Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICS5_LEIDO

TriTrypDb:

LdBPK_240520.1 , LdCL_240010000 , LDHU3_24.0630

Length:

777

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.536
CLV_C14_Caspase3-7	439	443	PF00656	0.533
CLV_C14_Caspase3-7	724	728	PF00656	0.552
CLV_NRD_NRD_1	464	466	PF00675	0.695
CLV_NRD_NRD_1	588	590	PF00675	0.573
CLV_PCSK_KEX2_1	333	335	PF00082	0.528
CLV_PCSK_KEX2_1	588	590	PF00082	0.555
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.486
CLV_PCSK_SKI1_1	141	145	PF00082	0.542
CLV_PCSK_SKI1_1	164	168	PF00082	0.525
CLV_PCSK_SKI1_1	409	413	PF00082	0.402
CLV_PCSK_SKI1_1	51	55	PF00082	0.472
CLV_PCSK_SKI1_1	632	636	PF00082	0.511
DEG_APCC_DBOX_1	186	194	PF00400	0.597
DEG_Nend_UBRbox_2	1	3	PF02207	0.640
DEG_SPOP_SBC_1	213	217	PF00917	0.618
DOC_CDC14_PxL_1	731	739	PF14671	0.492
DOC_CYCLIN_RxL_1	385	395	PF00134	0.446
DOC_CYCLIN_yClb5_NLxxxL_5	362	371	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.525
DOC_MAPK_gen_1	333	341	PF00069	0.585
DOC_MAPK_MEF2A_6	716	725	PF00069	0.487
DOC_PP1_RVXF_1	407	414	PF00149	0.478
DOC_PP1_SILK_1	765	770	PF00149	0.502
DOC_PP2B_LxvP_1	309	312	PF13499	0.506
DOC_PP2B_LxvP_1	367	370	PF13499	0.529
DOC_PP2B_LxvP_1	390	393	PF13499	0.554
DOC_PP2B_LxvP_1	590	593	PF13499	0.625
DOC_PP2B_LxvP_1	715	718	PF13499	0.459
DOC_USP7_MATH_1	162	166	PF00917	0.569
DOC_USP7_MATH_1	200	204	PF00917	0.619
DOC_USP7_MATH_1	218	222	PF00917	0.476
DOC_USP7_MATH_1	264	268	PF00917	0.487
DOC_USP7_MATH_1	34	38	PF00917	0.489
DOC_USP7_MATH_1	504	508	PF00917	0.528
DOC_USP7_MATH_1	596	600	PF00917	0.580
DOC_USP7_MATH_1	660	664	PF00917	0.526
DOC_USP7_MATH_1	688	692	PF00917	0.589
DOC_USP7_UBL2_3	47	51	PF12436	0.468
DOC_WW_Pin1_4	635	640	PF00397	0.597
LIG_14-3-3_CanoR_1	209	213	PF00244	0.678
LIG_14-3-3_CanoR_1	280	284	PF00244	0.621
LIG_14-3-3_CanoR_1	334	340	PF00244	0.614
LIG_14-3-3_CanoR_1	499	508	PF00244	0.404
LIG_14-3-3_CanoR_1	621	627	PF00244	0.508
LIG_14-3-3_CanoR_1	632	639	PF00244	0.447
LIG_14-3-3_CanoR_1	71	81	PF00244	0.484
LIG_14-3-3_CanoR_1	738	747	PF00244	0.516
LIG_14-3-3_CanoR_1	748	752	PF00244	0.461
LIG_APCC_ABBA_1	292	297	PF00400	0.617
LIG_BRCT_BRCA1_1	312	316	PF00533	0.593
LIG_BRCT_BRCA1_1	672	676	PF00533	0.529
LIG_BRCT_BRCA1_1	718	722	PF00533	0.559
LIG_Clathr_ClatBox_1	112	116	PF01394	0.471
LIG_CSL_BTD_1	288	291	PF09270	0.560
LIG_deltaCOP1_diTrp_1	235	242	PF00928	0.579
LIG_deltaCOP1_diTrp_1	284	289	PF00928	0.612
