3	352	358	PF00018	0.580
LIG_SH3_3	55	61	PF00018	0.495
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.455
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.522
LIG_SUMO_SIM_par_1	238	244	PF11976	0.453
LIG_SUMO_SIM_par_1	78	84	PF11976	0.446
LIG_TRAF2_1	185	188	PF00917	0.481
LIG_TYR_ITSM	159	166	PF00017	0.495
MOD_CDK_SPK_2	255	260	PF00069	0.558
MOD_CK1_1	129	135	PF00069	0.639
MOD_CK1_1	182	188	PF00069	0.489
MOD_CK1_1	251	257	PF00069	0.660
MOD_CK1_1	321	327	PF00069	0.623
MOD_CK1_1	395	401	PF00069	0.604
MOD_CK1_1	57	63	PF00069	0.514
MOD_CK1_1	65	71	PF00069	0.406
MOD_CK1_1	88	94	PF00069	0.628
MOD_CK2_1	136	142	PF00069	0.491
MOD_CK2_1	181	187	PF00069	0.582
MOD_CK2_1	383	389	PF00069	0.503
MOD_GlcNHglycan	110	113	PF01048	0.533
MOD_GlcNHglycan	225	228	PF01048	0.503
MOD_GlcNHglycan	348	351	PF01048	0.672
MOD_GlcNHglycan	355	358	PF01048	0.652
MOD_GlcNHglycan	408	411	PF01048	0.548
MOD_GSK3_1	251	258	PF00069	0.523
MOD_GSK3_1	346	353	PF00069	0.573
MOD_GSK3_1	393	400	PF00069	0.681
MOD_GSK3_1	433	440	PF00069	0.541
MOD_GSK3_1	53	60	PF00069	0.551
MOD_GSK3_1	62	69	PF00069	0.471
MOD_N-GLC_1	158	163	PF02516	0.399
MOD_N-GLC_1	179	184	PF02516	0.671
MOD_N-GLC_1	326	331	PF02516	0.687
MOD_N-GLC_1	337	342	PF02516	0.507
MOD_N-GLC_1	350	355	PF02516	0.423
MOD_N-GLC_1	416	421	PF02516	0.663
MOD_N-GLC_1	95	100	PF02516	0.603
MOD_NEK2_1	181	186	PF00069	0.655
MOD_NEK2_1	336	341	PF00069	0.635
MOD_NEK2_1	346	351	PF00069	0.592
MOD_NEK2_1	394	399	PF00069	0.634
MOD_NEK2_1	66	71	PF00069	0.406
MOD_NEK2_2	248	253	PF00069	0.594
MOD_NEK2_2	280	285	PF00069	0.558
MOD_PIKK_1	200	206	PF00454	0.524
MOD_PKA_2	118	124	PF00069	0.497
MOD_PKA_2	136	142	PF00069	0.583
MOD_PKA_2	384	390	PF00069	0.693
MOD_PKA_2	54	60	PF00069	0.555
MOD_Plk_1	158	164	PF00069	0.392
MOD_Plk_1	179	185	PF00069	0.673
MOD_Plk_1	200	206	PF00069	0.512
MOD_Plk_1	318	324	PF00069	0.522
MOD_Plk_1	337	343	PF00069	0.667
MOD_Plk_4	318	324	PF00069	0.609
MOD_Plk_4	54	60	PF00069	0.560
MOD_Plk_4	85	91	PF00069	0.556
MOD_ProDKin_1	255	261	PF00069	0.636
MOD_ProDKin_1	433	439	PF00069	0.550
MOD_ProDKin_1	57	63	PF00069	0.542
TRG_ENDOCYTIC_2	163	166	PF00928	0.525
TRG_ENDOCYTIC_2	213	216	PF00928	0.411
TRG_ENDOCYTIC_2	369	372	PF00928	0.532
TRG_ENDOCYTIC_2	404	407	PF00928	0.495
TRG_ER_diArg_1	105	107	PF00400	0.496
TRG_ER_diArg_1	448	450	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P2	Leptomonas seymouri	37%	97%
A0A1X0NSG2	Trypanosomatidae	21%	100%
A0A3R7NPG1	Trypanosoma rangeli	24%	100%
A4HEQ1	Leishmania braziliensis	72%	100%
A4I1Y1	Leishmania infantum	100%	100%
C9ZS38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AY27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9E6	Leishmania major	90%	100%