DnaJ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICS4_LEIDO

TriTrypDb:

LdBPK_170510.1 , LdCL_170010600 , LDHU3_17.0800

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8ICS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.497
CLV_NRD_NRD_1	153	155	PF00675	0.526
CLV_NRD_NRD_1	238	240	PF00675	0.427
CLV_NRD_NRD_1	353	355	PF00675	0.387
CLV_NRD_NRD_1	54	56	PF00675	0.524
CLV_PCSK_KEX2_1	116	118	PF00082	0.496
CLV_PCSK_KEX2_1	152	154	PF00082	0.502
CLV_PCSK_KEX2_1	238	240	PF00082	0.401
CLV_PCSK_KEX2_1	353	355	PF00082	0.382
CLV_PCSK_KEX2_1	54	56	PF00082	0.524
CLV_PCSK_PC7_1	149	155	PF00082	0.503
CLV_PCSK_SKI1_1	349	353	PF00082	0.374
CLV_PCSK_SKI1_1	60	64	PF00082	0.462
CLV_PCSK_SKI1_1	97	101	PF00082	0.541
CLV_Separin_Metazoa	265	269	PF03568	0.582
DEG_SPOP_SBC_1	82	86	PF00917	0.765
DOC_CKS1_1	275	280	PF01111	0.586
DOC_CKS1_1	32	37	PF01111	0.167
DOC_PP2B_LxvP_1	101	104	PF13499	0.657
DOC_USP7_MATH_1	187	191	PF00917	0.490
DOC_USP7_MATH_1	336	340	PF00917	0.635
DOC_USP7_MATH_1	82	86	PF00917	0.765
DOC_USP7_MATH_1	89	93	PF00917	0.754
DOC_WW_Pin1_4	132	137	PF00397	0.730
DOC_WW_Pin1_4	230	235	PF00397	0.595
DOC_WW_Pin1_4	274	279	PF00397	0.578
DOC_WW_Pin1_4	31	36	PF00397	0.167
DOC_WW_Pin1_4	344	349	PF00397	0.590
DOC_WW_Pin1_4	74	79	PF00397	0.727
LIG_14-3-3_CanoR_1	116	126	PF00244	0.733
LIG_14-3-3_CanoR_1	241	251	PF00244	0.578
LIG_14-3-3_CanoR_1	268	273	PF00244	0.578
LIG_14-3-3_CanoR_1	40	47	PF00244	0.762
LIG_14-3-3_CanoR_1	97	102	PF00244	0.760
LIG_Actin_WH2_2	25	42	PF00022	0.167
LIG_BRCT_BRCA1_1	304	308	PF00533	0.379
LIG_deltaCOP1_diTrp_1	341	351	PF00928	0.595
LIG_FHA_1	189	195	PF00498	0.491
LIG_FHA_1	212	218	PF00498	0.474
LIG_FHA_1	61	67	PF00498	0.662
LIG_FHA_1	88	94	PF00498	0.721
LIG_FHA_2	141	147	PF00498	0.729
LIG_FHA_2	159	165	PF00498	0.742
LIG_LIR_Gen_1	279	287	PF02991	0.470
LIG_LIR_Gen_1	305	316	PF02991	0.386
LIG_LIR_Nem_3	237	243	PF02991	0.610
LIG_LIR_Nem_3	246	252	PF02991	0.576
LIG_LIR_Nem_3	279	284	PF02991	0.470
LIG_LIR_Nem_3	305	311	PF02991	0.383
LIG_MLH1_MIPbox_1	304	308	PF16413	0.434
LIG_NRBOX	312	318	PF00104	0.356
LIG_PAM2_1	14	26	PF00658	0.160
LIG_Pex14_2	250	254	PF04695	0.570
LIG_Pex14_2	296	300	PF04695	0.348
LIG_SH2_CRK	126	130	PF00017	0.690
LIG_SH2_CRK	240	244	PF00017	0.592
LIG_SH2_CRK	252	256	PF00017	0.559
LIG_SH2_NCK_1	227	231	PF00017	0.476
LIG_SH2_STAP1	332	336	PF00017	0.377
LIG_SH2_STAP1	340	344	PF00017	0.574
LIG_SH2_STAT5	249	252	PF00017	0.569
LIG_SH2_STAT5	291	294	PF00017	0.386
LIG_SH3_3	10	16	PF00018	0.332
LIG_SH3_3	29	35	PF00018	0.145