LIG_deltaCOP1_diTrp_1	415	420	PF00928	0.491
LIG_EVH1_1	287	291	PF00568	0.567
LIG_FHA_1	135	141	PF00498	0.472
LIG_FHA_1	21	27	PF00498	0.584
LIG_FHA_1	215	221	PF00498	0.677
LIG_FHA_1	224	230	PF00498	0.508
LIG_FHA_1	336	342	PF00498	0.696
LIG_FHA_1	48	54	PF00498	0.467
LIG_FHA_1	514	520	PF00498	0.435
LIG_FHA_1	585	591	PF00498	0.588
LIG_FHA_1	643	649	PF00498	0.596
LIG_FHA_1	760	766	PF00498	0.535
LIG_FHA_2	142	148	PF00498	0.467
LIG_FHA_2	437	443	PF00498	0.525
LIG_FHA_2	55	61	PF00498	0.501
LIG_LIR_Apic_2	207	213	PF02991	0.535
LIG_LIR_Apic_2	282	288	PF02991	0.657
LIG_LIR_Gen_1	32	43	PF02991	0.489
LIG_LIR_Gen_1	577	586	PF02991	0.450
LIG_LIR_Gen_1	673	680	PF02991	0.538
LIG_LIR_Gen_1	719	730	PF02991	0.490
LIG_LIR_Nem_3	32	38	PF02991	0.497
LIG_LIR_Nem_3	496	501	PF02991	0.456
LIG_LIR_Nem_3	577	582	PF02991	0.440
LIG_LIR_Nem_3	673	679	PF02991	0.511
LIG_LIR_Nem_3	719	725	PF02991	0.497
LIG_MYND_1	290	294	PF01753	0.609
LIG_NRBOX	149	155	PF00104	0.488
LIG_NRBOX	168	174	PF00104	0.486
LIG_NRBOX	613	619	PF00104	0.425
LIG_PALB2_WD40_1	301	309	PF16756	0.515
LIG_PCNA_yPIPBox_3	71	81	PF02747	0.526
LIG_PCNA_yPIPBox_3	84	97	PF02747	0.385
LIG_Pex14_2	139	143	PF04695	0.473
LIG_Pex14_2	413	417	PF04695	0.460
LIG_RPA_C_Fungi	616	628	PF08784	0.391
LIG_SH2_CRK	210	214	PF00017	0.587
LIG_SH2_NCK_1	210	214	PF00017	0.587
LIG_SH2_STAP1	480	484	PF00017	0.471
LIG_SH2_STAT5	210	213	PF00017	0.578
LIG_SH2_STAT5	736	739	PF00017	0.477
LIG_SH3_3	285	291	PF00018	0.568
LIG_SUMO_SIM_anti_2	764	771	PF11976	0.547
LIG_SUMO_SIM_par_1	502	509	PF11976	0.451
LIG_SUMO_SIM_par_1	645	654	PF11976	0.597
LIG_TRAF2_1	267	270	PF00917	0.649
LIG_TRAF2_1	340	343	PF00917	0.593
LIG_TRAF2_1	774	777	PF00917	0.580
LIG_WRC_WIRS_1	140	145	PF05994	0.495
LIG_WRC_WIRS_1	193	198	PF05994	0.641
LIG_WW_2	290	293	PF00397	0.560
MOD_CK1_1	158	164	PF00069	0.512
MOD_CK1_1	20	26	PF00069	0.590
MOD_CK1_1	310	316	PF00069	0.651
MOD_CK1_1	513	519	PF00069	0.567
MOD_CK1_1	584	590	PF00069	0.619
MOD_CK1_1	663	669	PF00069	0.535
MOD_CK1_1	670	676	PF00069	0.498
MOD_CK1_1	695	701	PF00069	0.510
MOD_CK2_1	162	168	PF00069	0.550
MOD_CK2_1	264	270	PF00069	0.611
MOD_CK2_1	468	474	PF00069	0.449
MOD_CK2_1	54	60	PF00069	0.456
MOD_CK2_1	690	696	PF00069	0.631
MOD_CK2_1	747	753	PF00069	0.447
MOD_CK2_1	771	777	PF00069	0.564
MOD_CMANNOS	417	420	PF00535	0.643
MOD_GlcNHglycan	121	124	PF01048	0.466
MOD_GlcNHglycan	127	130	PF01048	0.411
MOD_GlcNHglycan	157	160	PF01048	0.545
