RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICS1_LEIDO

TriTrypDb:

LdBPK_261040.1 , LdCL_260016000 , LDHU3_26.1320

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICS1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.626
CLV_NRD_NRD_1	221	223	PF00675	0.640
CLV_PCSK_KEX2_1	221	223	PF00082	0.640
CLV_PCSK_SKI1_1	133	137	PF00082	0.694
CLV_PCSK_SKI1_1	63	67	PF00082	0.267
DEG_COP1_1	13	23	PF00400	0.450
DEG_SCF_FBW7_2	284	291	PF00400	0.676
DOC_CKS1_1	285	290	PF01111	0.658
DOC_MAPK_HePTP_8	237	249	PF00069	0.482
DOC_MAPK_MEF2A_6	240	249	PF00069	0.502
DOC_USP7_MATH_1	248	252	PF00917	0.452
DOC_USP7_MATH_1	267	271	PF00917	0.569
DOC_USP7_MATH_1	294	298	PF00917	0.724
DOC_USP7_MATH_1	309	313	PF00917	0.759
DOC_USP7_MATH_1	48	52	PF00917	0.349
DOC_USP7_MATH_1	58	62	PF00917	0.434
DOC_USP7_MATH_1	84	88	PF00917	0.462
DOC_WW_Pin1_4	189	194	PF00397	0.618
DOC_WW_Pin1_4	265	270	PF00397	0.552
DOC_WW_Pin1_4	284	289	PF00397	0.675
DOC_WW_Pin1_4	3	8	PF00397	0.522
LIG_14-3-3_CanoR_1	30	38	PF00244	0.381
LIG_BRCT_BRCA1_1	131	135	PF00533	0.649
LIG_BRCT_BRCA1_1	68	72	PF00533	0.454
LIG_FHA_1	100	106	PF00498	0.516
LIG_FHA_1	19	25	PF00498	0.463
LIG_FHA_2	299	305	PF00498	0.659
LIG_FHA_2	4	10	PF00498	0.590
LIG_GSK3_LRP6_1	265	271	PF00069	0.553
LIG_LIR_Apic_2	79	83	PF02991	0.462
LIG_LIR_Gen_1	203	209	PF02991	0.482
LIG_LIR_Nem_3	246	252	PF02991	0.510
LIG_LIR_Nem_3	4	8	PF02991	0.521
LIG_LIR_Nem_3	51	56	PF02991	0.464
LIG_LIR_Nem_3	60	65	PF02991	0.458
LIG_PDZ_Class_3	323	328	PF00595	0.647
LIG_SH2_CRK	80	84	PF00017	0.462
LIG_SH2_STAP1	205	209	PF00017	0.519
LIG_SH2_STAT3	32	35	PF00017	0.384
LIG_SH2_STAT5	252	255	PF00017	0.511
LIG_SH2_STAT5	32	35	PF00017	0.384
LIG_SH2_STAT5	91	94	PF00017	0.504
LIG_SH3_1	261	267	PF00018	0.633
LIG_SH3_3	261	267	PF00018	0.734
LIG_SH3_3	52	58	PF00018	0.504
LIG_SUMO_SIM_par_1	112	118	PF11976	0.577
LIG_WRC_WIRS_1	2	7	PF05994	0.577
MOD_CK1_1	117	123	PF00069	0.597
MOD_CK1_1	171	177	PF00069	0.653
MOD_CK1_1	268	274	PF00069	0.699
MOD_CK2_1	298	304	PF00069	0.677
MOD_CK2_1	48	54	PF00069	0.333
MOD_GlcNHglycan	117	120	PF01048	0.642
MOD_GlcNHglycan	159	162	PF01048	0.779
MOD_GlcNHglycan	193	196	PF01048	0.704
MOD_GlcNHglycan	46	49	PF01048	0.461
MOD_GlcNHglycan	67	71	PF01048	0.259
MOD_GlcNHglycan	74	77	PF01048	0.265
MOD_GSK3_1	114	121	PF00069	0.560
MOD_GSK3_1	157	164	PF00069	0.663
MOD_GSK3_1	265	272	PF00069	0.663
MOD_GSK3_1	294	301	PF00069	0.710
MOD_GSK3_1	44	51	PF00069	0.467
MOD_GSK3_1	72	79	PF00069	0.462
MOD_N-GLC_1	171	176	PF02516	0.663
MOD_NEK2_1	1	6	PF00069	0.557
MOD_NEK2_1	115	120	PF00069	0.564
MOD_NEK2_1	136	141	PF00069	0.627
MOD_NEK2_1	276	281	PF00069	0.619
MOD_NEK2_1	72	77	PF00069	0.462
MOD_PIKK_1	136	142	PF00454	0.656
MOD_PIKK_1	164	170	PF00454	0.550
MOD_PIKK_1	31	37	PF00454	0.375
MOD_PKA_2	136	142	PF00069	0.624
MOD_PKA_2	157	163	PF00069	0.686
MOD_Plk_1	84	90	PF00069	0.498
MOD_Plk_4	248	254	PF00069	0.569
MOD_ProDKin_1	189	195	PF00069	0.616
MOD_ProDKin_1	265	271	PF00069	0.553
MOD_ProDKin_1	284	290	PF00069	0.677
MOD_ProDKin_1	3	9	PF00069	0.522
MOD_SUMO_for_1	49	52	PF00179	0.504
MOD_SUMO_rev_2	206	214	PF00179	0.616
TRG_ENDOCYTIC_2	205	208	PF00928	0.472
TRG_ENDOCYTIC_2	56	59	PF00928	0.471
TRG_ENDOCYTIC_2	62	65	PF00928	0.451
TRG_ER_diArg_1	220	222	PF00400	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I9	Leptomonas seymouri	59%	98%
A0A422NSU1	Trypanosoma rangeli	42%	100%
A4HEW2	Leishmania braziliensis	82%	100%
A4I235	Leishmania infantum	100%	100%
E9AY85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q988	Leishmania major	92%	100%