LIG_SUMO_SIM_anti_2	33	40	PF11976	0.414
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.690
LIG_TRAF2_1	142	145	PF00917	0.656
LIG_TYR_ITAM	224	243	PF00017	0.588
LIG_TYR_ITIM	196	201	PF00017	0.476
LIG_Vh1_VBS_1	302	320	PF01044	0.395
MOD_CDK_SPK_2	132	137	PF00069	0.773
MOD_CDK_SPK_2	344	349	PF00069	0.590
MOD_CK1_1	190	196	PF00069	0.507
MOD_CK1_1	30	36	PF00069	0.410
MOD_CK1_1	69	75	PF00069	0.706
MOD_CK1_1	77	83	PF00069	0.658
MOD_CK2_1	140	146	PF00069	0.733
MOD_CMANNOS	272	275	PF00535	0.380
MOD_GlcNHglycan	109	112	PF01048	0.497
MOD_GlcNHglycan	120	123	PF01048	0.437
MOD_GlcNHglycan	174	177	PF01048	0.515
MOD_GlcNHglycan	278	281	PF01048	0.472
MOD_GlcNHglycan	48	51	PF01048	0.562
MOD_GlcNHglycan	79	82	PF01048	0.490
MOD_GSK3_1	102	109	PF00069	0.695
MOD_GSK3_1	168	175	PF00069	0.741
MOD_GSK3_1	228	235	PF00069	0.472
MOD_GSK3_1	27	34	PF00069	0.368
MOD_GSK3_1	39	46	PF00069	0.729
MOD_GSK3_1	60	67	PF00069	0.759
MOD_GSK3_1	77	84	PF00069	0.691
MOD_NEK2_1	27	32	PF00069	0.440
MOD_NEK2_1	302	307	PF00069	0.355
MOD_NEK2_1	316	321	PF00069	0.249
MOD_NEK2_1	330	335	PF00069	0.309
MOD_NEK2_1	39	44	PF00069	0.741
MOD_NEK2_1	83	88	PF00069	0.699
MOD_PIKK_1	188	194	PF00454	0.554
MOD_PIKK_1	244	250	PF00454	0.582
MOD_PKA_1	152	158	PF00069	0.767
MOD_PKA_2	152	158	PF00069	0.723
MOD_PKA_2	39	45	PF00069	0.766
MOD_Plk_4	302	308	PF00069	0.374
MOD_Plk_4	316	322	PF00069	0.260
MOD_Plk_4	330	336	PF00069	0.238
MOD_Plk_4	89	95	PF00069	0.717
MOD_ProDKin_1	132	138	PF00069	0.731
MOD_ProDKin_1	230	236	PF00069	0.594
MOD_ProDKin_1	274	280	PF00069	0.574
MOD_ProDKin_1	31	37	PF00069	0.167
MOD_ProDKin_1	344	350	PF00069	0.585
MOD_ProDKin_1	74	80	PF00069	0.729
TRG_ENDOCYTIC_2	126	129	PF00928	0.693
TRG_ENDOCYTIC_2	198	201	PF00928	0.476
TRG_ENDOCYTIC_2	227	230	PF00928	0.464
TRG_ENDOCYTIC_2	240	243	PF00928	0.588
TRG_ENDOCYTIC_2	251	254	PF00928	0.566
TRG_ENDOCYTIC_2	297	300	PF00928	0.351
TRG_ENDOCYTIC_2	332	335	PF00928	0.329
TRG_ER_diArg_1	116	118	PF00400	0.695
TRG_ER_diArg_1	152	154	PF00400	0.707
TRG_ER_diArg_1	194	197	PF00400	0.476
TRG_ER_diArg_1	238	240	PF00400	0.627
TRG_ER_diArg_1	352	354	PF00400	0.586
TRG_ER_diArg_1	54	57	PF00400	0.716
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK95	Leptomonas seymouri	77%	100%
A0A0S4J1V7	Bodo saltans	58%	100%
A0A1X0NSX2	Trypanosomatidae	63%	100%
A0A3R7MRU2	Trypanosoma rangeli	67%	100%
A4H8Y9	Leishmania braziliensis	88%	100%
A4HXB9	Leishmania infantum	99%	100%
C9ZU12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AR15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%