MOD_GlcNHglycan	164	167	PF01048	0.539
MOD_GlcNHglycan	201	205	PF01048	0.607
MOD_GlcNHglycan	220	223	PF01048	0.650
MOD_GlcNHglycan	262	265	PF01048	0.581
MOD_GlcNHglycan	266	269	PF01048	0.644
MOD_GlcNHglycan	324	327	PF01048	0.624
MOD_GlcNHglycan	511	515	PF01048	0.496
MOD_GlcNHglycan	632	635	PF01048	0.509
MOD_GlcNHglycan	692	695	PF01048	0.555
MOD_GlcNHglycan	741	744	PF01048	0.451
MOD_GSK3_1	158	165	PF00069	0.597
MOD_GSK3_1	192	199	PF00069	0.618
MOD_GSK3_1	20	27	PF00069	0.614
MOD_GSK3_1	208	215	PF00069	0.534
MOD_GSK3_1	218	225	PF00069	0.629
MOD_GSK3_1	260	267	PF00069	0.619
MOD_GSK3_1	307	314	PF00069	0.638
MOD_GSK3_1	395	402	PF00069	0.492
MOD_GSK3_1	432	439	PF00069	0.479
MOD_GSK3_1	468	475	PF00069	0.441
MOD_GSK3_1	47	54	PF00069	0.468
MOD_GSK3_1	506	513	PF00069	0.603
MOD_GSK3_1	663	670	PF00069	0.600
MOD_GSK3_1	688	695	PF00069	0.573
MOD_GSK3_1	759	766	PF00069	0.595
MOD_GSK3_1	767	774	PF00069	0.480
MOD_N-GLC_1	663	668	PF02516	0.544
MOD_NEK2_1	108	113	PF00069	0.410
MOD_NEK2_1	139	144	PF00069	0.499
MOD_NEK2_1	208	213	PF00069	0.677
MOD_NEK2_1	399	404	PF00069	0.489
MOD_NEK2_1	544	549	PF00069	0.552
MOD_NEK2_1	630	635	PF00069	0.560
MOD_NEK2_1	667	672	PF00069	0.569
MOD_NEK2_2	34	39	PF00069	0.487
MOD_PIKK_1	424	430	PF00454	0.558
MOD_PIKK_1	488	494	PF00454	0.484
MOD_PIKK_1	54	60	PF00454	0.486
MOD_PIKK_1	670	676	PF00454	0.480
MOD_PIKK_1	75	81	PF00454	0.556
MOD_PKA_2	100	106	PF00069	0.460
MOD_PKA_2	208	214	PF00069	0.613
MOD_PKA_2	279	285	PF00069	0.619
MOD_PKA_2	335	341	PF00069	0.612
MOD_PKA_2	494	500	PF00069	0.465
MOD_PKA_2	54	60	PF00069	0.502
MOD_PKA_2	747	753	PF00069	0.454
MOD_Plk_1	394	400	PF00069	0.513
MOD_Plk_1	475	481	PF00069	0.498
MOD_Plk_1	51	57	PF00069	0.473
MOD_Plk_1	510	516	PF00069	0.543
MOD_Plk_1	763	769	PF00069	0.540
MOD_Plk_2-3	468	474	PF00069	0.427
MOD_Plk_4	108	114	PF00069	0.411
MOD_Plk_4	311	317	PF00069	0.548
MOD_Plk_4	663	669	PF00069	0.562
MOD_ProDKin_1	635	641	PF00069	0.597
MOD_SUMO_rev_2	325	335	PF00179	0.543
TRG_DiLeu_BaEn_1	168	173	PF01217	0.559
TRG_DiLeu_BaEn_1	357	362	PF01217	0.501
TRG_DiLeu_BaEn_2	752	758	PF01217	0.438
TRG_DiLeu_LyEn_5	168	173	PF01217	0.559
TRG_ER_diArg_1	548	551	PF00400	0.510
TRG_ER_diArg_1	588	590	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L7	Leptomonas seymouri	35%	100%
A4HDA8	Leishmania braziliensis	71%	100%
A4I0P1	Leishmania infantum	99%	100%
E9AWP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QAT0	Leishmania major	89%	100%